scholarly journals Pemphigus Vulgaris in Old Patient

2021 ◽  
Vol 2021 ◽  
pp. 1-3
Author(s):  
Bassel Tarakji
Keyword(s):  
Differential Diagnosis ◽  
Autoimmune Disease ◽  
Oral Mucosa ◽  
Oral Prednisolone ◽  
Pemphigus Vulgaris ◽  
The Other ◽  
Oral Lesions ◽  
Oral Medicine ◽  
Mucous Membranes ◽  
Blistering Disease

Pemphigus vulgaris (PV) is a chronic, autoimmune, intraepidermal blistering disease of the skin and mucous membranes. The first clinical manifestation is often the development of intraoral lesions, and later, the lesions involve the other mucous membranes and skin. The etiological factors of this disease still remain unknown, although the presence of autoantibodies is consistent with an autoimmune disease. A 73-year-old man had bullous lesions on gingiva, oral mucosa first, then scalp, trunk, and face. An oral medicine specialist suspects the lesion in differential diagnosis in the first presentation of oral lesions and follows up the patient, and then these bullous lesions presented on the skin. In this article, a patient had received oral prednisolone (80 mg/kg/day) and azathioprine, then tapered oral prednisolone to 40 mg/day, with a reduction of 5 mg/day every three weeks. The patient shows remission of these lesions, and complication of this treatment includes osteoporosis, hyperglycemia, and hypertension.

scholarly journals Pemphigus Vulgaris Confined to the Gingiva: A Case Report

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Mitsuhiro Ohta ◽  
Seiko Osawa ◽  
Hiroyasu Endo ◽  
Kayo Kuyama ◽  
Hirotsugu Yamamoto ◽  
...  
Keyword(s):  
Case Report ◽  
Lichen Planus ◽  
Oral Mucosa ◽  
Pemphigus Vulgaris ◽  
Oral Lesions ◽  
Skin Involvement ◽  
Mucous Membranes ◽  
History Of ◽  
Blistering Disease ◽  
One Year

Pemphigus Vulgaris (PV) is an autoimmune intraepithelial blistering disease involving the skin and mucous membranes. Oral mucosa is frequently affected in patients with PV, and oral lesions may be the first sign of the disease in majority of patients. In some patients, oral lesions may also be followed by skin involvement. Therefore, timely recognition and therapy of oral lesions is critical as it may prevent skin involvement. Early oral lesions of PV are, however, often regarded as difficult to diagnose, since the initial oral lesions may be relatively nonspecific, manifesting as superficial erosions or ulcerations, and rarely presenting with the formation of intact bullae. Lesions may occur anywhere on the oral mucosa including gingiva; however; desquamtive gingivitis is less common with PV than other mucocutaneous conditions such as pemphigoid or lichen planus. This paper describes the case of a patient presenting with a one-year history of painful gingival, who is finally diagnosed as having PV.

scholarly journals MANIFESTASI DAN PENATALAKSANAAN PEMFIGUS VULGARIS DI RONGGA MULUT

2018 ◽  
Vol 2 (2) ◽  
pp. 117-124
Author(s):  
Indra Gunawan ◽  
Riani Setiadhi
Keyword(s):  
Case Report ◽  
Early Recognition ◽  
Pemphigus Vulgaris ◽  
Oral Lesions ◽  
Oral Manifestations ◽  
Skin Involvement ◽  
Mucous Membranes ◽  
Blistering Disease ◽  
Mouth Wash ◽  
Desmoglein 3

Background : Pemphigus Vulgaris (PV) is an autoimmune intraepithelial blistering disease involving the skin and mucous membranes. Oral lesions could be the first sign of the disease followed by the involvement of skin and other mucosa sites.Objectives : This is oral manifestations of pemphigus vulgaris case report, intended to help clinicians to recognize and treat the oral lesions.Case Reported : Male 27 yo admitted to RSUP Dr.Hasan Sadikin hospital with multiple blisters on the skin and oral mucosa, was diagnosed with Pemphigus Vulgaris.Case Management : Patient was treated with steroid mouth wash and oral paste. After two months of treatment, the patient was fully recovered from oral lesion.Discussion : In PV, autoantibodies are produced against desmosomes spesifically desmoglein 3 which responsible for holding the cells of the epithelium together. The loss of adhesive function due to anti Dsg 3 antibodies result in bulla formation on the oral mucosa.The aetiology for PV is still uncertain. Conclusion :Early recognition and treatment of oral lesions is important as it may prevent skin involvement. Early treatment, patient’s compliance and multi disciplinal teamwork ensure the treatment succes for this disease

Sweet Syndrome and Pemphigus Vulgaris

2012 ◽  
Vol 16 (2) ◽  
pp. 128-130 ◽  
Author(s):  
Ashley O'toole ◽  
Maureen O'malley
Keyword(s):  
Clinical Presentation ◽  
Pemphigus Vulgaris ◽  
Neutrophilic Dermatosis ◽  
Rare Presentation ◽  
Sweet Syndrome ◽  
Autoimmune Blistering Disease ◽  
Mucous Membranes ◽  
Blistering Disease ◽  
Erythematous Plaques ◽  
New Onset

Background: Pemphigus vulgaris is an autoimmune blistering disease of the skin and mucous membranes. Sweet syndrome is an uncommon reactive neutrophilic dermatosis. Objective: This case report describes the rare presentation of a 58-year-old female patient with newly diagnosed pemphigus vulgaris who later presented with erythematous plaques and leukocytosis highly suggestive of Sweet syndrome. Methods: Review of the literature using the PubMed and Medline databases. Results: The clinical presentation of new-onset Sweet syndrome in a patient with pemphigus has been reported in the literature only on one other occasion. Conclusion: The observation of an association between Sweet syndrome and autoimmune diseases, such as pemphigus vulgaris, may ultimately lead to better understanding of the pathophysiology of this disease.

scholarly journals Recurrent Oral Eosinophilic Ulcers of the Oral Mucosa. A Case Report

2018 ◽  
Vol 12 (1) ◽  
pp. 19-23
Author(s):  
Norberto Sugaya ◽  
Fernanda Martignago ◽  
Decio Pinto ◽  
Dante Migliari
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Autoimmune Disease ◽  
Oral Mucosa ◽  
White Woman ◽  
Recurrent Aphthous Stomatitis ◽  
Incisional Biopsy ◽  
Oral Herpes ◽  
Main Culprit ◽  
Proper Diagnosis

Objective: This article describes a case of an Oral Eosinophilic Ulcer (OEU) in an otherwise healthy 31-year-old white woman. Introduction: The importance of reporting this case was the presence of recurrent episodes with lesions appearing in different areas of the oral mucosa, a type of manifestation not commonly associated with this disease. A typical manifestation of OEU occurs as a single ulceration that goes into healing after an incisional biopsy, a procedure usually required for a proper diagnosis of the disease. In spite of trauma being suggested as the main culprit of OEU, the exact pathogenesis mechanism of this disease remains controversial. Case report: The pattern of the present case contradicts the usually common course of the disease, as the patient had experienced many recurrent episodes for almost 2.5 years, with the recurrences occurring even after biopsies performed during some of the relapses. Differential diagnosis included recurrent aphthous stomatitis, recurrent intra-oral herpes, autoimmune disease, Crohn’s disease and malignancy. Conclusion: Fortunately, the patient has been free of any recurrences for 1.5 years since the last biopsy was taken at the time she came to our clinic seeking treatment.

scholarly journals Amalgam Tattoo Mimicking Mucosal Melanoma: A Diagnostic Dilemma Revisited

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
K. Lundin ◽  
G. Schmidt ◽  
C. Bonde
Keyword(s):  
Differential Diagnosis ◽  
Oral Cavity ◽  
Oral Mucosa ◽  
Mucosal Melanoma ◽  
The Other ◽  
Case Vignette ◽  
Diagnostic Dilemma ◽  
Dental Restorations

Mucosal melanoma of the oral cavity is a rare but highly aggressive neoplasm. However, the clinicians need to be aware of the other and more frequent etiologies of intraoral pigmentation, such as amalgam tattoos. As amalgam has been extensively used for dental restorations and can cause pigmentations in the oral mucosa, this is a differential diagnosis not to be forgotten. We describe the characteristics of these two phenomena and present a case vignette illustrating the differential diagnostic issues. Other causes of intraoral pigmentation are summarized.

scholarly journals PÊNFIGO VULGAR A IMPORTÂNCIA DO CONHECIMENTO DO CIRURGIÃO DENTISTA PARA UM CORRETO DIAGNÓSTICO

2015 ◽  
Vol 5 (3) ◽  
Author(s):  
Deyvid Silva Rebouças ◽  
Lucas Souza Cerqueira ◽  
Tila Fortuna Costa ◽  
Thaise Gomes Ferreira ◽  
Roberta Catapano Naves ◽  
...  
Keyword(s):  
Autoimmune Disease ◽  
Early Diagnosis ◽  
Autoimmune Diseases ◽  
Female Patient ◽  
Clinical Case ◽  
Pemphigus Vulgaris ◽  
Primary Role ◽  
Oral Manifestations ◽  
Early Stages ◽  
Mucous Membranes

Pemphigus is the general name for a group of rare autoimmune diseases that affect the skin and mucous membranes and is presented with the formation of intraepidermal blisters. Pemphigus vulgaris (PV) is a chronic rare vesicular-bullous autoimmune disease that when not diagnosed and treated in its early stages has severe prognosis. This study aims to report a clinical case of a female patient, 32 years of age who had manifestation of pemphigus vulgaris. The oral manifestations are, in most cases, the first signs of the disease and the dentist has a primary role in the early diagnosis.

Differential Diagnosis of Superficial Ulcerations of the Oral Mucosa

1979 ◽  
Vol 87 (6) ◽  
pp. 734-740 ◽  
Author(s):  
Richard A. Chole ◽  
George H. Domb
Keyword(s):  
Differential Diagnosis ◽  
Oral Mucosa ◽  
Verrucous Carcinoma ◽  
Pemphigus Vulgaris ◽  
The Body ◽  
Stevens Johnson Syndrome ◽  
Mucous Membrane Pemphigoid ◽  
Diagnostic Challenge ◽  
Johnson Syndrome ◽  
Herpetic Gingivostomatitis

Superficial ulcerations of the oral mucosa often present a diagnostic challenge to the physician because of the similarity of one ulcer to another. A diagnosis is made by the analysis of multiple factors, including the lesion's location, size, grouping, onset, patient's age, involvement of other systems of the body, and course of the disease. The histopathology of the lesion may be specific, especially in certain potentially fatal diseases. This paper presents the means for the differential diagnosis of a variety of superficial ulcers of the oral mucosa: varicella, herpangina, recurrent aphthous stomatitis, Behcet's disease, Stevens-Johnson syndrome, traumatic ulcer, verrucous carcinoma, primary herpetic gingivostomatitis, recurrent herpetic stomatitis, pemphigus vulgaris, and benign mucous membrane pemphigoid.

scholarly journals A localized non-healing ulcer: an unusual clinical presentation of pemphigus vulgaris

2020 ◽  
Vol 6 (3) ◽  
pp. 413
Author(s):  
Sukhmani K. Brar ◽  
Gauri N. Bhale ◽  
Balvinder K. Brar
Keyword(s):  
Differential Diagnosis ◽  
Inflammatory Infiltrate ◽  
Clinical Presentation ◽  
Topical Steroid ◽  
Oral Prednisolone ◽  
Pemphigus Vulgaris ◽  
Healing Ulcer ◽  
Lupus Vulgaris ◽  
Recurrent Herpes ◽  
One Year

<p>Pemphigus vulgaris is an autoimmune blistering disorder commonly involving oral mucosa and skin<strong> </strong>with characteristic acantholysis that results in formation of fluid filled blisters and painful erosions. Herein we report a case distinguished by its unusual clinical presentation.<strong> </strong>A twenty-five year old man, presented to our outpatient department of dermatology, complaining of ulcer on   forehead in the last one year. Examination revealed single ulcer covered with crust on right side of forehead.  Clinically lupus vulgaris, pyoderma gangrenosum, recurrent herpes simplex, leishmaniasis and pemphigus vulgaris were kept as differential diagnosis. Tzanck smear revealed multiple acantholytic cells and mild neutrophilic inflammatory infiltrate. Histological examination of biopsy sample showed suprabasal clefting, acantholytic cells and mild perivascular dermal lymphocytic infiltrate. Features were suggestive of pemphigus vulgaris. Significant improvement   occurred after three months of treatment with oral prednisolone, azathioprine and topical steroid. Although oral and skin involve­ment is common, in the form of flaccid blisters and erosions, but non healing ulcer is unusual. This may represent a period of limited activity during this chronic disease. There is paucity of data in literature regarding this. So, this<strong> </strong>case report highlights a, perhaps unique, clinical presentation of this autoimmune disease.<strong></strong></p>

scholarly journals Management of pemphigus vulgaris: case report

MEDISAINS ◽  
2021 ◽  
Vol 19 (2) ◽  
pp. 56
Author(s):  
Widi Rahmaningsih ◽  
Agus Santosa
Keyword(s):  
Case Report ◽  
Autoimmune Disease ◽  
Rare Disease ◽  
General Hospital ◽  
Wound Care ◽  
Epidemiological Data ◽  
Pemphigus Vulgaris ◽  
Nursing Management ◽  
Central Java ◽  
Mucous Membranes

Background: Pemphigus Vulgaris is an autoimmune disease attacking the skin and mucous membranes. This disease is considered a rare disease. Epidemiological data for Pemphigus Vulgaris in Indonesia remains limited, correspondingly, nursing management in this disease. This study aims to describe nursing management in patients with Pemphigus Vulgaris.Case presentation: a case of Pemphigus Vulgaris in a 28-year-old male was reported, with complaints of blisters all over his body appearing since 2019 and have not been completely recovered at the Banyumas General Hospital, Central Java, Indonesia.Conclusion: A combination of wound care, nutrition, vitamins, and pharmacology can accelerate the recovery of patients with Pemphigus Vulgaris

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