scholarly journals Sarcopenia in Type 2 Diabetes Mellitus: A Cross-Sectional Observational Study

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
L. M. Pechmann ◽  
T. H. Jonasson ◽  
V. S. Canossa ◽  
H. Trierweiler ◽  
G. Kisielewicz ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Handgrip Strength ◽  
The Body ◽  
Control Group ◽  
Composition Analysis ◽  
Cross Sectional ◽  
Total Fat

Background. The aim of this study was to compare the prevalence of low muscle mass and sarcopenia in patients with type 2 diabetes mellitus (T2DM) versus paired controls (control group, CG) and the association between sarcopenia and chronic diabetes complications. Methods. Men and women ≥50 years with T2DM (T2DM group, T2DMG) were recruited during routine outpatient visits. Total body densitometry and handgrip strength (HGS) were evaluated in the T2DMG and CG, while the T2DMG was also evaluated for the physical performance using the gait speed (GS) test. Sarcopenia was diagnosed according to the criteria of the Foundation for the National Institutes of Health Sarcopenia Project (FNIH). Results. The study included 177 individuals in the T2DMG and 146 in the CG. The mean HGS value was lower in the T2DMG (24.4 ± 10.3 kg) compared with the CG (30.9 ± 9.15 kg), p < 0.001 , with low HGS in 46 (25.9%) and 10 (9%) in the T2DMG and CG, respectively ( p < 0.001 ). The prevalence of sarcopenia defined according to the FNIH criteria was higher in the T2DMG 23 (12.9%) compared with the CG 8 (5.4%), p < 0.03 . The presence of albuminuria increased the odds of sarcopenia (odds ratio (OR) 2.84, 95% confidence interval (CI) 1.07–7.68, p = 0.04 ) and osteoporosis (OR 3.38, 95% CI 1.12–9.89, p = 0.03 ), even in patients with mild to moderate nephropathy. The body composition analysis showed increased odds of sarcopenia with increased percentage of total fat (%TF) in women (OR 1.18, 95% CI, 1.03–1.43, p = 0.03 ) and men (OR 1.31, 95% CI, 1.10–1.75, p = 0.01 ). Conclusion. Patients with T2DM presenting with albuminuria, osteoporosis, and increased %TF were more likely to have sarcopenia. This finding emphasizes the need for patients with T2DM to be evaluated for sarcopenia to allow for early implementation of measures to prevent or treat this disorder.

scholarly journals Association of serum adenosine deaminase level with atherosclerotic index in type 2 diabetes mellitus patients

Biomedicine ◽  
2021 ◽  
Vol 41 (1) ◽  
pp. 150-152
Author(s):  
M Rasheed Khan ◽  
S Vinod Babu ◽  
V. KuzhandaiVelu
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Lipid Profile ◽  
Adenosine Deaminase ◽  
Control Group ◽  
P Value ◽  
Cross Sectional ◽  
Lipid Ratio

Introduction and Aim:The atherosclerosis is the major cause of morbidity and mortality among diabetes population. Diabetes mellitus can accelerate atherosclerotic processes. Adenosine deaminase (ADA) plays a significant role in both glucose and lipid metabolism through adenosine. This study aimed to correlate the atherosclerotic index with adenosine deaminase levels in Type 2 diabetes mellitus patients. The aim of the study is to find the association between serum ADA levels with atherosclerotic index.   Materials and Methods: A cross sectional study conducted in 100 subjects (50 control and 50 T2DM patients). The following biochemical parameter were estimated:total cholesterol, triacylglycerol, HDL- C and ADA. VLDL, LDL and other atherosclerotic index were calculated using formulae. Statistical analysis such as Student’s‘t’ test and Pearson’s correlation were performed.   Results: We found significant increase (p value <0.001) in lipid profile, Non-HDL-C and lipid ratio when compared to T2DM with control group. The correlation of serum ADA with lipid profile and lipid ratio didnot show any correlation.   Conclusion: Serum ADA used as a biomarker for evaluation of glycemic status. ADA was insignificant, when correlated with dyslipidemia and atherosclerotic index.

scholarly journals Adipokines, Oxidized Low-Density Lipoprotein, and C-Reactive Protein Levels in Lean, Overweight, and Obese Portuguese Patients with Type 2 Diabetes

ISRN Obesity ◽  
2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Maria João Neuparth ◽  
Jorge Brandão Proença ◽  
Alice Santos-Silva ◽  
Susana Coimbra
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
The Body ◽  
Control Group ◽  
Obese Patients ◽  
And Control

Aim. Our aim was to study how different BMI scores may influence the levels of inflammation, oxidative stress, adipogenesis, glucose, and lipid metabolism, in lean, overweight, and obese Portuguese patients with type 2 diabetes mellitus (T2DM). Methods. We studied 28 lean, 38 overweight, and 17 obese patients with T2DM and 20 controls (gender and age matched). The circulating levels of oxLDL, CRP, and some adipokines—adiponectin, leptin, and chemerin—and the lipid profile were evaluated. Results. Obese patients presented significantly lower levels of adiponectin and higher leptin, oxLDL, and chemerin levels, as compared to the overweight, lean, and control groups. Overweight, compared to lean and control, subjects showed significantly lower adiponectin and higher leptin and chemerin levels; oxLDL values were significantly higher in overweight than in lean patients. Lean patients presented significantly higher chemerin values than the control. Obese patients presented significantly higher CRP values, as compared to lean patients and the control group. Obese and overweight patients presented significantly higher triglycerides values than lean patients. Except for CRP, all the observed significant changes between control and patients remained significant after statistical adjustment for the body mass index (BMI). Conclusion. The levels of leptin, adiponectin, oxLDL, CRP, and triglycerides in patients with T2DM seem to be more associated with obesity and less with diabetes. Chemerin levels were raised in lean, overweight, and obese patients, suggesting that, independently of BMI, an adipocyte dysfunction occurs. Moreover, chemerin may provide an important early biomarker of adipocyte dysfunction and a link between obesity and type 2 diabetes mellitus.

scholarly journals Вплив ураження ацетамінофеном на тлі цукрового діабету типу 2 на зміни показників глутатіонової системи

2018 ◽  
Author(s):  
O. B. Furka
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Body Weight ◽  
Antioxidant System ◽  
The Body ◽  
Intraventricular Injection ◽  
Control Group ◽  
Starch Solution

Introduction. The most important function of the liver in the body is neutralization and destruction of toxic substances. Metabolism and utilization of chemical and biological toxins are carried out by neutralizing the hepatocyte system, followed by the removal of harmful products from the body.The aim of the study – to investigate the effect of acetaminophen on the background of type 2 diabetes mellitus on the main parameters of the glutathione unit of the antioxidant system in rat liver homogenate in time dynamics.Research Methods. The experiments were carried out on white mature rats weighing 180–220 g, contained on a standard ration of the vivarium and free access to water. We conducted 2 series of experiments. In the first, toxic acetaminophen was caused by a single intraventricular injection of acetaminophen in 2 % starch solution at a dose of 1250 mg/kg body weight (1/2 LD50), in the second suspension of acetaminophen in a 2 % starch solution at a dose of 55 mg/kg, which corresponds to the highest therapeutic dose for 7 days. The non-genetic form of experimental type 2 diabetes mellitus was modeled according to the method of Islam S., Choi H. (2007) by a single intraperitoneal injection of a streptozotocin solution (“Sigma”, USA) at a body weight (200±20) g at a rate of 65 mg/kg, which diluted with citrated buffer (pH 4.5) with a preliminary (within 15 minutes) intraperitoneal administration of nicotinamide in a dose of 230 mg/kg. For the control group, rats with the same body weight were administered with a similar volume of solvent (citrate buffer pH 4.5).Results and discussion. Activation of lipid peroximation reactions is one of the fundamental biological mechanisms of damage to biostructures and the development of cellular pathology for the actions of damaging factors of various genesis, especially under the conditions of xenobiotics.Conclusion. Acetaminophen poisoning against type 2 diabetes mellitus causes a significant disruption of compensatory mechanisms, especially the state of the enzyme and non-enzyme links of the antioxidant system.

The Relation between serum uric acid & HbA1c in geriatric patients of Type 2 Diabetes in Amravati, Maharashtra, India.

2016 ◽  
Vol 5 (06) ◽  
pp. 4630 ◽  
Author(s):  
Jagtap M. W. ◽  
Rohankar P. H. ◽  
Shital Ashokrao Kale*
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Geriatric Patients ◽  
Control Group ◽  
Cross Sectional ◽  
Positive Correlation

Type 2 Diabetes mellitus (DM) is a heterogeneous disease which is characterized by variable degrees of insulin resistance or/and impaired insulin secretion as well as its deficiency (absolute/relative). The study was carried out to determine the relationship between serum concentration of uric acid and HbA1c among the geriatric group with type 2 diabetes mellitus in diabetic camps carried out at Amravati. We performed a cross sectional study on 30 patients of both genders of geriatric group, and a control group of 30 age and sex matched normal healthy individuals. Serum uric acid was tested by Uricase/PAP method [7, 15] and HbA1c by NycoCard READER II (color reflectometry) [6]. We observed the positive correlation between uric acid and HbA1c, as 0.080 which was found to be significant as 2.50 between the uric acid and HbA1c in geriatric patients of type 2 Diabetes. In healthy controls, we observed the positive correlation between uric acid and HbA1c as 0.074 which was not significant.

scholarly journals Low dose allopurinol is associated with modest but significant improvements in glycemic control (GC) and glycemic variability (GV) in patients with type 2 diabetes mellitus: A cross-sectional study

2021 ◽  
Author(s):  
Manal M. Alem
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Low Dose ◽  
Control Group ◽  
Glycaemic Variability ◽  
Cross Sectional ◽  
Type 2 Dm

Abstract BackgroundType 2 diabetes mellitus (DM), gout, and asymptomatic hyperuricemia are inter-connected pathologies. Glycemic control (GC), involving a range of treatments is central to the management of DM, whereas allopurinol continues to be the most widely recommended urate lowering agent. Allopurinol has been shown to possess anti-oxidant properties: this study explores the favorable potential effect of allopurinol on glucose homeostasis.MethodsThis is an observational study with a cross-sectional design performed on patients with type 2 diabetes mellitus (DM), recruited from centers in Saudi Arabia. Patients were divided into two groups; allopurinol users; (for gout or asymptomatic hyperuricemia) and matching control patients. Patient demographics, co-morbid conditions, biochemical tests, and pharmacological treatments were extracted from electronic records to investigate the effect of allopurinol therapy on Glycemic control (GC), as assessed by glycated haemoglobin (HbA1c as primary endpoint), and on parameters of glycaemic variability (GV) (secondary endpoints).ResultsA total of 194 patients with type 2 DM were recruited (97 in both groups). The two groups were matched for age and sex: mean age: 59.4 years, 73% males in the allopurinol group vs 59.6 years, 73% males in the control group. Allopurinol, daily dose 100 mg, was prescribed for 77% of the patients, with median duration of 39.5 months treatment. HbA1c values were; 6.90% (6.20, 7.80) in the allopurinol group vs 7.30% (6.60, 8.40) in the control group (P=0.010). Parameters of GV were calculated from 3 consecutive fasting blood sugar (FBS) readings: variability independent of the mean (VIM) was 0.140 in the allopurinol group vs 0.987 in the control group (P<0.001).ConclusionConcomitant low-dose allopurinol therapy in patients with type 2 DM was associated with modest but significant improvements in GC and GV.

scholarly journals Relationship Of Stress Levels And Diet With Blood Sugar Levels In Patients Of Type 2 Diabetes Mellitus

2020 ◽  
Vol 9 (1) ◽  
pp. 241-247
Author(s):  
Ninik Ambar Sari ◽  
Ceria Nurhayati ◽  
Sri Anik Rustini
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Sugar ◽  
Fasting Blood Glucose ◽  
Sampling Technique ◽  
The Body ◽  
Cross Sectional ◽  
Sugar Levels

Diabetes mellitus type 2 is a condition in which the body tissue doesn’t respond to the action of insulin. Type 2 DM can cause complications if it doesn’t managed properly, good DM management behavior for patients needs to be done by maintaining a healthy diet and stress will increase blood sugar levels. This study uses analytic cross sectional design. The sampling technique in this study was purposive sampling of 60 respondents. Data processing using the SPSS program with the Spearman Rho test. Results: a correlation between stress level and fasting blood glucose level of type 2 diabetes mellitus patients with a correlation value of 0.544, which is located between 0.4 - <0.6, is in the medium category. While the statistical test for diet obtained a significant number or ρ = 0.002 then Ho is rejected, H1 is accepted.

scholarly journals Obesity, Hyperinsulinemia, IGF-1, and Hyperglycemia as Risk Factors for Colorectal Cancer in Patients with Type 2 Diabetes mellitus

2020 ◽  
Vol 0 (1-2) ◽  
pp. 60-63
Author(s):  
Т. С. Вацеба
Keyword(s):  
Diabetes Mellitus ◽  
Colorectal Cancer ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Study Groups ◽  
The Body ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Increased Risk

The latest studies prove an increased risk of colorectal cancer in patients with type 2 diabetes mellitus. The pathogenetic factors of type 2 diabetes have been recognized as mechanisms of association between these diseases. The objective: to investigate the effects of obesity, hyperinsulinemia, IGF-1 and hyperglycemia on the development of colorectal cancer in patients with type 2 diabetes. Materials and methods. 36 patients were divided into groups: I – healthy (control group), II – patients with type 2 diabetes mellitus, III – patients with colorectal cancer without diabetes, IV – patients with a combination of two diseases. Using the method of enzyme-linked immunosorbent assay were determined levels of insulin and insulin-like growth factor-1 (IGF-1). DM compensation was assessed by the level of glycosylated hemoglobin (HbA1c) that was determined by immuno-exchange chromatography. The data obtained were analyzed using Statistica 12.0 (StatSoft Inc.,USA). Differences between the values in the control and experimental groups were determined by the Student’s t-test. The differences were considered significant at р<0.05. Results. According to the data obtained, colorectal cancer was diagnosed in patients with the age of over 60 years old with obesity. The body mass index (BMI) in patients of all study groups was higher than 30 kg/m2. Patients of group IV with a combination of type 2 diabetes and a circle of rectal cancer had significantly higher BMI compared to the control group (р<0.05). Significant hyperinsulinemia and increased IGF-1 levels were detected in patients in all study groups (р<0.05). Most patients with diabetes in both groups had HbA1c levels higher than 7.5%. Conclusions. Obesity, hyperinsulinemia, increased bioavailability of IGF-1, and hyperglycemia are pathogenetic factors in the risk of colorectal cancer in patients with type 2 diabetes. Patients over the age of 55 with diabetes, obesity, and hyperinsulinemia are advised to be screened for colorectal cancer.

scholarly journals Assessment of liver marker enzymes and its association with type 2 diabetes mellitus in Northwest Ethiopia

2019 ◽  
Vol 12 (1) ◽  
Author(s):  
Tewodros Shibabaw ◽  
Gashaw Dessie ◽  
Meseret Derbew Molla ◽  
Muluken Fekadie Zerihun ◽  
Birhanu Ayelign
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Northwest Ethiopia ◽  
Control Group ◽  
Marker Enzymes ◽  
Cross Sectional ◽  
Gamma Glutamyltransferase ◽  
Liver Marker Enzymes

Abstract Objective This study aimed to assess the level of aspartate aminotransaminase (AST), alanine aminotransaminase (ALT) and gamma-glutamyltransferase (GGT), and their association with type 2 diabetes mellitus in Northwest Ethiopia. Results Using a cross-sectional study, blood samples were collected from 192 Type 2 diabetes mellitus (T2DM) participants and 192 healthy age and sex-matched volunteers. The study was carried out from May to August 2017. The serum concentration of aspartate aminotransaminase, alanine aminotransaminase, and gamma-glutamyltransferase were measured using A25 Bio-system fully automatic chemistry analyzer and using the manufacturer’s kit of the machine. Liver function test results of T2DM participant were significantly higher than those of the control group, serum ALT (46.06 ± 22. 38 IU/L) and serum AST (42.94 ± 19. 08 IU/L), P < 0.001, while the level of GGT in both study groups was not significantly associated (P = 0.065). In conclusion, the evaluation of liver marker enzymes showed a significant association with Type 2 diabetes participants compared with the controls.

scholarly journals Most Frequent Oral Lesions in Patients with Type 2 Diabetes Mellitus

2017 ◽  
Vol 18 (2) ◽  
pp. 107-111 ◽  
Author(s):  
João P De Carli ◽  
Igor FP Lima ◽  
Georgia Verardi ◽  
Michele De C Ferreira ◽  
Soluete O da Silva ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Control Group ◽  
Diabetic Patients ◽  
Oral Lesions ◽  
Chi Square ◽  
Cross Sectional ◽  
School Of Dentistry

ABSTRACT Aim Type 2 diabetes mellitus (DM2) is a chronic disease caused by the underproduction of insulin in the organism and it is considered a risk factor to periodontal disease. Materials and methods This study performed a cross-sectional research on the main oral changes in patients with DM2 and nondiabetics, in Passo Fundo, Rio Grande do Sul, Brazil. The sample included 116 patients examined at the Diabetes Outpatient Clinic of the School of Medicine of the University of Passo Fundo (UPF) and 134 nondiabetic patients examined at the Examinations, Triage, and Emergency Sector of the School of Dentistry of UPF. Inclusion criteria for the study were patients over 35-years old, diagnosed with DM2 for more than 2 years. The same criteria were used for the control group, except for the presence of diabetes. Data collected were analyzed by Statistical Package for the Social Sciences 18.0 for Windows™ software and the Chi-square test at 5% significance. This study showed that, overall, oral lesions were more prevalent in diabetic patients. Results The stomatological manifestations observed more frequently in such patients were pseudomembranous candidiasis, lichen planus, lingual varices, xerostomia, and prosthetic stomatitis (p > 0.001). Conclusion Therefore, based on the sample investigated, it is concluded that patients with DM2 present higher prevalence of oral lesions when compared with nondiabetics. Clinical significance It is important for the dentist to know about oral lesions because they may allow either early diagnosis in patients unaware of this condition or help diagnosing a potential decompensation. Moreover, oral lesions may represent a potential gateway for infectious agents, and the dentist may restrain this condition by performing treatment as early as possible. How to cite this article Trentin MS, Verardi G, De C Ferreira M, de Carli JP, da Silva SO, Lima IFP, Paranhos LR. Most Frequent Oral Lesions in Patients with Type 2 Diabetes Mellitus. J Contemp Dent Pract 2017;18(2):107-111.

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