scholarly journals Butea superba Roxb. Extract Ameliorates Scopolamine-Induced Cognitive and Memory Impairment in Aged Male Rats

2021 ◽  
Vol 2021 ◽  
pp. 1-15
Author(s):  
Kittipot Sirichaiwetchakoon ◽  
Sarawut Suksuphew ◽  
Rungrudee Srisawat ◽  
Griangsak Eumkeb
Keyword(s):  
Passive Avoidance ◽  
Memory Impairment ◽  
Neurodegenerative Disorder ◽  
Ex Vivo ◽  
Radical Scavenging ◽  
Male Rats ◽  
Passive Avoidance Test ◽  
Dependent Manner ◽  
Avoidance Test ◽  
Butea Superba

Butea superba Roxb. (B. superba) is a herb that has been used for rejuvenation, to improve sexual performance, or to prevent erectile dysfunction function. Alzheimer’s disease (AD) is a chronic neurodegenerative disorder that is the main cause of progressive dementia. This study aimed to investigate the amelioration for cognitive and memory dysfunction of B. superba ethanolic extract (BSE), a possible mechanism of action, and its toxicity. The results from the Y-maze test, novel object recognition test, and passive avoidance test exhibited that the administration of BSE at 50 mg/kg (BSL) and 200 mg/kg (BSH) could ameliorate scopolamine-induced cognitive impairment in all behavior testing. Moreover, BSE could prevent the cognitive deficit in a dose-dependent manner in a passive avoidance test. Furthermore, BSE inhibited acetylcholinesterase’s (AChE) ex vivo activity in the cerebral cortex and hippocampus. Also, the in vitro and ex vivo antioxidative effects of BSE revealed that BSE had free radical scavenging activities in both DPPH and FRAP assay. Furthermore, male rats treated with BSE at 200 mg/kg/day for two weeks could significantly increase serum testosterone compared with control ( P < 0.05 ). The GC-MS analysis and previous studies revealed that BSE contained propanoic acid, 3,3′-thiobis-, didodecyl ester, oleic acid, gamma-sitosterol, and stigmasterol which may play an important role in cognitive and memory impairment prevention. The toxicity test of BSE in rats at 50 and 200 mg/kg/day for two weeks showed that relative organ weight, serum creatinine, ALT, ALP, and CBC levels of both treated groups were not significantly different compared to the CON ( P > 0.05 ). These results suggest that BSE may not be toxic to the vital organ and blood. In conclusion, BSE has the potential to be developed as a health supplement product or medicine for AD prevention and treatment.

Maternal isobutyl-paraben exposure alters anxiety and passive avoidance test performance in adult male rats

2009 ◽  
Vol 65 (2) ◽  
pp. 136-140 ◽  
Author(s):  
Maiko Kawaguchi ◽  
Kaoru Irie ◽  
Kaori Morohoshi ◽  
Gen Watanabe ◽  
Kazuyoshi Taya ◽  
...  
Keyword(s):  
Passive Avoidance ◽  
Adult Male ◽  
Test Performance ◽  
Male Rats ◽  
Passive Avoidance Test ◽  
Avoidance Test

scholarly journals Protective Effects ofBorago officinalisExtract on Amyloidβ-Peptide(25–35)-Induced Memory Impairment in Male Rats: A Behavioral Study

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Fatemeh Ghahremanitamadon ◽  
Siamak Shahidi ◽  
Somayeh Zargooshnia ◽  
Ali Nikkhah ◽  
Akram Ranjbar ◽  
...  
Keyword(s):  
Passive Avoidance ◽  
Memory Impairment ◽  
Neurodegenerative Disorder ◽  
Male Rats ◽  
Avoidance Task ◽  
Protective Effects ◽  
Frap Assay ◽  
Antioxidant Power ◽  
Borago Officinalis ◽  
Learning Impairment

Alzheimer’s disease (AD) is a neurodegenerative disorder and most common form of dementia that leads to memory impairment. In the present study we have examined the protective effects ofBorago officinalis(borage) extract on Amyloidβ(Aβ)-Induced memory impairment. Wistar male rats received intrahippocampal (IHP) injection of the Aβ(25–35) and borage extract throughout gestation (100 mg/kg). Learning and memory functions in the rats were examined by the passive avoidance and the Morris water maze (MWM) tasks. Finally, the antioxidant capacity of hippocampus was measured using ferric ion reducing antioxidant power (FRAP) assay. The results showed that Aβ(25–35) impaired step-through latency and time in dark compartment in passive avoidance task. In the MWM, Aβ(25–35) significantly increased escape latency and traveled distance. Borage administration attenuated the Aβ-induced memory impairment in both the passive avoidance and the MWM tasks. Aβinduced a remarkable decrease in antioxidant power (FRAP value) of hippocampus and borage prevented the decrease of the hippocampal antioxidant status. This data suggests that borage could improve the learning impairment and oxidative damage in the hippocampal tissue following Aβtreatment and that borage consumption may lead to an improvement of AD-induced cognitive dysfunction.

scholarly journals Thiamine Alleviates Cognitive Impairment and Epileptogenesis by Relieving Brain Inflammation in PTZ-induced Kindling Rat Model

2021 ◽  
Author(s):  
SEBAHATTİN KARABULUT ◽  
Ahmet Kemal Filiz ◽  
Recep Akkaya
Keyword(s):  
Passive Avoidance ◽  
Interleukin 1 ◽  
Nuclear Factor Κb ◽  
Brain Inflammation ◽  
Male Rats ◽  
Passive Avoidance Test ◽  
Necrosis Factor Alpha ◽  
Avoidance Test ◽  
Ptz Kindling ◽  
The Brain

Abstract Epileptogenesis, the process by which the brain becomes epileptic, is related to neuroinflammation, hyperexcitability, and as a result cognitive deficits. Evidence suggests that therapeutic strategies targeting pathologic brain inflammation have emerged as a promising approach that prevents or disease-modifying therapy for epileptogenesis. Therefore, the PTZ kindling model of epilepsy was utilized to assess the neuroprotective role of thiamine in epileptogenesis. Male rats were exposed to PTZ-induced kindling and pretreated with low thiamine (25 mg/kg) or high thiamine (50 mg/kg). Cyclooxygenase (COX-1 and COX-2), interleukin 1-beta (IL-1β), tumor necrosis factor-alpha (TNF-α), and nuclear factor-κB (NF-κB) concentrations in the brain were analyzed using biochemical assays. Cognitive function was evaluated using the passive avoidance test. Thiamine ameliorated epileptogenesis and enhanced the rats' performance in the passive avoidance test. Also, thiamine significantly decreased the level of neuroinflammatory mediators in the brain induced by PTZ. These results provide evidence that thiamine alleviates PTZ-induced neuroinflammation and cognitive impairments.

Investigation of the Memory Impairment in Rats Fed with Oxidized-Cholesterol-Rich Diet Employing Passive Avoidance Test

Drug Research ◽  
2014 ◽  
Vol 65 (05) ◽  
pp. 231-237 ◽  
Author(s):  
A. Khorrami ◽  
S. Ghanbarzadeh ◽  
J. Mahmoudi ◽  
A. Nayebi ◽  
N. Maleki-Dizaji ◽  
...  
Keyword(s):  
Passive Avoidance ◽  
Memory Impairment ◽  
Passive Avoidance Test ◽  
Avoidance Test ◽  
Oxidized Cholesterol

Vasopressin analogues with effect on central nervous system: Synthesis and biological properties

1983 ◽  
Vol 48 (10) ◽  
pp. 2862-2873 ◽  
Author(s):  
František Brtník ◽  
Ivan Krejčí ◽  
Běla Kupková ◽  
Pavel Hrbas ◽  
Jana Škopková ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Amino Acid ◽  
Passive Avoidance ◽  
Biological Properties ◽  
Passive Avoidance Test ◽  
System Synthesis ◽  
Avoidance Test ◽  
Vasopressin Analogues

Synthesis of four vasopressin analogues which do not contain the glycinamine residue in position 9 and have a basic non-coded amino acid in position 8 is described. All the analogues exhibit very low endocrine activities and are effective in the passive avoidance test.

Effects of Clozapine and Sulpiride on Morphine State-Dependent Memory in the Step-Down Passive Avoidance Test

Pharmacology ◽  
2006 ◽  
Vol 79 (3) ◽  
pp. 149-153 ◽  
Author(s):  
Nazanin Malekmohamadi ◽  
Parviz Heidari ◽  
Mousa Sahebgharani ◽  
Mohammad-Reza Zarrindast
Keyword(s):  
Passive Avoidance ◽  
Passive Avoidance Test ◽  
Avoidance Test ◽  
State Dependent ◽  
Step Down

Continuous and not continuous 2-week treadmill training enhances the performance in the passive avoidance test in ischemic gerbils

2018 ◽  
Vol 665 ◽  
pp. 170-175 ◽  
Author(s):  
Ana Paula Cassiano Silveira ◽  
Takae Tamy Kitabatake ◽  
Vivian Mozol Pantaleo ◽  
Hélio Zangrossi ◽  
Guilherme Bertolino ◽  
...  
Keyword(s):  
Passive Avoidance ◽  
Treadmill Training ◽  
Passive Avoidance Test ◽  
Avoidance Test
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