scholarly journals Autonomic Dysfunctions in Parkinson’s Disease: Prevalence, Clinical Characteristics, Potential Diagnostic Markers, and Treatment

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Zhe Zhang ◽  
Sheng-Di Chen
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Clinical Characteristics ◽  
Treatment Options ◽  
Clinical Manifestations ◽  
The Elderly ◽  
Disease Prevalence ◽  
Autonomic Dysfunctions

Parkinson’s disease (PD) is a common neurodegenerative disease in the middle-aged and the elderly. Symptoms of autonomic dysfunctions are frequently seen in PD patients, severely affecting the quality of life. This review summarizes the epidemiology, clinical manifestations, and treatment options of autonomic dysfunctions. The clinical significance of autonomic dysfunctions in PD early diagnosis and differential diagnosis is also discussed.

scholarly journals Nocturnal Sleep Problems Mediate the Impact on Quality of Life of Early Morning Off in Parkinson's Disease

2021 ◽  
Vol 13 ◽  
Author(s):  
Yu Zhang ◽  
Zi en Zhang ◽  
De Shi ◽  
Yi Zhao ◽  
Lihong Huang ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Sleep Problems ◽  
Clinical Manifestations ◽  
Early Morning ◽  
Motor Symptoms ◽  
Nocturnal Sleep ◽  
The Impact

Background: Early morning off (EMO) refers to off-states in the morning in people diagnosed with Parkinson's disease (PwPD). This study determined the clinical manifestations of EMO and the association with nocturnal sleep problems and quality of life (QOL) in Chinese PwPD.Methods: In this multicenter, observational, cross-sectional study, data concerning the clinical manifestations of EMO were collected from PwPD in Shanghai by questionnaire. The stepwise logistic regression was performed to analyze the potential risk factors, as well as whether EMO was an independent risk factor for functional dependency in daily life. The mediation analyses were conducted to evaluate whether nocturnal sleep problems might mediate the association between EMO and the QOL.Results: Among the 454 subjects evaluated, EMO occurred in 39.43% of PwPD across all disease stages. The prevalence of EMO increased as the Hoehn and Yahr stage increased and was observed in 35.60% of patients in stages 1–2.5 and 48.85% of patients in stages 3–5. EMO was associated with non-motor symptoms (NMSs). The predominant NMSs associated with EMO were nocturnal sleep problems (98.90%), mood/cognition impairment (93.90%), decreased attention/memory (91.60%), gastrointestinal symptoms (91.60%), and urinary urgency (90.50%). The QOL of PwPD with EMO was significantly reduced (P < 0.001). Moreover, nocturnal sleep problems might partially mediate this relationship (indirect effect: β = 13.458, 95% boot CI: 6.436, 22.042).Conclusion: PwPD have EMO throughout all stages of the disease. Patients with EMO have severe motor symptoms and NMSs. EMO decreases the QOL in PwPD and this relationship is partially mediated by nocturnal sleep problems. In light of these findings, it is suggested that recognition and appropriate treatment of EMO and nocturnal sleep problems could improve the management of PwPD.

scholarly journals Physical activity benefits the elderly with Parkinson’s disease

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
S Lee
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Physical Activity Intervention ◽  
The Elderly ◽  
Negative Effect ◽  
Effect Of Pd

Abstract Background Growing number of ageing population adds to the increase in the number of the patients with Parkinson's disease (PD). PD is an idiopathic and progressive disease that significantly affects patients' daily activities and quality of life. The current study sought to explore the role of physical activity as correlates of coping strategies for the elderly with PD. Methods We employed a four-year follow-up study design using data drawn from the Survey of Health Ageing and Retirement in Europe (SHARE) - waves 4 and 6. A total of 421 who ever diagnosed or currently having PD (Wave 4) were followed-up (Wave 6). Cross-lagged associations were examined between self-rated health, limits of daily activities, psychological distress, CASP - quality of life scale (Control, Autonomy, Self-realization, Pleasure), and life satisfaction. A path model was developed to examine if moderate to vigorous physical activities mitigated negative effect of PD. Results ANOVA showed that well-being index in the older adults with PD decreased at follow-up point across the measured variables, self-rated health (p < .001), limits of daily activity (p < .001), depression (p < .001), loneliness (p < .001), CASP (p < .001) and life satisfaction (p < .001) after controlling for socio-demographic and other health variables. Moderate to vigorous level of physical activity appeared to significantly mitigate the negative effect of PD. Conclusions In order to improve the quality of life among the elderly with PD, multilayer intervention should be coupled with the medical treatment. Public health should design and implement enduring rehabilitation program and adaptive physical activity intervention that help psychological and behavioral adaptation process to chronic illness for Parkinson patients. Mobility assistance services or home care products can relieve the difficulties to perform activities of daily living of the elderly with Parkinson's disease. Key messages Parkinson patients are more likely to experience difficulties to perform activities of daily living. Physical activity intervention can enhance living of the elderly with Parkinson’s disease.

Impact of autonomic dysfunctions on the quality of life in Parkinson’s disease patients

2016 ◽  
Vol 117 (1) ◽  
pp. 207-211 ◽  
Author(s):  
Svetlana Tomic ◽  
Ines Rajkovaca ◽  
Vlasta Pekic ◽  
Tamer Salha ◽  
Sanja Misevic
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Autonomic Dysfunctions

Effects of Motor Symptom Laterality on Clinical Manifestations and Quality of Life in Parkinson’s Disease

2020 ◽  
Vol 10 (4) ◽  
pp. 1611-1620 ◽  
Author(s):  
Esther Cubo ◽  
Pablo Martínez-Martín ◽  
Jerónimo González-Bernal ◽  
Elena Casas ◽  
Sandra Arnaiz ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Effect Size ◽  
Clinical Manifestations ◽  
Motor Symptom ◽  
Life Questionnaire ◽  
Motor Symptoms ◽  
The Impact

Background: The asymmetry of motor manifestations present in Parkinson’s disease (PD) suggests the existence of differences between both hemispheres. As a consequence, this asymmetry might contribute to different PD clinical phenotypes. Objective: To study the relationship between motor symptom laterality with motor, non-motor symptoms (NMS), freezing of gait (FOG), and quality of life (QoL) impairment in PD. Methods: In this cross-sectional study, we measured motor symptoms severity and complications with the Unified Parkinsons’ disease Rating Scale (UPDRS), FOG with the FOG questionnaire, QoL with the 39-item PD Quality of Life Questionnaire Summary Index, and NMS with the NMS, Visual Analogue Scales for Pain and Fatigue, Beck Depression Inventory-II, Impulsive-Compulsive Disorders, and PD Sleep and Cognitive Rating scales. We defined left and right motor laterality using the UPDRS part III. We used comparative, regression, and effect size analyses to evaluate the impact of asymmetry on motor and NMS, FOG, and QoL. Results: 342 left (LPD) and 310 right (RPD) patients, with a mean age of 62.0±8.8 years, were included. In multivariate regression analysis, LPD was associated with a greater motor (OR = 1,50, 95% CI 1.02–2.21), FOG (OR = 1.56, 95% CI 1.01–2.41), and overall NMS impairment (OR = 1.43, 95% CI 1.001–2.06), and better QoL (OR = 0.52 95% CI 0.32–0.85). Overall, only a mild effect size was found for all comparisons in which significant differences were present. Conclusion: In this large multicenter study, motor symptom laterality seems to carry a mild but significant impact on PD clinical manifestations, and QoL.

scholarly journals Gender Differences and Quality of Life in Parkinson’s Disease

2020 ◽  
Vol 18 (1) ◽  
pp. 198
Author(s):  
Pietro Crispino ◽  
Miriam Gino ◽  
Elena Barbagelata ◽  
Tiziana Ciarambino ◽  
Cecilia Politi ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Gender Differences ◽  
Parkinson's Disease ◽  
Clinical Manifestations ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Non Motor Symptoms

Parkinson’s disease has been found to significantly affect health-related quality of life. The gender differences of the health-related quality of life of subjects with Parkinson’s disease have been observed in a number of studies. These differences have been reported in terms of the age at onset, clinical manifestations, and response to therapy. In general, women with Parkinson’s disease showed more positive disease outcomes with regard to emotion processing, non-motor symptoms, and cognitive functions, although women report more Parkinson’s disease-related clinical manifestations. Female gender predicted poor physical functioning and socioemotional health-related quality of life, while male gender predicted the cognitive domain of health-related quality of life. Some studies reported gender differences in the association between health-related quality of life and non-motor symptoms. Depression and fatigue were the main causes of poorer health-related quality of life in women, even in the early stages of Parkinson’s disease. The aim of this review was to collect the best available evidence on gender differences in the development of Parkinson’s disease symptoms and health-related quality of life.

Clinical characteristics and quality of life in Chinese patients with Parkinson’s disease beyond 20 years

2018 ◽  
Vol 40 (4) ◽  
pp. 312-317 ◽  
Author(s):  
Ruwei Ou ◽  
Yanbing Hou ◽  
Wei Song ◽  
Qianqian Wei ◽  
Yongping Chen ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Clinical Characteristics ◽  
Chinese Patients

scholarly journals Impact of Duodopa on Quality of Life in Advanced Parkinson's Disease: A UK Case Series

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
T. Foltynie ◽  
C. Magee ◽  
C. James ◽  
G. J. M. Webster ◽  
A. J. Lees ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Treatment Options ◽  
Symptom Control ◽  
Case Series ◽  
Objective Evaluation ◽  
Recording Time ◽  
Advanced Parkinson’S Disease

Treatment options in advanced Parkinson’s disease (PD) include subcutaneous apomorphine, pallidal or subthalamic nucleus Deep Brain Stimulation (DBS), or levodopa/carbidopa intestinal gel (LCIG/Duodopa). In this study, we describe the outcome of 12 PD patients with PD related complications started on LCIG, with respect to their quality of life measured by a disease specific validated scale—the PDQ39, together with diaries recording time spent “On,” “Off,” “Dyskinetic,” or “Asleep.” At the time of latest follow up, improvements were observed in both the PDQ39 Summary index as well as diary reports of PD symptom control following introduction of LCIG, supporting its use in well selected patients. The use of a trial period of LCIG via naso-jejunal administration allows objective evaluation of improvement in PD symptom control in advance of the placement of the more invasive percutaneous jejunostomy procedure. The decision to embark on LCIG, apomorphine or DBS should be supported by input from centres with experience of all 3 approaches. Since LCIG is an expensive option, development of the most appropriate future commissioning of this therapy in the absence of Class 1 evidence requires careful scrutiny of the outcomes of its use in a broad range of published series.

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