scholarly journals Deep Learning-Based Diagnosis Method of Emergency Colorectal Pathology

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Chen Wang ◽  
Ning Zhang
Keyword(s):  
Colorectal Cancer ◽  
Diagnostic Accuracy ◽  
Malignant Tumors ◽  
Network Models ◽  
Texture Features ◽  
Pathological Diagnosis ◽  
Data Sets ◽  
Deep Convolutional Neural Networks ◽  
Diagnosis Method ◽  
Diagnosis Model

One of the most common malignant tumors of the digestive tract is emergency colorectal cancer. In recent years, both morbidity and mortality rates, particularly in our country, are getting higher and higher. At present, diagnosis of colorectal cancer, specifically in the emergency department of a hospital, is based on the doctor's pathological diagnosis, and it is heavily dependent on the doctor's clinical experience. The doctor's workload is heavy, and misdiagnosis events occur from time to time. Therefore, computer-aided diagnosis technology is desperately needed for colorectal pathological images to assist pathologists in reducing their workload, improve the efficiency of diagnosis, and eliminate misdiagnosis. To address these issues, a gland segmentation of emergency colorectal pathology images and diagnosis of benign and malignant pathology is presented in this paper. Initially, a multifeatured auxiliary diagnosis is designed to enable diagnosis of benign and malignant diagnosis of emergency colorectal pathology. The proposed algorithm constructs an SVM-enabled pathological diagnosis model which is based on contour, color, and texture features. Additionally, their combination is used for pathological benign and malignant pathological diagnosis of two types of data sets D1 (original pathological image dataset) and D2 (dataset that has undergone glandular segmentation) diagnosis. Experimental results show that the proposed pathological diagnosis model has higher diagnostic accuracy on D2. Among these datasets, SVM based on the multifeature fusion of contour and texture achieved the highest diagnostic accuracy rate, i.e., 83.75%, which confirms that traditional image processing methods have limitations. Diagnosing benign and malignant colorectal pathology in an emergency is more difficult and must be treated on a priority basis. Finally, an emergency colorectal pathology diagnosis method, which is based on deep convolutional neural networks such as CIFAR and VGG, is proposed. After configuring and training process of the two networks, trained CIFAR and VGG network models are applied to the diagnosis of both datasets, i.e., D1 and D2, respectively.

scholarly journals Two Ensemble-CNN Approaches for Colorectal Cancer Tissue Type Classification

2021 ◽  
Vol 7 (3) ◽  
pp. 51
Author(s):  
Emanuela Paladini ◽  
Edoardo Vantaggiato ◽  
Fares Bougourzi ◽  
Cosimo Distante ◽  
Abdenour Hadid ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Deep Learning ◽  
Digital Pathology ◽  
Texture Features ◽  
Tissue Type ◽  
Cancer Tissue ◽  
Learning Methods ◽  
Feature Based ◽  
Type Classification ◽  
Whole Slide Images

In recent years, automatic tissue phenotyping has attracted increasing interest in the Digital Pathology (DP) field. For Colorectal Cancer (CRC), tissue phenotyping can diagnose the cancer and differentiate between different cancer grades. The development of Whole Slide Images (WSIs) has provided the required data for creating automatic tissue phenotyping systems. In this paper, we study different hand-crafted feature-based and deep learning methods using two popular multi-classes CRC-tissue-type databases: Kather-CRC-2016 and CRC-TP. For the hand-crafted features, we use two texture descriptors (LPQ and BSIF) and their combination. In addition, two classifiers are used (SVM and NN) to classify the texture features into distinct CRC tissue types. For the deep learning methods, we evaluate four Convolutional Neural Network (CNN) architectures (ResNet-101, ResNeXt-50, Inception-v3, and DenseNet-161). Moreover, we propose two Ensemble CNN approaches: Mean-Ensemble-CNN and NN-Ensemble-CNN. The experimental results show that the proposed approaches outperformed the hand-crafted feature-based methods, CNN architectures and the state-of-the-art methods in both databases.

Lung nodule classification using combination of CNN, second and higher order texture features

2021 ◽  
pp. 1-9
Author(s):  
Amrita Naik ◽  
Damodar Reddy Edla
Keyword(s):  
Malignant Tumors ◽  
Early Stage ◽  
Lung Nodule ◽  
Texture Features ◽  
Svm Classifier ◽  
Softmax Classifier ◽  
Spatial Features ◽  
High Level ◽  
Learning Architectures ◽  
Nodule Classification

Lung cancer is the most common cancer throughout the world and identification of malignant tumors at an early stage is needed for diagnosis and treatment of patient thus avoiding the progression to a later stage. In recent times, deep learning architectures such as CNN have shown promising results in effectively identifying malignant tumors in CT scans. In this paper, we combine the CNN features with texture features such as Haralick and Gray level run length matrix features to gather benefits of high level and spatial features extracted from the lung nodules to improve the accuracy of classification. These features are further classified using SVM classifier instead of softmax classifier in order to reduce the overfitting problem. Our model was validated on LUNA dataset and achieved an accuracy of 93.53%, sensitivity of 86.62%, the specificity of 96.55%, and positive predictive value of 94.02%.

scholarly journals Real-time intraoperative glioma diagnosis using fluorescence imaging and deep convolutional neural networks

2021 ◽  
Author(s):  
Biluo Shen ◽  
Zhe Zhang ◽  
Xiaojing Shi ◽  
Caiguang Cao ◽  
Zeyu Zhang ◽  
...  
Keyword(s):  
Neural Networks ◽  
Real Time ◽  
Fluorescence Imaging ◽  
Convolutional Neural Networks ◽  
Frozen Section ◽  
Fluorescent Imaging ◽  
Pathological Diagnosis ◽  
Pathological Examination ◽  
Deep Convolutional Neural Networks ◽  
Fluorescence Images

Abstract Purpose Surgery is the predominant treatment modality of human glioma but suffers difficulty on clearly identifying tumor boundaries in clinic. Conventional practice involves neurosurgeon’s visual evaluation and intraoperative histological examination of dissected tissues using frozen section, which is time-consuming and complex. The aim of this study was to develop fluorescent imaging coupled with artificial intelligence technique to quickly and accurately determine glioma in real-time during surgery. Methods Glioma patients (N = 23) were enrolled and injected with indocyanine green for fluorescence image–guided surgery. Tissue samples (N = 1874) were harvested from surgery of these patients, and the second near-infrared window (NIR-II, 1000–1700 nm) fluorescence images were obtained. Deep convolutional neural networks (CNNs) combined with NIR-II fluorescence imaging (named as FL-CNN) were explored to automatically provide pathological diagnosis of glioma in situ in real-time during patient surgery. The pathological examination results were used as the gold standard. Results The developed FL-CNN achieved the area under the curve (AUC) of 0.945. Comparing to neurosurgeons’ judgment, with the same level of specificity >80%, FL-CNN achieved a much higher sensitivity (93.8% versus 82.0%, P < 0.001) with zero time overhead. Further experiments demonstrated that FL-CNN corrected >70% of the errors made by neurosurgeons. FL-CNN was also able to rapidly predict grade and Ki-67 level (AUC 0.810 and 0.625) of tumor specimens intraoperatively. Conclusion Our study demonstrates that deep CNNs are better at capturing important information from fluorescence images than surgeons’ evaluation during patient surgery. FL-CNN is highly promising to provide pathological diagnosis intraoperatively and assist neurosurgeons to obtain maximum resection safely. Trial registration ChiCTR ChiCTR2000029402. Registered 29 January 2020, retrospectively registered

“ROLE OF FNAC IN THE DIAGNOSIS OF SALIVARY GLAND LESION”

2021 ◽  
pp. 69-71
Author(s):  
Rifat Qureishi ◽  
M.H. Usmani ◽  
U.R. Singh ◽  
P.C. Kol
Keyword(s):  
Salivary Gland ◽  
Diagnostic Accuracy ◽  
Malignant Tumors ◽  
Histopathological Examination ◽  
Standard Procedure ◽  
Neck Region ◽  
Invasive Procedure ◽  
Sensitivity Index ◽  
Cytologic Diagnosis ◽  
Wide Range

Background: Fine needle aspiration cytology (FNAC) has been used for diagnosis of salivary gland lesions for many years. Various studies in the existing literature have shown a wide range of sensitivity and diagnostic accuracy of cytologic diagnosis. FNAC is a safe, simple, cost effective, 1-4 accurate and minimal invasive procedure for the evaluation of salivary gland lesions. FNAC is not only useful in planning denitive preoperative 2,5-6 diagnosis but also can prevent unnecessary surgical intervention. Salivary gland swelling occur more commonly in 3rd decade of life with equal sex incidence. Parotid is one of the most commonly involved glands in the head & neck region swellings. FNAC appears to be highly sensitive for benign tumours and highly specic for malignant tumors and it should be the rst line of investigation in evaluating the salivary gland pathologies. 7 Early diagnosis and appropriate management carries good prognosis. Methods: Patients with suspected salivary gland enlargements, referred for FNAC, were included in this study. FNAC was performed by using the standard procedure. Cytologic diagnosis was compared with histopathologic diagnosis wherever it was available. Results: In the present study conducted in the department of pathology, Shyam Shah Medical College Rewa MP, over a period of 5 years, 152 Patients with suspected salivary gland enlargements were retrospectively appraised. The benign lesions of salivary gland were 133 (87.5%), out of which Pleomorphic adenoma was diagnosed in 75 (56.39%) cases, clinical correlation was found in 58 (77.33%) cases. 29 cases were subsequently correlated with histopathological examination 26 correctly correlated and the diagnostic accuracy of FNAC was found to be 89.65%. Inammatory lesions were proved correct in 08 out of 10 cases after histopathology. Therefore, accuracy of FNAC was 80.0%. Malignant lesions of salivary gland were found in 19 cases, out of which 15 (78.94%) cases correlated with clinical diagnosis. 13 cases were subjected to histopathology 10 correctly correlated and the diagnostic accuracy of FNAC was found to be 76.92%. Overall diagnostic accuracy of FNAC was 84.61%. Conclusion:In conclusions it can be established that FNAC is an efcient and accurate procedure with high sensitivity index, and its usefulness is enhanced due to it being a relatively easy procedure which can be carried out even on outdoor patients.

scholarly journals A data-driven neural network architecture for sentiment analysis

2019 ◽  
Vol 53 (1) ◽  
pp. 2-19 ◽  
Author(s):  
Erion Çano ◽  
Maurizio Morisio
Keyword(s):  
Neural Network ◽  
Sentiment Analysis ◽  
Network Architecture ◽  
Network Models ◽  
Data Sets ◽  
Feature Maps ◽  
Neural Network Architecture ◽  
Neural Network Models ◽  
Content Type ◽  
Max Pooling

Purpose The fabulous results of convolution neural networks in image-related tasks attracted attention of text mining, sentiment analysis and other text analysis researchers. It is, however, difficult to find enough data for feeding such networks, optimize their parameters, and make the right design choices when constructing network architectures. The purpose of this paper is to present the creation steps of two big data sets of song emotions. The authors also explore usage of convolution and max-pooling neural layers on song lyrics, product and movie review text data sets. Three variants of a simple and flexible neural network architecture are also compared. Design/methodology/approach The intention was to spot any important patterns that can serve as guidelines for parameter optimization of similar models. The authors also wanted to identify architecture design choices which lead to high performing sentiment analysis models. To this end, the authors conducted a series of experiments with neural architectures of various configurations. Findings The results indicate that parallel convolutions of filter lengths up to 3 are usually enough for capturing relevant text features. Also, max-pooling region size should be adapted to the length of text documents for producing the best feature maps. Originality/value Top results the authors got are obtained with feature maps of lengths 6–18. An improvement on future neural network models for sentiment analysis could be generating sentiment polarity prediction of documents using aggregation of predictions on smaller excerpt of the entire text.

scholarly journals Machine Learning Improves the Precision and Robustness of High-Content Screens

2011 ◽  
Vol 16 (9) ◽  
pp. 1059-1067 ◽  
Author(s):  
Peter Horvath ◽  
Thomas Wild ◽  
Ulrike Kutay ◽  
Gabor Csucs
Keyword(s):  
Machine Learning ◽  
User Interaction ◽  
Texture Features ◽  
Large Data ◽  
Complete Analysis ◽  
Data Sets ◽  
Reporter Protein ◽  
Fluorescent Intensity ◽  
Analysis Workflow

Imaging-based high-content screens often rely on single cell-based evaluation of phenotypes in large data sets of microscopic images. Traditionally, these screens are analyzed by extracting a few image-related parameters and use their ratios (linear single or multiparametric separation) to classify the cells into various phenotypic classes. In this study, the authors show how machine learning–based classification of individual cells outperforms those classical ratio-based techniques. Using fluorescent intensity and morphological and texture features, they evaluated how the performance of data analysis increases with increasing feature numbers. Their findings are based on a case study involving an siRNA screen monitoring nucleoplasmic and nucleolar accumulation of a fluorescently tagged reporter protein. For the analysis, they developed a complete analysis workflow incorporating image segmentation, feature extraction, cell classification, hit detection, and visualization of the results. For the classification task, the authors have established a new graphical framework, the Advanced Cell Classifier, which provides a very accurate high-content screen analysis with minimal user interaction, offering access to a variety of advanced machine learning methods.

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