scholarly journals Focal Segmental Glomerulosclerosis in Waldenström’s Macroglobulinemia

2020 ◽  
Vol 2020 ◽  
pp. 1-3
Author(s):  
Akshee Batra ◽  
Shatha Herz Allah ◽  
Bijin Thajudeen
Keyword(s):  
Focal Segmental Glomerulosclerosis ◽  
Oral Prednisone ◽  
Renal Involvement ◽  
Waldenström’S Macroglobulinemia ◽  
Segmental Glomerulosclerosis ◽  
Rare Manifestation ◽  
History Of ◽  
Waldenstrom's Macroglobulinemia ◽  
Waldenstrom’S Macroglobulinemia ◽  
Waldenström's Macroglobulinemia

Renal involvement in Waldenström’s macroglobulinemia is a rare manifestation. Although most renal involvement is due to monoclonal immune deposits, pathology can also be unrelated to it. Here, we describe a 68-year-old female with a history of Waldenström’s macroglobulinemia who presented with generalized edema and nephrotic range proteinuria. A renal biopsy showed findings consistent with focal segmental glomerulosclerosis. Treatment with oral prednisone leads to the resolution of proteinuria. This case highlights the importance of identifying pathology that might not be directly related to monoclonal gammopathy, which could have implications on the management.

scholarly journals Severe nephritis as initial sign of Waldenström’s macroglobulinemia

2019 ◽  
Vol 9 (4) ◽  
Author(s):  
Thomas Knoop ◽  
Kristin Kampevold Larsen ◽  
Friedemann Leh ◽  
Anette Lodvir Hemsing ◽  
Ingrid Anna Teigen ◽  
...  
Keyword(s):  
Renal Involvement ◽  
Therapeutic Approaches ◽  
Waldenström’S Macroglobulinemia ◽  
Rare Manifestation ◽  
Monoclonal Immunoglobulins ◽  
Initial Sign ◽  
Waldenstrom's Macroglobulinemia ◽  
Waldenstrom’S Macroglobulinemia ◽  
Nephrotic Range Proteinuria ◽  
Waldenström's Macroglobulinemia

Waldenström’s macroglobulinemia (WM), characterized with monoclonal immunoglobulins of type M and lymphoplasmacytic lymphoma, is a rare clonal Bcell disorder. WM usually present as an indolent lymphoma, and renal involvement is, in contrast to multiple myeloma, very rarely seen. We present a patient presenting with severe nephritis and nephrotic range proteinuria of more than 9 g/day as initial manifestations of WM. Furthermore, we discuss diagnostic and therapeutic approaches for this rare manifestation of the disease, in the light of recent research and treatment recommendations.

scholarly journals Bing-Neel Syndrome – A Challenging Diagnosis: Case Report

2020 ◽  
pp. 28-33
Author(s):  
Y. Davidkova ◽  
N. Simonoski ◽  
B. Spassov ◽  
G. Balatzenko ◽  
M. Guenova
Keyword(s):  
Cerebrospinal Fluid ◽  
Neurologic Complication ◽  
Waldenström’S Macroglobulinemia ◽  
History Of ◽  
The Central Nervous System ◽  
Waldenstrom's Macroglobulinemia ◽  
Waldenstrom’S Macroglobulinemia ◽  
Flow Cytometry Detection ◽  
One Year ◽  
Waldenström's Macroglobulinemia

Bing-Neel syndrome is a rare neurologic complication of Waldenström’s macroglobulinemia, characterized by infiltration of the central nervous system by clonal lymphoplasmacytes. We present a rare clinical case of a patient, who one year after the diagnosis of Waldenström’s macroglobulinemia, progressed with diverse neurologic presentation and cerebrospinal fluid involvement. The diagnosis was based on magnetic resonance imaging and flow cytometry detection of clonal B-cells in the cerebrospinal fluid. Bing-Neel syndrome should be considered in patients with neurologic symptoms and a history of Waldenström’s macroglobulinemia.

Positional Nystagmus in Association with Macroglobulinemia

1975 ◽  
Vol 84 (2) ◽  
pp. 223-227 ◽  
Author(s):  
Robert J. Keim ◽  
George B. Sachs
Keyword(s):  
Lymphoproliferative Disease ◽  
Positional Nystagmus ◽  
Waldenström’S Macroglobulinemia ◽  
History Of ◽  
Gravity Receptors ◽  
Alternate Mechanism ◽  
Vestibular Symptoms ◽  
Waldenstrom's Macroglobulinemia ◽  
Waldenstrom’S Macroglobulinemia ◽  
Waldenström's Macroglobulinemia

Waldenstrom's macroglobulinemia is a malignant lymphoproliferative disease associated with a monoclonal macroglobulinemia. Most explanations of the cochlear and vestibular symptoms in this disease have dealt with vascular thrombotic or hemorrhagic phenomena. Five patients currently being treated for macroglobulinemia have been reviewed. Three patients gave a history of periodic dizziness and underwent extensive neuro-otologic examination. The results suggested an alternate mechanism for the pathophysiology of the vestibular disturbance in macroglobulinemia. Vestibular examination by use of electronystagmography provided information which suggests that the cupulae may be altered by the macroglobulins to act as gravity receptors.

Waldenström's macroglobulinemia developing in a patient with multiple sclerosis: coincidence or association?

2004 ◽  
Vol 10 (5) ◽  
pp. 598-600 ◽  
Author(s):  
S Deftereos ◽  
D Farmakis ◽  
A Papadogianni ◽  
B Besleme ◽  
E Diamanti-Kandarakis ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Bone Marrow ◽  
Sedimentation Rate ◽  
Waldenström’S Macroglobulinemia ◽  
Erythrocyte Sedimentation ◽  
History Of ◽  
Plasma Cell Dyscrasias ◽  
Waldenstrom's Macroglobulinemia ◽  
Waldenstrom’S Macroglobulinemia ◽  
Waldenström's Macroglobulinemia

Multiple sclerosis (MS) has been reported in association with haematological abnormalities, including monoclonal gammopathies. We present a 54-year-old male patient with a 30-year history of MS who was admitted to our hospital for investigation of anaemia and increased erythrocyte sedimentation rate. A monoclonal IgM protein was detected by serum protein immunofixation, while bone marrow biopsy indicated a 70% infiltration by small lymphoplasmacytoid cells, in the context of a lymphoplasmacytoid immunocytoma, findings compatible to the diagnosis of Waldenström's macroglobulinemia (WM). To our knowledge, this is the first report of WM in a patient with MS. Further to the coexistence of the two diseases observed in the case presented here, there is additional evidence suggesting that the association of MS with plasma cell dyscrasias may not be coincidental.

Predictive Factors for Response to Rituximab in Waldenström's Macroglobulinemia

2005 ◽  
Vol 5 (4) ◽  
pp. 270-272 ◽  
Author(s):  
Meletios A. Dimopoulos ◽  
Athanasios Anagnostopoulos ◽  
Constantinos Zervas ◽  
Marie C. Kyrtsonis ◽  
Athanasios Zomas ◽  
...  
Keyword(s):  
Predictive Factors ◽  
Waldenström’S Macroglobulinemia ◽  
Waldenstrom's Macroglobulinemia ◽  
Waldenstrom’S Macroglobulinemia ◽  
Waldenström's Macroglobulinemia
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