scholarly journals Surface-Modified Graphene Oxide with Compatible Interface Enhances Poly-L-Lactic Acid Bone Scaffold

2020 ◽  
Vol 2020 ◽  
pp. 1-11 ◽  
Author(s):  
Guoyong Wang ◽  
Chongxian He ◽  
Wengjing Yang ◽  
Fangwei Qi ◽  
Guowen Qian ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Lactic Acid ◽  
Selective Laser Sintering ◽  
Nucleating Agent ◽  
High Specific Surface Area ◽  
Hybrid Scaffold ◽  
Uniform Dispersion ◽  
Modified Graphene Oxide ◽  
The Matrix ◽  
Surface Modified

Graphene oxide (GO) usually serves as a reinforce phase in polymer because of its superior mechanical strength and high specific surface area. In this work, GO was grafted with L-lactic acid monomer (denoted as GO@PLLA) to overcome the aggregation in matrix and then incorporated into the poly-L-lactic acid (PLLA) scaffold fabricated by selective laser sintering. In hybrid scaffold, GO@PLLA exhibited uniform dispersion in the matrix. Furthermore, mechanical interlock between GO@PLLA and PLLA matrix formed and reinforced the interface bonding. On the other hand, the heterogeneous distributed GO acted as effective nucleating agent and resultantly enhanced the crystallization. Results showed that the tensile and compressive strength of scaffolds increased by 143.3% and 127.6%, respectively. Meanwhile, the scaffold exhibited an increased degradation rate of 37.9%, which could be attributed to the abundant hydrophilic functional groups on GO. Moreover, the scaffold exhibited favorable bioactivity and biocompatibility. Herein, the developed hybrid scaffold showed potential capacity for bone tissue engineering.

scholarly journals HDPE/UHMWPE hybrid nanocomposites with surface functionalized graphene oxide towards improved strength and cytocompatibility

2019 ◽  
Vol 16 (150) ◽  
pp. 20180273 ◽  
Author(s):  
Shardul Atul Bhusari ◽  
Vidushi Sharma ◽  
Suryasarathi Bose ◽  
Bikramjit Basu
Keyword(s):  
Graphene Oxide ◽  
Hybrid Approach ◽  
Hybrid Nanocomposites ◽  
Micro Computed Tomography ◽  
Functionalized Graphene Oxide ◽  
Polyethylene Blend ◽  
Uniform Dispersion ◽  
Synthesis Strategy ◽  
Modified Graphene Oxide ◽  
Myoblast Cells

High-density polyethylene (HDPE)-based and ultra-high molecular weight polyethylene (UHMWPE)-based composites with carbonaceous reinforcements are being widely investigated for biomedical applications. The enhancement of material properties critically depends on the nature, amount and compatibility of the reinforcement with the polymeric matrix. To this end, this study demonstrates the efficacy of a ‘dual’ hybrid approach of incorporating modified inorganic nanofiller into an optimized polyethylene blend. In particular, a unique synthesis strategy was adopted to design a covalently bonded maleated polyethylene (mPE) grafted modified graphene oxide (mGO) hybrid nanocomposite. In this scheme, polyethyleneimine (PEI) was initially attached onto GO to synthesize amine functionalized GO (GO–PEI). This is followed by mPE grafting, resulting in mGO. Melt-extrusion together with injection moulding of a polymer mix (60% HDPE–40% UHMWPE) with different proportions (less than or equal to 3 wt%) of surface functionalized GO was conducted to develop nanocomposites of different sizes and shapes. When compared with unreinforced PE blend, the nanocomposites with 1 wt% mGO exhibited an increase in ultimate tensile strength by 120% (up to 65 MPa) and elastic modulus by 40% (up to 908 MPa). The uniform dispersion of modified GO nanofillers, confirmed using X-ray micro-computed tomography and transmission electron microscopy, facilitated effective interfacial adhesion and compatibility with the hybrid polymer matrix. The variation in mechanical properties with GO/mGO addition to PE blend was critically discussed in reference to the structural modification of GO, crystallinity and nature of dispersion of fillers. Importantly, the nanocomposites support the attachment and proliferation of C2C12 murine myoblast cells over 3 days in culture in a statistically insignificant manner with respect to polymer blends without any nanofiller. Taken together, the experimental results suggest that HDPE/UHMWPE/mGO is a promising biomaterial for bone tissue engineering applications.

Surface modified graphene oxide/poly(vinyl alcohol) composite for enhanced hydrogen gas barrier film

2016 ◽  
Vol 50 ◽  
pp. 49-56 ◽  
Author(s):  
Hongyu Liu ◽  
Parthasarathi Bandyopadhyay ◽  
Nam Hoon Kim ◽  
Bongho Moon ◽  
Joong Hee Lee
Keyword(s):  
Graphene Oxide ◽  
Vinyl Alcohol ◽  
Hydrogen Gas ◽  
Poly Vinyl Alcohol ◽  
Gas Barrier ◽  
Modified Graphene Oxide ◽  
Surface Modified ◽  
Modified Graphene ◽  
Barrier Film

scholarly journals Graphene Oxide Induces Ester Bonds Hydrolysis of Poly-l-lactic Acid Scaffold to Accelerate Degradation

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Cijun Shuai ◽  
Yang Li ◽  
Wenjing Yang ◽  
Li Yu ◽  
Youwen Yang ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Lactic Acid ◽  
Functional Groups ◽  
Selective Laser Sintering ◽  
Water Molecules ◽  
Plla Scaffold ◽  
Bonding Interaction ◽  
Good Biocompatibility ◽  
Hydrolysis Of ◽  
Accelerate Degradation

Poly-l-lactic acid (PLLA) possesses good biocompatibility and bioabsorbability as scaffold material, while slow degradation rate limits its application in bone tissue engineering. In this study, graphene oxide (GO) was introduced into the PLLA scaffold prepared by selective laser sintering to accelerate degradation. The reason was that GO with a large number of oxygen-containing functional groups attracted water molecules and transported them into scaffold through the interface microchannels formed between lamellar GO and PLLA matrix. More importantly, hydrogen bonding interaction between the functional groups of GO and the ester bonds of PLLA induced the ester bonds to deflect toward the interfaces, making water molecules attack the ester bonds and thereby breaking the molecular chain of PLLA to accelerate degradation. As a result, some micropores appeared on the surface of the PLLA scaffold, and mass loss was increased from 0.81% to 4.22% after immersing for 4 weeks when 0.9% GO was introduced. Besides, the tensile strength and compressive strength of the scaffolds increased by 24.3% and 137.4%, respectively, due to the reinforced effect of GO. In addition, the scaffold also demonstrated good bioactivity and cytocompatibility.

Reduced and Surface‐Modified Graphene Oxide with Nonlinear Resistivity

2017 ◽  
Vol 38 (16) ◽  
pp. 1700291 ◽  
Author(s):  
Martin Wåhlander ◽  
Fritjof Nilsson ◽  
Richard L. Andersson ◽  
Anna Carlmark ◽  
Henrik Hillborg ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Modified Graphene Oxide ◽  
Surface Modified ◽  
Modified Graphene
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