scholarly journals Relationship between Urinary Alzheimer-Associated Neuronal Thread Protein and Apolipoprotein Epsilon 4 Allele in the Cognitively Normal Population

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Yuxia Li ◽  
Meimei Kang ◽  
Can Sheng ◽  
Guanqun Chen ◽  
Taoran Li ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Normal Population ◽  
Subjective Cognitive Decline ◽  
Cognitively Normal ◽  
Gene Testing ◽  
Significant Difference ◽  
History Of ◽  
Work Family ◽  
The Relationship ◽  
Chinese Subjects

We investigated the relationship between urinary Alzheimer-associated neuronal thread protein (AD7c-NTP) levels and apolipoprotein epsilon 4 (ApoE ɛ4) alleles, as well as other factors that cause cognitive decline, in the cognitively normal population. We recruited 329 cognitively normal right-handed Han Chinese subjects who completed ApoE gene testing and urinary AD7c-NTP testing. There was no significant difference in urinary AD7c-NTP levels between the normal control and subjective cognitive decline groups. Urinary AD7c-NTP levels were significantly higher in subjects with ApoE ɛ3/4 and 4/4 [0.6074 (0.6541) ng/mL] than in subjects without ApoE ɛ4 [0.4368 (0.3392) ng/mL and 0.5287 (0.3656) ng/mL], and urinary AD7c-NTP levels positively correlated with ApoE genotype grade (r=0.165, p=0.003). There were significant differences in urinary AD7c-NTP levels between subjects with and without a history of coronary heart disease or diabetes. Urinary AD7c-NTP levels were not related to years of education, nature of work, family history of dementia, a history of hypertension, stroke, anemia, or thyroid dysfunction. Urinary AD7c-NTP levels were positively correlated with ApoE grade in the cognitively normal population. The relationship between risk factors of cognitive decline and urinary AD7c-NTP levels provides a new way for us to understand AD and urinary AD7c-NTP.

scholarly journals Lower functional hippocampal redundancy in mild cognitive impairment

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Stephanie Langella ◽  
◽  
Muhammad Usman Sadiq ◽  
Peter J. Mucha ◽  
Kelly S. Giovanello ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Decline ◽  
Resting State ◽  
Memory Performance ◽  
Potential Mechanism ◽  
Network Efficiency ◽  
Cognitively Normal ◽  
Normal Individuals ◽  
The Relationship

AbstractWith an increasing prevalence of mild cognitive impairment (MCI) and Alzheimer’s disease (AD) in response to an aging population, it is critical to identify and understand neuroprotective mechanisms against cognitive decline. One potential mechanism is redundancy: the existence of duplicate elements within a system that provide alternative functionality in case of failure. As the hippocampus is one of the earliest sites affected by AD pathology, we hypothesized that functional hippocampal redundancy is protective against cognitive decline. We compared hippocampal functional redundancy derived from resting-state functional MRI networks in cognitively normal older adults, with individuals with early and late MCI, as well as the relationship between redundancy and cognition. Posterior hippocampal redundancy was reduced between cognitively normal and MCI groups, plateauing across early and late MCI. Higher hippocampal redundancy was related to better memory performance only for cognitively normal individuals. Critically, functional hippocampal redundancy did not come at the expense of network efficiency. Our results provide support that hippocampal redundancy protects against cognitive decline in aging.

scholarly journals Subjective cognitive decline in cognitively normal elders from the community or from a memory clinic: Differential affective and imaging correlates

2016 ◽  
Vol 13 (5) ◽  
pp. 550-560 ◽  
Author(s):  
Audrey Perrotin ◽  
Renaud La Joie ◽  
Vincent de La Sayette ◽  
Louisa Barré ◽  
Florence Mézenge ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Subjective Cognitive Decline ◽  
Memory Clinic ◽  
Cognitively Normal ◽  
Community Or

scholarly journals Association of CSF Aβ, amyloid PET, and cognition in cognitively unimpaired elderly adults

Neurology ◽  
2020 ◽  
Vol 95 (15) ◽  
pp. e2075-e2085 ◽  
Author(s):  
Tengfei Guo ◽  
Leslie M. Shaw ◽  
John Q. Trojanowski ◽  
William J. Jagust ◽  
Susan M. Landau ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Amyloid Pet ◽  
Elderly Adults ◽  
Cognitively Normal ◽  
Longitudinal Measurements ◽  
Normal Individuals ◽  
Aβ Amyloid ◽  
Discordant Group ◽  
Amyloid Aβ ◽  
The Relationship

ObjectiveTo compare CSF β-amyloid (Aβ) and florbetapir PET measurements in cognitively unimpaired (CU) elderly adults in order to detect the earliest abnormalities and compare their predictive effect for cognitive decline.MethodsA total of 259 CU individuals were categorized as abnormal (+) or normal (−) on CSF Aβ1-42/Aβ1-40 analyzed with mass spectrometry and Aβ PET measured with 18F-florbetapir. Simultaneous longitudinal measurements of CSF and PET were compared for 39 individuals who were unambiguously Aβ-negative at baseline (CSF−/PET−). We also examined the relationship between baseline CSF/PET group membership and longitudinal changes in CSF Aβ, Aβ PET, and cognition.ResultsThe proportions of individuals in each discordant group were similar (8.1% CSF+/PET− and 7.7% CSF−/PET+). Among baseline Aβ-negative (CSF−/PET−) individuals with longitudinal CSF and PET measurements, a larger proportion subsequently worsened on CSF Aβ (odds ratio 4 [95% confidence interval (CI) 1.1, 22.1], p = 0.035) than Aβ PET over 3.5 ± 1.0 years. Compared to CSF−/PET− individuals, CSF+/PET− individuals had faster (estimate 0.009 [95% CI 0.005, 0.013], p < 0.001) rates of Aβ PET accumulation over 4.4 ± 1.7 years, while CSF−/PET+ individuals had faster (estimate −0.492 [95% CI −0.861, −0.123], p = 0.01) rates of cognitive decline over 4.5 ± 1.9 years.ConclusionsThe proportions of discordant PET and CSF Aβ-positive individuals were similar cross-sectionally. However, unambiguously Aβ-negative (CSF−/PET−) individuals are more likely to show subsequent worsening on CSF than PET, supporting the idea that CSF detects the earliest Aβ changes. In discordant cases, only PET abnormality predicted cognitive decline, suggesting that abnormal Aβ PET changes are a later phenomenon in cognitively normal individuals.

P4-381: DISCLOSURE OF AMYLOID STATUS FOR RISK OF ALZHEIMER'S DISEASE TO COGNITIVELY NORMAL PERSONS WITH SUBJECTIVE COGNITIVE DECLINE

2006 ◽  
Vol 14 (7S_Part_31) ◽  
pp. P1620-P1620
Author(s):  
Taisei Wake ◽  
Hajime Tabuchi ◽  
Kei Funaki ◽  
Daisuke Ito ◽  
Bun Yamagata ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Decline ◽  
Subjective Cognitive Decline ◽  
Cognitively Normal

P4-089: THE RELATIONSHIP BETWEEN BRAIN MARKERS OF NEURODEGENERATION AND COGNITION IN PERSONS WITH SUBJECTIVE COGNITIVE DECLINE: A STUDY FROM THE CIMA-Q COHORT

2006 ◽  
Vol 14 (7S_Part_28) ◽  
pp. P1470-P1470
Author(s):  
Sylvie Belleville ◽  
Carol Hudon ◽  
Samira Mellah ◽  
Benjamin Boller ◽  
Simon Cloutier ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Subjective Cognitive Decline ◽  
The Relationship

scholarly journals The Relationship between Subjective Cognitive Decline and Health Literacy in Healthy Community-Dwelling Older Adults

Healthcare ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 567
Author(s):  
Akio Goda ◽  
Shin Murata ◽  
Hideki Nakano ◽  
Koji Nonaka ◽  
Hiroaki Iwase ◽  
...  
Keyword(s):  
Older Adults ◽  
Health Literacy ◽  
Cognitive Function ◽  
Cognitive Decline ◽  
Depression Scale ◽  
Community Dwelling ◽  
Subjective Cognitive Decline ◽  
Healthy Community ◽  
Community Dwelling Older Adults ◽  
The Relationship

Few studies have examined the effects of health literacy on people at risk of developing dementia; its effects on the pathogenesis of subjective cognitive decline (SCD) are particularly unclear. This study aimed to clarify the relationship between health literacy and SCD in a population of healthy community-dwelling older adults. SCD status was assessed using the Cognitive Function domain of the Kihon Checklist (KCL-CF). Health literacy, in turn, was evaluated using the Communicative and Critical Health Literacy (CCHL) scale. Global cognitive function and depressive symptoms were evaluated using the Mini-Mental State Examination (MMSE) and a five-item version of the Geriatric Depression Scale (GDS-5), respectively. Participants who were suspected of having SCD were significantly older than their non-SCD peers, and scored significantly worse on the CCHL, MMSE, and GDS-5. In addition, SCD status was found to be associated with CCHL and GDS-5 scores, as well as age, according to a logistic regression analysis. These findings suggest that low health literacy is linked to SCD morbidity in healthy community-dwelling older adults and should prove useful in the planning of dementia prevention and intervention programs for this population.

scholarly journals P3-447: MINOR NEUROPSYCHOLOGICAL DEFICITS IN COGNITIVELY NORMAL OLDER INDIVIDUALS WITH SUBJECTIVE COGNITIVE DECLINE: RESULTS FROM THE DELCODE STUDY

2019 ◽  
Vol 15 ◽  
pp. P1133-P1134
Author(s):  
Steffen Wolfsgruber ◽  
Luca Kleineidam ◽  
Oliver Peters ◽  
Katharina Buerger ◽  
Michael Ewers ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Neuropsychological Deficits ◽  
Subjective Cognitive Decline ◽  
Older Individuals ◽  
Cognitively Normal
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