scholarly journals Vhavenda Herbal Remedies as Sources of Antihypertensive Drugs: Ethnobotanical and Ethnopharmacological Studies

2020 ◽  
Vol 2020 ◽  
pp. 1-18
Author(s):  
Gundo Mudau ◽  
Samuel Odeyemi ◽  
John Dewar
Keyword(s):  
Blood Pressure ◽  
High Blood Pressure ◽  
Antihypertensive Drugs ◽  
Traditional Healers ◽  
Modern Medicine ◽  
Herbal Remedies ◽  
Ethnobotanical Survey ◽  
First Choice ◽  
Vhembe District

Hypertension is a dominant risk factor for the development of cardiovascular, kidney, and eye diseases. In Africa, it increasingly leads to hospitalisation and a strain on the public health system. However, rather than modern medicine, African traditional healers are the first choice for most South Africans. Therefore, this study is aimed at gathering information on herbal remedies traditionally used for the treatment of high blood pressure in Vhavenda, South Africa, and comparing this information with reports in the literature regarding plants used to manage high blood pressure. An ethnobotanical survey was carried out in Vhembe district and its environs with 53 herbalists and indigenous people aged between 36 and 66 years from January to October 2019 using a semistructured questionnaire. The plants were collected with each respondent; they were authenticated and kept in herbarium. A total of 51 different plants were mentioned as being most commonly used for hypertension treatment. Of these, 44 plants were identified, with those from the Fabaceae family followed by plants from the Celastraceae family being commonly mentioned. Of these, the Elaeodendron transvaalense, Tabernaemontana elegans, Elephantorrhiza elephantina, and Aloe vossii were commonly cited species. According to the literature data, most of the identified plants are yet to be scientifically investigated for the treatment of hypertension, whereas only preliminary investigations have been carried out on other plants, suggesting that these preliminary investigations may have highlight promising antihypertensive activities in vitro that are indicative of their potential as antihypertensive drugs. Therefore, there is a need to scientifically investigate the antihypertensive potentials of these plants as a potential source of antihypertensive treatment and compounds.

scholarly journals Obstructive sleep apnea syndrome and sleep quality in hypertensive patients

2017 ◽  
Vol 63 (12) ◽  
pp. 1055-1060 ◽  
Author(s):  
Marcelo Rodrigues Bacci ◽  
Jonathan Naim Mora Emboz ◽  
Beatriz da Costa Aguiar Alves ◽  
Glaucia Luciano da Veiga ◽  
Neif Murad ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Sleep Quality ◽  
High Blood Pressure ◽  
Antihypertensive Drugs ◽  
Poor Sleep ◽  
Hypertensive Patients ◽  
Group I ◽  
Obstructive Sleep

Summary Introduction: Obstructive sleep apnea and hypopnea syndrome (OSAHS) is one of the developmental factors of high blood pressure (HBP), a relevant global public health problem. OSAHS is characterized by the reduction or complete cessation of respiratory airflow due to intermittent airway collapse. Additionally, significant changes in sleep rhythm and pattern are observed in these patients. Objective: To evaluate the association between OSAHS and sleep quality in essential and resistant hypertensives. Method: A cross-sectional, observational study evaluated 43 hypertensive patients treated at the outpatient clinics of the Faculdade de Medicina do ABC (FMABC) who were medicated with two or more antihypertensive drugs and divided into nonresistant or resistant to treatment. Results: Group I (using up to two antihypertensive agents – 60.47% of the sample) presented mean systolic blood pressure (SBP) of 127.5±6.4 mmHg, mean diastolic blood pressure (DBP) of 79.6±5.2 mmHg, mean body mass index (BMI) of 27.2±5.3 kg/m2 and mean age of 51.2±15.1 years. Group II (using more than two antihypertensive drugs – 37.2% of the sample) presented mean SBP of 132.1±9.3 mmHg, mean DBP of 84.5±5.8 mmHg, mean BMI of 27.2±7.2 kg/m2 and mean age of 55.5±13.4 years. The patients presented low quality of sleep/sleep disorder evaluated by the Pittsburgh Sleep Quality Index (PSQI), which represents a preponderant factor for OSAHS. Conclusion: Patients at high risk for OSAHS had poor sleep quality and high levels of DBP, suggesting a causal relation between these parameters. However, they did not present a higher prevalence of resistant high blood pressure (RHBP).

scholarly journals Ethnopharmacological Survey of Herbal Remedies Used for the Treatment of Cancer in the Greater Casablanca-Morocco

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Mohammed Bourhia ◽  
Abdelaaty Abdelaziz Shahat ◽  
Omer Mohammed Almarfadi ◽  
Fahd Ali Naser ◽  
Wael Mostafa Abdelmageed ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Medicinal Plants ◽  
Cancer Treatment ◽  
Traditional Medicine ◽  
Local Population ◽  
Traditional Healers ◽  
Herbal Remedies ◽  
Traditional Herbal Medicine ◽  
Ethnobotanical Survey ◽  
Scientific Validity

Medicinal plants played an important role in traditional medicine for the treatment of diseases since antiquities. The aim of the study is to carry out an ethnobotanical survey on medicinal plants used traditionally in cancer treatment in the region of Greater Casablanca-Morocco, and to enhance the traditional herbal medicine knowledge. 110 traditional healers in the study area were interviewed face to face to response a survey questionnaire including the names of plants used in cancer treatment, used parts, methods of preparation, and route of administration. Indices of Fidelity Level (FL), Use Value (UV), and Relative Frequency of Citation (RFC) were calculated to identify the most effective plants used for cancer treatment. Eight species were specified including Aristolochia baetica, Aristolochia paucinervis, Bryonia dioica, Aquilaria malaccensis, Marrubium vulgare, Lavandula maroccana, Ephedra alata, and Euphorbia resinifera belonging to 7 families. Aristolochiaceae, Aquilariaceae, and Cucurbitaceae were the most useful families in cancer treatment with high significant indices of UV, FL, and RFC with values of 1, 100%, and 1, respectively. Roots and leaves were the most commonly used plant parts. Decoction and powder mixed with honey were the frequently used method for remedies preparation. The present study showed that the people living in Morocco’s economic capital are still highly dependent on traditional herbal medicine for the treatment of cancer. Therefore, it seems that herbal medicine still plays a crucial role in the primary healthcare system for the local population. During this survey, it was reported that even some plant families are highly toxic for humans like Aristolochiaceae that are frequently used in cancer treatment in the study area. As many people still rely on natural traditional medicine considering (it is safe with no side effects), so combined effort between all social categories including scientists and traditional healers should be established for involving the scientific validity of the used plants in the treatment of diseases.

5-HT2B-receptor antagonist LY-272015 is antihypertensive in DOCA-salt-hypertensive rats

1999 ◽  
Vol 276 (3) ◽  
pp. H944-H952 ◽  
Author(s):  
Stephanie W. Watts ◽  
Gregory D. Fink
Keyword(s):  
Blood Pressure ◽  
Receptor Antagonist ◽  
High Blood Pressure ◽  
Reduce Blood Pressure ◽  
Receptor Expression ◽  
Hypertensive Rats ◽  
Arterial Blood ◽  
Salt Hypertension

We previously demonstrated a change in the receptors mediating 5-hydroxytryptamine (5-HT)-induced contraction in arteries of deoxycorticosterone acetate (DOCA)-salt-hypertensive rats. Specifically, contraction to 5-HT is mediated primarily by 5-HT2A receptors in arteries from normotensive sham rats and by both 5-HT2A and 5-HT2B receptors in arteries from hypertensive rats. We hypothesized that the 5-HT2B receptor may play a role in maintaining the high blood pressure of DOCA-salt-hypertensive rats, and herein we provide data connecting in vitro and in vivo findings. The endothelium-denuded isolated superior mesenteric artery of DOCA-salt rats displayed a marked increase in maximum contraction to the newly available 5-HT2B-receptor agonist BW-723C86 compared with that of arteries from sham rats, confirming that the 5-HT2B receptor plays a greater role in 5-HT-induced contraction in arteries from DOCA-salt rats. In chronically instrumented rats, the 5-HT2B-receptor antagonist LY-272015 (0.3, 1.0, and 3.0 mg/kg iv at 30-min intervals) was given cumulatively 1 time/wk during 4 wk of continued DOCA-salt treatment. LY-272015 did not reduce blood pressure of the sham-treated rats at any time or dose. However, LY-272015 (1.0 and 3.0 mg/kg) significantly reduced mean blood pressure in a subgroup of week 3 (−20 mmHg) and week 4 DOCA-salt (−40 mmHg) rats that had extremely high blood pressure (mean arterial blood pressure ∼200 mmHg). Blockade of 5-HT2Breceptors by in vivo administration of LY-272015 (3.0 mg/kg) was verified by observing reduced 5-HT-induced contraction in rat stomach fundus, the tissue from which the 5-HT2B receptor was originally cloned. These data support the novel hypothesis that 5-HT2B-receptor expression is induced during the development of DOCA-salt hypertension and contributes to the maintenance of severe blood pressure elevations.

scholarly journals HYPERTENSION: AN AYURVEDIC PERSPECTIVE

2021 ◽  
Vol 9 (8) ◽  
pp. 1748-1753
Author(s):  
Anshika Rao
Keyword(s):  
Blood Pressure ◽  
High Blood Pressure ◽  
Antihypertensive Drugs ◽  
Medical Condition ◽  
Good Health ◽  
Chronic Medical Condition ◽  
Public Health Issue ◽  
Arterial Blood ◽  
Prime Concern ◽  
The World

Hypertension (HTN) is a major public health issue worldwide, because of its high prevalence and concomitant increase in the risk of disease. In the contemporary situation Hypertension is the most critical disease in the world. If we focus on the present situation then we can see that due to rapid globalization we are facing Hypertension. Due to rapid modernization, people are leading more stressful lives. As a result, hypertension is one of the wide- spread disorders which came across in practice. Ab. India is labelled as the global capital of hypertension. Nowa- days, not only lifestyle disorders are becoming more common, but they are also affecting younger populations. Hence, the population at risk shifts from 40+ to maybe 30+ or even younger. Hypertension results from a variety of reasons like stress, obesity, genetic factors, overuse of the salts in the diet and ageing etc. As we all know, Hy- pertension is called a silent killer because it rarely exhibits symptoms before it damages the heart, brain or kidney. Though a lot of potent antihypertensive drugs are available today in modern medicine, none of them is free from untoward effects. The principal focus of Ayurveda is on maintaining good health and adopting a healthy way of life. In Ayurveda, there is no description of such a single disease that can resemble hypertension. As per Ayurve- dic principles, in case of an unknown disease, the physician should try to understand the nature of the disease through Dosha, Dushya and Samprapti; then should initiate the treatment. So, it becomes our prime concern to understand hypertension thoroughly with an Ayurvedic perspective. Hypertension (HTN or HT), also known as High blood pressure or arterial hypertension, is a chronic medical condition in which the blood pressure in the arteries is persistently elevated. Hypertension is one of the major causes of cardiovascular morbidity and mortalityworldwide. It is a global health problem affecting people of different ethnicity and ages around the world. It is an asymptomatic medical condition in which systemic arterial blood pressure is elevated beyond the normal value. Keywords: High Blood Pressure, Lifestyle disorders, Silent killer.

scholarly journals A Novel Vasoactive Peptide “PG1” from Buffalo Ice-Cream Protects from Angiotensin-Evoked High Blood Pressure

Antioxidants ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 441
Author(s):  
Albino Carrizzo ◽  
Manuela Giovanna Basilicata ◽  
Giacomo Pepe ◽  
Kasper K. Sørensen ◽  
Michele Ciccarelli ◽  
...  
Keyword(s):  
Blood Pressure ◽  
High Blood Pressure ◽  
Ex Vivo ◽  
Ice Cream ◽  
Inhibitory Effect ◽  
Cardiovascular Complications ◽  
Vascular Effect ◽  
Consequent Reduction

Background: Arterial hypertension is the most important risk factor for cardiovascular diseases, myocardial infarction, heart failure, renal failure and peripheral vascular disease. In the last decade, milk-derived bioactive peptides have attracted attention for their beneficial cardiovascular properties. Methods: Here, we combined in vitro chemical assay such as LC-MS/MS analysis of buffalo ice cream, ex vivo vascular studies evaluating endothelial and smooth muscle responses using pressure myograph, and translational assay testing in vivo the vascular actions of PG1 administration in murine models. Results: We demonstrate that a novel buffalo ice-cream-derived pentapeptide “QKEPM”, namely PG1, is a stable peptide that can be obtained at higher concentration after gastro-intestinal digestions (GID) of buffalo ice-cream (BIC). It owns potent vascular effect in counteract the effects of angiotensin II-evoked vasoconstriction and high blood pressure levels. Its effects are mediated by the inhibitory effect on AT1 receptor leading to a downregulation of p-ERK½/Rac1-GTP and consequent reduction of oxidative stress. Conclusions: These results strongly candidate PG1, as a novel bioactive peptide for the prevention and management of hypertension, thus expanding the armamentarium of preventive strategies aimed at reducing the incidence and progression of hypertension and its related cardiovascular complications.

scholarly journals The vasodilatory effects of medicinal herbs on the cardiovascular system: A systematic review

2021 ◽  
Vol 10 (4) ◽  
pp. 367-374
Author(s):  
Nasrollah Moradifar ◽  
Ali Asghar Kiani ◽  
Navid Bakhtiari ◽  
Morteza Amraei ◽  
Arash Amin
Keyword(s):  
Systematic Review ◽  
Blood Pressure ◽  
Medicinal Plants ◽  
Essential Oil ◽  
High Blood Pressure ◽  
Meta Analysis ◽  
Ethanolic Extract ◽  
Extraction Methods ◽  
Medicinal Herbs ◽  
Herbal Remedies

Vasodilators are drugs that induce or start the widening of blood vessels and are commonly applied to treat disorders with irregularly high blood pressure, including hypertension, congestive heart failure, and angina. The present study aims to systematically review the studies on the vasodilation effects of medicinal herbs. The study was done according to the 06- Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines and registered in the CAMARADES-NC3Rs Preclinical Systematic Review and Meta-Analysis Facility (SyRF) database. Various English databases, such as Scopus, PubMed, Web of Science, EMBASE, and Google Scholar, were used to find publications about the vasodilation effects of medicinal herbs with no date limitation. The searched terms and keywords words were: "medicinal herbs", "medicinal plants", "vasodilator", "vasorelaxant", "hypertension", "high blood pressure", "vasodilation", "extract", "essential oil". Out of 1820 papers (up to 2020), 31 papers met the inclusion criteria and were reviewed. The most important medicinal plants with vasodilation/vasorelaxant activity belonged to the family Asteraceae (19.4%) followed by Zingiberaceae (9.7%). Aerial parts (30.5%), leaves (30.5%), followed by roots (11.1%) were the most common parts used in the studies. The findings showed that ethanolic extract (33.3%), followed by aqueous extract (22.2%) and methanolic extract (19.4%) was the frequency used extraction methods, whereas the essential oil (13.9%) and hydroalcoholic extract (8.3%) were the second most used herbal remedies. The results of the current review study revealed that the plant vasodilatory agents were might be used as an alternative and complementary source to treat hypertension as they had lower important toxicity. Nevertheless, more investigations, particularly clinical trials, are needed to clear this suggestion.

scholarly journals Contribution to the ethnobotanical inventory of medicinal plants used for the treatment of typhoid fever in Adamaoua region, Cameroon

2021 ◽  
Vol 14 (9) ◽  
pp. 3078-3096
Author(s):  
Simeon Pierre Fodouop Chegaing ◽  
Didiane Yemele Mefokou ◽  
Benjamin Talom Tangue ◽  
Jean Baptiste Sokoudjou ◽  
Serge Telemgone Menoudji ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Typhoid Fever ◽  
Traditional Healers ◽  
Herbal Remedies ◽  
Ancient Greek ◽  
Ethnobotanical Survey ◽  
Research Institution ◽  
Whole Plant ◽  
Therapeutic Properties ◽  
Structured Questionnaire

Since ancient Greek-Roman times, the use of plants to cure many human diseases is still common. The present ethnobotanical survey was conducted to contribute to the knowledge of medicinal plants used for the treatment of typhoid fever in three sub divisions of Vina division, Adamawa Cameroon. After having explained the importance of this study to interviewees, 41 traditional healers have agreed and delivered information regarding the medicinal plants they use as well as the different preparation and administration through a well- structured questionnaire that was given to them on this matter. Among 41 traditional healers whose attended this study, 32 were men and 09 were women. The ethnobotanical survey allowed the identification of 70 plants belonging to 38 families. With a frequency of 11/70, the Fabaceae family was the most represented followed by that of Rubiaceae and Asteraceae (04/70 each). The leaves are the most used parts (34.28%) followed by leaves + roots (14.28%) and the whole plant (12.86%). The majority of the recipes consisted of four to six plants (34.66), and were prepared by decoction (50%), with water as the main solvent (87.80%). 41.56% of typhoid preparations are administered twice daily for a duration of 14 days (46.77%). This is the first report on antityphoid herbal remedies in Vina division-Adamawa Cameroon. It would therefore be judicious for our government and research institution to investigate on their therapeutic properties in order to develop ameliorated and efficient phytomedicines.

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