scholarly journals Promising Natural Products in Crop Protection and Food Preservation: Basis, Advances, and Future Prospects

2020 ◽  
Vol 2020 ◽  
pp. 1-28
Author(s):  
Temitope A. Ogunnupebi ◽  
Abimbola P. Oluyori ◽  
Adewumi O. Dada ◽  
Oluwole S. Oladeji ◽  
Adejumoke A. Inyinbor ◽  
...  
Keyword(s):  
Natural Products ◽  
Natural Product ◽  
Crop Protection ◽  
Food Preservation ◽  
Plant Diseases ◽  
Future Prospects ◽  
Food Preservatives ◽  
The Past ◽  
Agricultural Produce ◽  
Synthetic Pesticides

The increase in demand for agricultural produce necessitates the continuous search for affordable, ecofriendly, readily available crop protectors, and food preservatives. Historically, the use of various chemicals was employed in controlling plant diseases and to maintain food quality. In the past few decades, several natural product-based alternatives have been discovered and projected as better alternatives to synthetic pesticides and other synthetic agrochemicals. Recent studies focusing on the application of different botanicals in crop protection and food preservation were carefully selected and reviewed. The application of plant extract in the biogenic preparation of nanoparticles was also reviewed. This review confirms that several natural products can be used as a safe replacement for synthetic agrochemicals. Different plant extracts have also served as feed for the synthesis of nanoparticle, which is increasingly applicable in crop protection and food preservation.

Synthesis of α-exo-Methylene-γ-butyrolactone: Recent Developments and Applications in Natural Product Synthesis

Synthesis ◽  
2021 ◽  
Author(s):  
Weilong Liu ◽  
Nicolas Winssinger
Keyword(s):  
Natural Products ◽  
Biological Activity ◽  
Total Synthesis ◽  
Natural Product ◽  
Natural Product Synthesis ◽  
Vast Array ◽  
The Past ◽  
New Approaches ◽  
Recent Developments

The α-exo-methylene-γ-butyrolactone moiety is present in a vast array of structurally diverse natural products and is often central to their biological activity. In this review, we summarize new approaches to α-exo-methylene-γ-butyrolactones developed over the past decade as well as their applications in total synthesis.

scholarly journals Naturally Occurring Diarylheptanoids

2010 ◽  
Vol 5 (10) ◽  
pp. 1934578X1000501 ◽  
Author(s):  
Haining Lv ◽  
Gaimei She
Keyword(s):  
Antioxidant Activity ◽  
Natural Products ◽  
Natural Product ◽  
Spectral Data ◽  
The Past ◽  
Naturally Occurring ◽  
Natural Product Research ◽  
Structural Skeleton ◽  
Antimicrobial And Antioxidant Activity ◽  
C Nmr

Diarylheptanoids, natural products with a 1,7-diphenylheptane structural skeleton, are mainly distributed in the roots, rhizomes and bark of Alpinia, Zingiber, Curcuma and Alnus species. They have become of interest in natural product research over the past twenty years because of their remarkable anticancer, anti-emetic, estrogenic, antimicrobial and antioxidant activity. This paper compiles all 307 naturally occurring diarylheptanoids from 46 plants as reported in 137 references with their distributions, physiological activities and 13C-NMR spectral data.

A Decade with Dötz Benzannulation in the Synthesis of Natural Products

Synlett ◽  
2020 ◽  
Vol 31 (05) ◽  
pp. 403-420 ◽  
Author(s):  
Rodney A. Fernandes ◽  
Anupama Kumari ◽  
Ramdas S. Pathare
Keyword(s):  
Natural Products ◽  
Natural Product ◽  
Natural Product Synthesis ◽  
General Description ◽  
The Past ◽  
Rapid Construction ◽  
Molecular Architectures

The Dötz benzannulation is a named reaction that utilizes Fischer chromium carbenes in a formal [3+2+1] cycloaddition with an alkyne and CO to produce the corresponding benzannulated product. Since its development in the 1970s, this reaction has been extensively used in the synthesis of natural products and various molecular architectures. Although the reaction sometimes suffers from the formation of other competing side products, the rapid construction of naphthol structures with a 1,4-dihydroxy unit makes it the most appropriate reaction for the synthesis of p-naphthoquinones. This review focuses on our group’s efforts over the past decade on the extensive use of this annulation reaction along with the contributions of others on the synthesis of different natural products.1 Introduction2 General Description and Mechanism of the Dötz Benzannulation Reaction3 Applications of the Dötz Benzannulation in Natural Product Synthesis over the Last Decade4 Conclusion

Stereoconfining macrocyclizations in the total synthesis of natural products

2019 ◽  
Vol 36 (11) ◽  
pp. 1546-1575 ◽  
Author(s):  
Kuan Zheng ◽  
Ran Hong
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Natural Product ◽  
The Past

This review covers selected examples of point chirality-forming macrocyclizations in natural product total synthesis in the past three decades.

Manipulating nature's sugar biosynthetic machineries for glycodiversification of macrolides: Recent advances and future prospects

2007 ◽  
Vol 79 (4) ◽  
pp. 785-799 ◽  
Author(s):  
Christopher J. Thibodeaux ◽  
Hung-wen Liu
Keyword(s):  
Natural Products ◽  
Natural Product ◽  
Biosynthetic Pathway ◽  
Effective Means ◽  
Future Prospects ◽  
Research Groups ◽  
Targeted Disruption ◽  
In Vitro Methods

Changing the sugar structures and glycosylation patterns of natural products is an effective means of altering the biological activity of clinically useful drugs. Several recent strategies have provided researchers with the opportunity to manipulate sugar structures and to change the sugar moieties attached to these natural products via a biosynthetic approach. In this review, we explore the utility of contemporary in vivo and in vitro methods to achieve natural product glycodiversification. This study will focus on recent progress from our laboratory in elucidating the biosynthesis of D-desosamine, a deoxysugar component of many macrolide antibiotics, and will highlight how we have engineered the D-desosamine biosynthetic pathway in Streptomyces venezuelae through targeted disruption and heterologous expression of the sugar biosynthetic genes to generate a variety of new glycoforms. The in vitro exploitation of the substrate flexibility of the endogenous D-desosamine glycosyltransferase (GT) to generate many non-natural glycoforms will also be discussed. These experiments are compared with recent work from other research groups on the same topics. Finally, the significance of these studies for the future prospects of natural product glycodiversification is discussed.

scholarly journals Natural Products from Actinobacteria Associated with Fungus-Growing Termites

Antibiotics ◽  
2018 ◽  
Vol 7 (3) ◽  
pp. 83 ◽  
Author(s):  
René Benndorf ◽  
Huijuan Guo ◽  
Elisabeth Sommerwerk ◽  
Christiane Weigel ◽  
Maria Garcia-Altares ◽  
...  
Keyword(s):  
Natural Products ◽  
Chemical Analysis ◽  
Natural Product ◽  
Culture Broth ◽  
Insect Host ◽  
Development Programs ◽  
Fungus Garden ◽  
The Past ◽  
Future Drug ◽  
Axenic Strains

The chemical analysis of insect-associated Actinobacteria has attracted the interest of natural product chemists in the past years as bacterial-produced metabolites are sought to be crucial for sustaining and protecting the insect host. The objective of our study was to evaluate the phylogeny and bioprospecting of Actinobacteria associated with fungus-growing termites. We characterized 97 Actinobacteria from the gut, exoskeleton, and fungus garden (comb) of the fungus-growing termite Macrotermes natalensis and used two different bioassays to assess their general antimicrobial activity. We selected two strains for chemical analysis and investigated the culture broth of the axenic strains and fungus-actinobacterium co-cultures. From these studies, we identified the previously-reported PKS-derived barceloneic acid A and the PKS-derived rubterolones. Analysis of culture broth yielded a new dichlorinated diketopiperazine derivative and two new tetracyclic lanthipeptides, named rubrominins A and B. The discussed natural products highlight that insect-associated Actinobacteria are highly prolific natural product producers yielding important chemical scaffolds urgently needed for future drug development programs.

Identifying Natural Products (NPs) as potential UPR inhibitors for crop protection

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381 ◽  
Author(s):  
A Bruguière ◽  
AM Le Ray ◽  
D Bréard ◽  
N Blon ◽  
N Bataillé ◽  
...  
Keyword(s):  
Natural Products ◽  
Crop Protection

Synthesis and Biological Evaluation of the Antimicrobial Natural Product Lipoxazolidinone A

2018 ◽  
Author(s):  
Jonathan J. Mills ◽  
Kaylib R. Robinson ◽  
Troy E. Zehnder ◽  
Joshua G. Pierce
Keyword(s):  
Natural Products ◽  
Natural Product ◽  
Mechanism Of Action ◽  
Marine Natural Products ◽  
Biological Evaluation ◽  
Lead Compounds ◽  
Follow Up Studies ◽  
Initial Resistance ◽  
Synthesis And Biological Evaluation

The lipoxazolidinone family of marine natural products, with an unusual 4-oxazolidinone heterocycle at their core, represents a new scaffold for antimicrobial discovery; however, questions regarding their mechanism of action and high lipophilicity have likely slowed follow-up studies. Herein, we report the first synthesis of lipoxazolidinone A, 15 structural analogs to explore its active pharmacophore, and initial resistance and mechanism of action studies. These results suggest that 4-oxazolidinones are valuable scaffolds for antimicrobial development and reveal simplified lead compounds for further optimization.

Unzipping Natural Products: Improved Natural Product Structure Predictions by Ensemble Modeling and Fingerprint Matching

2018 ◽  
Author(s):  
William A. Shirley ◽  
Brian P. Kelley ◽  
Yohann Potier ◽  
John H. Koschwanez ◽  
Robert Bruccoleri ◽  
...  
Keyword(s):  
Natural Products ◽  
Open Source ◽  
Natural Product ◽  
Gene Cluster ◽  
Public Domain ◽  
Product Structure ◽  
Fingerprint Matching ◽  
Ensemble Modeling ◽  
Chemical Structures ◽  
Source Gene

This pre-print explores ensemble modeling of natural product targets to match chemical structures to precursors found in large open-source gene cluster repository antiSMASH. Commentary on method, effectiveness, and limitations are enclosed. All structures are public domain molecules and have been reviewed for release.

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