scholarly journals Treatment Efficacy of Chuang Ling Ye, a Traditional Chinese Herbal Medicine Compound, on Idiopathic Granulomatous Mastitis: A Randomized Controlled Trial

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Jing-xian Xue ◽  
Bei Ye ◽  
Shun Liu ◽  
Si-han Cao ◽  
Wei-he Bian ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Controlled Trial ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Granulomatous Mastitis ◽  
Idiopathic Granulomatous Mastitis ◽  
Traditional Chinese Herbal Medicine ◽  
Chinese Herbal ◽  
Dressing Change

Objective. To explore whether Chuang Ling Ye (CLY), a traditional Chinese herbal medicine compound, could improve the treatment of idiopathic granulomatous mastitis (IGM) via decreasing inflammatory response. Methods. Herein, 40 patients with IGM who had wounds requiring dressing change were enrolled and randomly divided into two groups: the CLY group and the control group. The size of the neoplasm and pain score of patients were followed-up for 4 weeks. Local tissues were taken during dressing change and examined by commercial enzyme-linked immunosorbent assay (ELISA) kits. The levels of inflammatory markers, including interleukin-1β (IL-1β), IL-2, IL-6, interferon gamma (IFN-γ), and tumor necrosis factor-α (TNF-α) were measured. Results. After treatment, the size of the neoplasm in the CLY group was significantly smaller than that in the control group (14.28 cm ± 8.96 cm vs. 21.14 cm ± 0.12 cm, P=0.038), and the pain scores were markedly reduced (P=0.004). Besides, CLY downregulated the expression levels of IL-1β, IFN-γ, and TNF-α. Conclusion. External use of CLY could reduce the neoplasm of IGM by inhibiting local inflammation. This trial is registered with ChiCTR1800017744.

Efficacy of quxie capsule in metastatic colorectal cancer: Update of a double-blind, randomized, placebo controlled trial.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e15030-e15030
Author(s):  
Tong Zhang ◽  
Wenting He ◽  
Yun Xu ◽  
Bin He ◽  
Yufei Yang
Keyword(s):  
Colorectal Cancer ◽  
Treatment Group ◽  
Herbal Medicine ◽  
Metastatic Colorectal Cancer ◽  
Chinese Herbal Medicine ◽  
Conventional Therapy ◽  
Controlled Trial ◽  
Control Group ◽  
Double Blind ◽  
Chinese Herbal

e15030 Background: To verify the efficacy of Quxie Capsule in patients with metastatic colorectal cancer (mCRC). Methods: This is a update of a randomized, double-blind, placebo-controlled trial. Between April 2014 and July 2015, 121 patients were enrolled in the study. Sixty patients were eligible and randomized to the two groups at a 1:1 ratio. Treatment group received conventional therapy and Chinese herbal medicine combined with Quxie Capsule for 3 months. Control group received conventional therapy and Chinese herbal medicine combined with placebo for 3 months. Main outcome measures were overall survival (OS) and progression-free survival (PFS). As of Dec 31st 2018, one patient in the control group was still alive, and all the other patients reached the main clinical endpoint. Median follow-up time was 19.4 months. Bo Ao Tong (Beijing) Medical Technology Co. Ltd. was responsible for the protocols of blind and block randomization. Results: The median OS were 23.9 months in the treatment group [95% confidence interval (CI) 15.9–28.5] vs. 14.3 months in the control group (95% CI 11.3–21.4) (Kaplan–Meier, Log-rank P=0.032), hazard ratio (95%CI)= 0.55 (0.31, 0.95), P=0.04. In the subgroups of left-sided colon, RAS wild type, non-targeted therapy, colon cancer and ≥second-line therapy, the median OS of the treatment group and the control group were respectively: 20.9 vs 12.2m, 17.4 vs 14.4m, 20.8 vs 12.0m, 25.1 vs 18.5m, 25.1 vs 12.0m ( P=0.037, 0.019, 0.022, 0.018, 0.007). There were no significant differences between the two groups in PFS. Conclusions: Quxie Capsule showed good efficacy, can reduce the risk of death and prolong the OS of patients with mCRC. Clinical trial information: ChiCTR-IOR-16009733.

Effect of Spirulina-Chinese herbal medicine on quality of eggs and serum biochemical indexes of egg-laying hens

2017 ◽  
Author(s):  
Liu Peipei ◽  
Zang Sumin
Keyword(s):  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Laying Hens ◽  
Egg Yolk ◽  
Egg Laying ◽  
Control Group ◽  
Egg Weight ◽  
Traditional Chinese Herbal Medicine ◽  
Chinese Herbal ◽  
Laying Performance

This study used three-factor linear regression orthogonal design to examine the impacts of traditional Chinese herbal medicine on egg quality and egg-laying hens’ biochemical indexes. 495 and 210d Hy-Line gray commercial egg-laying hens were selected and spirulina powder was added to their diet at 5 g/kg, 10g/kg, 15g/kg in the diet, rchmannia glutnosa polysaccharides were added at 2.5g/kg, 3 g/kg, 3.5 g/kg, and Leonurus Japonicas was added at 0.7 g/kg, 0.9g/kg, 1.1 g/kg. The hens were randomly allocated to a control group and ten test groups, in order to study the herbs’ effects on laying performance and immunity parameters. The results showed that: (1)When spirulina-Chinese herbal medicine was added, the average egg weight, yolk color, and Hartz unit increased significantly.(2) When spirulina powder levels were increased, the egg yolk color and iron content significantly increased while the cholesterol and triglyceride levels were significantly lower (P>0.05). With the increase of rchmannia glutnosa polysaccharides extracts, eggshell strength increased significantly (P>0.01). Egg yolk color and eggshell strength increased significantly (P>0.05 and P>0.01, respectively) when Leonurus Japonicas increased. (3) Spirulina powder and rchmannia glutnosa polysaccharides extracts were significantly antagonistic to average egg weight and eggshell strength (P>0.01). Leonurus Japonicus and rchmannia glutnosa polysaccharides were significantly antagonistic to eggshell strength and cholesterol levels (P>0.05).

scholarly journals Chinese Herbal Medicine Dingji Fumai Decoction for Ventricular Premature Contraction: A Real-World Trial

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Bo Liang ◽  
Fei-Hu Zou ◽  
Ling Fu ◽  
Hui-Ling Liao
Keyword(s):  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Clinical Symptoms ◽  
Medication Compliance ◽  
Controlled Trial ◽  
Ventricular Premature Contraction ◽  
Traditional Chinese Medicine Syndrome ◽  
Chinese Herbal ◽  
Double Blinded

Background. Chinese herbal medicine Dingji Fumai Decoction (DFD) is widely clinically used for ventricular premature contraction (VPC). This real-word trial was designed to assess the safety and effectiveness of DFD for VPC. Methods. This was a double-blinded, randomized placebo-controlled trial. Patients with VPC were randomized (1 : 1) to treatment with DFD combined with metoprolol (DFD arm) or metoprolol combined with placebo (MET arm). A primary end point was a composite of clinical symptoms and signs determined by the traditionalChinese medicine syndrome score and the number of VPC determined by the Holter examination. Second outcomes were adverse events, medication compliance, and laboratory examination. Results. 144 patients were randomized to DFD arm (76 patients) or MET arm (68 patients), and 136 cases (71 in DFD arm and 65 in MET arm) finally completed this trial. After a 12-week follow-up, DFD arm significantly decreased traditional Chinese medicine syndrome score and the number of VPC compared with MET arm (P=0.003 and 0.034, respectively). There was no adverse drug effect and patient medication compliance was good. Conclusions. Superiority with DFD arm for VPC was demonstrated over MET arm for both the safety and effectiveness end points.

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