scholarly journals Assessment of Larval Toxicity and the Teratogenic Effect of Three Medicinal Plants Used in the Traditional Treatment of Urinary Tract Infections in Benin

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Phénix Assogba ◽  
Victorien Dougnon ◽  
Edna Hounsa ◽  
Pierre Badjabaissi ◽  
Rachida Moussa Tari ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Medicinal Plants ◽  
Urinary Tract Infections ◽  
Plant Extracts ◽  
Mangifera Indica ◽  
Artemia Salina ◽  
Teratogenic Effect ◽  
Traditional Treatment ◽  
Tract Infections ◽  
Larval Toxicity

Objective. Mangifera indica Linn, Bridelia ferruginea Benth, and Alstonia boonei De Wild are three plants commonly used in the traditional treatment of urinary tract infections in Benin. This study sets out to assess the cytotoxic and teratogenic effects of extracts of these plants on Artemia salina larvae and hen embryos. Methods and Results. The aqueous and ethanolic extracts were obtained by maceration of the powders in solvents. Larval cytotoxicity was performed on Artemia salina larvae. The teratogenic effect of these plants was evaluated on chick embryos at 100 mg/kg and 300 mg/kg. The extracts were injected on the 7th and 14th days of incubation. The quality of the hatched chicks was evaluated by the Tona score followed by the hematological and the biochemical parameter assays. The extracts did not show cytotoxicity on the larvae. The eggs treated with plant extracts at 300 mg/kg significantly lowered the hatchability rate, except for the Mangifera indica Linn. The chicks obtained were all at the very good quality. Then, no significant variation was observed between hematological parameters except white blood cells. For the biochemical parameters, only ASAT showed some significant variations for a few extracts. It would be important to assess the genotoxicity of the plant extracts to determine more broader toxicity. These data justify the use of these medicinal plants in traditional Beninese medicine and constitute in fact a source of production of anti-infectious drugs.

scholarly journals Ethnopharmacological survey of six medicinal plants used in the traditional treatment of urinary tract infections and other infectious diseases

2021 ◽  
Author(s):  
Phénix Assogba ◽  
Eric Agbodjento ◽  
Remi Akotegnon ◽  
Victorien Dougnon ◽  
Jean Robert Klotoe
Keyword(s):  
Urinary Tract ◽  
Medicinal Plants ◽  
Infectious Diseases ◽  
Urinary Tract Infections ◽  
Mangifera Indica ◽  
Structured Interview ◽  
Traditional Treatment ◽  
Bridelia Ferruginea ◽  
Toxicological Studies ◽  
Tract Infections

Benin has attractive ethnobotanical potential with a vast diversity of medicinal plants widely used to treat human diseases. Urinary tract infections are among the diseases traditionally treated by medicinal plants. Mangifera indica, Bridelia ferruginea, Alstonia boonei, Morodora myristica, Xylopia aethiopica and Zanthoxylum zantoxyloides are six plants used in the traditional treatment of urinary infections in Benin. The general objective of this study was to identify the ethnopharmacological uses of these six plants used in traditional medicine in South Benin. To this end, an ethnopharmacological survey was conducted using the semi-structured interview method among herbalists in the markets of South Benin. The ethnobotanical data collected were analyzed using the use-value, the informant consensus factor and the medicinal plant fidelity index. A total of 98 herbalists participated in this study. The six plants studied were involved in 15 different diseases divided into seven disease categories. The most mentioned disease categories are infectious diseases, blood and digestive diseases. Malaria, ulcers, anemia and urinary tract infections are the pathologies most commonly treated by these plants. Informants agreed on the use of these plants in these disease categories. Bark, leafy stems and roots are the parts of the plants most used to treat diseases. Decoction and maceration are the two main methods of preparation, and the oral and cutaneous routes are the main routes of administration. These data constitute ethnopharmacological documentation that can be used for further pharmacological and toxicological studies.

scholarly journals BIO-CONTROL OF MULTIPLE DRUG-RESISTANT UROPATHOGENS USING MEDICINAL PLANT EXTRACTS

2019 ◽  
pp. 371-376
Author(s):  
VIGI CHAUDHARY ◽  
RAGHUVANSHI RK ◽  
NAVEEN CHAUDHARY ◽  
GAURAV SHARMA
Keyword(s):  
Urinary Tract ◽  
Medicinal Plants ◽  
Plant Extracts ◽  
Resistant Bacteria ◽  
Multiple Drug ◽  
Drug Resistant ◽  
Human Pathogens ◽  
Multiple Drug Resistant ◽  
Medicinal Plant Extracts ◽  
Tract Infections

Objective: The present study was conducted to evaluate the potential of some medicinal plants used in Ayurveda in treating multiple drug-resistant human pathogens causing urinary tract infections (UTIs). Methods: Dried parts of six medicinal plants used in Ayurveda for treating UTI were Soxhlet extracted, and the extract was concentrated in vacuo. Various concentrations of the extract were tested for antimicrobial activity against three clinical isolates of multiple drug-resistant bacteria causing UTI. Results: Preliminary results showed the promising antibacterial effect of plant extracts. Escherichia coli, the most common pathogen associated with UTI, was susceptible to aqueous extracts of all the six medicinal plants. Conclusion: This study concluded that the medicinal plants used in Ayurveda to treat UTIs are effective against multiple drug-resistant uropathogens. Further study in this regard may lead to the identification of novel antimicrobial agent for treating multiple drug-resistant urinary tract pathogens.

Antimicrobial Activity of Medicinal Plants and Urinary Tract Infections

2017 ◽  
Vol 9 (1) ◽  
Author(s):  
Imad Hadi Hameed ◽  
Abeer Fauzi Al-Rubaye ◽  
Mohanad Jawad Kadhim
Keyword(s):  
Urinary Tract ◽  
Medicinal Plants ◽  
Urinary Tract Infections ◽  
World Health ◽  
World Population ◽  
Main Stream ◽  
Human Society ◽  
Care Needs ◽  
Traditional Medicines ◽  
Tract Infections

Medicinal plants are part and parcel of human society to combat diseases from the dawn of civilization. According to World Health Organization (WHO), about 80% of the world population rely chiefly on plant based traditional medicine specially for their primary health care needs and there has been a worldwide move towards the use of traditional medicines due to concerns over the more invasive, expensive and potentially toxic main stream practices. This review gives a bird’s eye view on the updated information on urinary tract infections (UTIs), different categories of urologic herbs, historical use and modern scientific investigations on some important urologic herbs, clinical studies, some isolated chemical compounds and their possible side effects

scholarly journals Natural therapeutics for urinary tract infections—a review

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Sarita Das
Keyword(s):  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Plant Extracts ◽  
Alternative Therapy ◽  
Exclusion Principle ◽  
Main Body ◽  
E Coli ◽  
Potential Vaccine ◽  
Conventional Antibiotics ◽  
Tract Infections

Abstract Background The recurrence of the urinary tract infections (UTI), following the antibiotic treatments suggests the pathogen’s resistance to conventional antibiotics. This calls for the exploration of an alternative therapy. Main body The anti-uropathogenic and bactericidal activity of many plant extracts was reported by many researchers, which involves only preliminary antibacterial studies using different basic techniques like disk diffusion, agar well diffusion, or minimum inhibitory concentration (MIC) of the crude plant extracts, but reports on the specific action of the phytoconstituents against uropathogens are limited. Vaccinium macrocarpon Aiton (cranberry) is the best-studied home remedy for UTI. Some evidences suggest that proanthocyanins present in cranberry, prevent bacteria from adhering to the walls of the urinary tract, subsequently blocking the further steps of uropathogenesis. Probiotics such as Lactobacillus and Bifidobacterium are beneficial microorganisms that may act by the competitive exclusion principle to defend against infections in the urogenital tracts. Reports on potential vaccine agents and antibodies targeting the different toxins and effecter proteins are still obscure except uropathogenic E. coli. Conclusion This review highlights some of the medicinal herbs used by aborigines to prevent or treat acute or chronic urinary tract infections, botanicals with established urobactericidal activity, clinical trials undertaken to compare the efficacy of cranberry products in UTI prevention, and other natural therapeutics reported for UTI.

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