scholarly journals Relationship between Urinary AD7c-NTP with Cerebral Microbleeds Based on APOE Genotype

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Yong-peng Yu ◽  
Ya-li Zheng
Keyword(s):  
Standard Deviation ◽  
Cerebral Infarction ◽  
Apolipoprotein E ◽  
Enzyme Immunoassay ◽  
Odds Ratio ◽  
Apoe Genotype ◽  
Cerebral Microbleeds ◽  
Human Enzyme ◽  
Ε4 Allele ◽  
Apoe Genotypes

Objective. This study was performed to investigate the association between urinary Alzheimer-associated neuronal thread protein (AD7c-NTP) with cerebral microbleeds (CMBs) based on the apolipoprotein E (APOE) genotypes. Methods. A total of 471 patients with acute cerebral infarction screened by magnetic sensitive imaging were enrolled in this study. Among them, twenty-seven cases of mixed CMBs were excluded. A total of 444 patients were divided into two groups according to the presence or absence of CMBs: CMBs group ( n = 92 ) and noncerebral microbleeds group (nCMBs) ( n = 352 ). Urine AD7c-NTP levels were measured using a human enzyme immunoassay kit. Results. In patients with lobar CMBs, there was an interaction between urine AD7c-NTP levels and APOE genotypes ( p = 0.01 ). In patients with APOE ε3/ε3 allele, the odds ratio of lobar CMBs per standard deviation of urinary AD7c-NTP levels was 0.92 (95% CI: 0.70-1.19). In patients with APOE ε2+ or ε4+ allele, the multivariate-corrected odds ratio of lobar CMBs per standard deviation of urinary AD7c-NTP levels was 2.95 (95% CI: 1.38-6.27). Conclusion. A higher level of urinary AD7c-NTP is involved in lobar CMBs, not deep CMBs.

scholarly journals Influence of brain-derived neurotrophic factor and apolipoprotein E genetic variants on hemispheric and lateral ventricular volume of young healthy adults

2011 ◽  
Vol 23 (3) ◽  
pp. 132-138 ◽  
Author(s):  
Christos Sidiropoulos ◽  
Kourosh Jafari-Khouzani ◽  
Hamid Soltanian-Zadeh ◽  
Panayiotis Mitsias ◽  
Panagiotis Alexopoulos ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Neurotrophic Factor ◽  
Late Onset ◽  
Apoe Genotype ◽  
Ventricular Volume ◽  
Brain Derived Neurotrophic Factor ◽  
Healthy Adults ◽  
Ventricular Volumes ◽  
Neuronal Processes ◽  
Apoe Genotypes

Objective: Brain-derived neurotrophic factor (BDNF) and apolipoprotein E (ApoE) are thought to be implicated in a variety of neuronal processes, including cell growth, resilience to noxious stimuli and synaptic plasticity. A Val to Met substitution at codon 66 in the BDNF protein has been associated with a variety of neuropsychiatric conditions. The ApoE4 allele is considered a risk factor for late-onset Alzheimer's disease, but its effects on young adults are less clear. We sought to investigate the effects of those two polymorphisms on hemispheric and lateral ventricular volumes of young healthy adults.Methods: Hemispheric and lateral ventricular volumes of 144 healthy individuals, aged 19–35 years, were measured using high resolution magnetic resonance imaging and data were correlated with BDNF and ApoE genotypes.Results: There were no correlations between BDNF or ApoE genotype and hemispheric or lateral ventricular volumes.Conclusion: These findings indicate that it is unlikely that either the BDNF Val66Met or ApoE polymorphisms exert any significant effect on hemispheric or lateral ventricular volume. However, confounding epistatic genetic effects as well as relative insensitivity of the volumetric methods used cannot be ruled out. Further imaging analyses are warranted to better define any genetic influence of the BDNF Val6Met and ApoE polymorphism on brain structure of young healthy adults.

scholarly journals Associations between depression, sleep disturbance, and apolipoprotein E in the development of Alzheimer's disease: dementia

2016 ◽  
Vol 28 (9) ◽  
pp. 1409-1424 ◽  
Author(s):  
Shanna L. Burke ◽  
Peter Maramaldi ◽  
Tamara Cadet ◽  
Walter Kukull
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Apolipoprotein E ◽  
Sleep Disturbance ◽  
Reference Group ◽  
Synergistic Effects ◽  
Apoe Genotype ◽  
The Elderly ◽  
Prodromal Symptom ◽  
Apoe Genotypes

ABSTRACTBackground:Alzheimer's disease (AD) is a neurodegenerative brain disease that causes cognitive impairment and dementia. Within the US, AD is the most common form of dementia in the elderly, affecting 1 in 10 people over the age of 65. Sleep disturbance has been called a “public health epidemic” and, like depression, is a prodromal symptom of AD but may also contribute to the risk of developing AD. It was hypothesized that sleep disturbance, depression, and the apolipoprotein E (APOE) genotype increase the likelihood of AD.Methods:Utilizing data from the National Alzheimer's Coordinating Center, information from evaluations of 11,453 cognitively asymptomatic participants was analyzed. Survival analysis was used to explore the independent relationships between depression, sleep disturbance, and APOE genotypes with eventual AD diagnosis. Cox proportional hazard models were utilized to explore the main effects and synergistic effects of psychosocial factors as moderated by APOE genotypes.Results:This study reinforced the association between APOE and AD. The hazard of developing AD was eight times higher for those with recent depression and the Ɛ4 homozygote (HR = 8.15 [3.70–17.95]). Among Ɛ4 carriers with clinician-verified depression, the hazard was ten times that of the reference group (HR = 10.11 [4.43–23.09]). The hazard for Ɛ4 carriers reporting sleep disturbance was almost 7 times greater than the reference group (HR = 6.79 [2.38–19.37]).Conclusion:Findings suggest that sleep disturbance, depression, and APOE Ɛ4 genotype are associated with AD during follow-up evaluations among a group of initially cognitively asymptomatic participants. This study contributes to the literature base exploring an increased hazard or risk of AD due to potential modifiable risk factors as well as genetic biomarkers, such as APOE.

scholarly journals Genetic Variation of Apolipoprotein E (ApoE) in Surabaya, Palu and Alor Populations of Indonesia

2015 ◽  
Vol 16 (2) ◽  
pp. 118
Author(s):  
Pramudji Hastuti ◽  
Abdul Salam Mudzakir Sofro ◽  
Ahmad Husain Asdie ◽  
Ahmad Hamim Sadewa
Keyword(s):  
Genetic Variation ◽  
Apolipoprotein E ◽  
Fragment Length Polymorphism ◽  
Chain Reaction ◽  
Lipoprotein Level ◽  
Ε4 Allele ◽  
The Common ◽  
Polymerase Chain ◽  
Apoe Genotypes ◽  
Apparently Healthy

Apolipoprotein E (ApoE) has been considered to play an important role in cardiovascular disorders.Several studies reported that genetic variation in ApoE locus influence plasma lipoprotein level. The objectivesof this study was to compare the frequency of ApoE genotypes and alleles in some populations of Indonesia.One hundred and ninety five voluntarily unrelated apparently healthy individuals were recruited fromSurabaya, Palu and Alor representing the western, middle and eastern populations of Indonesia, respectively.Blood samples were collected from each subject for DNA extraction. The common allelic variants of ApoE werescreened using polymerase chain reaction (PCR) and restriction fragment length polymorphism. Three allelesi.e. ε2, ε3 and ε4 were identified and five genotypes i.e. ApoE ε2/ε2, ApoE ε2/ε3, ApoE ε3/ε3, ApoE ε2/ε4, ApoE ε3/ε4 were found in three populations studied, while ApoE ε4/ε4 was absent in Surabaya, representing the westernpopulations of Indonesia. The frequency of ε2, ε3 and ε4 alleles in the western population were 0.208, 0.701and 0.092 respectively; in the middle population were 0.242, 0.618 and 0.140 respectively and in the easternpopulation of Indonesia were 0.267, 0.466 and 0.267 respectively. The highest frequency of ε2 and ε4 allelewas found in the eastern population of Indonesia. The distribution of ε2 allele were not significantly differentamong all Indonesian populations, but significantly different were found in ε3 and ε4 allele in the easternpopulation compared to those in the western and middle populations of Indonesian. It can be concluded thatthe frequency of three ApoE alleles in the western and middle populations of Indonesia was not significantlydifferent however, significantly different was observed in the frequency of ApoE ε3 and ε4 alleles from theeastern compared to those in the western and middle populations of Indonesia.

scholarly journals Association of ApoE Gene Polymorphisms With Cardio-cerebrovascular Complications in Type 2 Diabetes Mellitus in the Chinese Population

2021 ◽  
Author(s):  
Lulu Kong ◽  
Yinting Gao ◽  
Wei Li ◽  
Bimin Shi
Keyword(s):  
Type 2 Diabetes ◽  
Carotid Plaque ◽  
Apoe Genotype ◽  
Apoe Gene ◽  
Control Group ◽  
Case Group ◽  
Cerebrovascular Complications ◽  
Ε4 Allele ◽  
Apoe Genotypes

Abstract Objective To analyze and study the relationship between ApoE gene polymorphism and cardio-cerebrovascular complications in type 2 diabetes mellitus(T2DM) in the Chinese Population.Methods From January 2018 to January 2019, 1140 patients with type 2 diabetes admitted to the Department of Endocrinology, the Affiliated Hospital of Xuzhou Medical University were selected as the case group, including 590 patients with coronary heart disease(CHD) and 550 patients with cerebral infarction(CI), and 1198 patients with type 2 diabetes without complications during the same period were selected as the control group. General baseline data of the two groups were collected, such as gender, age, course of disease, lipid profile, HbA1C, BMI, blood pressure, carotid plaque and complications. ApoE genotypes were identified in all participants who participated in the study.Results This study showed that the ApoE genotypes in both the case group and the control group had the highest frequency of E3/E3. The E3/E4 genotype frequency and ε4 allele frequency in the case group were higher than those in the control group (P<0.05). In the case group, the frequency of E2/E3 and E3/E4 genotypes of CI group was lower than that of CHD group, while the frequency of E3/E3 genotype was higher than that of CHD group. TC and LDL-c levels were significantly increased in patients with ApoE E3/E4 genotype(P<0.05). ApoE genotype E3/E4 was more associated with carotid plaque than E2/E3. ApoE genotype and ApoE allele were positively correlated with TC and LDL-c levels (P<0.05).Logistic regression results show that carotid plaque, diabetes duration and ApoE E3/E4 genotype are independent risk factors of cardio-cerebrovascular complications of T2DM(P< 0.05). ApoE E3/E4 genotype and allele ε4 may be risk factors for T2DM patients with cardio-cerebrovascular complications.Conclusion ApoE E3/E4 genotypes and T2DM patients carrying ε4 allele have a higher risk of cardio-cerebrovascular complications than other genotypes. ApoE ε2 allele has a certain protective effect , however ε4 allele may be a risk factor for cardio-cerebrovascular complications in T2DM patients, and its mechanism may be related to the effect of ApoE gene on lipid metabolism.

scholarly journals The Apolipoprotein E ε4 Allele Increases the Odds of Chronic Cerebral Infarction Detected at Autopsy in Older Persons

Stroke ◽  
2005 ◽  
Vol 36 (5) ◽  
pp. 954-959 ◽  
Author(s):  
J.A. Schneider ◽  
J.L. Bienias ◽  
R.S. Wilson ◽  
E. Berry-Kravis ◽  
D.A. Evans ◽  
...  
Keyword(s):  
Cerebral Infarction ◽  
Apolipoprotein E ◽  
Older Persons ◽  
Ε4 Allele

Dementia, asymmetry of temporal lobe structures, and Apolipoprotein E genotype: Relationships to cerebral atrophy and neuropsychological impairment

2002 ◽  
Vol 8 (7) ◽  
pp. 925-933 ◽  
Author(s):  
ERIN D. BIGLER ◽  
DAVID F. TATE ◽  
MICHAEL J. MILLER ◽  
SARA A. RICE ◽  
CORY D. HESSEL ◽  
...  
Keyword(s):  
Temporal Lobe ◽  
Apoe Genotype ◽  
Cerebral Atrophy ◽  
Hippocampal Volume ◽  
Neuropsychological Performance ◽  
Intracranial Volume ◽  
Risk Effect ◽  
Ε4 Allele ◽  
The Right ◽  
Apoe Genotypes

We examined asymmetry of hippocampal volume as well as other temporal lobe structures (temporal lobe, temporal horn of the lateral ventricular system, parahippocampal and fusiform gyri) in 194 subjects from the Cache County, Utah study, with varying disorders [85 with Alzheimer's disease (AD), 59 with some cognitive or neuropsychiatric disorder—referenced as a Mixed Neuropsychiatric group, 30 with mild ambiguous/mild cognitive impairment (MA/MCI) and 20 controls] and APOE genotypes. Asymmetry was determined by subtracting left-side volume from the right corrected by total intracranial volume. No significant asymmetry was observed to be associated with presence of the ε4 allele. Since the AD-ε4 allele risk effect may be expressed early in the course of the disorder, we also examined asymmetry indices in AD, MA/MCI and Mixed Neuropsychiatric subjects early in the course of their disorder (2 years or less) to those with longer duration illness (greater than 2 years). We observed a leftward asymmetry (i.e., left side larger) regardless of APOE genotype in hippocampal volume where both AD and MCI subjects demonstrated a leftward shift in hippocampal size when length of disease (LOD) was less but not more than 2 years. Leftward asymmetry was not associated with LOD in the Mixed Neuropsychiatric group. These findings do not support an association between ε4 and hippocampal asymmetry in dementia. We also examined whether asymmetry influenced neuropsychological performance, but minimal effects were observed. Where significance or strong trends were observed, better neuropsychological performance was associated with larger parenchymal volume of temporal lobe structures. These findings were interpreted as representing cognitive reserve effects where larger volume was protective against impairment. The role of asymmetry research in understanding neuropsychological performance in dementia is discussed. (JINS, 2002, 8, 925–933.)

scholarly journals Apolipoprotein E polymorphism and functional disability in Brazilian elders: the Bambuí Health and Aging Study

2016 ◽  
Vol 32 (2) ◽  
Author(s):  
Rodrigo Zunzarren Megale ◽  
◽  
Antônio Ignácio de Loyola Filho ◽  
Josélia Oliveira Araújo Firmo ◽  
Maria Fernanda Lima-Costa ◽  
...  
Keyword(s):  
Activities Of Daily Living ◽  
Apolipoprotein E ◽  
Daily Living ◽  
Functional Disability ◽  
Functional Performance ◽  
Apoe Genotype ◽  
Thrifty Gene ◽  
Aging Study ◽  
Apolipoprotein E Polymorphism ◽  
Ε4 Allele

Abstract Numerous studies have associated the apolipoprotein E (apoE) ε4 allele with worse health status, but few have assessed the existence of genotype-dependent variations in functional performance. Among participants in the Bambuí Health and Aging Study, Minas Gerais State, Brazil, 1,408 elderly underwent apoE genotyping. Functionality was assessed with a questionnaire, and individuals were classified as dependent in basic activities of daily living (BADLs), instrumental activities of daily living (IADLs), and mobility. The association between apoE genotype and functional status was assessed by logistic regression, taking confounding factors into account. Presence of ε4 allele was associated with lower odds of mobility deficit (OR = 0.65; 95%CI: 0.47-0.92) in the adjusted analysis. There were no significant differences in relation to presence of dependency in BADLs and IADLs. The reasons are not entirely understood, but they may involve the role of ε4 allele as a “thrifty gene” in a sample exposed to high risk of infectious and nutritional diseases in the past.

scholarly journals The association of apolipoprotein-E (APOE) gene polymorphisms with coronary artery disease: a systematic review and meta-analysis

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Sana Ashiq ◽  
Kanwal Ashiq
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Apolipoprotein E ◽  
Odds Ratio ◽  
English Language ◽  
Meta Analysis ◽  
Final Analysis ◽  
Ε4 Allele ◽  
Artery Disease

Abstract Background Numerous studies have investigated the role of apolipoprotein E (APOE) polymorphisms in coronary artery disease (CAD), but some controversies exist regarding the outcomes as the results were not consistent and remain uncertain. Therefore, the present meta-analysis was conducted to evaluate the association of APOE polymorphisms with coronary artery disease. Methods All the relevant studies published in English language till August 2020 were identified by searching through various electronic databases. The complete data was independently extracted by the two researchers. The data were analyzed by using the Comprehensive Meta-Analysis program and MetaGenyo program. The pooled odds ratio was used to check the associations between CAD and APOE polymorphisms. The following genetic models were used to calculate the odds ratio: ε2 vs. ε3 and ε4 vs. ε3. Results In the final analysis, we include 12 studies regarding the role of APOE polymorphism in CAD. The pooled odds ratio for ε4 allele was higher (OR 2.00; 95% and CI, 1.48–2.71). There is no statistical significant association for ε2 allele with CAD (OR 1.38; 95% CI, 1.18–1.62). This analysis showed no publication bias exists in the current meta-analysis. Conclusions Our findings suggest that the apolipoprotein ε4 allele appears as a significant genetic risk factor for coronary artery disease while the ε2 allele is beneficial to alleviate the CAD risk. Trial registration Registered with PROSPERO International Prospective Register of Systematic Reviews. PROSPERO registration number CRD42020190464

Lack of association between the apolipoprotein E gene and aneurysmal subarachnoid hemorrhage in an Italian population

2007 ◽  
Vol 106 (2) ◽  
pp. 245-249 ◽  
Author(s):  
Marco Fontanella ◽  
Innocenzo Rainero ◽  
Salvatore Gallone ◽  
Elisa Rubino ◽  
Chiara Rivoiro ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Apolipoprotein E ◽  
Clinical Characteristics ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
Apoe Genotype ◽  
Italian Population ◽  
Genotype Frequencies ◽  
Apolipoprotein E Gene ◽  
Disease Modifier ◽  
Apoe Genotypes

Object The results of genome-wide scan studies have suggested the presence of a genetic risk factor for aneurysmal subarachnoid hemorrhage (SAH) on chromosome 19 (at 19p13). The apolipoprotein E (APOE) gene is located in this chromosomal region and encodes a protein that exerts several neuroprotective and neurotrophic functions in the brain. The purpose of this study was to evaluate whether a particular allele or genotype of the APOE gene would modify the occurrence or the clinical features of SAH. Methods Genomic DNA was extracted from 146 patients with aneurysmal SAH and 222 age- and sex-matched healthy controls and genotyped for the triallelic polymorphism of the APOE gene (ε2, ε3, and ε4). Allele and genotype frequencies were compared between patients and controls. The clinical characteristics of the disease were compared according to the different APOE genotypes. Allele and genotype frequencies of the APOE gene polymorphism were nearly identical in cases and controls. Patients carrying the APOE ε4 allele had a significantly higher Hunt and Hess grade on admission (p = 0.0014). There was no significant relationship between any of the other clinical characteristics and the APOE genotype. Conclusions The authors’ data do not support the hypothesis that genetic variations within the APOE gene are associated with aneurysmal SAH. However, the APOE gene influences the disease phenotype and may be regarded as a disease modifier gene.

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