scholarly journals Lifestyle and Sociodemographic and Economic Characteristics of Patients with Lung Cancer in Morocco

2020 ◽  
Vol 2020 ◽  
pp. 1-8 ◽  
Author(s):  
Imane Harkati ◽  
Mohamed Kamal Hilali ◽  
Nezha Oumghar ◽  
Mouna Khouchani ◽  
Mohamed Loukid
Keyword(s):  
Lung Cancer ◽  
Cancer Patients ◽  
Negative Impact ◽  
Demographic Factors ◽  
Normal Weight ◽  
World Health ◽  
Cancer Disease ◽  
Lung Cancer Patients ◽  
Health Organization ◽  
Socioeconomic And Demographic Factors

Background. Lifestyle maintenance is a crucial condition before and after lung cancer disease. According to the previous research in the scientific databases, the effect of the interaction between socioeconomic and demographic factors on the lifestyle of lung cancer patients in Southern Morocco regions remains unexamined. Accordingly, this study was designed to examine the relationship between socioeconomic factors, demographic factors, and the lifestyle of lung cancer patients. Methods. A total of 133 patients with lung cancer were divided into 103 men and 30 women with a sex ratio of 3.43 and ages varying between 28 and 82 years, and they served as informants for the study and filled in a questionnaire to provide information on their sociodemographic background, various economic characteristics, and their lifestyle. These patients have also been submitted to an anthropometric examination following the standardized procedure recommended by the World Health Organization. The survey was conducted from July 2013 to March 2015 at the Oncology and Radiotherapy Department, at Mohammed VI Hospital Center in Marrakech, Morocco. Results. The preliminary results showed that the average age of patients was 59 ± 9 years. A proportion of 81% lived in the Marrakech-Safi region and 19% lived in four other southern regions. Among the patients, 6% were smokers, while 14% were nonsmokers and 80% were ex smokers. Following the discovery of the disease, 26% revealed that they had sleep disorders and 98% were reported to have a lack of appetite. Obesity, normal weight, and underweight were also taken as criteria to categorize the patients; thus, obese informants represented 23% of the total number, those having normal weight reached 67% and the patients having underweight represented 10%. Conclusion. Sociodemographic variables and various economic characteristics were shown to have a negative impact on the lifestyle of lung cancer patients.

scholarly journals Clinical management of lung cancer patients during the outbreak of COVID-19 epidemic

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Li Wang ◽  
Man Jiang ◽  
Jialin Qu ◽  
Na Zhou ◽  
Xiaochun Zhang
Keyword(s):  
Lung Cancer ◽  
Cancer Patients ◽  
International Health ◽  
World Health ◽  
Tumor Treatment ◽  
Lung Cancer Patients ◽  
Major Threat ◽  
Routine Medical Care ◽  
Novel Coronavirus ◽  
Health Organization

Abstract The rapid growth of 2019 novel coronavirus (COVID-19) outbreak in Wuhan, China, at the early December 2019. COVID-19 spread all over the word just a few months. The outbreak of COVID-19 infection poses major threat to international health and economy. World Health Organization (WHO) announced that the new coronavirus was an international public health emergency on January 30, 2020. However, with the spread of COVID-19, the routine medical care of lung cancer patients was affected. Because lung cancer patients have low immunity after anti-tumor treatment, they should become the main targets for epidemic prevention. Lung cancer patients are increasingly concerned about the prevention of COVID-19. It is necessary to provide individualized medical treatment and management for lung cancer patients based on patients’ conditions and regional epidemic patterns.

scholarly journals Sequencing and structure analysis of UBC gene for breast and ‎lung cancer

2019 ◽  
Vol 10 (3) ◽  
pp. 1640-1645
Author(s):  
Saleen Salam Abdulhadi ◽  
Abbas Abdullah Mohammed‎
Keyword(s):  
Lung Cancer ◽  
Cancer Patients ◽  
Genetic Alterations ◽  
Cancer Disease ◽  
Blood Samples ◽  
Lung Cancer Patients ◽  
Control Subjects ◽  
Exon 1 ◽  
Healthy Control ◽  
Transition Mutation

In the present study, sequencing approach has been adopted for exploring the ‎genetic alteration of sequences for the ubiquitin gene (UBC) in patients of breast and ‎lung cancer and comparing the results with a normal sequence that obtained from NCBI. ‎The aim of this study was to detect for genetic alterations of UBC gene in the breast and ‎lung cancer patients then compare with healthy control subjects, to investigate the ‎association between the mutations at the intron region of the UBC gene and cancer disease, ‎‎40 blood samples were examined from patients with breast and lung cancer aged ranged from (17-65) years, were collected at Al-Amal Hospital of cancer in Baghdad ‎province/Iraq, the period of collecting samples were from October/2018 to January/2019. ‎While twenty-two blood samples from healthy control subjects were collected at ages ‎ranged from(19-59). After DNA extraction, the PCR primer was designed to amplify the ‎region in the UBC gene (part of exon 1 and the whole intron). Here we report the polymorphism of the intron sequence of the UBC gene in Iraqi population as the results of sequencing the PCR amplified products showed three different transition mutation G→A, ‎C→T, T→C in patients with breast cancer were also appeared in healthy control subjects. While nine transition mutations appeared in lung cancer patients, at different locations ‎of the sequence were detected by BLAST tool. ‎

scholarly journals Radiotherapy for Lung Cancer During the COVID Pandemic – A Narrative Review of Practical Recommendations

2021 ◽  
Vol 1 (1) ◽  
pp. 99-117
Author(s):  
Prasenjit Chatterjee ◽  
Jibak Bhattacharya ◽  
Tanmay Ghosh ◽  
Biplap Sarkar ◽  
Monica-Emilia Chirilă ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Patients ◽  
Negative Impact ◽  
Clinical Stage ◽  
Performance Status ◽  
Treatment Decision ◽  
Original Research ◽  
Curative Intent ◽  
Lung Cancer Patients ◽  
Pubmed Database

"Background: The coronavirus disease pandemic produced changes in the treatment approach of lung cancer patients. They represent a vulnerable population due to the negative impact of delays in diagnosis and treatment and also because of the impaired immune system. Radiation Therapy plays a crucial role in both curative and palliative settings, so finding the best approach for these patients in this context was attempted by many professionals. The aim of this study was to make a synthesis of the current published literature on this topic and summarize the recommendations. Material and methods: We searched the PubMed database for articles published between 20th December 2019 and 30th August 2020. We used 14 key words related to COVID 19 and Lung Cancer. The articles were selected by two senior clinicians who excluded overlapping information and prioritized original research reports and professional organization’s official recommendations. Results: There were 562 papers corresponding to the search criteria, of which 64 were analyzed. Treatment decision must be tailored according to the status of SARS CoV-2 positivity, the aim of the treatment (curative VS palliative), pathological type and clinical stage, disease complications, symptoms, prognostic, performance status, and alternative treatments. Hypofractionation is preferred whenever possible in order to minimize risk for patients and staff. Safety measures have to be implemented, with extra cautions if SARS CoV-2 positive patients have to be treated. Cone beam CT can be used early identification of lung infiltrates and special attention is recommended to differentiate Radiation pneumonitis from COVID-19 pneumonia. Journal of Medical and Radiation Oncology Journal homepage: www.jmedradonc.org Review 94 Conclusion: For SARS CoV-2 positive lung cancer patients the treatment should be postponed, until they are tested negative. For patients which are SARS CoV-2 negative treated with curative intent, hypofractionated schedules are preferred. Palliative treatments should be given according to the life threatening risk."

scholarly journals Clinical Impact of Association Between Diabets and Lung Cancer

2019 ◽  
Vol 70 (4) ◽  
pp. 1149-1151 ◽  
Author(s):  
Laura Mazilu ◽  
Dana Lucia Stanculeanu ◽  
Andreea Daniela Gheorghe ◽  
Adrian Paul Suceveanu ◽  
Irinel Raluca Parepa ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Lung Cancer ◽  
Cancer Patients ◽  
Negative Impact ◽  
Cancer Prognosis ◽  
Lung Cancer Patients ◽  
High Prevalence ◽  
Cancer Outcome ◽  
The Impact

The main objective of this analysis is to evaluate the impact of lung cancer and diabetes association on cancer treatment and outcome of lung cancer patients. Lung cancer, as well as diabetes mellitus, are two diseases with very high prevalence. Lung cancer, despite the improvement in diagnosis and therapeutic methods, is still the 1st cause of cancer-related deaths. The influence of diabetes on cancer patients survival is well established among patients with hepatic, pancreatic or breast cancer. Diabetes implication on lung cancer outcome is not well known. Several studies reported a negative impact, whereas other studies reported a better prognosis for these patients. Our study took place in the Oncology Department of the Clinical Emergency Hospital of Constanta, Romania. 80 patients with diagnosis of non-small cell lung cancer were elected to participate in this study; 29 patients had also diabetes. Selected patients were divided in 2 groups, one group of lung cancer and diabetes, and one group without diabetes. Features of the patients among both groups were analyzed. Our study showed that preexisting diabetes is an unfavorable factor, and has influence on lung cancer prognosis, treatment adhesion and quality of life. To amend the outcome of patients with lung cancer, a better evaluation of patients� co-morbidities, including diabetes mellitus, is required.

Analysis of differential metabolites in lung cancer patients based on metabolomics and bioinformatics

2020 ◽  
Vol 16 (18) ◽  
pp. 1269-1287 ◽  
Author(s):  
Chenchen Zhao ◽  
Xianbin Kong ◽  
Shuang Han ◽  
Xiaojiang Li ◽  
Tong Wu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Patients ◽  
Biological Significance ◽  
Underlying Disease ◽  
Multivariate Statistical ◽  
Clinical Trial Registration ◽  
Cancer Disease ◽  
Metabolic Markers ◽  
Urine Metabolites ◽  
Lung Cancer Patients

Aim: Based on metabonomics, the metabolic markers of lung cancer patients were analyzed, combined with bioinformatics to explore the underlying disease mechanism. Materials & methods: Based on case–control design, using UPLC-Q-TOF/MS, urine metabolites were detected in discovery and validation set. Multivariate statistical analysis were performed to identify potential markers for lung cancer. A network analysis was constructed to integrate lung cancer disease targets with the above metabolic markers, and its possible mechanism and biological significance were explained. Results: A total of 35 potential markers were identified, 11 of which overlapped. Five key markers have a good linear correlation with serum biochemical indicators. Conclusion: The occurrence and development of lung cancer are closely related to disturbance of D-Glutamine and D-glutamate metabolism, amino acid imbalance. This test was registered on China clinical trial registration center ( www.chictr.org.cn/index.aspx ), registration number was ChiCTR1900025543.

A retrospective review of nutritional status and immunotherapy in lung cancer.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e14112-e14112
Author(s):  
Chung-Shien Lee ◽  
Rebecca Sin ◽  
Joanna Stein Fishbein ◽  
Craig E. Devoe ◽  
Xinhua Zhu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Nutritional Status ◽  
Cancer Patients ◽  
Retrospective Review ◽  
Cox Regression ◽  
Checkpoint Inhibitors ◽  
Normal Weight ◽  
Rank Test ◽  
Cancer Center ◽  
Lung Cancer Patients

e14112 Background: Immunotherapy has transformed cancer treatment, including lung cancer. Approximately 20-25% of patients respond, therefore making it pivotal in understanding what factors may effect outcomes. There have been previous reports of obesity associated with an increased efficacy of PD-1/PD-L1 blockade and cachectic patients not responding as well. In this study, we aim to assess the association of body mass index (BMI) with outcomes of lung cancer patients being treated with immunotherapy. Methods: An IRB approved retrospective review of lung cancer patients receiving immunotherapy between 2014 and 2017 at the Monter Cancer Center, Northwell Health was conducted. Patients were categorized in underweight (BMI < 18.5), normal weight (BMI of 18.5 to < 25), overweight (BMI 25 to 30) or obese (BMI > 30) arms. The groups were compared using the log-rank test. Kaplan-Meier was used for overall survival (OS) and progression free survival (PFS) and Cox regression models were used to adjust for potential confounders. Results: A total of 116 were included in the analysis, with a median age of 70 (95% CI, 62.5 to 75.5). Ten (8.6%) were underweight, 44 (37.9%) were normal weight, 32 (27.6%) were overweight, and 30 (25.9%) were obese. BMI classification were not found to be a significant predictor of survival, after adjusting for therapy duration (p = 0.44). PFS was 6.6, 6.0, and 6.9 months for patients in the underweight, normal weight, and overweight/obese groups, respectively. Of 116 subjects, 46 (40%) died within the follow up period: 3 (30%), 17 (39%), 11 (34%), and 15 (50%) respectively. Additional post hoc analysis showed that patients with low nutritional status as defined by either a BMI < 18.5 and/or baseline albumin < 3.5 mg/dL had a median PFS of 2.2 months compared to those who did not of 5.2 months (p < 0.00032). Conclusions: In this single institution retrospective review, BMI or albumin as solitary factors did not have a significant effect on outcomes receiving immunotherapy in lung cancer patients. However, a more comprehensive nutritional assessment using a composite endpoint of BMI and serum albumin predicted response to checkpoint inhibitors. Additional studies are needed to validate these findings.

scholarly journals Negative Impact of Coexisting Interstitial Lung Disease on Clinical Outcomes in Small-cell Lung Cancer Patients

2018 ◽  
Vol 38 (11) ◽  
pp. 6543-6550
Author(s):  
KIMITAKA AKAIKE ◽  
KOICHI SARUWATARI ◽  
HIROKO OKABAYASHI ◽  
SHOHEI HAMADA ◽  
YASUMIKO JODAI ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Interstitial Lung Disease ◽  
Small Cell Lung Cancer ◽  
Lung Disease ◽  
Cancer Patients ◽  
Clinical Outcomes ◽  
Negative Impact ◽  
Small Cell ◽  
Small Cell Lung ◽  
Lung Cancer Patients

Rasch models suggested the satisfactory psychometric properties of the World Health Organization Quality of Life—Brief among lung cancer patients

2016 ◽  
Vol 22 (4) ◽  
pp. 397-408 ◽  
Author(s):  
Chung-Ying Lin ◽  
Szu-Chun Yang ◽  
Wu-Wei Lai ◽  
Wu-Chou Su ◽  
Jung-Der Wang
Keyword(s):  
Quality Of Life ◽  
Lung Cancer ◽  
World Health Organization ◽  
World Health ◽  
World Health Organization Quality ◽  
Lung Cancer Patients ◽  
The World ◽  
Organization Quality ◽  
Health Organization

The study examined whether the items of the World Health Organization Quality of Life—Brief questionnaire can assess its four underlying domains (Physical, Psychological, Social, and Environment) in a sample of lung cancer patients. All patients ( n = 1150) were recruited from a medical center in Tainan, and each participant completed the World Health Organization Quality of Life—Brief. Several Rasch rating scale models were used to examine the data-model fit, and Rasch analyses corroborated that each domain of the World Health Organization Quality of Life—Brief could be unidimensional. Although three items were found to have a poor fit, all the other items fit the unidimensionality with ordered thresholds.

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