scholarly journals Cerebral Blood Flow Alterations in High Myopia: An Arterial Spin Labeling Study

2020 ◽  
Vol 2020 ◽  
pp. 1-7 ◽  
Author(s):  
Huihui Wang ◽  
Shanshan Li ◽  
Xi Chen ◽  
Yanling Wang ◽  
Jing Li ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Arterial Spin Labeling ◽  
High Myopia ◽  
Brain Plasticity ◽  
Pearson Correlation ◽  
Three Dimensional ◽  
Image Data ◽  
Blood Perfusion ◽  
Spin Labeling

Objective. The aim of this study was to explore cerebral blood flow (CBF) alterations in subjects with high myopia (HM) using three-dimensional pseudocontinuous arterial spin labeling (3D-pcASL). Methods. A total of sixteen patients with bilateral HM and sixteen age- and sex-matched healthy controls (HCs) were recruited. All subjects were right-handed. Image data preprocessing was performed using SPM8 and the DPABI toolbox. Clinical parameters were acquired in the HM group. Two-sample t-tests and Pearson correlation analysis were applied in this study. Results. Compared to HCs, patients with HM exhibited significantly increased CBF in the bilateral cerebellum, and no decreases in CBF were detected in the brain. However, no relationship was found between the mean CBF values in the different brain areas and the disease duration (P>0.05). Conclusions. Using ASL analysis, we detected aberrant blood perfusion in the cerebellum in HM patients, contributing to a better understanding of brain abnormalities and brain plasticity through a different perspective.

scholarly journals Microstructural and Cerebral Blood Flow Abnormalities in Subjective Cognitive Decline Plus: Diffusional Kurtosis Imaging and Three-Dimensional Arterial Spin Labeling Study

2021 ◽  
Vol 13 ◽  
Author(s):  
Zhongxian Yang ◽  
Yu Rong ◽  
Zhen Cao ◽  
Yi Wu ◽  
Xinzhu Zhao ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cognitive Decline ◽  
Arterial Spin Labeling ◽  
Verbal Learning ◽  
Three Dimensional ◽  
Mean Diffusivity ◽  
Spin Labeling ◽  
Subjective Cognitive Decline ◽  
Diffusional Kurtosis Imaging

Objective: To explore microstructural and cerebral blood flow (CBF) abnormalities in individuals with subjective cognitive decline plus (SCD plus) using diffusional kurtosis imaging (DKI) and three-dimensional (3D) arterial spin labeling (ASL).Methods: Twenty-seven patients with SCD plus, 31 patients with amnestic mild cognitive impairment (aMCI), and 33 elderly controls (ECs) were recruited and underwent DKI and 3D ASL using a GE 3.0-T MRI. Mean kurtosis (MK), fractional anisotropy (FA), mean diffusivity (MD), and CBF values were acquired from 24 regions of interest (ROIs) in the brain, including the bilateral hippocampal (Hip) subregions (head, body, and tail), posterior cingulate cortex (PCC), precuneus, dorsal thalamus subregions (anterior nucleus, ventrolateral nucleus, and medial nucleus), lenticular nucleus, caput nuclei caudati, white matter (WM) of the frontal lobe, and WM of the occipital lobe. Pearson's correlation analysis was performed to assess the relationships among the DKI-derived parameters, CBF values, and key neuropsychological tests for SCD plus.Results: Compared with ECs, participants with SCD plus showed a significant decline in MK and CBF values, mainly in the Hip head and PCC, and participants with aMCI exhibited more significant abnormalities in the MK and CBF values than individuals with ECs and SCD plus in multiple regions. Combined MK values showed better discrimination between patients with SCD plus and ECs than that obtained using CBF levels, with areas under the receiver operating characteristic (ROC) curve (AUC) of 0.874 and 0.837, respectively. Similarly, the AUC in discriminating SCD plus from aMCI patients obtained using combined MK values was 0.823, which was also higher than the combined AUC of 0.779 obtained using CBF values. Moreover, MK levels in the left Hip (h) and left PCC positively correlated with the auditory verbal learning test-delayed recall (AVLT-DR) score in participants with SCD plus. By contrast, only the CBF value in the left Hip head positively correlated with the AVLT-DR score.Conclusions: Our results provide new evidence of microstructural and CBF changes in patients with SCD plus. MK may be used as an early potential neuroimaging biomarker and may be a more sensitive DKI parameter than CBF at the very early stage of Alzheimer's disease (AD).

scholarly journals N-acetyl cysteine administration affects cerebral blood flow as measured by Arterial Spin Labeling MRI in patients with multiple sclerosis

Heliyon ◽  
2021 ◽  
pp. e07615
Author(s):  
Shiva Shahrampour ◽  
Justin Heholt ◽  
Andrew Wang ◽  
Faezeh Vedaei ◽  
Feroze B. Mohamed ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Acetyl Cysteine

scholarly journals Patient-Specific Detection of Cerebral Blood Flow Alterations as Assessed by Arterial Spin Labeling in Drug-Resistant Epileptic Patients

PLoS ONE ◽  
2015 ◽  
Vol 10 (5) ◽  
pp. e0123975 ◽  
Author(s):  
Ilaria Boscolo Galazzo ◽  
Silvia Francesca Storti ◽  
Alessandra Del Felice ◽  
Francesca Benedetta Pizzini ◽  
Chiara Arcaro ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Patient Specific ◽  
Drug Resistant ◽  
Specific Detection ◽  
Epileptic Patients
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