scholarly journals Ovarian Steroid Cell Tumor (Not Otherwise Specified): A Case Report of Ovarian Hyperandrogenism

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Hadjkacem Faten ◽  
Ghorbel Dorra ◽  
Charfi Slim ◽  
Safi Wajdi ◽  
Charfi Nadia ◽  
...  
Keyword(s):  
Transvaginal Ultrasound ◽  
Cell Tumor ◽  
Ovarian Mass ◽  
Stromal Tumors ◽  
Not Otherwise Specified ◽  
Fertility Sparing Surgery ◽  
Fertility Sparing ◽  
Steroid Cell Tumor ◽  
Ovarian Hyperandrogenism ◽  
Sex Cord Stromal Tumors

Steroid cell tumors (SCTs) (not otherwise specified (NOS)) are rare sex cord-stromal tumors of the ovary. These are associated with hormonal disturbances resulting in menstrual bleeding patterns and androgenic effects. We report the case of a 36-year-old female presented with hirsutism, signs of virilization, and elevated androgen levels. Transvaginal ultrasound showed a solid-appearing right ovarian mass. She underwent fertility-sparing surgery with a laparoscopic left oophorectomy. Histological examination showed a benign steroid cell tumor, NOS. These tumors often small can then present a problem of positive diagnosis responsible for a delay in the diagnosis.

scholarly journals An Early Diagnosis of an Ovarian Steroid Cell Tumor Not Otherwise Specified in a Woman

2019 ◽  
Vol 2019 ◽  
pp. 1-3 ◽  
Author(s):  
Patrícia Alves ◽  
Inês Sá ◽  
Miguel Brito ◽  
Cátia Carnide ◽  
Osvaldo Moutinho
Keyword(s):  
Histological Finding ◽  
Cell Tumor ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Ovarian Steroid ◽  
Stromal Tumors ◽  
Not Otherwise Specified ◽  
Steroid Cell Tumor ◽  
Laparoscopic Cystectomy ◽  
Sex Cord Stromal Tumors

Steroid cell tumor not otherwise specified is a subtype of steroid ovary tumors. These are a rare subgroup of ovarian sex cord-stromal tumors. We present a case of a young woman submitted to laparoscopic cystectomy with ovarian steroid cell tumor as histological finding. This represents the second case where laparoscopic cystectomy is performed in this type of tumor. Up to 36 months after surgery, the woman remains under surveillance, without recurrence of the tumor, and attempts to conceive. This case suggests that steroid cell tumors can be asymptomatic, and gynecologists must think about preserving fertility in women of reproductive age.

scholarly journals Retiform Sertoli-Leydig Cell Tumor in a 38-Year-Old Woman: A Case Report, Retrospective Review, and Review of Current Literature

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Laura C. Nwogu ◽  
Josh A. Showalter ◽  
Suvra Roy ◽  
Michael T. Deavers ◽  
Bihong Zhao
Keyword(s):  
Leydig Cell ◽  
Stromal Cells ◽  
Ovarian Neoplasms ◽  
Leydig Cell Tumor ◽  
Cell Tumor ◽  
Ovarian Mass ◽  
Immunohistochemical Examination ◽  
Stromal Tumors ◽  
Sex Cord Stromal Tumors ◽  
Leydig Cell Tumors

Ovarian sex cord-stromal tumors arise from the stromal cells that surround and support the oocytes. Sertoli-Leydig cell tumors belong to this category of ovarian neoplasms. We present the case of a 38-year-old woman who was found to have a right ovarian mass. The mass was resected and diagnosed as Stage I Sertoli-Leydig cell tumor, retiform variant, following histopathologic and immunohistochemical examination. This case is unusual given the rarity of the retiform variant of Sertoli-Leydig cell tumor and the atypically older age of 38 years at presentation.

scholarly journals Analysis of the Safety and Pregnant Outcomes of Fertility-Sparing Surgery in Ovarian Malignant Sex Cord-Stromal Tumors: A Multicenter Retrospective Study

2021 ◽  
Author(s):  
Junting Li ◽  
Ran Chu ◽  
Gang Chen ◽  
Yuanming Shen ◽  
Yanhui Lou ◽  
...  
Keyword(s):  
Risk Factors ◽  
Regression Analysis ◽  
High Risk ◽  
Stromal Tumors ◽  
High Risk Factors ◽  
Fertility Sparing Surgery ◽  
Fertility Sparing ◽  
Stage Ia ◽  
Staging Surgery ◽  
Sex Cord Stromal Tumors

Abstract Background: To assess the difference in survival between fertility-sparing surgery (FSS) and radical surgery (RS) and explore pregnant outcomes after FSS in stage I malignant sex cord-stromal tumors (MSCSTs).Methods: We performed a multicenter retrospective cohort study on patients who were diagnosed with stage IA or IC MSCSTs. Inverse Probability of Treatment Weighting was performed between the FSS and RS groups. The Chi-square test and Kaplan-Meier method were used to compare the categorical variables and disease-free survival (DFS). The binary logistic regression analysis and Cox proportional hazards regression analysis were used to identify high-risk factors related to DFS and pregnancy.Results: A total of 107 patients were included, of whom 54 (50.5%) women underwent FSS, and 53 (49.5%) women underwent RS. After IPTW, 208 patients were obtained, and all of the covariates were well balanced. After a median follow-up time of 50 months (range 7-156 months), there was no significant difference of DFS between the two groups in both unweighted cohort (P=0.969) or weighted cohort (P=0.792). In the weighted cohort, stage IC (P=0.014), tumor diameter >8 cm (P=0.003), incomplete staging surgery (P=0.003) and no adjuvant chemotherapy (P <0.001) were 4 high-risk factors associated with a shorter DFS. Among 14 patients who had pregnancy desire, 11 (78.6%) women conceived successfully, and the live birth rate was 76.9%. In univariate analysis, only adjuvant chemotherapy (P=0.009) was associated with infertility.Conclusions: On the premise of complete staging surgery, FSS is safe and feasible in stage IA and IC MSCSTs with satisfactory reproductive outcomes.

scholarly journals MON-004 Ovarian Steroid Cell Tumor, Not Otherwise Specified (NOS): A Case Report and Clinical Review

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Miry Lobaton ◽  
Luz M Malanco ◽  
Liliana Trejo
Keyword(s):  
Multidisciplinary Team ◽  
Transvaginal Ultrasound ◽  
Cell Tumor ◽  
Ovarian Tumors ◽  
Total Testosterone ◽  
Ovarian Steroid ◽  
Endocrine Activity ◽  
Not Otherwise Specified ◽  
Imaging Results ◽  
Steroid Cell Tumor

Abstract Background: Ovarian tumors are divided into non functioning and functioning, within the last group, we can find those with endocrine activity that produce androgenization. Ovarian cell tumors, not otherwise specified (SCT-NOS) is a rare type of ovarian sex cordomal tumor and represents the 60% of this tumors, which compromise less than 0.1% of the ovarian tumors. (1) Clinical Case: We here present a 28 year old woman who was referred to the Endocrine Clinic due to secondary amenorrhea and virilization signs. At the age of twelve a diagnosis of polycystic ovarian syndrome (POS) was made and treated with combined oral anticonceptive (COA). Menses became regular only with medication. Six months after she stopped medication, amenorrhea and virilization signs worsened. Biochemically she had levels of serum total testosterone 6.8 ng/mL (0.02-0.45) and free testosterone 42 pg/mL (0.1-6.4) since only pelvic ultrasonography has been made by physician, a transvaginal ultrasound and abdomen – pelvic CT scan showed a anexial tumor. After analysis of biochemical and imaging results a multidisciplinary team performed a surgical extirpation of the primary lesion, which was diagnosed by histopathology as a tumor of lipoidic cells NOS. A month after the surgery, menses became regular. Conclusion: The purpose of this article is to present the available information about this kind of tumors and the treatment recommended. It is mandatory to follow a correct approach among a multidisciplinary team, in order to get the correct diagnosis at the proper time. (1) Zang L, Ye M, Yang G, Li J, Liu M, Du J et al. Accessory ovarian steroid cell tumor producing testosterone and cortisol. Medicine. 2017;96(37):e7998.

scholarly journals Preoperative Differentiation of Benign and Malignant Non-epithelial Ovarian Tumors: Clinical Features and Tumor Markers

2020 ◽  
Vol 42 (09) ◽  
pp. 555-561
Author(s):  
Tiago Augusto Gomes ◽  
Elizabeth Aparecida Campos ◽  
Adriana Yoshida ◽  
Luís Otavio Sarian ◽  
Liliana Aparecida Lucci de Angelo Andrade ◽  
...  
Keyword(s):  
Germ Cell ◽  
Clinical Features ◽  
Germ Cell Tumors ◽  
Serum Levels ◽  
Cell Tumor ◽  
Ovarian Tumors ◽  
Stromal Tumors ◽  
Fertility Sparing ◽  
Sex Cord Stromal Tumors ◽  
Sex Cord Stromal Tumor

Abstract Objective To evaluate the role of clinical features and preoperative measurement of cancer antigen 125 (CA125), human epididymis protein (HE4), and carcinoembryonic antigen (CEA) serum levels in women with benign and malignant non-epithelial ovarian tumors. Methods One hundred and nineteen consecutive women with germ cell, sex cord-stromal, and ovarian leiomyomas were included in this study. The preoperative levels of biomarkers were measured, and then surgery and histopathological analysis were performed. Information about the treatment and disease recurrence were obtained from the medical files of patients. Results Our sample included 71 women with germ cell tumors (64 benign and 7 malignant), 46 with sex cord-stromal tumors (32 benign and 14 malignant), and 2 with ovarian leiomyomas. Among benign germ cell tumors, 63 were mature teratomas, and, among malignant, four were immature teratomas. The most common tumors in the sex cord-stromal group were fibromas (benign) and granulosa cell tumor (malignant). The biomarker serum levels were not different among benign and malignant non-epithelial ovarian tumors. Fertility-sparing surgeries were performed in 5 (71.4%) women with malignant germ cell tumor. Eleven (78.6%) patients with malignant sex cord-stromal tumors were treated with fertility-sparing surgeries. Five women (71.4%) with germ cell tumors and only 1 (7.1%) with sex cord-stromal tumor were treated with chemotherapy. One woman with germ cell tumor recurred and died of the disease and one woman with sex cord-stromal tumor recurred. Conclusion Non-epithelial ovarian tumors were benign in the majority of cases, and the malignant cases were diagnosed at initial stages with good prognosis. The measurements of CA125, HE4, and CEA serum levels were not useful in the preoperative diagnosis of these tumors.

scholarly journals The effect of fertility-sparing surgery on sexuality and global quality of life in women with malignant ovarian germ cell and sex cord stromal tumors: an analysis of the CORSETT database of the AGO study group

2021 ◽  
Author(s):  
Annette Hasenburg ◽  
Hellmut Plett ◽  
Bernhard Krämer ◽  
Elena Braicu ◽  
Bastian Czogalla ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Study Group ◽  
Sexually Active ◽  
Stromal Tumors ◽  
Fertility Sparing Surgery ◽  
Global Quality ◽  
Fertility Sparing ◽  
Global Quality Of Life ◽  
Sex Cord Stromal Tumors

Abstract Purpose Malignant ovarian germ cell (MOGCT) and sex cord stromal tumors (SCST) are ovarian neoplasms that affect disproportionally young women. Little is known about the impact of surgical and adjuvant management of these patient’s sexual life. This study investigated the effect of fertility-sparing surgery on sexual activity and global quality of life (gQoL) in women with MOGCT and SCST. Methods CORSETT was an observational, multicenter, mixed retrospective/prospective cohort study of the AGO study group. Women of any age who had been diagnosed with MOGCTs and SCSTs between 2001 and 2011 were asked to complete the Sexual Activity Questionnaire (SAQ) and the EORTC QLQ-C30. Results In total, 355 patients were included. Of these, 152 patients with confirmed histological diagnosis had completed the questionnaires. A total of 106 patients were diagnosed with SCST and 46 with MOGCT. Totally, 83 women (55%) were sexually active. After fertility-sparing surgery, patients had a 2.6 fold higher probability for being sexually active than after non-fertility-conserving treatment (unadjusted odds ratio (OR) 2.6, p = 0.01). After adjustment for age, time since diagnosis, FIGO stage, histology and phase of disease, the OR dropped to 1.8 (p = 0.22). Of the sexually active patients, 35 (42%) reported high levels of discomfort during intercourse; 38% after fertility-sparing; and 58% after non-fertility-sparing surgery (adjusted OR 2.8, p = 0.18). Women with fertility-conserving treatment reported a significantly better global QoL (Fadj 2.1, 6.2 points difference, p = 0.03) but not more pleasure during intercourse than women without fertility-sparing surgery (Fadj 0.4, p = 0.52). Conclusion Fertility preserving approaches should be offered to every patient, when oncologically acceptable.

scholarly journals Hyperandrogenism, Elevated 17-Hydroxyprogesterone and Its Urinary Metabolites in a Young Woman with Ovarian Steroid Cell Tumor, Not Otherwise Specified: Case Report and Review of the Literature

2019 ◽  
Vol 2019 ◽  
pp. 1-8
Author(s):  
Felix C. K. Wong ◽  
Angela Z. Chan ◽  
W. S. Wong ◽  
Angel H. W. Kwan ◽  
Tracy S. M. Law ◽  
...  
Keyword(s):  
Polycystic Ovary ◽  
Transvaginal Ultrasound ◽  
Cell Tumor ◽  
Total Testosterone ◽  
Acth Stimulation ◽  
Hydroxylase Deficiency ◽  
Not Otherwise Specified ◽  
Steroid Cell Tumor ◽  
17 Hydroxyprogesterone ◽  
21 Hydroxylase Deficiency

We describe a case of a 24-year-old overweight woman who presented with hirsutism, secondary amenorrhea, clitoromegaly, and symptoms of diabetes mellitus (DM). While a diagnosis of polycystic ovary syndrome (PCOS) with its associated metabolic disturbances was initially considered, serum total testosterone, androstenedione, and 17-hydroxyprogesterone (17-OHP) measured by liquid chromatography tandem mass spectrometry (LC-MS/MS) were significantly increased. As 17-OHP did not increase upon ACTH (Synacthen) stimulation and the urinary steroid profile (USP) was compatible with an ovarian source of 17-OHP excess rather than adrenal, non classical congenital adrenal hyperplasia (NCCAH) was unlikely and an androgen-secreting tumor was suspected. Transabdominal ultrasound revealed the presence of an enlarged right ovary with a polycystic ovary morphology and no discrete mass. Transvaginal ultrasound and [18F]− fluorodeoxyglucose positron emission tomography–computed tomography (FDG PET–CT) enabled the localization of a right ovarian tumor. Laparoscopic right salpingo-oophorectomy was performed and a histological diagnosis of steroid cell tumor, not otherwise specified (SCT–NOS) was made. Hyperandrogenism and menstrual disturbances resolved postoperatively. A literature review revealed that 17-OHP-secreting SCT–NOS may uncommonly show positive responses to ACTH stimulation similar to 21-hydroxylase deficiency. Alternatively, USP might be useful in localizing the source of 17-OHP to the ovaries. Its diagnostic performance should be evaluated in further studies.

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