scholarly journals Severe Thrombocytosis in a Newborn with Subcutaneous Fat Necrosis and Maternal Chorioamnionitis

2020 ◽  
Vol 2020 ◽  
pp. 1-3
Author(s):  
Mitali Sahni ◽  
Pooja Patel ◽  
Akila Muthukumar
Keyword(s):  
Platelet Count ◽  
Subcutaneous Fat ◽  
Metabolic Abnormalities ◽  
Fat Necrosis ◽  
Unique Case ◽  
Subcutaneous Fat Necrosis ◽  
Case Presentation ◽  
Subcutaneous Nodules ◽  
Increased Risk ◽  
History Of

Background. Subcutaneous fat necrosis (SFN) is a form of transient panniculitis that presents commonly in infants with a history of perinatal insult, particularly hypothermia. It is characterized by subcutaneous nodules and plaques that appear over bony prominences on cheeks, shoulders, buttock, and thighs. SFN is usually associated with various complications including hypercalcemia, thrombocytopenia, hypertriglyceridemia, and hyperglycemia. Case Presentation. We present a unique case of a female infant with a history of maternal chorioamnionitis who presented with SFN at 11 days of life with thrombocytosis. The platelet count decreased during the hospital stay, and thrombocytosis resolved over the course of the next two weeks. She did not have any other hematological or metabolic abnormalities associated with SFN. Conclusion. Infants with perinatal stress are at increased risk of developing SFN during the first month of life. Infants with a diagnosis of SFN should be monitored closely for various hematological and metabolic abnormalities that can have serious consequences.

Hypercalcemia in Association with Subcutaneous Fat Necrosis of the Newborn: Studies of Calcium-Regulating Hormones

PEDIATRICS ◽  
1992 ◽  
Vol 90 (1) ◽  
pp. 93-96 ◽  
Author(s):  
JENNIFER S. COOK ◽  
MARY SEABURY STONE ◽  
JAMES R. HANSEN
Keyword(s):  
Subcutaneous Fat ◽  
Full Term ◽  
Fat Necrosis ◽  
Subcutaneous Fat Necrosis ◽  
Subcutaneous Nodules ◽  
Term Newborns

Subcutaneous fat necrosis of the newborn is an uncommon disorder that occurs during the first few weeks of life as firm subcutaneous nodules on the cheeks, buttocks, back, arms, and thighs. This disorder, which initially was described by Harrison and McNee in 1926,1 typically affects full-term newborns who have experienced perinatal distress. Subcutaneous fat necrosis of the newborn usually resolves over a period of months, but may result in death due to its association with hypercalcemia. The association between subcutaneous fat necrosis of the newborn and hypercalcemia was first reported by Clay in 19562; however, the mechanism that results in hypercalcemia remains incompletely understood.3-7

scholarly journals Subcutaneous fat necrosis of newborn - A rare case report of lobular panniculitis in a neonate

2021 ◽  
Vol 7 (3) ◽  
pp. 264-267
Author(s):  
Samagani Akshay ◽  
Pemmanda Raju Belliappa ◽  
Raveendra Leena
Keyword(s):  
Subcutaneous Fat ◽  
Dietary Vitamin ◽  
Inflammatory Cell Infiltrate ◽  
Fat Necrosis ◽  
Subcutaneous Fat Necrosis ◽  
Danger Signs ◽  
Subcutaneous Nodules ◽  
Recommended Treatment ◽  
Rare Case Report ◽  
Lobular Panniculitis

Subcutaneous fat necrosis of newborn is a rare cutaneous disorder affecting neonates. It usually presents as subcutaneous nodules or plaques, within the first few weeks of life, following an eventful delivery. It is characterized by hypercalcemia, which may present with lethargy, irritability, hypotonia and dehydration, mimicking sepsis. Histopathology is proven to be the gold standard in diagnosis with characteristic lobular panniculitis, mixed inflammatory cell infiltrate and radially arranged crystals. This needs to be differentiated from other causes of lobular panniculitis, as early diagnosis and treatment to prevent long‑term complications are advocated. Education of parents regarding the disease and danger signs of hypercalcemia and weekly monitoring of serum calcium is recommended. Treatment based on rehydration, dietary vitamin D and calcium restriction, Furosemide and prednisolone are considered. We have discussed a case of subcutaneous fat necrosis, in an 8-week-old male baby.Key Messages: Subcutaneous fat necrosis is an important differential in neonates presenting with palpable subcutaneous nodules, along with sclerema neonatorum. Severe complications like hypercalcemia should be detected early and managed aggressively to prevent morbidities and mortalities associated with it. Symptomatic management, use of calcium lowering drugs and regular monitoring of calcium levels are recommended.

scholarly journals Subcutaneous fat necrosis of the newborn and nephrolithiasis

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Nicole A. Karikari ◽  
FNU Nutan
Keyword(s):  
Risk Factors ◽  
African American ◽  
African American Male ◽  
Subcutaneous Fat ◽  
Fat Necrosis ◽  
Current Standard ◽  
Subcutaneous Fat Necrosis ◽  
Case Presentation ◽  
Multiple Risk Factors ◽  
Frequent Monitoring

Abstract Objectives Subcutaneous fat necrosis of the newborn (SCFN) is a rare panniculitis that can affect newborn patients who have experienced perinatal stress, hypoxia, or hypothermia. Risk factors include gestational diabetes and pre-eclampsia. This condition is usually self-limiting; however, it can lead to severe complications, including hypercalcemia. After diagnosis, it is important to monitor calcium levels. There is no current standard for how frequently these levels should be monitored. Case presentation We present a full-term African American male with multiple risk factors, who was diagnosed with SCFN. The patient’s hypercalcemia secondary to SCFN led to renal complications. Conclusions This case highlights the importance of early and frequent monitoring of calcium levels in patients with SCFN.

Subcutaneous Fat Necrosis of the Newborn With Initial Hypocalcemia and Familial Recurrence: A Case Report

2017 ◽  
Vol 22 (2) ◽  
pp. 223-225 ◽  
Author(s):  
Amelia Kellar ◽  
Jennifer Aileen Tangtatco ◽  
Miriam Weinstein ◽  
Natasha Saunders
Keyword(s):  
Case Report ◽  
Perinatal Asphyxia ◽  
Subcutaneous Fat ◽  
Fat Necrosis ◽  
Extensive Disease ◽  
Subcutaneous Fat Necrosis ◽  
Severe Hypercalcemia ◽  
Familial Association ◽  
History Of ◽  
Posterior Trunk

Subcutaneous fat necrosis of the newborn (SFNN) is a rare disorder characterised by indurated plaques or nodules with or without erythema, typically distributed over the cheeks, extremities, posterior trunk, buttocks, and thighs, and appears during the first 2 weeks of life. It is commonly associated with perinatal asphyxia and, while usually self-limited, can lead to severe hypercalcemia. There is no known familial association. The present article describes a neonate with extensive disease, counterintuitive hypocalcemia, and a family history of SFNN and reviews the existing literature on SFNN.

Subcutaneous fat necrosis in an infant with hypoxic ischaemic encephalopathy stage 3: an uncommon association

2021 ◽  
Vol 14 (7) ◽  
pp. e237933
Author(s):  
Sonalika Mehta ◽  
Naveen Parkash Gupta ◽  
Anil Batra ◽  
Rashmi Sharma
Keyword(s):  
Perinatal Asphyxia ◽  
Subcutaneous Fat ◽  
Birth Asphyxia ◽  
Oral Prednisolone ◽  
Fat Necrosis ◽  
Subcutaneous Fat Necrosis ◽  
Dihydroxyvitamin D ◽  
History Of ◽  
Low Levels ◽  
25 Oh Vitamin D

Subcutaneous fat necrosis (SCFN) is inflammation and necrosis of adipose tissue associated with hypoxia and hypothermia. It leads to various metabolic abnormalities, of which the most dreaded is hypercalcaemia. We report a case of a 7-week-old boy with history of birth asphyxia (hypoxic ischaemic encephalopathy stage 3) who presented to us with features suggestive of hypercalcaemia with bilateral nephrocalcinosis. On examination, there were multiple subcutaneous nodules on both arms. Evaluation revealed suppressed parathyroid activity along with low levels of 25(OH)vitamin D3 and elevated 1,25-dihydroxyvitamin D3. Skin biopsy confirmed the diagnosis of SCFN. He was managed with intravenous fluids, single dose of intravenous furosemide and oral prednisolone. Hypercalcaemia responded within 14 days of admission, prednisolone was tapered and stopped in a month. SCFN, in our case, can be attributed to the underlying perinatal asphyxia along with use of therapeutic hypothermia. Through this case, we wish to sensitise practicing neonatologists for the need of screening and early identification of these abnormalities, which if missed can be fatal.

Computed Tomography (CT) Appearances of Acute Pancreatitis Presenting as Polyarthropathy with Subcutaneous Fat Necrosis

1993 ◽  
Vol 38 (6) ◽  
pp. 183-184 ◽  
Author(s):  
J.C. Patel ◽  
E.M. Robertson
Keyword(s):  
Computed Tomography ◽  
Acute Pancreatitis ◽  
Abdominal Pain ◽  
Soft Tissue ◽  
Subcutaneous Fat ◽  
Pancreatic Disease ◽  
Fat Necrosis ◽  
Abdominal Ct ◽  
Subcutaneous Fat Necrosis ◽  
Subcutaneous Nodules

A case of severe acute pancreatitis presenting with polyarthropathy and subcutaneous nodules but no abdominal pain is described. Abdominal CT showed multiple subcutaneous soft tissue densities which on histological examination were identified as areas of fat necrosis consistent with pancreatic disease. Such CT appearances have not been described previously.

Repeated Occurrence of Skin Necrosis Twice Following Coumarin Intake and Subsequently During Decrease of Vitamin K Dependent Coagulation Factors Associated with Cholestasis

1982 ◽  
Vol 48 (03) ◽  
pp. 245-246 ◽  
Author(s):  
V Hofmann ◽  
P G Frick
Keyword(s):  
Skin Necrosis ◽  
Oral Anticoagulants ◽  
Subcutaneous Fat ◽  
Coagulation Factors ◽  
Fat Necrosis ◽  
Subcutaneous Fat Necrosis ◽  
Skin Changes ◽  
Factors Associated ◽  
Therapeutic Anticoagulation ◽  
Coumarin Necrosis

SummaryA female patient is described who developed skin and subcutaneous fat necrosis on two occasions after intake of acenocoumarol.Several months later identical skin changes occurred during an episode of cholestasis associated with a prolongation of the prothrombin time to an extent comparable with therapeutic anticoagulation; intake of oral anticoagulants could be excluded.This association gives new insights in the pathogenetic mechanisms responsible for the so-called coumarin necrosis and indicates that it may be not due to drug toxicity or allergy.

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