scholarly journals RANKL/RANK/OPG Pathway: A Mechanism Involved in Exercise-Induced Bone Remodeling

2020 ◽  
Vol 2020 ◽  
pp. 1-11 ◽  
Author(s):  
Mohammad Tobeiha ◽  
Mohammed H. Moghadasian ◽  
Negin Amin ◽  
Sadegh Jafarnejad
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Bone Remodeling ◽  
Bone Health ◽  
Bone Modeling ◽  
Health It ◽  
Previous Evidence ◽  
The World ◽  
Exercise Induced ◽  
Bone Modeling And Remodeling

Bones as an alive organ consist of about 70% mineral and 30% organic component. About 200 million people are suffering from osteopenia and osteoporosis around the world. There are multiple ways of protecting bone from endogenous and exogenous risk factors. Planned physical activity is another useful way for protecting bone health. It has been investigated that arranged exercise would effectively regulate bone metabolism. Until now, a number of systems have discovered how exercise could help bone health. Previous studies reported different mechanisms of the effect of exercise on bone health by modulation of bone remodeling. However, the regulation of RANKL/RANK/OPG pathway in exercise and physical performance as one of the most important remodeling systems is not considered comprehensive in previous evidence. Therefore, the aim of this review is to clarify exercise influence on bone modeling and remodeling, with a concentration on its role in regulating RANKL/RANK/OPG pathway.

Prevalence of and factors associated with insufficient physical activity among adolescents: evidence from a nationwide survey in Bangladesh

2021 ◽  
pp. 1-14
Author(s):  
Md Mokbul Hossain ◽  
Fahmida Akter ◽  
Abu Abdullah Mohammad Hanif ◽  
Md Showkat Ali Khan ◽  
Abu Ahmed Shamim ◽  
...  
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
World Health Organization ◽  
Adolescent Girls ◽  
World Health ◽  
Factors Associated ◽  
Adolescent Girls And Boys ◽  
The World ◽  
Insufficient Physical Activity ◽  
Health Organization

Abstract The World Health Organization set a target of a 15% relative reduction in the prevalence of insufficient physical activity (IPA) by 2025 among adolescents and adults globally. In Bangladesh, there are no national estimates of the prevalence of IPA among adolescents. The aim of this study was to estimate the prevalence of and risk factors associated with IPA among adolescent girls and boys. Data for 4865 adolescent girls and 4907 adolescent boys, collected as a part of a National Nutrition Surveillance in 2018–19, were analysed for this study. A modified version of the Global Physical Activity Questionnaire (GPAQ) was used to collect physical activity data. The World Health Organization recommended cut-off points were used to estimate the prevalence of IPA. Bivariate and multivariable logistic regression was performed to identify factors associated with IPA. Prevalences of IPA among adolescent girls and boys were 50.3% and 29.0%, respectively, and the prevalence was significantly higher among early adolescents (10–14 years) than late adolescents (15–19 years) among both boys and girls. The IPA prevalence was highest among adolescents living in non-slum urban areas (girls: 77.7%; boys: 64.1%). For both boys and girls, younger age, non-slum urban residence, higher paternal education and increased television viewing time were significantly associated with IPA. Additionally, residing in slums was significantly associated with IPA only among the boys. Higher maternal education was associated with IPA only among the girls. This study identified several modifiable risk factors associated with IPA among adolescent boys and girls in Bangladesh. These factors should be addressed through comprehensive public health interventions to promote physical activity among adolescent girls and boys.

scholarly journals The effects of physical inactivity

2021 ◽  
Vol 5 (6) ◽  
pp. 241-243
Author(s):  
Ferhan Soyuer
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
World Health Organization ◽  
Physical Inactivity ◽  
Causes Of Death ◽  
World Health ◽  
Culturally Appropriate ◽  
The World ◽  
Sedentary Life ◽  
Health Organization

Physical inactivity constitutes the basis of diseases that reduce life duration and quality and rank first among the causes of death in the world. Worldwide, it has been determined that 23 % of adults aged 18 and over are not active enough. According to the World Health Organization, sedentary life is among the main risk factors for deaths from non-communicable diseases worldwide and causes approximately 3.2 million deaths per year. For this reason, the issue of reducing inactivity has gained importance in the world today. As a solution, it is thought that increasing physical activity requires not only individual but also community-specific, multi-sectoral, multi-disciplinary and culturally appropriate approaches.

scholarly journals Retrospective analysis of the cardiovascular risk factors in hypertensive patients in Mongolia

2019 ◽  
Vol 25 (1) ◽  
pp. 14-24
Author(s):  
B. Tsetsegdulam ◽  
T. M. Maksikova ◽  
A. N. Kalyagin ◽  
G. M. Orlova ◽  
G. M. Sinkova ◽  
...  
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
World Health ◽  
Hypertensive Patients ◽  
The World ◽  
Medium Level ◽  
The Russian Federation ◽  
Health Organization

The review analyzes the structure of cardiovascular risk factors in patients with hypertension in Mongolia. According to the WHO data from 2014 the prevalence of hypertension in Mongolia is high among men and above medium level among women. In adults (≥ 18 years old), the prevalence of hypertension constituted 28,7% (25,8 % among men and 22,9 % among women), and when adjusted for age it achieved 31,8% (34,8% and 28,8 %, respectively). The most important modifable (non-nutritious food, low physical activity, smoking, alcohol abuse, obesity, hyperglycemia) and non-modifable risk factors of cardiovascular diseases are considered. We perform a comparative analysis of the Mongolian data with the data of the World Health Organization, the Russian Federation and other countries.

Colorectal Cancer

2019 ◽  
pp. 391-410
Author(s):  
George Kunnackal John ◽  
Mohammed Razvi
Keyword(s):  
Physical Activity ◽  
Colorectal Cancer ◽  
Risk Factors ◽  
Protective Factors ◽  
Integrative Approach ◽  
Meat Intake ◽  
Balanced Diet ◽  
The World ◽  
Red Meat Intake ◽  
Related Mortality

Colorectal cancer (CRC) is a leading cause of cancer-related mortality globally. However, the adoption of a healthier lifestyle, including modifications in diet, physical activity, and regular screening can drastically reduce the risk for CRC. Major risk factors for CRC include lack of a balanced diet, high red meat intake, physical inactivity, alcohol, and smoking. There is widespread geographic variation in the rates of CRC across the world, reflecting differences in exposure to these risk factors and the influence of protective factors in these regions. In this chapter, we summarize the epidemiology, pathogenesis, and risk factors, and focus on the prevention of CRC through an integrative approach.

scholarly journals Physical Activity, Health Benefits, and Mortality Risk

2012 ◽  
Vol 2012 ◽  
pp. 1-14 ◽  
Author(s):  
Peter Kokkinos
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Mortality Risk ◽  
Health Benefits ◽  
Physical Exertion ◽  
Cardiac Events ◽  
Epidemiologic Evidence ◽  
Exercise Induced

A plethora of epidemiologic evidence from large studies supports unequivocally an inverse, independent, and graded association between volume of physical activity, health, and cardiovascular and overall mortality. This association is evident in apparently healthy individuals, patients with hypertension, type 2 diabetes mellitus, and cardiovascular disease, regardless of body weight. Moreover, the degree of risk associated with physical inactivity is similar to, and in some cases even stronger than, the more traditional cardiovascular risk factors. The exercise-induced health benefits are in part related to favorable modulations of cardiovascular risk factors observed by increased physical activity or structured exercise programs. Although the independent contribution of the exercise components, intensity, duration, and frequency to the reduction of mortality risk is not clear, it is well accepted that an exercise volume threshold defined at caloric expenditure of approximately 1,000 Kcal per week appears to be necessary for significant reduction in mortality risk. Further reductions in risk are observed with higher volumes of energy expenditure. Physical exertion is also associated with a relatively low and transient increase in risk for cardiac events. This risk is significantly higher for older and sedentary individuals. Therefore, such individuals should consult their physician prior to engaging in exercise.

Measuring Children’s Vertical Ground Reaction Forces with Accelerometry during Walking, Running, and Jumping: The Iowa Bone Development Study

2003 ◽  
Vol 15 (1) ◽  
pp. 34-43 ◽  
Author(s):  
Kathleen F. Janz ◽  
Smita Rao ◽  
Hope J. Baumann ◽  
Jaime L. Schultz
Keyword(s):  
Physical Activity ◽  
Bone Development ◽  
Correlation Coefficients ◽  
Bone Modeling ◽  
Ground Reaction Forces ◽  
Slow Walking ◽  
Reaction Forces ◽  
Vertical Ground ◽  
Vertical Ground Reaction Forces ◽  
Bone Modeling And Remodeling

Ground reaction forces (GRF) are associated with bone hypertrophy; therefore, they are important to understanding physical activity’s role in children’s bone health. In this study, we examined the ability of accelerometry to predict vertical GRF in 40 children (mean age 8.6 yr) during slow walking, brisk walking, running, and jumping. Correlation coefficients between accelerometry-derived movement counts and GRF were moderate to high and significant during walking and running, but not during jumping. Given a large proportion of children’s daily physical activity involves ambulation, accelerometry should be useful as a research method in bone-related research. However, this method underestimates GRF during jumping, an important physical activity for bone modeling and remodeling.

Haematocrit: Relationships with Blood Lipids, Blood Pressure and other Cardiovascular Risk Factors

1994 ◽  
Vol 72 (01) ◽  
pp. 058-064 ◽  
Author(s):  
Goya Wannamethee ◽  
A Gerald Shaper
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Blood Pressure ◽  
Body Mass Index ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Alcohol Intake ◽  
Blood Lipids ◽  
The Other ◽  
The Relationship

SummaryThe relationship between haematocrit and cardiovascular risk factors, particularly blood pressure and blood lipids, has been examined in detail in a large prospective study of 7735 middle-aged men drawn from general practices in 24 British towns. The analyses are restricted to the 5494 men free of any evidence of ischaemic heart disease at screening.Smoking, body mass index, physical activity, alcohol intake and lung function (FEV1) were factors strongly associated with haematocrit levels independent of each other. Age showed a significant but small independent association with haematocrit. Non-manual workers had slightly higher haematocrit levels than manual workers; this difference increased considerably and became significant after adjustment for the other risk factors. Diabetics showed significantly lower levels of haematocrit than non-diabetics. In the univariate analysis, haematocrit was significantly associated with total serum protein (r = 0*18), cholesterol (r = 0.16), triglyceride (r = 0.15), diastolic blood pressure (r = 0.17) and heart rate (r = 0.14); all at p <0.0001. A weaker but significant association was seen with systolic blood pressure (r = 0.09, p <0.001). These relationships remained significant even after adjustment for age, smoking, body mass index, physical activity, alcohol intake, lung function, presence of diabetes, social class and for each of the other biological variables; the relationship with systolic blood pressure was considerably weakened. No association was seen with blood glucose and HDL-cholesterol. This study has shown significant associations between several lifestyle characteristics and the haematocrit and supports the findings of a significant relationship between the haematocrit and blood lipids and blood pressure. It emphasises the role of the haematocrit in assessing the risk of ischaemic heart disease and stroke in individuals, and the need to take haematocrit levels into account in determining the importance of other cardiovascular risk factors.

Hygienic characteristics of the cosmetologists' lifestyle

2020 ◽  
Vol 60 (12) ◽  
pp. 958-963
Author(s):  
Natalia I. Latyshevskaya ◽  
Tatyana L. Yatsyshena ◽  
Elena L. Shestopalova ◽  
Irina Yu. Krainova
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Information And Communication Technologies ◽  
Health Risks ◽  
Healthy Lifestyle ◽  
Personal Hygiene ◽  
Risk Category ◽  
Essential Components ◽  
Group A ◽  
Group B

Modern trends in the deterioration of health and the growth of non-communicable diseases among the adult working-age population, including medical workers, actualize the importance of a healthy lifestyle for maintaining health and professional longevity. There were almost no studies related to cosmetologists' experienced group as representatives of aesthetic medicine. There is no scientific evidence on behavioral risks of this group. It justifies the relevance of this study. The study aims to analyze the essential components of the cosmetologists' lifestyle depending on age and the argumentation of priority behavioral health risk factors for preventive and recreational work justification. Sixty women (practicing cosmetologists in Volgograd at the age of 28-39 years (group A) and 40-53 (group B)) took part in the study. Lifestyle assessment included a modified questionnaire. The questionnaire consists of 5 blocks (block 1 - nutrition; 2 - physical activity, including hardening and active rest; 3 - daily regimen; 4 - personal hygiene; 5 - bad habits). It allows the analysis of the adherence to a healthy lifestyle based on the provision of quantitative data. Statistical data processing was carried out using the Excel package. The authors identified the essential and statistically significant differences in the cosmetologists' lifestyle depending on age. The respondents of group B demonstrated hygienically rational indicators in all blocks of the lifestyle more often. They had a more formed adherence to a healthy lifestyle: 504 answers in the category "insignificant risk" of respondents in group B versus 354 in group A. Distribution of answers in the "high risk" category: 119 responses in group B and 185 in group A. The lifestyle of 46.7% of the respondents in group B refers to a healthy lifestyle. 3.3% of the group B respondents have an anxious lifestyle, 50% have health risks. 10% of Group A respondents' lifestyle refers to a healthy lifestyle. 13.3% of Group A respondents' lifestyle refers to an anxious lifestyle; 76.7% of this group have health risks. There was almost no complex hygienic research profession of medical cosmetologists. Cosmetologists of the older age group (40-53 years old) are more conscious of maintaining a hygienically rational lifestyle. The most significant defects among cosmetologists aged 28-39 years are low physical activity, nutritional defects, insufficient duration of night rest, and excessive use of information and communication technologies for rest, accompanied by manifestations of neurotization and signs of pronounced fatigue. The obtained results argue the need to develop and implement informational and educational measures to prevent risk behavior patterns, taking into account the age of cosmetologists and the priority of the identified behavioral risk factors.

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