scholarly journals The Efficacy of Concentrated Growth Factor in the Healing of Alveolar Osteitis: A Clinical Study

2020 ◽  
Vol 2020 ◽  
pp. 1-9 ◽  
Author(s):  
Aqsa Kamal ◽  
Basheer Salman ◽  
Noor Hayati Abdul Razak ◽  
Ali Al Qabbani ◽  
A. R. Samsudin
Keyword(s):  
Growth Factor ◽  
Pain Score ◽  
Granulation Tissue ◽  
Conventional Treatment ◽  
Tooth Extraction ◽  
Tissue Formation ◽  
Granulation Tissue Formation ◽  
Dry Socket ◽  
Group I ◽  
Alveolar Osteitis

Background. A dry socket also referred to as alveolar osteitis (AO) is a common postoperative complication following tooth extraction, due to the disruption of the clot within the wound. This study aimed to evaluate the efficacy of concentrated growth factor (CGF) in the healing of alveolar osteitis following tooth extraction. Methods. The study was conducted at University Dental Hospital Sharjah, UAE. Patients undergoing tooth extraction at the oral surgery clinic were advised to return immediately if they suffer from pain. Over the following first week after tooth extraction, patients who reported pain symptoms were recalled and all dry sockets were identified. The patients were divided into two groups. Group I patients received conventional treatment with socket curettage and saline irrigation only, while in group II CGF was inserted into the socket. Both groups were observed for pain score and quantification of granulation tissue formation. Results. A total of 40 dry socket patients, aged between 18 and 60 years, from a total of 1,250 patients, were included in the study. 30 patients were given conventional treatment while another 10 patients were given CGF. Patients who received CGF had a pain score of 7–10 at presentation, and the pain score dropped to 0–3 on day 4 and further improved to 0-1 on day 7 (p=0.001). Granulation tissue formation appeared in the conventional group I on day 7 while the CGF group II showed earlier granulation tissue formation by day 4 (p=0.001). The posttreatment pain score is inversely proportional to the amount and rate of granulation tissue formation in the socket. Conclusion. The study suggests that delivery of CGF into a dry socket helps relieve pain and expedite the wound healing process as shown by a statistically much lower pain score and earlier and more rapid formation of granulation tissue when compared to the conventional alveolar osteitis therapy.

scholarly journals A Comparative Clinical Study between Concentrated Growth Factor and Low-Level Laser Therapy in the Management of Dry Socket

2020 ◽  
Vol 14 (04) ◽  
pp. 613-620 ◽  
Author(s):  
Aqsa Kamal ◽  
Basheer Salman ◽  
Noor Hayatie Abdul Razak ◽  
AB Rani Samsudin
Keyword(s):  
Statistical Analysis ◽  
Granulation Tissue ◽  
Conventional Treatment ◽  
Low Level Laser Therapy ◽  
Tissue Formation ◽  
Granulation Tissue Formation ◽  
Group Iii ◽  
Dry Socket ◽  
Group I ◽  
Level Laser

Abstract Objective A dry socket is a well-recognized complication of wound healing following tooth extraction. Its etiology is poorly understood and commonly occur among healthy patients. As such, management strategies for dry socket has always been empirical rather than scientific with varying outcome. The aim of this study is to investigate the efficacy of concentrated growth factor (CGF) and low-level laser therapy (LLLT) and compared them to the conventional treatment in the management of dry socket. Materials and Methods Sixty patients with one dry socket each, at University Dental Hospital Sharjah, were divided into three treatment groups based on their choice. In group I (n = 30), conventional treatment comprising of gentle socket curettage and saline irrigation was done. Group II (n = 15) dry sockets were treated with CGF and group III (n = 15) sockets were lased with LLLT. All dry socket patients were seen at day 0 for treatment and subsequently followed-up at 4, 7, 14, and 21 days. Pain score, perisocket inflammation, perisocket tenderness, and amount of granulation tissue formation were noted. Statistical Analysis Data were analyzed as mean values for each treatment group. Comparisons were made for statistical analysis within the group and among the three groups to rank the efficacy of treatment using one-way analysis of variance (ANOVA). Statistically significant difference is kept at p < 0.05. Results  Conventional treatment group I took more than 7 days to match the healing phase of group II CGF treated socket and group III LLLT irradiated socket (p = 0.001). When healing rate between CGF and LLLT are compared, LLLT group III showed a delay of 4 days compared with CGF in granulation tissue formation and pain control. Conclusion  CGF treated socket was superior to LLLT in its ability to generate 75% granulation tissue and eliminate pain symptom by day 7 (p = 0.001).

scholarly journals The Effect of Ethanol Extract Of Sarang Semut Plant (Hypnophytum Formicarum) to Granulation Tissue for Wound Healing After Teeth Extraction Experimental Research on Marmot (Cavia cobaya)

2017 ◽  
Vol 1 ◽  
Author(s):  
Efa Ismardianita ◽  
Fitri Ellanda ◽  
Suci Amalia Agus ◽  
Sartika Amelia Putri
Keyword(s):  
Wound Healing ◽  
Granulation Tissue ◽  
Tooth Extraction ◽  
Ethanol Extract ◽  
Control Group ◽  
Tissue Formation ◽  
Control Group Design ◽  
Granulation Tissue Formation ◽  
Group I ◽  
Teeth Extraction

Tooth extraction is a common thing, more often after extraction patients have any complication, to prevent it, physician provide some drugs from chemicals that often give adverse effects, so that required for a safe substitute medicine, which derived from herbs. One of the herbs are often used by people in the Mentawai Islands is a sarang semut's root species of Hypnophytum formicarum jack. This study aimed to determine the effect of sarang semut’s extract orally for granulation tissue formation in wound healing after tooth extraction. This research is experimental with posttest only control group design. Subjects were 48-animal guinea pigs, were divided into 4 groups: group I (control 0.5% CMC, treatment group II, III, IV with 4,65mg, and 9.3 mg 6,2 mg dose tuber ethanol extract dissolved anthill in CMC 0.5%), were given 3 ml orally, 3 times a day until the day of decapitation. Early research conducted identification and phytochemical screening, this plant belongs to the species Hypnophytum formicarum jack, contain flavonoids, phenols, triterpenoids and tannins. The data was analyzed with non-parametric Kruskal-Wallis, to see the significance between doses used Mann-Whitney. The results showed that the extract of sarang semut effect (<em>p</em> &lt; 0.05) on the formation of granulation system in wound healing after tooth extraction. The most effective concentration was 4.65 mg

scholarly journals Platelet-Derived Growth Factor B-Chain of Hematopoietic Origin Is Not Necessary for Granulation Tissue Formation and Its Absence Enhances Vascularization

2001 ◽  
Vol 159 (5) ◽  
pp. 1869-1876 ◽  
Author(s):  
Bernard S. Buetow ◽  
Jeffrey R. Crosby ◽  
Wolfgang E. Kaminski ◽  
Ravi K. Ramachandran ◽  
Per Lindahl ◽  
...  
Keyword(s):  
Growth Factor ◽  
Granulation Tissue ◽  
Platelet Derived Growth Factor ◽  
Tissue Formation ◽  
Factor B ◽  
Granulation Tissue Formation

Antibody Neutralization of Vascular Endothelial Growth Factor Inhibits Wound Granulation Tissue Formation

2001 ◽  
Vol 96 (2) ◽  
pp. 173-182 ◽  
Author(s):  
Thomas R. Howdieshell ◽  
Dianne Callaway ◽  
Whitney L. Webb ◽  
Michael D. Gaines ◽  
Charles D. Procter ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Granulation Tissue ◽  
Vascular Endothelial ◽  
Tissue Formation ◽  
Antibody Neutralization ◽  
Granulation Tissue Formation ◽  
Endothelial Growth Factor

scholarly journals RapidlyIn SituForming Platelet-Rich Plasma Gel Enhances Angiogenic Responses and Augments Early Wound Healing after Open Abdomen

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Bo Zhou ◽  
Jianan Ren ◽  
Chao Ding ◽  
Yin Wu ◽  
Dong Hu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Growth Factor ◽  
Granulation Tissue ◽  
Open Abdomen ◽  
Transforming Growth Factor ◽  
Platelet Rich Plasma ◽  
Tissue Formation ◽  
Granulation Tissue Formation ◽  
Abdominal Hypertension ◽  
Early Wound

Objective.The purposes of our present study were to evaluate the potential of platelet-rich plasma gel to enhance granulation tissue formation after open abdomen and to examine whether the effect was attributable to stimulating rapid neovascularization.Methods.Twenty-four rats underwent colon ascendens stent peritonitis surgery to induce sepsis, followed by intraperitoneal injection of nitrogen to create intra-abdominal hypertension. Four hours later, laparotomies were performed. The rats were randomized into three groups (n=8for each group): control, platelet-poor plasma (PPP), and platelet-rich plasma (PRP) groups. One week after the treatment, granulation tissue formation and angiogenesis were evaluated by histological and laser Doppler analysis.Results.The resultant platelet count in platelet-rich plasma was higher than that of PPP. The concentrations of platelet-derived growth factor BB, transforming growth factorβ-1, and vascular endothelial growth factor in PRP were significantly higher when compared with that of PPP. Myofibroblast count, granulation tissue thickness, vessel numbers, and blood perfusion were increased in PRP group, followed by PPP group, with control being the least.Conclusion.Rapidlyin situforming platelet-rich plasma gel promoted remarkable neovascularization and early wound healing after open abdomen and may lead to novel and effective treatments for open abdominal wounds.

COMPARATIVE STUDY OF ROLE OF WOUND OUTCOME IN VACUUM ASSISTED CLOSURE OF WOUNDS TO CLASSICAL (MOIST) WOUND CLOSURES

2021 ◽  
Vol 5 (6) ◽  
Author(s):  
Aprajita Kumari ◽  
Atul Vyas
Keyword(s):  
Granulation Tissue ◽  
Average Rate ◽  
Maximum Length ◽  
Research Centre ◽  
Tissue Formation ◽  
Vacuum Assisted Closure ◽  
Maximum Width ◽  
Granulation Tissue Formation ◽  
Group I ◽  
Group Ii

Background & Method: This study is conducted at General Surgery department of Index Medical College Hospital and Research Centre, Indore (M.P.) To Analysis of wound outcome in Vacuum assisted closure of wounds in comparison to classical (moist) wound closure in terms of rate of granulation tissue formation, culture at presentation, complications and recommendations. The wound of the patient was assessed by measuring the maximum length and maximum width of the wound. Then on day 7th, 14th and day 21st, the maximum length and maximum width of the granulation tissue covering the same wound was measured. Result: In Group I Mean age of patients is 39 ± 13 years and in Group II it is 42 ± 14 years. In Group I and Group II there is no difference in the gender wise distribution. The most common disease in both the groups I and II is bed sore followed by compound fractures. The most common organism on culture in group I is S. aureus (9) followed by polymicrobial growth (7), and in group II is S. aureus (10) followed by E.coli (7). The average rate of granulation in group I on day 7th is 27.63 ± 23.23, on day 14th it increased to 35.92 ± 25.75, and on day 21st it further increased to 65.6 ± 15.20. The average rate of granulation in group II on day 7th is 31.34 ± 18.22, on day 14th it is increased to 57.4 ± 17.55, and on day 21st it further increased to 75.16 ± 6.732. Group I had higher number of complications (8) in comparison to group II (6). There is no complication in 44 patients of group II and 42 patients of group I. Conclusion: In our present study it was concluded that the rate of granulation tissue formation was better in the VAC group in comparison to the conventional dressing group. Vacuum assisted closure dressing was found to be totally safe, although technically demanding. Thus, we conclude that the surgeon’s discretion is very much needed in VAC being the choice of dressings in certain wounds and where there is much difficulty in performing VAC dressings, the conventional dressings should be the choice. Keywords: wound, vacuum, moist & outcome.

Overexpression of hepatocyte growth factor/scatter factor promotes vascularization and granulation tissue formation in vivo

FEBS Letters ◽  
2001 ◽  
Vol 509 (1) ◽  
pp. 95-100 ◽  
Author(s):  
Mitsuo Toyoda ◽  
Hisashi Takayama ◽  
Norio Horiguchi ◽  
Toshiyuki Otsuka ◽  
Toshio Fukusato ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Granulation Tissue ◽  
Tissue Formation ◽  
Scatter Factor ◽  
Granulation Tissue Formation ◽  
Hepatocyte Growth

Epidermal growth factor increases granulation tissue formation dose dependently

1987 ◽  
Vol 43 (4) ◽  
pp. 322-328 ◽  
Author(s):  
Anne Buckley ◽  
Jeffrey M. Davidson ◽  
Craig D. Kamerath ◽  
Stephen C. Woodward
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Granulation Tissue ◽  
Tissue Formation ◽  
Granulation Tissue Formation ◽  
Epidermal Growth
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