scholarly journals 4-tert-Octylphenol Exposure Disrupts Brain Development and Subsequent Motor, Cognition, Social, and Behavioral Functions

2020 ◽  
Vol 2020 ◽  
pp. 1-17
Author(s):  
Dinh Nam Tran ◽  
Eui-Man Jung ◽  
Yeong-Min Yoo ◽  
Eui-Bae Jeung
Keyword(s):  
Brain Development ◽  
Mouse Brain ◽  
Histone H3 ◽  
Consumer Products ◽  
Endocrine Disrupting Chemical ◽  
Neuronal Progenitor ◽  
Endocrine Disrupting ◽  
Estrogenic Chemical ◽  
Induced Apoptosis ◽  
And Behavior

The endocrine-disrupting chemical 4-tert-octylphenol (OP) is a widespread estrogenic chemical used in consumer products such as epoxy resins and polycarbonate plastic. However, the effects of OP on brain development are unknown. The present study examined the effects of OP on neuron and neurobehavioral development in mice. By using primary cortical neuron cultures, we found that OP-treated showed a decreased length of axons and dendrites and an increased number of primary and secondary dendrites. OP reduced bromodeoxyuridine (BrdU), mitotic marker Ki67, and phospho-histone H3 (p-Histone-H3), resulting in a reduction of neuronal progenitor proliferation in offspring mouse brain. Moreover, OP induced apoptosis in neuronal progenitor cells in offspring mouse brain. Furthermore, offspring mice from OP-treated dams showed abnormal cognitive, social, and anxiety-like behaviors. Taken together, these results suggest that perinatal exposure to OP disrupts brain development and behavior in mice.

scholarly journals Distribution of parthenogenetic cells in the mouse brain and their influence on brain development and behavior.

1995 ◽  
Vol 92 (23) ◽  
pp. 10782-10786 ◽  
Author(s):  
N. D. Allen ◽  
K. Logan ◽  
G. Lally ◽  
D. J. Drage ◽  
M. L. Norris ◽  
...  
Keyword(s):  
Brain Development ◽  
Mouse Brain ◽  
And Behavior

scholarly journals Gestational Exposure to Bisphenol A Produces Transgenerational Changes in Behaviors and Gene Expression

Endocrinology ◽  
2012 ◽  
Vol 153 (8) ◽  
pp. 3828-3838 ◽  
Author(s):  
Jennifer T. Wolstenholme ◽  
Michelle Edwards ◽  
Savera R. J. Shetty ◽  
Jessica D. Gatewood ◽  
Julia A. Taylor ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Social Interactions ◽  
Complex Disease ◽  
Neurological Diseases ◽  
Gene Transcript ◽  
Brain Organization ◽  
Endocrine Disrupting Chemical ◽  
Endocrine Disrupting ◽  
And Behavior ◽  
Heritable Effects

Bisphenol A (BPA) is a plasticizer and an endocrine-disrupting chemical. It is present in a variety of products used daily including food containers, paper, and dental sealants and is now widely detected in human urine and blood. Exposure to BPA during development may affect brain organization and behavior, perhaps as a consequence of its actions as a steroid hormone agonist/antagonist and/or an epigenetic modifier. Here we show that BPA produces transgenerational alterations in genes and behavior. Female mice received phytoestrogen-free chow with or without BPA before mating and throughout gestation. Plasma levels of BPA in supplemented dams were in a range similar to those measured in humans. Juveniles in the first generation exposed to BPA in utero displayed fewer social interactions as compared with control mice, whereas in later generations (F2 and F4), the effect of BPA was to increase these social interactions. Brains from embryos (embryonic d 18.5) exposed to BPA had lower gene transcript levels for several estrogen receptors, oxytocin, and vasopressin as compared with controls; decreased vasopressin mRNA persisted into the F4 generation, at which time oxytocin was also reduced but only in males. Thus, exposure to a low dose of BPA, only during gestation, has immediate and long-lasting, transgenerational effects on mRNA in brain and social behaviors. Heritable effects of an endocrine-disrupting chemical have implications for complex neurological diseases and highlight the importance of considering gene-environment interactions in the etiology of complex disease.

Bisphenol A, an endocrine-disrupting chemical, and brain development

2012 ◽  
Vol 32 (4) ◽  
pp. 447-457 ◽  
Author(s):  
Kyoko Itoh ◽  
Takeshi Yaoi ◽  
Shinji Fushiki
Keyword(s):  
Bisphenol A ◽  
Brain Development ◽  
Endocrine Disrupting Chemical ◽  
Endocrine Disrupting

scholarly journals A Study on the Relationship between Fatigue, Psychosocial Stress, and Behavior that Reduces Endocrine Disrupting Chemicals Exposure in Infertile Males

2021 ◽  
Vol 25 (3) ◽  
pp. 211-220
Author(s):  
Sung Ju Kim ◽  
So Young Choi
Keyword(s):  
Psychosocial Stress ◽  
Intervention Program ◽  
Endocrine Disrupting Chemicals ◽  
Nursing Intervention ◽  
Baseline Data ◽  
Endocrine Disrupting Chemical ◽  
Endocrine Disrupting ◽  
The Mean ◽  
And Behavior ◽  
The Relationship

Purpose: This study aimed to identify the relationships between fatigue, psychosocial stress, and behavior of infertile males that reduces endocrine-disrupting chemical (EDC) exposure and to provide baseline data needed for nursing intervention. Methods: A total of 110 infertile males were recruited from a special fertility hospital in Gwangju city in Korea. The participants were administered a self-reported questionnaire. Results: The mean scores were as follows: for fatigue, 59.1 out of 133; for psychosocial stress, 20.3 out of 54; and for behavior that reduced EDC exposure, 52.6 out of 85. Fatigue and psychosocial stress had a positive correlation(r=0.68, p<0.001), behavior that reduces EDC exposure was negatively correlated with fatigue and psychosocial stress(r=-0.54, p<0.001; r=-0.61, p<0.001) Conclusion: Fatigue and stress were higher in infertile males. Our findings suggest that a nursing intervention program should focus on reducing fatigue and stress in infertile males and induce behaviors that decrease EDC exposure.

XLF/Cernunnos Loss Impairs Mouse Brain Development by Altering Symmetric Proliferative Divisions of Neural Progenitors

2020 ◽  
Author(s):  
Amandine Bery ◽  
Olivier Etienne ◽  
Laura Mouton ◽  
Sofiane Mokrani ◽  
Christine Granotier-Beckers ◽  
...  
Keyword(s):  
Brain Development ◽  
Mouse Brain ◽  
Neural Progenitors ◽  
Mouse Brain Development

scholarly journals Endocrine disrupting chemical-associated hair product use during pregnancy and gestational age at delivery: a pilot study

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Emma V. Preston ◽  
Victoria Fruh ◽  
Marlee R. Quinn ◽  
Michele R. Hacker ◽  
Blair J. Wylie ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Black Women ◽  
Pilot Study ◽  
Gestational Age ◽  
Endocrine Disrupting Chemical ◽  
Product Use ◽  
Frequent Use ◽  
Increased Risk ◽  
Endocrine Disrupting ◽  
Gestational Age At Delivery

Abstract Background Prenatal endocrine disrupting chemical (EDC) exposure has been associated with increased risk of preterm birth. Non-Hispanic Black women have higher incidence of preterm birth compared to other racial/ethnic groups and may be disproportionately exposed to EDCs through EDC-containing hair products. However, research on the use of EDC-associated hair products during pregnancy and risk of preterm birth is lacking. Therefore, the objective of this pilot study was to estimate associations of prenatal hair product use with gestational age at delivery in a Boston, Massachusetts area pregnancy cohort. Methods The study population consisted of a subset of participants enrolled in the Environmental Reproductive and Glucose Outcomes (ERGO) Study between 2018 and 2020. We collected self-reported data on demographics and hair product use using a previously validated questionnaire at four prenatal visits (median: 12, 19, 26, 36 weeks’ gestation) and abstracted gestational age at delivery from medical records. We compared gestational age and hair product use by race/ethnicity and used linear regression to estimate covariate-adjusted associations of product use and frequency of use at each study visit with gestational age at delivery. Primary models were adjusted for maternal age at enrollment and delivery method. Results Of the 154 study participants, 7% delivered preterm. Non-Hispanic Black participants had lower mean gestational age at delivery compared to non-Hispanic White participants (38.2 vs. 39.2 weeks) and were more likely to report ever and more frequent use of hair products. In regression models, participants reporting daily use of hair oils at visit 4 had lower mean gestational age at delivery compared to non-users (β: -8.3 days; 95% confidence interval: -14.9, -1.6). We did not find evidence of associations at earlier visits or with other products. Conclusions Frequent use of hair oils during late pregnancy may be associated with shorter gestational duration. As hair oils are more commonly used by non-Hispanic Black women and represent potentially modifiable EDC exposure sources, this may have important implications for the known racial disparity in preterm birth.

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