scholarly journals MicroRNA-451 as an Early Predictor of Chronic Kidney Disease in Diabetic Nephropathy

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Mostafa Abdelsalam ◽  
A. M. Wahab ◽  
Maysaa El Sayed Zaki ◽  
Mohamad Motawea
Keyword(s):  
Chronic Kidney Disease ◽  
Diabetic Nephropathy ◽  
Kidney Disease ◽  
Early Diagnosis ◽  
Serum Creatinine ◽  
High Sensitivity ◽  
Urinary Albumin ◽  
Significant Difference ◽  
Plasma Microrna ◽  
Stage Renal Disease

Background. Diabetes mellitus is the leading cause of end-stage renal disease worldwide. Microalbuminuria is the cornerstone for the diagnosis of diabetic nephropathy. However, it is an inadequate marker for early diagnosis. MicroRNAs are not only new and promising markers for early diagnosis but also, but they may also play a role in the prevention of disease progression. Methods. This study included ninety patients with type 2 DM in addition to 30 control subjects. MicroRNA-451 expression in blood and plasma using real-time PCR was evaluated in addition to the classic diabetic nephropathy markers (serum creatinine, urinary albumin, and eGFR). Results. There was a significant difference between the studied groups versus control regarding serum creatinine, eGFR, urinary, and plasma microRNA-451 with p=0.0001. Patients with eGFR 60 ml/min/1.73 m2 showed a significantly higher plasma microRNA-451 (29.6 ± 1.6) and significantly lower urinary microRNA-451 (21 ± 0.9) in comparison to patients with eGFR >60 ml/min/1.73 m2 and p=0.0001. eGFR showed a positive correlation with urinary microRNA-451 and negative correlation with both plasma microRNA-451 and urinary albumin. Both plasma and urinary microRNA-451 are highly sensitive and specific markers for chronicity in diabetic nephropathy patients with sensitivity of 90.9% and 95.5% and specificity of 67.6% and 95.6%, respectively. Conclusion. MicroRNA-451 is a promising early biomarker for chronic kidney disease in diabetic nephropathy with high sensitivity and specificity.

scholarly journals Serum and urinary SOD3 in patients with type 2 diabetes: comparison with early chronic kidney disease patients and association with development of diabetic nephropathy

2019 ◽  
Vol 316 (1) ◽  
pp. F32-F41 ◽  
Author(s):  
Chia-Wen Kuo ◽  
Hsiao-Ling Chen ◽  
Min-Yu Tu ◽  
Chuan-Mu Chen
Keyword(s):  
Type 2 Diabetes ◽  
Chronic Kidney Disease ◽  
Diabetic Nephropathy ◽  
Kidney Disease ◽  
Serum Creatinine ◽  
Urinary Albumin ◽  
Renal Diseases ◽  
Heparin Binding ◽  
Patients With Diabetes

Extracellular superoxide dismutase 3 (SOD3), one member of the antioxidant defense system and a superoxide scavenger, has been noted to be downregulated in the kidneys of diabetic mice and is characterized by a heparin-binding domain that can anchor the protein to the endothelium and extracellular matrix. The association of the serum and urinary SOD3 levels with diabetic nephropathy in different stages has never been evaluated. It remains unclear how urinary SOD3 changes in different renal diseases. We recruited 98 Taiwanese patients with type 2 diabetes and 10 patients with early chronic kidney disease (CKD) into this study. Biochemical analyses were performed, including evaluation of the serum SOD3, urinary SOD3, urinary albumin, urinary vascular endothelial growth factor (VEGF), and urinary angiotensinogen (ANG). The Kruskal-Wallis rank sum test was used to compare various parameters among the three groups of patients: early CKD, diabetes alone, and diabetes with CKD. Results showed that lower serum and urinary SOD3 levels were observed in the group of patients with diabetes alone. Higher serum and urinary SOD3 levels were observed in the group of patients with diabetes and CKD, which had higher albuminuria and serum creatinine levels. The serum SOD3 levels were significantly positively correlated with renal function, according to the serum creatinine level. The urinary levels of SOD3 were significantly correlated with other urinary biomarkers such as urinary ANG and VEGF. Furthermore, albuminuria can positively predict the serum SOD3 level for the ratio of urinary albumin to urinary creatinine (ACR) >1,190.769 mg/g and the urinary SOD3 level for ACR ≥300 mg/g.

scholarly journals Initial Concentrations of miR-1 MicroRNA Precursor and High-Sensitivity Troponin in the Diagnosis of Non-ST Myocardial Infarction among Patients with and Those without Chronic Kidney Disease

2019 ◽  
Vol 9 (5) ◽  
pp. 274-283
Author(s):  
Tong Su ◽  
Xiaonan Shao ◽  
Xiaopu Zhang ◽  
Zhijun Han ◽  
Chengjian Yang ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Chronic Kidney Disease ◽  
Chest Pain ◽  
Kidney Disease ◽  
Early Diagnosis ◽  
Roc Curve ◽  
High Sensitivity ◽  
Circulating Microrna ◽  
St Segment ◽  
Significant Difference

Background: The early diagnosis of non-ST-segment elevation myocardial infarction (NSTEMI) in patients with chronic kidney disease (CKD) remains a challenge. Methods: The study consecutively enrolled patients who had suffered from chest pain within 3 h whose electrocardiogram had no elevation in the ST segment. CKD was defined as an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2, and the diagnostic criteria for NSTEMI were defined according to the recommended guideline. Circulating microRNA-1 was collected and determined by quantitative real-time reverse transcription polymerase chain reaction. Results: A total of 456 patients with suspected NSTEMI were included. There were 115 patients in the CKD group, including 67 with NSTEMI, 20 with stable angina, 7 with unstable angina, 18 with heart failure, and 3 with other disorders. Compared with the NSTEMI group, the non-NSTEMI group just had significant differences in microRNA-1 and high-sensitivity cardiac troponin I (hs-cTnI) (both p < 0.05). The relative expression of microRNA-1 was significantly increased in the NSTEMI group as compared with that in the other disease groups (all p < 0.05). A receiver operating characteristic (ROC) curve analysis suggested that microRNA-1 and hs-cTnI had advantages in the early diagnosis of NSTEMI with CKD (AUC [area under the ROC curve] 0.879 and 0.812, respectively, both p < 0.05). Compared with that in the non-CKD group, the accuracy of microRNA-1 was almost as good in the CKD group (84.3 vs. 89.4%, p > 0.05). However, the diagnostic accuracy of hs-cTnI was significantly decreased (79.1 vs. 91.5%, p < 0.05), as was its specificity (75.0 vs. 95.5%, p < 0.05). There was no significant difference in the correlation between microRNA-1 and eGFR (p > 0.05), but a statistically significantly negative correlation between hs-cTnI and eGFR (p < 0.05). Conclusion: Circulating microRNA-1 is capable of early diagnosis of NSTEMI in patients with CKD suffering from chest pain.

Abstract 145: Rates of Transfusion and Progression to End-Stage Renal Disease in Chronic Kidney Disease Patients Undergoing Transradial Versus Transfemoral Cardiac Catheterization - An Analysis from the VA CART Program

2014 ◽  
Vol 7 (suppl_1) ◽  
Author(s):  
Amit N Vora ◽  
Maggie A Stanislawski ◽  
John S Rumsfeld ◽  
Thomas M Maddox ◽  
Mladen Vidovich ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Cardiac Catheterization ◽  
High Risk Population ◽  
Post Procedure ◽  
Increased Risk ◽  
Significant Difference ◽  
Independent Association ◽  
Stage Renal Disease ◽  
End Stage

Background: Patients with chronic kidney disease (CKD) are at increased risk of bleeding and transfusion after cardiac catheterization. Whether rates of these complications or progression to new dialysis are increased in this high-risk population undergoing transradial (TR) access compared to transfemoral (TF) access is unknown. Methods: From the Veterans Affairs Clinical Assessment, Reporting, and Tracking (CART) Program between 10/2007-09/2012 we identified 40,160 CKD patients undergoing cardiac catheterization with baseline glomerular filtration rate (GFR) ≤ 60 ml/min. We used multivariable Cox modeling to determine the independent association between TR access and post-procedure transfusion as well as progression to new dialysis using TF as the reference. Results: Overall, 3,828 (9.5%) of CKD patients underwent TR access and tended to be slightly younger but overall had similar rates of CKD severity compared with TF patients (GFR 45-60 ml/min: 77.0% vs. 77.0%; GFR 30-44 ml/min: 19.7% vs. 19.3%; GFR 15-29 ml/min: 3.3% vs. 3.7%, p=0.35). TR patients had longer fluoroscopy times (8.1 vs 6.9 minutes, p=<0.0001) but decreased contrast use (90.0 vs 100.0 ml, p=<0.0001). Among the 31,692 patients with a full year of follow-up, 42 (1.7%) of TR patients and 545 (1.9%) of TF patients progressed to new dialysis within 1 year (p=0.64). However, only 33 (0.9%) of TR patients compared with 570 TF patients (1.6%) needed post-procedure blood transfusion (p=0.0006). After multivariable adjustment, there was no significant difference in progression to ESRD between TR and TF patients but TR was associated with a significant decrease in transfusion (Figure). Conclusion: Among CKD patients undergoing cardiac catheterization in the VA health system, TR access is associated with a decreased risk for post-procedure transfusion compared with TF access. There was no significant difference between the two approaches with respect to progression to ESRD. These data suggest that TR is a reasonable option for patients with any level of CKD undergoing cardiac catheterization.

Telehealth for the management of blood pressure in patients with chronic kidney disease: A systematic review

2017 ◽  
Vol 25 (2) ◽  
pp. 80-92 ◽  
Author(s):  
Li Luo ◽  
Meiqin Ye ◽  
Jiaowang Tan ◽  
Qiong Huang ◽  
Xindong Qin ◽  
...  
Keyword(s):  
Systematic Review ◽  
Blood Pressure ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Serum Creatinine ◽  
Randomised Controlled Trials ◽  
Controlled Trials ◽  
Dialysis Patients ◽  
Significant Difference ◽  
Randomised Controlled

Background Most patients with chronic kidney disease (CKD) fail to achieve blood pressure (BP) management as recommended. Meanwhile, the effects of promising intervention and telehealth on BP control in CKD patients remain unclear. We aimed to evaluate the efficacy of telehealth for BP in CKD non-dialysis patients. Methods Databases including MEDLINE, EMBASE, CENTRAL, CNKI, Wanfang, VIP and CBM were systematically searched for randomised controlled trials or quasi-randomised controlled trials on telehealth for BP control of CKD3-5 non-dialysis patients. We analysed systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), serum creatinine, and estimated glomerular filtration rate (eGFR) with a fixed-effects model. Results Three studies, with total 680 subjects, were included in our systematic review and two were included for meta-analysis. Pooled estimates showed decreased SBP (pooled mean difference (MD), −5.10; 95% confidence interval (CI), −11.34, 1.14; p > 0.05, p = 0.11), increased DBP (pooled MD, 0.45; 95% CI, −4.24, 5.13; p > 0.05, p = 0.85), decreased serum creatinine (pooled MD, −0.38; 95% CI, −0.83, 0.07; p > 0.05, p = 0.10) and maintained eGFR (pooled MD, 4.72; 95% CI, −1.85, 11.29; p > 0.05, p = 0.16) in the telehealth group. There was no significant difference from the control group. MAP (MD, 0.6; 95% CI, −6.61, 7.81; p > 0.05, p = 0.87) and BP control rate ( p > 0.05, p = 0.8), respectively, shown in two studies also demonstrated no statistical significance in the telehealth group. Conclusions There was no statistically significant evidence to support the superiority of telehealth for BP management in CKD patients. This suggests further studies with improved study design and optimised intervention are needed in the future.

scholarly journals Silent brain infarcts in chronic kidney disease patients with nonspecific neurological symptoms

2021 ◽  
Vol 9 (4) ◽  
pp. 274-279
Author(s):  
P Sasanka ◽  
◽  
Dr. T. Jaya Chandra ◽  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Density Lipoprotein ◽  
High Sensitivity ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Female Ratio ◽  
Exact Test ◽  
Brain Infarcts ◽  
Significant Difference

Introduction: Silent brain infarcts (SBI) are parenchymal lesions of previous infarcts, classified astype III cerebrovascular disorder. A study was undertaken to find the relation between SBIs andnonspecific neurological complaints, an association of high sensitivity C-reactive protein (hsCRP)with silent brain infarcts. Methodology: It was a cross-sectional study conducted in the departmentof Nephrology, GSL Medical College, from January to December 2020. Individuals aged > 18 yearswith nonspecific neurological complaints were included. MRI brain, hsCRP and electrocardiogramwere also carried as per the standard protocol. Fischer exact test was used to find the statisticalsignificance; P < 0.05 was considered statistically significant. Results: A total of 51 members haveincluded the male-female ratio was 1.04. SBI was presented in 27.4% (14). Age-wise, among thecortical SBI patients, maximum (75%) were in the> 61 years group. High density lipoprotein levelswere > 40 mg/dL in 39.2%, normal triglycerides (TGL) were observed in 71% and raised hsCRP in62.7% (32). Statistically, there was no significant difference in TGL levels. hsCRP levels were raisedin 3 (75%) members with cortical SBI; statistically, there was no significant difference. Conclusion:The traditional risk factors associated with stroke were present in the patients with SBI. hsCRP wasraised in chronic kidney disease patients having NSCL and having SBI.

scholarly journals Specialist physician knowledge of chronic kidney disease: A comparison of internists and family physicians in West Africa

2012 ◽  
Vol 4 (1) ◽  
Author(s):  
Emmanuel I. Agaba ◽  
Patricia A. Agaba ◽  
Musa Dankyau ◽  
Maxwell O. Akanbi ◽  
Comfort A. Daniyam ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
West Africa ◽  
Lupus Erythematosus ◽  
Family Physicians ◽  
Quality Initiatives ◽  
Adequate Knowledge ◽  
Significant Difference ◽  
Stage Renal Disease ◽  
End Stage

Background: Postgraduate training is aimed at equipping the trainee with the necessary skills to practise as an expert. Non-nephrology specialist physicians render the bulk of pre-end-stage renal disease care for patients with chronic kidney disease (CKD). We sought to ascertain the knowledge of CKD amongst non-nephrology specialist physicians who serve as trainers and examiners for a training, accrediting and certifying body in postgraduate medicine in West Africa. We also compared the knowledge of family physicians and non-nephrology internists. Methods: Self-administered questionnaires were distributed to non-nephrology specialist physicians who serve as examiners for the West African College of Physicians.Results: Only 19 (27.5%) of the respondents were aware of the Kidney Disease Outcomes Quality Initiatives guidelines for CKD management. Twenty five (36.2%) of the respondents had adequate knowledge of CKD. There was no significant difference in the proportion of family physicians and non-nephrology internists who had adequate knowledge of CKD (27.3% vs. 40.4% respectively; p = 0.28). Hypertension and diabetes mellitus were identified by all of the physicians as risk factors for CKD. Non-nephrology internists more frequently identified systemic lupus erythematosus as a risk factor for CKD, urinalysis with microscopy as a laboratory test for CKD evaluation, and bone disease as a complication of CKD than family physicians.Conclusion: There is a lack of adequate CKD knowledge amongst non-nephrology specialist physicians, since many of them are unaware of the CKD management guidelines. Educational efforts are needed to improve the knowledge of CKD amongst non-nephrology specialist physicians. Guidelines on CKD need to be widely disseminated amongst these physicians.

Secondary Hyperparathyroidism in the Diabetic Patient with Chronic Kidney Disease

2005 ◽  
Vol 00 (01) ◽  
pp. 39
Author(s):  
Steven Cheng ◽  
Daniel Coyne
Keyword(s):  
Chronic Kidney Disease ◽  
Diabetic Nephropathy ◽  
Kidney Disease ◽  
Renal Involvement ◽  
Urine Albumin Excretion ◽  
Albumin Excretion ◽  
Urine Albumin ◽  
Overt Proteinuria ◽  
Stage Renal Disease ◽  
End Stage

In the US, diabetic nephropathy accounts for the majority of chronic kidney disease (CKD). It contributes significantly to morbidity and mortality among the diabetic population1,2and accounts for approximately 40% of patients with end-stage renal disease.3The earliest manifestation of renal involvement in diabetes is the presence of microalbuminuria, as defined by urine albumin excretion of 30–300mg/day.4Progression to overt proteinuria (urine albumin excretion greater than 300mg/day) and diabetic nephropathy occur more frequently in those with poor glycemic control, glomerular hyperfiltration, and hypertension.5

scholarly journals Association between Oral Health Status and Diabetic Nephropathy-Related Indices in Japanese Middle-Aged Men

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Masami Yoshioka ◽  
Yoshifumi Okamoto ◽  
Masahiro Murata ◽  
Makoto Fukui ◽  
Shizuko Yanagisawa ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Chronic Kidney Disease ◽  
Diabetic Nephropathy ◽  
Health Status ◽  
Oral Health ◽  
Kidney Disease ◽  
Serum Creatinine ◽  
Body Mass ◽  
Oral Health Status ◽  
Middle Aged

Oral health status is known to be associated with lifestyle-related diseases such as diabetes and chronic kidney disease. In Japan, around 40% of hemodialysis cases are patients with diabetic nephropathy. The aim of this study was to clarify the association between oral health status and diabetic nephropathy-related indices in Japanese middle-aged men. Sixty-six men (age range: 55–64 years) with ≥20 remaining teeth and who received public medical checkups and oral examinations were enrolled. We examined correlations of age, body mass index, HbA1c, HDL-C, LDL-C, neutral fat, serum creatinine, and the estimated glomerular filtration rate (eGFR) with the number of remaining teeth or the community periodontal index (CPI) score (periodontal pocket<4 mm: 0, 4–6 mm: 1, ≥6 mm: 2). A positive correlation between the CPI score and serum creatinine and a negative correlation between CPI score and eGFR (Spearman’s rank correlation coefficient, r=0.459, p<0.01, and r=−0.460, p<0.01, respectively) were observed. The mean eGFR in the CPI score 0 group was significantly higher than that in the CPI score 1/2 group (82.6 vs. 70.7, Student’s t-test, p<0.01). Logistic regression analysis using eGFR as a dependent variable and age, CPI score, body mass index, HbA1c, and neutral fat as independent variables suggested that low eGFR (<60) could be attributed to CPI score (OR=3.169, 95% CI: 1.031–9.742, p=0.044). These results suggest a possible association between periodontal status and renal function in Japanese middle-aged men. Periodontal condition is controlled by oral prophylaxis, and periodontal disease and chronic kidney disease have some common risk factors. Thus, periodontal management can contribute to the prevention of severe chronic kidney disease.

scholarly journals Anemia in chronic kidney disease patients in predialysis and postdialysis stages

1970 ◽  
Vol 1 (1) ◽  
pp. 26-29 ◽  
Author(s):  
S Bhatta ◽  
G Aryal ◽  
RK Kafle
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Serum Creatinine ◽  
Peripheral Blood ◽  
Peripheral Blood Smear ◽  
Cross Sectional Study ◽  
Moderate Degree ◽  
Cross Sectional ◽  
Significant Difference ◽  
Red Cell Indices

Background: Chronic kidney disease is usually associated with anemia and the level of anemia correlates with the severity of renal failure. This study was carried out to evaluate the profile of anemia and to find the correlation between the severity of anemia and serum creatinine levels in predialysis and postdialysis Chronic kidney disease patients. Materials and Methods: A cross-sectional study was conducted in 40 chronic kidney disease patients in the department of pathology and nephrology, KIST Medical College. Hemoglobin, hematocrit, red cell indices, peripheral blood smears and serum creatinine levels were examined using standard techniques. Results: There was a significant difference in the hemoglobin and hematocrit levels in predialysis and postdialysis patients (P <0.005). All 40 patients (100%) were anemic. Although moderate anemia was most common in both groups of patients, severe anemia was more common in postdialysis patients (5% in predialysis and 15% in postdialysis patients). The peripheral blood smear examinations showed that normocytic normochromic anemia was most frequent (90% in predialysis and 77.5 % in postdialysis patients). There was no significant correlation between the severity of anemia and serum creatinine levels (P > 0.05), r=-0.14 and -0.17 in predialysis and postdialysis group respectively.  Conclusion: The most frequent anemia in chronic kidney disease patients was normocytic and normochromic type of a moderate degree. Significant correlation was not found between the severity of anemia and serum creatinine levels in both pre and postdialysis group of patients. Keywords: Chronic Kidney Disease; Anemia; Creatinine; Hemoglobin; Hematocrit; Hemodialysis DOI: 10.3126/jpn.v1i1.4446 Journal of Pathology of Nepal (2011) Vol.1, 26-29

scholarly journals Anthropometry-based Body Fat Percentage Predicts High hs-CRP in Chronic Kidney Disease Patients

2018 ◽  
Vol 10 (2) ◽  
pp. 184-91
Author(s):  
Mochammad Thaha ◽  
Maulana Antiyan Empitu ◽  
Ika Nindya Kadariswantiningsih ◽  
Cahyo Wibisono Nugroho ◽  
Nurina Hasanatuludhhiyah ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Body Fat ◽  
High Sensitivity ◽  
Low Grade ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Cross Sectional ◽  
Significant Difference ◽  
Hs Crp

BACKGROUND: Obesity is an important cardiovascular risk factor and associated with low grade inflammation in chronic kidney disease (CKD) patients. This study aims to assess the association between body fat with serum high sensitivity C-reactive protein (hs-CRP) level in CKD patients.METHODS: A cross-sectional study was performed in 71 CKD patients. Anthropometric measurements included body weight, height, body mass index (BMI), body fat percentage (BFP), skinfold thickness (SKF) of triceps and biceps were performed by trained physician. BFP was calculated using Kwok’s Formula and hs-CRP was measured by Particle enhanced Turbidimetry.RESULTS: The averaged BMI of our subjects was 25.8±4.4. There was no significant difference in BMI between pre-dialysis and hemodialysis CKD patients. Positive correlation was found between BFP and hs-CRP (r=0.266; p<0.05), while there was no significant correlation between BMI and hs-CRP.CONCLUSION: Body fat percentage was associated with hs-CRP. Hence, it will be more beneficial to assess nutritional status in CKD using BFP rather than BMI alone since it was demonstrated to correlate with hs-CRP in our studyKEYWORDS: CKD, obesity, inflammation, body fat, hs-CRP

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