scholarly journals Successful Kidney Transplantation in a Recipient Coinfected with Hepatitis C Genotype 2 and HIV from a Donor Infected with Hepatitis C Genotype 1 in the Direct-Acting Antiviral Era

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Dimitrios Farmakiotis ◽  
Zoe Weiss ◽  
Amy L. Brotherton ◽  
Paul Morrissey ◽  
Reginald Gohh ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Hepatitis C ◽  
Antiviral Treatment ◽  
Holistic Approach ◽  
Kidney Graft ◽  
Genotype 1 ◽  
Direct Acting Antiviral ◽  
First Case ◽  
Genotype 2 ◽  
Transplant Candidates

Despite significant advances in transplantation of HIV-infected individuals, little is known about HIV coinfected patients with hepatitis C virus (HCV) genotypes other than genotype 1, especially when receiving HCV-infected organs with a different genotype. We describe the first case of kidney transplantation in a man coinfected with hepatitis C and HIV in our state. To our knowledge, this is also the first report of an HIV/HCV/HBV tri-infected patient with non-1 (2a) HCV genotype who received an HCV-infected kidney graft with the discordant genotype (1a), to which he converted after transplant. Our case study highlights the following: (1) transplant centers need to monitor wait times for an HCV-infected organ and regularly assess the risk of delaying HCV antiviral treatment for HCV-infected transplant candidates in anticipation of the transplant from an HCV-infected donor; (2) closer monitoring of tacrolimus levels during the early phases of anti-HCV protease inhibitor introduction and discontinuation may be indicated; (3) donor genotype transmission can occur; (4) HIV/HCV coinfected transplant candidates require a holistic approach with emphasis on the cardiovascular risk profile and low threshold for cardiac catheterization as part of their pretransplant evaluation.

scholarly journals Successful direct-acting antiviral treatment of three patients with genotype 2/1 recombinant hepatitis C virus

2018 ◽  
Vol 12 (3) ◽  
pp. 213-217
Author(s):  
Masako Okada ◽  
Hoang Hai ◽  
Akihiro Tamori ◽  
Sawako Uchida-Kobayashi ◽  
Masaru Enomoto ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Antiviral Treatment ◽  
Recombinant Hepatitis ◽  
Direct Acting Antiviral ◽  
Genotype 2 ◽  
Direct Acting

Direct-acting antiviral treatment for hepatitis C in liver transplant candidates and recipients

2017 ◽  
Vol 6 (S3) ◽  
pp. S598-S602
Author(s):  
Nobuhisa Akamatsu ◽  
Junichi Togashi ◽  
Kiyoshi Hasegawa ◽  
Norihiro Kokudo
Keyword(s):  
Hepatitis C ◽  
Liver Transplant ◽  
Antiviral Treatment ◽  
Direct Acting Antiviral ◽  
Transplant Candidates ◽  
Direct Acting

scholarly journals Glecaprevir/Pibrentasvir in patients with hepatitis C virus genotype 1 or 4 and past direct-acting antiviral treatment failure

Hepatology ◽  
2018 ◽  
Vol 67 (4) ◽  
pp. 1253-1260 ◽  
Author(s):  
Fred Poordad ◽  
Stanislas Pol ◽  
Armen Asatryan ◽  
Maria Buti ◽  
David Shaw ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Treatment Failure ◽  
Antiviral Treatment ◽  
Genotype 1 ◽  
Virus Genotype ◽  
Direct Acting Antiviral ◽  
Direct Acting

scholarly journals Reassessment of Genotype 1 Hepatitis C Virus Subtype Misclassification by LiPA 2.0: Implications for Direct-Acting Antiviral Treatment

2014 ◽  
Vol 52 (11) ◽  
pp. 4027-4029 ◽  
Author(s):  
J. R. Guelfo ◽  
J. Macias ◽  
K. Neukam ◽  
F. A. Di Lello ◽  
J. A. Mira ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Antiviral Treatment ◽  
Genotype 1 ◽  
Direct Acting Antiviral ◽  
Direct Acting ◽  
Virus Subtype

scholarly journals Direct-Acting Antiviral Treatment Failure Among Hepatitis C and HIV–Coinfected Patients in Clinical Care

2019 ◽  
Vol 6 (3) ◽  
Author(s):  
Carmine Rossi ◽  
Jim Young ◽  
Valérie Martel-Laferrière ◽  
Sharon Walmsley ◽  
Curtis Cooper ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Treatment Failure ◽  
Real World ◽  
High Frequency ◽  
Antiviral Treatment ◽  
Injection Drug ◽  
Genotype 1 ◽  
Direct Acting Antiviral ◽  
Increased Risk ◽  
Direct Acting

Abstract Background There are limited data on the real-world effectiveness of direct-acting antiviral (DAA) treatment in patients coinfected with hepatitis C virus (HCV) and HIV—a population with complex challenges including ongoing substance use, cirrhosis, and other comorbidities. We assessed how patient characteristics and the appropriateness of HCV regimen selection according to guidelines affect treatment outcomes in coinfected patients. Methods We included all patients who initiated DAA treatment between November 2013 and July 2017 in the Canadian Co-Infection Cohort. Sustained virologic response (SVR) was defined as an undetectable HCV RNA measured between 10 and 18 weeks post-treatment. We defined treatment failure as virologic failure, relapse, or death without achieving SVR. Bayesian logistic regression was used to estimate the posterior odds ratios (ORs) associated with patient demographic, clinical, and treatment-related risk factors for treatment failure. Results Two hundred ninety-five patients initiated DAAs; 31% were treatment-experienced, 29% cirrhotic, and 80% HCV genotype 1. Overall, 92% achieved SVR (263 of 286, 9 unknown), with the highest rates in females (97%) and lowest in cirrhotics (88%) and high-frequency injection drug users (89%). Many patients (38%) were prescribed regimens that were outside current clinical guidelines. This did not appreciably increase the risk of treatment failure—particularly in patients with genotype 1 (prior odds ratio [OR], 1.5; 95% credible interval [CrI], 0.38–6.0; posterior OR, 1.0; 95% CrI, 0.40–2.5). Conclusions DAAs were more effective than anticipated in a diverse, real-world coinfected cohort, despite the use of off-label, less efficacious regimens. High-frequency injection drug use and cirrhosis were associated with an increased risk of failure.

scholarly journals Glecaprevir and pibrentasvir for 12 weeks for hepatitis C virus genotype 1 infection and prior direct-acting antiviral treatment

Hepatology ◽  
2017 ◽  
Vol 66 (2) ◽  
pp. 389-397 ◽  
Author(s):  
Fred Poordad ◽  
Franco Felizarta ◽  
Armen Asatryan ◽  
Mark S. Sulkowski ◽  
Robert W. Reindollar ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Antiviral Treatment ◽  
Genotype 1 ◽  
Virus Genotype ◽  
Direct Acting Antiviral ◽  
Direct Acting
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