scholarly journals The Metabolomic Rationale for Treating Perimenopausal Syndrome as Kidney Deficiency

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Xueqin Chen ◽  
Caiming Wu ◽  
Wen’na Liang ◽  
Jianying Shen ◽  
Zewei Zhuo ◽  
...  
Keyword(s):  
1H Nmr ◽  
Molecular Basis ◽  
Disease Model ◽  
Aged Rats ◽  
Treatment Protocols ◽  
Kidney Deficiency ◽  
Metabolic States ◽  
Younger Age ◽  
Stratification System ◽  
Perimenopausal Syndrome

Background. Traditional Chinese medicine (TCM) typically attributes the etiopathogenesis of perimenopausal syndrome (PMS) to kidney deficiency in the TCM stratification system for diagnosis. However, the molecular basis of this classical attribution remains to be investigated. Aim of the Study. By unraveling the responses to TCM treatment for kidney deficiency, the metabolomic link between PMS and kidney deficiency can be evaluated for in-depth understanding of the mechanism of TCM treatment and development of better treatment protocols. Materials and Methods. With naturally aged rats as a model for PMS, the metabolomic response to TCM treatment for kidney deficiency was investigated by 1H NMR. Results. 1H NMR metabolomic evidence of plasma samples demonstrates that treatments with two classical TCM prescriptions for kidney deficiency, decoctions of Yougui and Zuogui, result in modulating the metabolic state of the disease model towards that of rats of younger age. Conclusion. The data support the notion that kidney deficiency is responsible, in part at least, for PMS, and the relevant prescriptions are helpful in dampening the changes in the body’s metabolic states to alleviate symptoms of the disorder.

scholarly journals The molecular basis of kirromycin(mocimycin) action. A 1H NMR study using deuterated elongation factor Tu.

1988 ◽  
Vol 41 (2) ◽  
pp. 202-206 ◽  
Author(s):  
JILL BARBER ◽  
JOHN A. CARVER ◽  
REUBEN LEBERMAN ◽  
GRAHAM M. V. TEBB
Keyword(s):  
1H Nmr ◽  
Molecular Basis ◽  
Elongation Factor ◽  
Elongation Factor Tu ◽  
Nmr Study

On the molecular basis of H2O/DMSO eutectic mixtures by using natural products as molecular sensors: a combined NMR and DFT study

2021 ◽  
Author(s):  
Sana Fatima ◽  
Panayiotis C Varras ◽  
Atia-tul Wahab ◽  
Muhammad I Choudhary ◽  
Michael Siskos ◽  
...  
Keyword(s):  
Natural Products ◽  
1H Nmr ◽  
Molecular Basis ◽  
Molecular Level ◽  
Chemical Shifts ◽  
Dft Study ◽  
Dft Studies ◽  
Molecular Sensors ◽  
Nmr Chemical Shifts ◽  
Eutectic Mixtures

NMR and DFT studies of phenol containing natural products as molecular sensors were carried out to investigate H2O/DMSO eutectic mixtures at a molecular level. The 1H NMR chemical shifts of...

Perspectives on using pulsed electric field to enhance biogas yield in anaerobic digestion

TECHNOLOGY ◽  
2015 ◽  
Vol 03 (02n03) ◽  
pp. 141-146 ◽  
Author(s):  
Uwe Pliquett
Keyword(s):  
Microbial Community ◽  
Side Effects ◽  
Electric Field ◽  
Large Scale ◽  
Direct Action ◽  
Deep Understanding ◽  
Treatment Protocols ◽  
Biogas Yield ◽  
Electric Treatment ◽  
Metabolic States

Controlling large-scale biogas fermenters needs a deep understanding of the interaction between process parameters and microbiology. Therefore, monitoring of not only critical metabolic states of the microbial community, but also relationships between sub-processes is required. Once the process is understood, manipulation, for instance, by application of a brief, intense electric field in a controlled way can increase the methane yield. The electric treatment protocols depend not only on the location within the process, but also on the composition of the raw substrate and the process temperature. Besides the direct action of the electric field, side effects like shockwaves, Joule heating, electrowetting or the generation of reactive electrode byproducts can influence the effectiveness of the treatment.

scholarly journals Extracellular and intraneuronal HMW-AbetaOs represent a molecular basis of memory loss in Alzheimer's disease model mouse

2011 ◽  
Vol 6 (1) ◽  
pp. 20 ◽  
Author(s):  
Ayumi Takamura ◽  
Yasuhide Okamoto ◽  
Takeshi Kawarabayashi ◽  
Tatsuki Yokoseki ◽  
Masao Shibata ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Molecular Basis ◽  
Disease Model ◽  
Memory Loss ◽  
Model Mouse

scholarly journals Simulation model for breast cancer management in India

2020 ◽  
pp. 19-22
Author(s):  
Vinod K Ramani ◽  
Radheshyam Naik
Keyword(s):  
Natural History ◽  
Disease Model ◽  
Treatment Protocol ◽  
Treatment Protocols ◽  
Host Interactions ◽  
Cancer Management ◽  
Project Outcomes ◽  
History Of Disease ◽  
Breast Cancer Management ◽  
History Of

The natural history of cancer in a patient can be simulated in a flexible broad-based disease model. Such models describe events and outcomes at the person level, the results of which can be aggregated to estimate the population morbidity. With minimal assumptions regarding the natural history of disease, models could project outcomes of interventions for cancer screening and treatment.The same could be used for testing conventional treatment protocols and assess the reasons for failure of a particular strategy. Leads from the analysis can be utilized for proposing improvisations for the treatment protocol such as combinatorial strategies, which enables better suppression of tumor despite the resistant cells.This commentary describes relevant concepts associated with simulation modeling of tumor growth and tumor-host interactions, and summarizes some of the prominent approaches.

scholarly journals Gene expression analysis of glioblastomas identifies the major molecular basis for the prognostic benefit of younger age

2008 ◽  
Vol 1 (1) ◽  
Author(s):  
Yohan Lee ◽  
Adrienne C Scheck ◽  
Timothy F Cloughesy ◽  
Albert Lai ◽  
Jun Dong ◽  
...  
Keyword(s):  
Gene Expression ◽  
Expression Analysis ◽  
Molecular Basis ◽  
Gene Expression Analysis ◽  
Younger Age

Peculiarities of Emotional Behavior of Aged Rats in Preclinical Parkinson’s Disease Model

2018 ◽  
Vol 54 (6) ◽  
pp. 502-505 ◽  
Author(s):  
M. V. Chernyshev ◽  
I. V. Ekimova ◽  
A. R. Gazizova ◽  
O. A. Sapach ◽  
Yu. F. Pastukhov
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Disease Model ◽  
Emotional Behavior ◽  
Aged Rats

Renilla Bioluminescence: A Morphologic Approach to the Location of Photocytes

1974 ◽  
Vol 32 ◽  
pp. 208-209
Author(s):  
Ben O. Spurlock ◽  
Milton J. Cormier
Keyword(s):  
Excited State ◽  
Ground State ◽  
Molecular Basis ◽  
Light Emission ◽  
Chemical Basis ◽  
Electronic Excited State ◽  
Colonial Form ◽  
The Common ◽  
Eighteenth And Nineteenth Centuries ◽  
Catalyzed Oxidation

The phenomenon of bioluminescence has fascinated layman and scientist alike for many centuries. During the eighteenth and nineteenth centuries a number of observations were reported on the physiology of bioluminescence in Renilla, the common sea pansy. More recently biochemists have directed their attention to the molecular basis of luminosity in this colonial form. These studies have centered primarily on defining the chemical basis for bioluminescence and its control. It is now established that bioluminescence in Renilla arises due to the luciferase-catalyzed oxidation of luciferin. This results in the creation of a product (oxyluciferin) in an electronic excited state. The transition of oxyluciferin from its excited state to the ground state leads to light emission.

Androgen-induced plasticity at a “vocal” neuromuscular synapse

1994 ◽  
Vol 52 ◽  
pp. 32-33
Author(s):  
Darcy B. Kelley ◽  
Martha L. Tobias ◽  
Mark Ellisman
Keyword(s):  
Xenopus Laevis ◽  
Motor Neurons ◽  
Sexual Differentiation ◽  
Molecular Basis ◽  
Neuromuscular Synapse ◽  
Sexually Dimorphic ◽  
Intracellular Protein ◽  
Developmental Program ◽  
Androgen Action ◽  
Clawed Frog

Brain and muscle are sexually differentiated tissues in which masculinization is controlled by the secretion of androgens from the testes. Sensitivity to androgen is conferred by the expression of an intracellular protein, the androgen receptor. A central problem of sexual differentiation is thus to understand the cellular and molecular basis of androgen action. We do not understand how hormone occupancy of a receptor translates into an alteration in the developmental program of the target cell. Our studies on sexual differentiation of brain and muscle in Xenopus laevis are designed to explore the molecular basis of androgen induced sexual differentiation by examining how this hormone controls the masculinization of brain and muscle targets.Our approach to this problem has focused on a highly androgen sensitive, sexually dimorphic neuromuscular system: laryngeal muscles and motor neurons of the clawed frog, Xenopus laevis. We have been studying sex differences at a synapse, the laryngeal neuromuscular junction, which mediates sexually dimorphic vocal behavior in Xenopus laevis frogs.

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