Drug Release Effect on Large-Clearance TiO2 Nanotube Arrays Decorated with P25 Nanoparticles
Large-clearance TiO2 nanotube arrays (LTAs) were synthesized by anodization, and evenly distributed P25 nanoparticles (P25 NPs) decorated on this were prepared by the hydrothermal treatment. The effect of P25 concentrations on the morphology of LATs was studied. LTAs decorated with P25 NPs (LTAs-P25) were loaded with ibuprofen (IBU), and the release properties were investigated. Interestingly, P25 NPs were successfully decorated on the surface of LTAs, with an optimal concentration of 1.2 × 10 − 3 M. The total amount of drug released from LTAs increased by 49.5% compared to that from TiO2 nanotube arrays without large clearance. LTAs-P25 provided a lower burst and longer release time.