scholarly journals Keratorefractive Surgery Outcomes in Keratoconus Suspect Patients

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Milad Abdolahian ◽  
Mohammad Ali Moalem ◽  
Mohammadreza Jahady Hoseiny ◽  
Farsad Noorizadeh ◽  
Athar Zareei
Keyword(s):  
Corneal Thickness ◽  
Mean Values ◽  
Corrected Visual Acuity ◽  
Surgical Methods ◽  
Significant Difference ◽  
The Mean ◽  
Keratorefractive Surgery ◽  
Surgery Outcomes ◽  
Orbscan Ii

Purpose. To examine the outcomes of keratorefractive surgeries in keratoconus suspect patients. Methods. This study included 192 keratoconus suspects (351 eyes), treated with photorefractive keratectomy (PRK) (211 eyes), Lasik (96 eyes), and Femto-Lasik (44 eyes) surgeries in an eye clinic. The best spectacle-corrected visual acuity (BSCVA) and subjective refraction were evaluated preoperatively and postoperatively (three months and five years after the procedure). The Orbscan II topography system was also used preoperatively and five years after the procedure. Results. The patients’ mean age was 31.6 ± 5.49 years (range: 21–47 years) in the last follow-up. There was no significant difference between the preoperative and postoperative mean values of BSCVA in any of the surgical methods ( P  = 0.49). The mean spherical equivalent, cylindrical power, corneal curvature, the thinnest corneal thickness, and the central corneal thickness decreased significantly in the last follow-up ( P  < 0.001). Four patients (3.50%) in the PRK group and one patient (1.85%) in the Lasik group needed glasses in the last follow-up. Eleven cases of corneal ectasia were detected in the last follow-up (six eyes of four patients [2.84%] and five eyes of four patients [5.20%] in the PRK and Lasik groups, respectively). Conclusion. In the present study, the high risk of postoperative ectasia was detected in keratoconus suspects following PRK and Lasik surgeries. According to the results, it can be concluded that Femto-Lasik surgery provides better outcomes than Lasik and PRK. Overall, the surgical criteria are suggested to be evaluated case by case, and the patients must be followed up over time to assess the corneal topography and refraction stability.

scholarly journals Two-Year Accelerated Corneal Cross-Linking Outcome in Patients with Progressive Keratoconus

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Arleta Waszczykowska ◽  
Piotr Jurowski
Keyword(s):  
Visual Acuity ◽  
Corneal Thickness ◽  
Long Term Results ◽  
Cross Linking ◽  
Mean Values ◽  
Significant Difference ◽  
Uncorrected Visual Acuity ◽  
The Mean

Purpose. To evaluate the long-term results of accelerated corneal cross-linking (CXL) in patients with progressive keratoconus.Methods. Sixteen patients underwent accelerated CXL at 6 mW/cm2for 15 minutes in one eye. The follow-up visits were scheduled on 7 days, 14 days, and 3, 12, and 24 months after the treatment.Results. There were no significant differences (P>0.05) between preoperative and 2-year postoperative mean values, respectively, in terms of uncorrected visual acuity, best spectacle-corrected visual acuity, maximum keratometryKmax⁡, minimum keratometryKmin⁡, corneal astigmatism, and corneal eccentricity index. We noted a significant flattening of the cornea in 18.7% of patients with a higher preoperativeKmax⁡value (>50 D) and its steepening in patients with a lowerKmax⁡value (<50 D) (6.25%). There was no significant difference in the central corneal thickness and the apical corneal thickness preoperatively and 2 years postoperatively. The mean demarcation line depth was282±11 μm. Persistent corneal haze was noted in 25% of patients.Conclusions. Accelerated CXL appears to be a relatively effective procedure for the treatment of keratoconus in 2-year follow-up.

scholarly journals Real-World Results of Aflibercept versus Ranibizumab for the Treatment of Exudative AMD Using a Fixed Regimen

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Joana Providência ◽  
Tiago M. Rodrigues ◽  
Mariana Oliveira ◽  
João Bernardes ◽  
João Pedro Marques ◽  
...  
Keyword(s):  
Real World ◽  
Age Related Macular Degeneration ◽  
Treatment Protocols ◽  
Corrected Visual Acuity ◽  
Age Related ◽  
Significant Difference ◽  
Clinical Practice Setting ◽  
The Mean ◽  
Endothelial Growth Factors

Intravitreal injections of antivascular endothelial growth factors have been considered a milestone in the treatment of neovascular age-related macular degeneration (nAMD). However, the increasing incidence of AMD and the burden of visits and injections overcharge both the patient and the healthcare systems. Real-world solutions depend on treatment protocols aimed at optimizing the number of clinical visits while guaranteeing good functional outcomes. We performed a retrospective analysis of 72 eyes from 63 naïve patients diagnosed with nAMD that underwent a fixed intravitreal protocol consisting of bimonthly injections after a three-month loading dose, with either Aflibercept or Ranibizumab (no predefined criteria for treatment selection). Best corrected visual acuity (BCVA) and optical coherence tomography were analyzed at baseline and during follow-up clinical visits (months 3, 6, 12, and 18). From the included participants, 42 followed a fixed regimen with Aflibercept and 30 with Ranibizumab. At the 12-month visit, there was not a statistically significant difference in the mean change of BCVA between the two groups (p=0.121); however, the mean difference in the central retinal thickness was significantly superior in the Aflibercept group (-142.2 versus -51.5, p=0.011). The described fixed regimen seems to be efficient in the treatment of nAMD in a clinical practice setting.

scholarly journals EFFECTIVENESS OF SPIRULINA MOUTHWASH ON REDUCTION OF DENTAL PLAQUE AND GINGIVITIS: A CLINICAL STUDY

2017 ◽  
Vol 9 (7) ◽  
pp. 136
Author(s):  
Radhika Maniyar ◽  
Umashankar G. K.
Keyword(s):  
Visual Analog Scale ◽  
Dental Plaque ◽  
Rank Test ◽  
Analog Scale ◽  
Mean Values ◽  
Significant Difference ◽  
Intervention Protocol ◽  
The Mean ◽  
The Individual

Objective: The present study evaluated the effectiveness of Spirulina mouthwash on the reduction of dental plaque and gingivitis.Methods: A single-blind clinical trial was conducted among thirty patient’s aged 18-40 y visiting dental college and hospital in Bangalore city. Mouthwash was prepared using 0.5% Spirulina. Intervention protocol consisted of instructing the patients to rinse with 10 ml of mouthwash for 1 minute twice daily for 7 d. Plaque index and Gingival index were used to assess the variables at the baseline and after the intervention. The perception of the individual subjects with regard to the use of mouthwash was assessed using 10 cm long visual analog scale (VAS). Statistical analysis was carried out using Wilcoxon signed rank test for mean pre and post plaque and gingival scores respectively. Descriptive statistics was performed for VAS questionnaireResults: The results showed a highly significant difference (p<0.001) between the mean plaque scores at the baseline (2.16±0.34) and at the follow up (1.27±0.46). The mean gingival scores at the baseline (1.86±0.38) and at the follow-up (1.05±0.43) also showed a highly significant difference (p<0.001). Regarding the Visual Analog Scale, the mean values of 5 or greater than suggested the responses to be favourable as the values were reflectedConclusion: The study showed that Spirulina mouthwash resulted in significant reduction in dental plaque and gingivitis. Also, the mouthwash was convenient to use without any adverse effects. Hence, the use of herbal mouth rinses such as Spirulina should be supported.

scholarly journals Surgery Outcomes of Lamellar Macular Eyes with or without Lamellar Hole-Associated Epiretinal Proliferation: A Meta-Analysis

2020 ◽  
Author(s):  
hanyue xu ◽  
Ling Qin ◽  
Yifan Zhang ◽  
Ming Zhang
Keyword(s):  
Retrospective Studies ◽  
Meta Analysis ◽  
Lamellar Macular Hole ◽  
Pooled Data ◽  
Corrected Visual Acuity ◽  
Significant Difference ◽  
Surgery Outcomes ◽  
The Stability ◽  
Lamellar Hole

Abstract Background: To compare the visual outcomes and rate of restored ellipsoid zone (REZ) after surgery of lamellar macular hole (LMH) with and without lamellar hole-associated epiretinal proliferation (LHEP). Method: Publications up to November 2019 that compared the outcomes of LMH patients with and without LHEP who were managed by surgery were included. Forest plots were created using a weighted summary of proportion meta-analysis. A random effects mode was used and I2 heterogeneity estimates were calculated. Sensitivity analysis was carried out to evaluate the stability of the meta-analysis. Result: Eight pertinent publications studying a total of 176 eyes without LHEP and 173 eyes with LHEP were identified. They were all retrospective studies and had a mean follow-up of at least 6 months. In all studies, the best corrected visual acuity (BCVA) had no significant differences before surgery and improved in both groups, and in two studies the post-operative BCVA had no significant differences between two groups. The rate of REZ were different among studies included. Meta-analytic pooling of the improved BCVA between with and without LHEP groups was 0.18 (95 % CI, 0.10 to 0.26; P< 0.01), and the pooled data revealed an odd ratio of 0.80 (95% CI, 0.26 to 2.44; p = 0.69) in the rate of REZ, comparing the group without LHEP and the group with LHEP. In conclusion, patients without LHEP had better postoperative BCVA than patients with LHEP. No significant difference was found in REZ among the two groups.

scholarly journals Two-year Changes in Postoperative Central Macular Thickness and Subfoveal Choroidal Thickness in Epiretinal Membrane Patients

2021 ◽  
Vol 62 (12) ◽  
pp. 1607-1616
Author(s):  
Woo Seok Choi ◽  
Jihae Park ◽  
Kyoo Won Lee ◽  
Hyun Gu Kang
Keyword(s):  
Epiretinal Membrane ◽  
Choroidal Thickness ◽  
Macular Thickness ◽  
Control Group ◽  
Central Macular Thickness ◽  
Subfoveal Choroidal Thickness ◽  
Corrected Visual Acuity ◽  
Significant Difference ◽  
The Mean

Purpose: To evaluate changes in central macular thickness (CMT) and subfoveal choroidal thickness (SFCT) after phacovitrectomy over a 2-year period in idiopathic epiretinal membrane (ERM) patients.Methods: The records of 52 idiopathic ERM patients (52 eyes) who underwent phacovitrectomy, without recurrence of the condition over a 2-year follow-up period, were reviewed retrospectively. Changes in CMT and SFCT, as measured by optical coherence tomography, were analyzed and compared with those of a normal control group over a 2-year period.Results: The mean preoperative CMT and SFCT were 425.67 ± 84.67 and 257.56 ± 90.13 μm, respectively. Postoperative CMT was reduced significantly to 372.17 ± 45.26 μm at 1 year and 363.15 ± 47.35 μm at 2 years (p < 0.001). SFCT at 1 and 2 years postoperatively was significantly reduced to 238.85 ± 84.85 and 230.31 ± 87.95 μm, respectively (p < 0.001). In the control group, there was no significant change in CMT; however, the SFCT decreased by 11.09 ± 22.36 μm during the 2-year follow-up (p = 0.007). In contrast, in the patient group, CMT and SFCT decreased by 62.52 ± 71.45 and 27.25 ± 41.97 μm, respectively, showing a significant difference from the control group (p < 0.001 and p = 0.043, respectively). Both before surgery and at 1 year postoperatively, the thinner the CMT, the better the best-corrected visual acuity (BCVA) (p = 0.010 and p = 0.018, respectively). A better postoperative BCVA at 2 years was associated with a thinner CMT and better BCVA before surgery (p < 0.001 and p < 0.001, respectively).Conclusions: Following a phacovitrectomy procedure, ERM patients showed significant reductions in both the CMT and SFCT at the 2-year follow-up.

scholarly journals Surgery Outcomes of Lamellar Macular Eyes with or without Lamellar Hole-Associated Epiretinal Proliferation: A Meta-Analysis

2020 ◽  
Author(s):  
hanyue xu ◽  
Ling Qin ◽  
Yifan Zhang ◽  
Ming Zhang
Keyword(s):  
Functional Outcomes ◽  
Retrospective Studies ◽  
Meta Analysis ◽  
Lamellar Macular Hole ◽  
Corrected Visual Acuity ◽  
Significant Difference ◽  
Surgery Outcomes ◽  
The Stability ◽  
Lamellar Hole

Abstract Purpose: This study aimed at comparing both the structural and functional outcomes of lamellar macular hole (LMH) with and without lamellar hole-associated epiretinal proliferation (LHEP) after surgery. Method: Publications up to July 2020 that compared the surgical outcomes of LMH patients with and without LHEP were included. Forest plots were created using a weighted summary of proportion meta-analysis. Fixed or random effects modes were used based on I2 heterogeneity estimates. To evaluate the stability of the meta-analysis, sensitivity analysis was carried out. Result: Eight pertinent publications containing a total of 176 eyes without LHEP and 173 eyes with LHEP were included. They were all retrospective studies and had a mean follow-up of at least 6 months. In all studies, the preoperative best corrected visual acuity (BCVA) had no significant differences between the two groups and BCVA improved in both groups after surgery. Pooled results of the improved BCVA was 0.18 (95 % CI, 0.10 to 0.26; P< 0.01) between with and without LHEP groups. However, the odd ratio of restored ellipsoid zone was 0.80 (95% CI, 0.26 to 2.44; p = 0.69) among the group with LHEP and the group without LHEP. In conclusion, patients without LHEP had better postoperative BCVA than patients with LHEP. No significant difference was found in REZ among the two groups. The necessity of surgery for patients with LHEP needs more studies to identify.

scholarly journals MyoRing Implantation in Comparison with MyoRing Implantation Combined with Corneal Collagen Crosslinking for Keratoconus

2019 ◽  
Vol 16 (1S) ◽  
pp. 85-90
Author(s):  
G. M. Kazakbaeva
Keyword(s):  
Corneal Thickness ◽  
Efficacy And Safety ◽  
Collagen Crosslinking ◽  
Corrected Visual Acuity ◽  
Number Of Patients ◽  
Significant Difference ◽  
Corneal Collagen Crosslinking ◽  
The Difference ◽  
Corneal Collagen

Purpose: tо estimate the effectiveness of complete corneal ring (MyoRing) implantation compared with MyoRing implantation combined with corneal collagen crosslinking (CXL) for keratoconus treatment for 36 months follow-up. Patients and Methods. There were 101 patients (124 eyes) with progressing keratoconus aged 18–59 years in the study. Intracorneal rings were implanted in all patients. The patients were divided into 2 groups. MyoRing implantation was performed in a series of 59 patients (76 eyes) with keratoconus II–III Amsler classification, 42 patients (48 eyes) had MyoRing implantation combined with CXL. Implantation of a MyoRing in the corneal pocket was performed using a PocketMaker microkeratome and corneal intrastromal implantation system. Results. Keratometry was reduced in both groups; after MyoRing implantation for 8,45 D and MyoRing combined with CXL for 7,44 D, the spherical equivalent decreased for 7,72 and 6,29 D respectively, after 36 months. The cylinder decreased to 3,33 D with MyoRing alone and to 3,11 D with MyoRing combined with CXL. The smallest corneal thickness remained stable during 36 months after the procedure. There was an improvement in uncorrected and corrected visual acuity, and the difference in the CRF within the period of up to 12 months after the operation. It can be explained by the pseudochase formation in the group with a combined procedure. Conclusion. The implantation of the MyoRing IRC and the combination of MyoRing with CXL showed efficacy and safety in stabilizing keratoconus stabilization, as well as correction of comorbided ametropia 3 years after surgery. Both MyoRing implantation and MyoRing combined with CXL were effective in the stabilization of progressive keratoconus, as well as the correction of ametropia 3 years after surgery. There was no significant difference in MyoRing implantation and its combination with corneal crosslinking in visual and refractive results. The refractive power of the cornea was only one exeption. Long follow-up and randomized prospective studies with a large number of patients are needed.

scholarly journals FUNCTIONAL RESULTS IN PATIENTS SUBMITTED TO SURGERY FOR DEGENERATIVE LUMBAR DISEASE

2017 ◽  
Vol 16 (4) ◽  
pp. 307-310
Author(s):  
Ricardo Dantas Rocha ◽  
Raphael de Rezende Pratali ◽  
Rodrigo de Luca Motta ◽  
Carlos Eduardo Gonçales Barsotti ◽  
Francisco Prado Eugenio dos Santos ◽  
...  
Keyword(s):  
Degenerative Disc Disease ◽  
Functional Disability ◽  
Functional Results ◽  
Disc Disease ◽  
Mean Values ◽  
Degenerative Disc ◽  
Scoliosis Research Society ◽  
Significant Difference ◽  
The Mean

ABSTRACT Objective: To evaluate functional results in patients submitted to lumbar arthrodesis for the treatment of degenerative disc disease. Methods: This is a retrospective study that considered patients submitted to surgery due to degenerative disc disease, with a minimum of 12 months of postoperative follow-up. The Oswestry Disability Index (ODI) and Scoliosis Research Society-22 (SRS-22) questionnaires, including total value and domains, were considered indicators of functional outcome and quality of life. Results: Sixty-one patients (mean age 60.4 years) met the inclusion criteria and had ODI and SRS-22 data recorded. Nineteen were male and 42 female. The mean of postoperative follow-up was 29 months (12-67 months). There was no statistically significant difference in any score between sexes. The mean values obtained by the questionnaires were ODI 43.4%; SRS-22 Total 2.7; Function/Activity 2.6; Pain 2.8; Appearance 2.6; Mental Health 3.0; Satisfaction 3.4. Conclusion: The values of the surgical outcome indicators were consistent with important functional disability, although the satisfaction indicator with the treatment showed satisfied patients.

scholarly journals Surgery Outcomes of Lamellar Macular Eyes with or without Lamellar Hole-Associated Epiretinal Proliferation: A Meta-Analysis

2020 ◽  
Author(s):  
hanyue xu ◽  
Ling Qin ◽  
Yifan Zhang ◽  
Yinan Xiao ◽  
Ming Zhang
Keyword(s):  
Functional Outcomes ◽  
Meta Analysis ◽  
Epiretinal Membranes ◽  
Random Effects Models ◽  
Corrected Visual Acuity ◽  
Significant Difference ◽  
Surgery Outcomes ◽  
The Stability ◽  
Lamellar Hole

Abstract Purpose: Given the two different kind of epiretinal membranes, this study aimed to compare both the structural and functional outcomes of lamellar macular hole (LMH) with and without lamellar hole-associated epiretinal proliferation (LHEP) after surgery. Method: Publications up to July 2020 that compared the surgical outcomes of LMH patients with and without LHEP were included. Forest plots were created by using a weighted summary of proportion meta-analysis. Fixed or random effects models were used based on I2 heterogeneity estimates. Meanwhile, to evaluate the stability of the meta-analysis, sensitivity analysis was carried out.Result: Eight pertinent publications were included, which contained a total of 176 eyes without LHEP and 173 eyes with LHEP. They were all retrospective studies and had a follow-up of at least 6 months. In all studies, the preoperative best corrected visual acuity (BCVA) had no significant differences between the two groups and improved in both groups after surgery. Pooled results of the improved BCVA was 0.18 (95 % CI, 0.10 to 0.26; P< 0.01) between the with and without LHEP groups. The odds ratio of restored ellipsoid zone (REZ) was 0.80 (95% CI, 0.26 to 2.44; p = 0.69) among the group with LHEP and without LHEP.In conclusion, patients without LHEP had better postoperative BCVA than patients with LHEP. No significant difference was found in REZ among the two groups.

scholarly journals Corneal Debridement Combined with Intrastromal Voriconazole for Recalcitrant Fungal Keratitis

2018 ◽  
Vol 2018 ◽  
pp. 1-8
Author(s):  
Yajie Sun ◽  
Zhuo Sun ◽  
Yukai Chen ◽  
Guohua Deng
Keyword(s):  
Surgical Intervention ◽  
Healing Time ◽  
Fungal Keratitis ◽  
Therapeutic Effects ◽  
Optic Nerve Atrophy ◽  
Corrected Visual Acuity ◽  
Medicinal Treatment ◽  
Significant Difference ◽  
The Mean

Background. To analyze the therapeutic effects of corneal debridement combined with intrastromal voriconazole in recalcitrant fungal keratitis. Methods. This is a retrospective study. Fourteen patients with recalcitrant fungal keratitis were treated by corneal debridement combined with intrastromal voriconazole (50 μg/0.1 ml). This paper reviews and analyzes the patients’ basic state, surgical intervention, medicinal treatment, and outcomes. Results. The mean sizes of infiltration and ulcer were (5.54 ± 1.32)mm and (3.46 ± 1.03)mm, respectively, and the mean depth was (315.43 ± 57.72)μm. Twelve of the patients had satellite lesion, and 2 suffered hypopyon. After intrastromal voriconazole, the size of infiltration decreased significantly to (4.32 ± 1.10)mm (P<0.001), but there was no significant change in ulcer size ((3.36 ± 0.92)mm, P=0.082). Thirteen patients were cured after corneal debridement. The mean healing time was (15.38 ± 7.38) days. Excluding one cured patient with optic nerve atrophy and one patient for whom the treatment failed, the mean best-corrected visual acuity after healing was (0.23 ± 0.18)LogMAR, a significant improvement compared to pretreatment (0.87 ± 0.57(LogMAR), P=0.01). The mean corneal astigmatism was (1.3 ± 1.6)D of 12 cured patients after healing and (1.0 ± 0.7)D at final follow-up, and there was no significant difference (P=0.374). Conclusions. Corneal debridement combined with intrastromal voriconazole is a secure and effective treatment for recalcitrant fungal keratitis.

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