scholarly journals Serum Kisspeptin and Its Relation to Metabolic Parameters and Glucose Metabolism in Prepubertal and Pubertal Obese Children

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Kochakorn Sithinamsuwan ◽  
Pat Mahachoklertwattana ◽  
Somboon Wankanit ◽  
Suwannee Chanprasertyothin ◽  
Sarunyu Pongratanakul ◽  
...  

Objective. Kisspeptin, a puberty control neuropeptide, has been discovered to have an additional role in metabolism and glucose homeostasis regulation. This study aimed to determine the association of serum kisspeptin with metabolic parameters and glucose metabolism in obese children. Design, Patients and Measurements. A cross-sectional study of 270 obese children was conducted. All children underwent an oral glucose tolerance test and had serum kisspeptin, glycated hemoglobin (HbA1c), and lipid profile measurements. Body fat mass was assessed by bioelectrical impedance analysis. Serum kisspeptin levels of both prepubertal and pubertal children with two HbA1c ranges, <5.7% (normal range) and 5.7–6.4% (prediabetes range), were analyzed and correlated with metabolic parameters and glucose metabolism status. Results. The median (IQR) serum kisspeptin level of only pubertal (not prepubertal) children with prediabetes HbA1c was higher than those with normal HbA1c (53.2 (33.9, 69.8) and 37.8 (29.6, 67.5) pg/mL; p = 0.015 , respectively). There were no differences in serum kisspeptin levels among children with different glucose metabolism status. During pubertal progression, serum kisspeptin reached the highest level at Tanner stage II only in obese boys. Additionally, there was a positive correlation between serum kisspeptin and HbA1c after adjusting for puberty (β = 12.87; p = 0.001 ). No correlations between serum kisspeptin and insulin sensitivity indices, insulin secretion indices, lipid profile, blood glucose, as well as percentage of body fat were demonstrated. Conclusions. Serum kisspeptin levels in pubertal obese children with prediabetes HbA1c were greater than those with normal HbA1c. Serum kisspeptin was positively associated with HbA1c, but not with glucose metabolism status.

Author(s):  
Roselya Mutiara Pratiwi ◽  
Ni Luh Putu Arum Puspitaning Ati

Backgound: Measurement of body fat percentage as estimates of obesity, which can be done with the method of measuring the bioelectrical impedance analysis (BIA) and the meter inches inelastic. Both of these methods can be used as a simple, safe and non-nvasive. Objective: To analyze the comparative measurement of obesity with the BIA and the meter inches inelastic. Method: The study was observational analytic with cross sectional design. Sample were taken and selected through simple ramdomize sampling method. Data obtained directly by measuring samples that met the inclusion criteria. Obesity screening data obtained by measuring the percentage of body fat using BIA method and meter inches inelastic. Results: Based on the calculationn, as many as 65 samples taken by proportional random sampling in each specialization the student of the Faculty of Public Health 2014 Airlangga University. The percentage of female students with obesity using the BIA was 29,2% and inelastic inch meter is 21,5%. The statistical test showed t test was 0,897 ( sig>0,05). Conclusion: There are differences in the measurement result mean obesity BIA metered inches inelastic screening tools and have a good validity in measuring obesity. Suggestion : For further research it is recommended to be more accurate in measuring using an inelastic inch meter, while when using BIA  it  should use altimeter measurement because it is needed for data input. 


2019 ◽  
Vol 7 (2) ◽  
Author(s):  
Nandita Nury Latifah ◽  
Ani Margawati ◽  
Ayu Rahadiyanti

Komposisi tubuh yang tidak optimal dapat menurunkan kesegaran jasmani atlet sehingga dapat terjadi penurunan performa ketika bertanding. Tujuan dari penelitian ini adalah mengetahui hubungan persen lemak tubuh, persen massa otot, dan somatotype dengan kesegaran jasmani pada atlet hockey. Desain penelitian yaitu cross-sectional dengan jumlah subjek 35 atlet di Pelatihan Hockey Universitas Negeri Semarang dan Universitas Negeri Yogyakarta yang dipilih dengan purposive sampling. Data persen lemak tubuh dan persen massa otot diukur menggunakan bioelectrical impedence analysis (BIA). Data somatotype menggunakan metode antropometri Heath-Carter dan data kesegaran jasmani berupa nilai VO2max diambil menggunakan metode Balke. Analisis data menggunakan uji Pearson, Rank Spearman dan uji regresi linier. Sebagian besar atlet hockey (54,3%) memiliki nilai VO2max dengan kategori baik. Nilai persen lemak tubuh terendah 6,8% dan nilai tertinggi 35%. Nilai persen massa otot terendah 23,9% dan nilai tertinggi 40,9%. Nilai rata-rata dari nilai endomorph, mesomorph, dan ectomorph adalah (-0,04)±0,3; 4,2±0,9; dan 2,3±1,2. Ada hubungan yang signifikan antara persen lemak tubuh (p<0,001), persen massa otot (p<0,001), nilai endomorph (p<0,001), dan nilai ectomorph (p=0,016) dengan nilai VO2max. Variabel yang paling berkaitan dengan nilai VO2max adalah persen lemak (p<0,001). Correlation of body composition with physical fitness of hockey athletes AbstractSuboptimal body composition could reduce the physical fitness and performance of athletes. This study analyzed the relationship of percent body fat, percent muscle mass and somatotype on physical fitness in hockey athletes. This study was a cross-sectional study with 35 athletes in Pelatihan Hockey Universitas Negeri Semarang and Universitas Negeri Yogyakarta which selected by purposive sampling. Percent body fat and percent muscle mass were measured using bioelectrical impedance analysis (BIA). Somatotype measurement used the anthropometric Heath-Carter method and physical fitness (VO2max) measurement by the Balke method. Data were analyzed using the Pearson test, Rank-Spearman test, and Linear Regression test. Most hockey athletes (54.3%) had good VO2max value. The lowest percentage of body fat was 6.8%. The highest percentage of muscle mass was 40.9%. The average value of the endomorph, mesomorph, and ectomorph values were (-0.04) ± 0.3; 4.2 ± 0,9; and 2.3 ± 1.2.  There were a significant relationship between percent body fat (p <0.001), percent muscle mass (p <0.001), endomorph value (p <0.001), and ectomorph value (p = 0.016) with VO2max value. Percent of body fat was the most related variable to VO2max (p<0.001).


2011 ◽  
Vol 17 (1) ◽  
pp. 18-24
Author(s):  
Chang Hung HUNG

LANGUAGE NOTE | Document text in English; abstract also in Chinese. This study explored the association between BMI and body fat assessed by bioelectrical impedance analysis (BIA) in college students. Cross-sectional studies of 2,531 college students were measured. BIA was used to quantify body fat mass (BFM), percentage of body mass (%BF) and visceral fat area (VFA). Significant correlations between BMI and BFM, %BF, VFA were fund, respectively (r=0.923, 0.836, 0.912 in male, p<0.001; r=0.920, 0.741, 0.920 in female, p<0.001). Regression analysis revealed that 85.3%, 69.9%, and 83.1% of the variance for BFM, %BF, and VFA could be explained by BMI in male students (p<0.001); and 84.7%, 54.9%, and 84.6% of the variance for BFM, %BF, VFA could be explained by BMI in female students (p<0.001). BFM and VFA were highly associated with BMI in college students, suggesting that BMI serves as a good surrogate marker for obesity in college students aged 18-24 years. However, a significantly medium correlation existed in BMI and %BF, which may be a limitation for BMI, when used to study risk factors for cardiovascular or metabolic diseases. 本研究主要探討大學生身體質量指數 (BMI) 與體脂肪之關連性。總共有2,531位大學生進行測量。以生物電阻分析(BIA) 身體脂肪量 (BFM)、身體脂肪百分比 (%BF) 與內臟脂肪 (VFA),結果顯示: BMI與BFM、%BF、VFA均達顯著相關 (p<0.001)。本研究結果顯示大學生族群BMI與BFM、VFA有高度的關連性。因此,建議BMI可以做為18–24歲大學生族群評估肥胖之替代指標。然而,由於BMI與%BF僅存著中等的關連性,如果以BMI作為研究心血管或代謝疾病的危險因子,可能會成為研究之限制。


2018 ◽  
Vol 14 (3) ◽  
pp. 99
Author(s):  
Rahmani Welan ◽  
Gusti Revilla ◽  
Desmawati Desmawati

Background: One of the conditions on premenopausal period is the increase in body fat, among which are caused by levels of the fluctuating estrogen hormone. Increase fat affects the body fat percentage and adipsin levels. Adipsin plays a role in the stimulation of insulin secretion by producing C3a, in which C3AR1 (C3a Receptor 1) fragments interact with beta cells to secrete insulin.Objective: The purpose of this study is to determine correlation of body fat percentage with adipsin levels on premenopause.Design: This was an analytical study with cross-sectional design. Body fat percentage was obtained by examination using Bioelectrical Impedance Analysis (BIA). Venous blood was taken at the mediana cubiti area used for serum adipsin levels. Adipsin levels were analyzed by Enzyme-linked Immunosorbent Assay (ELISA) technique.Results: The mean of body fat percentage on premenopausal was 36,18 ± 8,35%. The mean of adipsin levels on premenopausal was 117,05 ± 87,93 ng/ml. Result of Pearson test analysis got value r = 0,632 and value p = 0.0005 (p <0,05).Conclusions: There is a positive significant correlation between the percentage of body fat with adipsin levels on premenopause.


PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0242782
Author(s):  
In Cheol Hwang ◽  
Kyoung Kon Kim ◽  
Kyu Rae Lee

Cryolipolysis has been considered as a noninvasive alternative to surgical procedures for reducing subcutaneous fat without affecting the surrounding tissues. However, no clinical trial has investigated changes in the abdominal fat tissue by 12 weeks after cryolipolysis. Therefore, in this split-body trial, we explored whether a single session of unilateral cryolipolysis could change visceral and subcutaneous adipose tissue over a period of 12 weeks. We compared the cross-sectional areas of the abdominal adipose tissue of 15 subjects (9 women; 38.3 [10.8] years) by computed tomography before and at 12 weeks after a single treatment of cryolipolysis to the left abdomen and used the right abdomen as untreated control. In addition, we measured participants’ waist circumference, percentage of body fat (by bioelectrical impedance analysis) at baseline and at 6- and 12-weeks post-treatment. Single unilateral cryolipolysis tended to reduce the cross-sectional areas of visceral adipose tissue, by 8.4 cm2 (9.9%), the waist circumferences, and the percent body fat, by 2.8 cm2 (0.6%), overall. The cross-sectional area of visceral adipose tissues on the treated side significantly decreased, by 6.8 cm2 (15.6%; P = 0.003), and that of the untreated side tended to decrease by 1.2 cm2 (3.6%). Thus, a single unilateral session of noninvasive selective cryolipolysis can be considered as a safe and effective treatment for reduction of visceral adipose tissue over a period of 12 weeks, which should result in metabolic improvement.


2020 ◽  
Author(s):  
Divanei Zaniqueli ◽  
Rafael de Oliveira Alvim ◽  
Rosane Harter Griep ◽  
Isabela Martins Benseñor ◽  
Sandhi Maria Barreto ◽  
...  

Abstract Background Conflicting results have been reported on the association of fat-free mass (FFM) and insulin resistance (IR). The way of indexing FFM may be a bias. This study sought to test the association of FFM and IR after indexing FFM to avoid collinearity. Methods This cross-sectional study comprised 11,284 volunteers, ages 38-79 years. Body composition was assessed by multi-frequency bioelectrical impedance. FFM indexed to body surface area (FFMbsa) was calculated. Excess body fat was assigned to individuals with percent body fat ≥ 85th percentile for age and sex. Fasting insulin and glucose, and 2h glucose in the oral glucose tolerance test were obtained. Homeostasis model assessment-insulin resistance (HOMA-IR) > 3.0 was set as the cut-off for IR.Results Percent body fat decreased from the 1st to the 5th quintile of FFMbsa in both women (Eta 2 = 0.166) and men (Eta 2 = 0.133). In women, fasting insulin (Eta 2 = 0.002), glucose (Eta 2 = 0.006), and HOMA-IR (Eta 2 = 0.007) increased slightly, whereas 2h glucose did not change towards the highest quintile of FFMbsa. In men, fasting insulin and HOMA-IR were similar across the quintiles of FFMbsa, whereas fasting glucose increased slightly (Eta 2 = 0.002) and 2h glucose decreased (Eta 2 = 0.005) towards the highest quintile of FFMbsa. Greater FFMbsa explained 1.8% of the odds of IR among women and 0.9% among men.Conclusion The lack of association of FFM and 2h glucose contrasted with greater odds of IR (by HOMA-IR) associated with greater FFM. The association of greater FFM and IR may be overestimated when the diagnosis is provided by HOMA-IR.


2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Tatsuya Ishige ◽  
Hiroshi Odaguchi ◽  
Toshihiko Hanawa

Shofuku-fujin is an abnormal physical finding in Kampo medical practice. It is assumed to be often found in the elderly and contributes to the selection of Kampo formulas used mainly in elderly patients. However, few objective reports about Shofuku-fujin have been published to date. The aim of this study was to clarify the clinical features of patients showing Shofuku-fujin by using bioelectrical impedance analysis (BIA) and to objectively assess the potential clinical implications of these findings. We conducted a cross-sectional study of 1330 patients who visited our institute to undergo a medical examination by using data collected from September 2010 to March 2016. We extracted data on patient sex and age, anthropometric data, and body composition data that could potentially affect the appearance of Shofuku-fujin. Logistic regression analyses were performed by sex to analyze the various factors related to the appearance of Shofuku-fujin. Of the 1330 patients, the data of 386 men and 942 women were used for analysis. Multivariate logistic regression analysis showed that Shofuku-fujin was associated with older age (odds ratio (OR), 1.07; 95% confidence interval (CI), 1.05–1.10; p  < 0.001), lower skeletal muscle mass index (SMI) (OR, 0.60; 95% CI, 0.43–0.85; p  = 0.004), and lower body fat percentage (OR, 0.89; 95% CI, 0.85–0.93; p  < 0.001) in men and older age (OR, 1.06; 95% CI, 1.04–1.07, p  < 0.001) and lower body fat percentage (OR, 0.94; 95% CI, 0.92–0.96; p  < 0.001) in women. On the basis of these results, the factors causing the appearance of Shofuku-fujin were aging, decreased muscle mass, and decreased body fat in men and aging and decreased body fat in women. Our results demonstrated that it may be better to consider a loss of muscle mass when examining a male patient with Shofuku-fujin.


2018 ◽  
Vol 12 (2) ◽  
pp. 191
Author(s):  
Anisaul Makarimah ◽  
Lailatul Muniroh

Menarche is first menstruation that an indicator of teenage girlsenter puberty phase. Nowadays the age of menarche has decreasedin tothe younger. The purpose of this study was to analyze the relation between nutritional status and body fat percentage with menarche age. This research used cross sectional design with sample size of 37 female students who had experienced menstruation and selected using simple random sampling. Data were collected by anthropometric measurements to assess nutritional status, body fat percentage using Bioelectrical Impedance Analysis (BIA). Data were analyzed by Spearman correlation test. The results showed that more than half of respondents had normal nutritional status (51.4%) and healthy body fat percentage. There was a correlation between nutritional status (p=0.029, r= -0.360) and body fat percentage (p =0.048, r=-0.328) with age of menarche among teenage girls at the Muhammadiyah GKB 1 Gresik Elementary School. The conclusion of this study was higher nutritional status (score of z-score) and fat percentage will decrease the age of menarche. Research suggestion is to normalize nutritional status and percent body fat. By maintaining consumption pattern and increase physical activity, such as cycling, swimming, and others.


Author(s):  
Manman Chen ◽  
Jieyu Liu ◽  
Ying Ma ◽  
Yanhui Li ◽  
Di Gao ◽  
...  

To investigate the associations between body fat percentage (BF%) with childhood blood pressure (BP) levels and elevated BP (EBP) risks, and further examine the validity of bioelectrical impedance analysis (BIA), we conducted a cross-sectional study of 1426 children and adolescents aged 7–17 years in Beijing, 2020. EBP, including elevated systolic BP (ESBP) and elevated diastolic BP (EDBP), was defined based on the age- and sex-specific 90th BP reference values of children and adolescents in China. BF% was measured by dual-energy X-ray absorptiometry (DEXA) and BIA devices, and was divided into four quartiles. Log-binomial models were applied to calculate odds ratios (ORs) and 95% confidence intervals (95%CI). Girls tended to have higher BF% levels than boys (p < 0.05). There was 41.0% of girls who developed EBP. High BF% was associated with increased BP levels with ORs of 0.364 (95%CI = 0.283–0.444) for SBP, 0.112 (95%CI = 0.059–0.165) for DBP, and 1.043 (95%CI = 1.027–1.059) for EBP, while the effects were more pronounced in girls and older-aged children. BIA devices agreed well with BF% assessment obtained by DEXA. High BF% might have negative effects on childhood BP. Convenient measurements of body fat might help to assess childhood obesity and potential risks of hypertension.


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