scholarly journals Disseminated Endometriosis and Low-Grade Endometrioid Stromal Sarcoma in a Patient with a History of Uterine Morcellation for Adenomyosis

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Daniel P. Stefanko ◽  
Ramez Eskander ◽  
Omonigho Aisagbonhi
Keyword(s):  
Uterine Cavity ◽  
Endometrial Stromal Sarcoma ◽  
Unintended Consequence ◽  
Low Grade ◽  
Shared Decision ◽  
Patient Counseling ◽  
Stromal Sarcoma ◽  
Uterine Tumors ◽  
History Of ◽  
Pathologic Processes

Morcellation of benign uterine tumors allows for removal of the tumors via minimally invasive laparoscopic procedures. However, in rare cases, morcellation has been associated with upstaging of unexpected malignancies. Morcellation has also been associated with dissemination of benign pathologic processes such as endometriosis and leiomyomas. Endometrial stromal sarcoma typically arises in the uterine cavity, although cases of extrauterine endometrioid stromal sarcoma arising out of foci of endometriosis have been reported. Dissemination of endometrial stromal sarcomas can be an unintended consequence of morcellation procedures, as can dissemination of endometriosis, from which endometrioid stromal sarcomas can arise. Herein, we report a case of a 55-year-old woman who was found to have disseminated endometriosis and low-grade endometrioid stromal sarcoma, with bowel and liver parenchymal metastasis, 7 years after undergoing supracervical hysterectomy with unconfined uterine morcellation for adenomyosis. Our case highlights the potential for malignant transformation of disseminated adenomyosis/endometriosis and the importance of patient counseling and shared decision-making prior to morcellation procedures.

scholarly journals Pleural Metastasis of High-Grade Endometrial Stromal Sarcoma With YWHAE Gene (17p13.3) Rearrangement, A Rare Case Report

2021 ◽  
Vol 156 (Supplement_1) ◽  
pp. S41-S41
Author(s):  
A C Re ◽  
M Enrique ◽  
S Ren
Keyword(s):  
Case Report ◽  
Spindle Cell ◽  
Malignant Neoplasm ◽  
Endometrial Stromal Sarcoma ◽  
Low Grade ◽  
High Grade ◽  
Stromal Sarcoma ◽  
Uterine Tumors ◽  
Uterine Neoplasm ◽  
Left Pleural Effusion

Abstract Introduction/Objective Endometrial stromal sarcoma (ESS), a rare malignant neoplasm of endometrial stroma, accounts for less than 1% of all uterine tumors. High grade ESS (HGESS) is aggressive and commonly relapses even after surgical and neoadjuvant therapy. Abdominal and pelvic regions are common sites of metastasis, however, distant metastases to the liver, lung, vertebrae, and brain have been reported. Methods/Case Report We encountered a 49-year-old female who presented with shortness of breath, found to have a left pleural effusion and multiple pleural masses. She initially presented three years ago with heavy irregular menses and left pelvic pain for one year. D&C revealed prominent small spindle cells for which a stromal nodule and low-grade or malignant process was probable. CT scan showed an enlarged uterus. Hysterectomy with bilateral salpingo- oophorectomy, bilateral pelvic and para-aortic lymph node dissection, and partial omentectomy were performed. The uterus revealed an intramural 7 cm mass with a serpiginous growth pattern and lymphovascular invasion. Tumor cells were plump to spindled with areas of high cellularity, rounded nuclei, increased atypia and mitosis. Atypical areas were positive for cyclin D1, focally positive for CD10, and negative for ER, PR, SMA, desmin, AE1/3 and CAM5.2. FISH studies showed rearrangement of YWHAE gene (17p13.3) and no rearrangement of JAZF1 or PHF1 gene regions. Findings supported the diagnosis of HGESS. The patient received post-operative chemotherapy. Biopsy of the current pleural lesion revealed a nonspecific malignant spindle cell neoplasm positive for BCL1, CD56, CD117, CD99, TLE1 and INI1, while negative for AE1/3, CAM5.2, EMA, ER, PR, CK5/6, calretinin, SMA, desmin and S100. The CD10 stain was inconclusive. FISH studies showed rearrangement of YWHAE gene (17p13.3) and no rearrangement involving JAZF1 or PHF1 gene regions. No rearrangement of the SS18 gene region was observed and synovial sarcoma was excluded. Overall findings support the diagnosis of metastatic HGESS. Results (if a Case Study enter NA) NA Conclusion HGESS, a rare tumor with a nonspecific immunostain profile, has the ability to metastasize to rare body sites, such as the pleura in our case. Display of spindle cell morphology is a nonspecific finding that raises broad differential diagnoses. In women, with or without a history of uterine neoplasm, HGESS is a clinically worthwhile diagnosis to be mindful of.

scholarly journals Endometrial Stromal Sarcoma Arising in Colorectal Endometriosis: A Case Report and Review of the Literature

2015 ◽  
Vol 2015 ◽  
pp. 1-4
Author(s):  
Qiao Wang ◽  
Xia Zhao ◽  
Ping Han
Keyword(s):  
Differential Diagnosis ◽  
English Literature ◽  
Tumor Resection ◽  
Endometrial Stromal Sarcoma ◽  
Low Grade ◽  
Review Of The Literature ◽  
Primary Tumors ◽  
Colorectal Endometriosis ◽  
Stromal Sarcoma ◽  
History Of

Extrauterine endometrial stromal sarcoma (ESS) arising in endometriosis is extremely rare, particularly in the colorectum. It should always be included in the differential diagnosis of primary tumors originating from gastrointestinal tract in females, given that preoperative endoscopical biopsy may reveal no specific changes. We reported a case of ESS arising in colorectal endometriosis and reviewed the previous 7 cases reported in the English literature. Our patient, who was unavailable for tumor resection and refused further adjuvant therapy, played a role in representing the natural history of low-grade extragenital ESS. This case was the only death from ESS arising in colorectal endometriosis.

scholarly journals Cystic fibrohistiocytic tumor of the lung presenting as a solitary lesion

Rare Tumors ◽  
2010 ◽  
Vol 2 (1) ◽  
pp. 40-42 ◽  
Author(s):  
Massimiliano Paci ◽  
Alberto Cavazza ◽  
Valerio Annessi ◽  
Tommaso Ricchetti ◽  
Cristian Rapicetta ◽  
...  
Keyword(s):  
Lower Lobe ◽  
Pulmonary Nodules ◽  
Endometrial Stromal Sarcoma ◽  
Pleuropulmonary Blastoma ◽  
Low Grade ◽  
Solitary Lesion ◽  
Stromal Sarcoma ◽  
Pulmonary Cysts ◽  
History Of ◽  
Single Lesion

Cystic fibrohistiocytic tumor of the lung is a rare neoplasm. In many cases it represents a metastasis from a benign or low-grade fibrohistiocytic tumor of the skin, but occasionally it may be primary. Radiologically it usually occurs as a cystic change of multiple pulmonary nodules, and pneumothorax is the most frequent presenting symptom. We present here a 16-year-old man with recurrent right pneumothorax. The patient had no history of cutaneous fibrohistiocytic lesions. He underwent videothoracoscopic right apical segmentectomy, right lower lobe nodulectomy, and pleuroabrasion. Microscopy of the apical segmentectomy showed a cystic fibrohistiocytic tumor, whereas the nodule of the lower lobe was an intraparenchymal lymph node. The patient is alive with no tumor recurrence. The differential diagnosis includes Langerhans cell histiocytosis, lymphangioleiomyomatosis, pleuropulmonary blastoma, and metastatic endometrial stromal sarcoma. This disease usually occurs with multiple pulmonary cysts and cavitation. This case is the first reported presenting as a single lesion.

scholarly journals ENDOMETRIAL STROMAL SARCOMA PADA SERVIKS UTERI

2015 ◽  
Vol 7 (3) ◽  
Author(s):  
Poppy M. Lintong ◽  
Meilany F. Durry
Keyword(s):  
Abdominal Pain ◽  
Uterine Cervix ◽  
Histopathological Examination ◽  
Clinical Signs ◽  
Uterine Cavity ◽  
Endometrial Stromal Sarcoma ◽  
Pelvic Cavity ◽  
Stromal Sarcoma ◽  
Uterine Tumors ◽  
Exophytic Tumor

Abstract: Endometrial stromal sarcoma (ESS) is a rare malignant tumor, about 0.2% of all malignant uterine tumors. Around 75% of ESS cases occur in females under 50 years, with clinical signs such as abdominal pain and bleeding per vaginam. The uterus usually enlarges, associated with polypoid tumors protruding into the uterine cavity which can be misdiagnosed with a leiomyoma. ESS occurs in the cervix, ovarium, or retroperitoneal areas, and can be derived from endometriosis in the pelvic cavity. The immunohistochemical test of the tumor cells is positive for CD10, which is typical to differ it from a leiomyoma. We reported a case of ESS in a woman of 43 years old, with a clinical diagnosis of myoma geburt. She complained of abdominal pain and a mass that came out of her vagina. Post operation, she was diagnosed as having a cervical myoma. The macroscopic examination showed enlargement of uterus tissues 15x6x7 cm, thickened endometrium, and an exophytic tumor mass (8 cm) in the cervix, with cystic and necrotic parts in it. The microscopic examination showed endometrium hypertrophy in secretion phase, cervix with endometriosis, and ESS. ESS in uterine cervix is a rare case, and in this case it is related to endometriosis in the uterine cervix. Conclusion: This case was diagnosed as endometrial stromal sarcoma in the uterine cervix based on anamnesis, physical examination, histopathological examination, and immunohistochemistry positive for CD10.Keywords: endometrial stromal sarcoma, endometriosis, uterine cervixAbstrak: Endometrial stromal sarcoma (ESS) merupakan tumor ganas yang jarang terjadi, hanya 0,2 % dari semua tumor ganas di uterus. Sekitar 75% kasus terjadi pada wanita usia di bawah 50 tahun dengan gejala klinis nyeri perut dan perdarahan melalui jalan lahir. Uterus biasanya membesar disertai tumor polipoid menonjol dalam rongga uterus dan bisa disalah diagnosis sebagai leiomioma. ESS dapat terjadi juga di serviks uteri, ovarium, retroperitoneal, dan di rongga pelvis; dapat berasal dari endometriosis. Pemeriksaan imunohistokimia dari sel-sel tumor ESS yaitu positif untuk CD10, merupakan petanda tipikal untuk membedakannya dari leiomioma. Kami melaporkan kasus ESS pada seorang wanita berusia 43 tahun dengan keluhan nyeri perut dan adanya massa jaringan yang keluar dari jalan lahir. Diagnosis klinis ialah mioma geburt dan pasca operasi diduga sebagai mioma servikal. Pemeriksaan makroskopik menunjukkan jaringan uterus membesar berukuran 15x6x7 cm, dan pada serviks terdapat massa tumor berukuran 8 cm eksofitik, dengan fokus kistik dan nekrotik. Hasil pemeriksaan mikroskopik menunjukkan serviks dengan endometriosis dan ESS. Pemeriksaan imunohistokimia positif untuk CD10. ESS pada serviks uteri merupakan kasus jarang yang berkembang dari endometriosis serviks uteri. Simpulan: Pada kasus ini diagnosis ESS pada serviks uterus ditegakkan berdasarkan anamnesis, pemeriksaan klinis, pemeriksaan histopatlogik, dan imunohistokimia CD10 positif.Kata kunci: endometrial stromal sarcoma, endometriosis, serviks uteri

scholarly journals CT, MRI, and FDG-PET imaging findings of low-grade extrauterine endometrial stromal sarcoma arising from the mesentery: A case report

2021 ◽  
Vol 16 (9) ◽  
pp. 2774-2779
Author(s):  
Satoshi Suzuki ◽  
Ryo Kurokawa ◽  
Tetsushi Tsuruga ◽  
Mayuyo Mori‑Uchino ◽  
Haruka Nishida ◽  
...  
Keyword(s):  
Case Report ◽  
Pet Imaging ◽  
Fdg Pet ◽  
Endometrial Stromal Sarcoma ◽  
Low Grade ◽  
Imaging Findings ◽  
Stromal Sarcoma

scholarly journals Fusion genes in gynecologic tumors: the occurrence, molecular mechanism and prospect for therapy

2021 ◽  
Vol 12 (8) ◽  
Author(s):  
Bingfeng Lu ◽  
Ruqi Jiang ◽  
Bumin Xie ◽  
Wu Wu ◽  
Yang Zhao
Keyword(s):  
Tumor Progression ◽  
Massively Parallel Sequencing ◽  
Gynecologic Cancer ◽  
Endometrial Stromal Sarcoma ◽  
Driver Mutations ◽  
Fusion Genes ◽  
Stromal Sarcoma ◽  
Uterine Tumors ◽  
Rearrangement Mechanism ◽  
Gynecologic Tumors

AbstractGene fusions are thought to be driver mutations in multiple cancers and are an important factor for poor patient prognosis. Most of them appear in specific cancers, thus satisfactory strategies can be developed for the precise treatment of these types of cancer. Currently, there are few targeted drugs to treat gynecologic tumors, and patients with gynecologic cancer often have a poor prognosis because of tumor progression or recurrence. With the application of massively parallel sequencing, a large number of fusion genes have been discovered in gynecologic tumors, and some fusions have been confirmed to be involved in the biological process of tumor progression. To this end, the present article reviews the current research status of all confirmed fusion genes in gynecologic tumors, including their rearrangement mechanism and frequency in ovarian cancer, endometrial cancer, endometrial stromal sarcoma, and other types of uterine tumors. We also describe the mechanisms by which fusion genes are generated and their oncogenic mechanism. Finally, we discuss the prospect of fusion genes as therapeutic targets in gynecologic tumors.

Low-grade endometrial stromal sarcoma developing in a postmenopausal woman under toremifene treatment for breast cancer

2012 ◽  
Vol 39 (1) ◽  
pp. 424-429 ◽  
Author(s):  
Tomoko Kashiyama ◽  
Katsutoshi Oda ◽  
Kei Kawana ◽  
Takahide Arimoto ◽  
Yukiko Kanetaka ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Postmenopausal Woman ◽  
Endometrial Stromal Sarcoma ◽  
Low Grade ◽  
Stromal Sarcoma

Low-Grade Endometrial Stromal Sarcoma with Florid Intravenous Component

2008 ◽  
Vol 66 (1) ◽  
pp. 8-11 ◽  
Author(s):  
Keith Wing-Kit Lo ◽  
Mei-Yung Yu ◽  
Tak-Hong Cheung
Keyword(s):  
Endometrial Stromal Sarcoma ◽  
Low Grade ◽  
Stromal Sarcoma
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