scholarly journals Synthesis of Uniformly Excited Concentric Ring Arrays by the Strategy of Partial Density Tapering and the Algorithm of Differential Evolution

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Xin-Kuan Wang ◽  
Gui-Bao Wang ◽  
Jianke Jia ◽  
Chao-Jun Huang

A new strategy of density tapering called the partial density tapering (PDT) accompanied with the algorithm of differential evolution (DE) is proposed to suppress the peak sidelobe level (PSL) of uniform excited concentric ring arrays (UECRA) with isotropic elements. Through performing the PDT, a sound starting solution for DE can be generated. Then, the ring filling factor (RFF) is introduced so that the optimization of the number of elements can be transformed into the optimization of RFFs within the tapered thresholds, and thereby the real coding can be directly used with respect to the consideration of parallel encoding strategy. Finally, the UECRA featuring improved PSL performance can be obtained by limited runs of conventional DE. Several numerical instances for UECRA, with aperture sizes ranging from small to large scale, confirmed the outperformance of the proposed method.

2021 ◽  
Vol 3 (1) ◽  
Author(s):  
Sun Sook Chung ◽  
Joseph C F Ng ◽  
Anna Laddach ◽  
N Shaun B Thomas ◽  
Franca Fraternali

Abstract Direct drug targeting of mutated proteins in cancer is not always possible and efficacy can be nullified by compensating protein–protein interactions (PPIs). Here, we establish an in silico pipeline to identify specific PPI sub-networks containing mutated proteins as potential targets, which we apply to mutation data of four different leukaemias. Our method is based on extracting cyclic interactions of a small number of proteins topologically and functionally linked in the Protein–Protein Interaction Network (PPIN), which we call short loop network motifs (SLM). We uncover a new property of PPINs named ‘short loop commonality’ to measure indirect PPIs occurring via common SLM interactions. This detects ‘modules’ of PPI networks enriched with annotated biological functions of proteins containing mutation hotspots, exemplified by FLT3 and other receptor tyrosine kinase proteins. We further identify functional dependency or mutual exclusivity of short loop commonality pairs in large-scale cellular CRISPR–Cas9 knockout screening data. Our pipeline provides a new strategy for identifying new therapeutic targets for drug discovery.


2021 ◽  
pp. 2100193
Author(s):  
Peng Liu ◽  
Bingqian Zhang ◽  
Qing Liao ◽  
Guifen Tian ◽  
Chunling Gu ◽  
...  

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Hua-Wei Zhou ◽  
Xue-Xia Yang ◽  
Sajjad Rahim

Beam capture efficiency (BCE) is one key factor of the overall efficiency for a microwave power transmission (MPT) system, while sparsification of a large-scale transmitting array has a practical significance. If all elements of the transmitting array are excited uniformly, the fabrication, maintenance, and feed network design would be greatly simplified. This paper describes the synthesis method of the sparse uniform-amplitude transmitting array with concentric ring layout using particle swarm optimization (PSO) algorithm while keeping a higher BCE. Based on this method, uniform exciting strategy, reduced number of elements, and a higher BCE are achieved simultaneously for optimal MPT. The numerical results of the sparse uniform-amplitude concentric ring arrays (SUACRAs) optimized by the proposed method are compared with those of the random-located uniform-amplitude array (RLUAA) and the stepped-amplitude array (SAA), both being reported in the literatures for the maximum BCE. Compared to the RLUAA, the SUACRA saves 32% elements with a 1.1% higher BCE. While compared to the SAA, the SUACRA saves 29.1% elements with a bit higher BCE. The proposed SUACRAs have higher BCEs, simple array arrangement and feed network, and could be used as the transmitting array for a large-scale MPT system.


2014 ◽  
Vol 7 (6) ◽  
pp. 775-781 ◽  
Author(s):  
Anirban Chatterjee ◽  
Gautam Kumar Mahanti ◽  
Narendra Nath Pathak

Thinning a large concentric ring array by an evolutionary algorithm needs to handle a large amount of variables. The computational time to find out the optimum elements set increases with the increase of array size. Moreover, thinning significantly reduces the directivity of the array. In this paper, the authors propose a pattern synthesis method to reduce the peak sidelobe level (peak SLL) while keeping first null beamwidth (FNBW) of the array fixed by thinning the outermost rings of the array based on Gravitational Search Algorithm (GSA). Two different cases have been studied. In the first case only the outermost ring of the array is thinned and in the second case the two outermost rings are thinned. The FNBW of the optimized array is kept equal to or less than that of a fully populated, uniformly excited and 0.5 λ spaced concentric ring array of same number of elements and rings. The directivity of the optimized array for the above two cases are compared with an array optimized by thinning all the rings, while keeping the design criteria same as the above two cases. The optimized array by thinning the outermost rings gives higher directivity over the optimized array by thinning all the rings. Time required for computing the optimum elements state for the above two cases using GSA are shown lesser compared to the optimized array by thinning all the rings using the same algorithm. The peak SLL and the FNBW of the optimized array for the above two cases are also compared with the optimized array by thinning all the rings.


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