scholarly journals Large-Scale Screening in General Population Children for Celiac Disease with a Multiplex Electrochemiluminescence (ECL) Assay

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Ling He ◽  
Xiaofan Jia ◽  
Yong Gu ◽  
Dongmei Miao ◽  
Kathleen Waugh ◽  
...  
Keyword(s):  
Celiac Disease ◽  
General Population ◽  
Large Scale ◽  
Initial Screening ◽  
Efficient Tool ◽  
High Efficient ◽  
Single Well ◽  
Radiobinding Assay ◽  
Large Scale Screening

Background. Autoimmunity Screening for Kids (ASK) study was launched to screen general population children for type 1 diabetes (T1D) and celiac disease (CD). Methods. A total of 23,319 children from general population were screened. A high throughput multiplex electrochemiluminescence (ECL) assay to screen multiautoantibodies in a single well was applied, parallel with a standard radiobinding assay (RBA). All children with any positive autoantibodies in screening were revisited within one month for confirmation and followed every 6 months. Results. Among 23,319 children, 2.6% (606/23,319) of children were tested positive for TGA. Multiplex ECL assay detected more TGA (584/23,319) in the initial screening than RBA (490/23,319, p = 0.004 ) and was able to detect TGA earlier than RBA in a subset of children by 0.8 to 34.8 months. Prevalence of TGA by either ECL or RBA in children with islet autoantibodies was found significantly higher than overall prevalence in general population screened. Conclusions. A multiplex ECL assay was more sensitive than standard RBA by identifying more TGA positivity and detecting TGA earlier in general population screening. It also provides a high efficient tool with its unique advantage of multiplexing measurements to screen for multiple autoimmune diseases simultaneously in general population.

scholarly journals The Epidemiology of Celiac Disease in the General Population and High-Risk Groups in Arab Countries: A Systematic Review

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Ashraf El-Metwally ◽  
Paivi Toivola ◽  
Khalid AlAhmary ◽  
Salwa Bahkali ◽  
Ali AlKhathaami ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Saudi Arabia ◽  
Celiac Disease ◽  
General Population ◽  
Abdominal Distension ◽  
Autoimmune Disorder ◽  
Risk Groups ◽  
Geographic Region ◽  
Arab Countries

Background and Aims. Celiac disease (CD) is possibly the most common autoimmune disorder, which may lead to dietary problems in the Arab region. This paper is aimed at exploring the epidemiology of the celiac disease in Arab countries, including its prevalence, associated risk factors, and clinical patterns. Methods. An extensive search of the literature was conducted from electronic databases such as PubMed, Embase, and Google Scholar. In total, 134 research papers were retrieved. We extracted studies published from January 1996 to December 2019. Our search was limited to studies published in English. Findings. The review included 35 studies with 22,340 participants from 12 countries and demonstrated a wide variation in the prevalence of CD. The highest prevalence among the general population (3.2%) was reported in Saudi Arabia, and the lowest (0.1%) was reported in Tunisia. Women demonstrated a higher prevalence of celiac disease relative to men. The peak age at diagnosis fell between 1 and 3 years and 9-10 years. Most studies focused on type 1 diabetes. Children with type 1 diabetes have a higher prevalence of CD (range from 5.5% to 20%), while the prevalence of CD in Down’s syndrome patients was 1.1% and 10.7% in UAE and Saudi Arabia, respectively. Other autoimmune diseases associated with CD are thyroid disease and irritable bowel disease. The most widely recognized clinical presentation was an inability to flourish and poor weight gain, followed by short stature, abdominal pain, abdominal distension, bloating, and chronic diarrhea. Conclusion. The prevalence of the celiac disease in Arab countries varies with sex and age. However, we found that celiac disease presented similar clinical characteristics independent of the geographic region. Longitudinal population-based studies are needed to better identify the true burden and determinants of celiac disease.

scholarly journals The Immune-Buffer COVID-19 Exit Strategy that Protects the Elderly

2020 ◽  
Author(s):  
Vered Rom-Kedar ◽  
Omer Yaniv ◽  
Roy Malka ◽  
Ehud Shapiro
Keyword(s):  
At Risk ◽  
General Population ◽  
Large Scale ◽  
Respiratory Illness ◽  
The Elderly ◽  
Disease Spread ◽  
Population At Risk ◽  
The Family ◽  
Large Scale Screening ◽  
Viral Respiratory

COVID-19 is a viral respiratory illness, caused by the SARS-CoV-2 virus with frequent symptoms of fever and shortness of breath. COVID-19 has a high mortality rate among elders. The virus has spread world-wide, leading to shut-down of many countries around the globe with the aim of stopping the spread of the disease. To date, there are uncertainties regarding the main factors in the disease spread, so sever social distancing measures and broad testing are required in order to protect the population at risk. With the increasing spread of the virus, there is growing fraction of the general population that may be immune to COVID-19, following infection. This immunised cohort can be uncovered via large-scale screening for the SARS-CoV-2 (Corona) virus and/or its antibodies. We propose that this immune cohort be deployed as a buffer between the general population and the population most at risk from the disease. Here we show that under a broad range of realistic scenarios deploying such an immunized buffer between the general population and the population at risk may lead to a dramatic reduction in the number of deaths from the disease. This provides an impetus for: screening for the SARS-CoV-2 virus and/or its antibodies on the largest scale possible, and organizing at the family, community, national and international levels to protect vulnerable populations by deploying immunized buffers between them and the general population wherever possible.

scholarly journals Cost and Cost-effectiveness of Large-scale Screening for Type 1 Diabetes in Colorado

Diabetes Care ◽  
2020 ◽  
Vol 43 (7) ◽  
pp. 1496-1503 ◽  
Author(s):  
R. Brett McQueen ◽  
Cristy Geno Rasmussen ◽  
Kathleen Waugh ◽  
Brigitte I. Frohnert ◽  
Andrea K. Steck ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Cost Effectiveness ◽  
Large Scale ◽  
Large Scale Screening

Training Aides to Screen Children for Speech and Language Problems

1976 ◽  
Vol 7 (4) ◽  
pp. 236-241 ◽  
Author(s):  
Marisue Pickering ◽  
William R. Dopheide
Keyword(s):  
Rural Areas ◽  
Large Scale ◽  
School Personnel ◽  
School Age Children ◽  
Speech And Language ◽  
Elementary School Age ◽  
Evaluation Procedures ◽  
Language Problems ◽  
Competency Based ◽  
Large Scale Screening

This report deals with an effort to begin the process of effectively identifying children in rural areas with speech and language problems using existing school personnel. A two-day competency-based workshop for the purpose of training aides to conduct a large-scale screening of speech and language problems in elementary-school-age children is described. Training strategies, implementation, and evaluation procedures are discussed.

Celiac disease and risk of subsequent type 1 diabetes

2009 ◽  
Vol 47 (05) ◽  
Author(s):  
É Micskey ◽  
P Pánczél ◽  
L Blatniczky ◽  
K Lukács
Keyword(s):  
Type 1 Diabetes ◽  
Celiac Disease

Diagnostic Accuracy of Serologic Screening Tests for Celiac Disease in Asymptomatic Adults and Children with Type 1 Diabetes

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1579-P
Author(s):  
MICHELLE GOULD ◽  
FARID H. MAHMUD ◽  
ANTOINE B. CLARKE ◽  
ESTHER ASSOR ◽  
AMISH PARIKH ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Diagnostic Accuracy ◽  
Screening Tests ◽  
Adults And Children ◽  
Serologic Screening
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