scholarly journals Effects on Vaginal Microbiota Restoration and Cervical Epithelialization in Positive HPV Patients Undergoing Vaginal Treatment with Carboxy-Methyl-Beta-Glucan

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Giada Lavitola ◽  
Luigi Della Corte ◽  
Nicoletta De Rosa ◽  
Carmine Nappi ◽  
Giuseppe Bifulco
Keyword(s):  
Treatment Group ◽  
Pap Test ◽  
Vaginal Microbiota ◽  
Control Group ◽  
Low Grade ◽  
Beta Glucan ◽  
Hpv Test ◽  
Group A ◽  
Vaginal Health ◽  
Carboxy Methyl

Objective. Evaluate the effects of carboxy-methyl-beta-glucan on cervical epithelialization and on the vaginal microbiota in patients with HPV infection or low-grade cervical preneoplastic lesion (CIN 1). Materials and Methods. Seven-hundred eighty-four women with positive HPV tests or diagnosed with CIN 1 were enrolled in a retrospective case-control study. All the recruited women performed, at baseline and after 6 months, Pap test, HPV test, evaluation of vaginal health according to the Amsel criteria, colposcopy, and punch biopsy. The study population was then divided into 2 groups in relation to the therapy performed during the follow-up period. Group A performed treatment with vaginal gel based on carboxy-methyl-beta-glucan (1 application/day for 20 days per month for 3 months). Group B was the control group. Results. The patients of group A had a significant improvement in the ectopia pattern and a greater number of cases with metaplasia in the maturation phase with a significant increase in Lugol uptake. In the experimental group, a significant improvement in the pH indices, a negative Swift test and a resolution of the leucorrhoea were observed. A negative result of the 37.1% Pap test and the 39.9% HPV test (vs. 15.2% and 16.5%, respectively) were demonstrated in the treatment group with respect to the control group. A negativization of the colposcopic pictures was observed with a reduction in the amount of CIN 1 found higher in the treatment group. Conclusions. Vaginal therapy based on carboxy-methyl-beta-glucan has been able to improve overall vaginal health; this effect seemed to positively impact the risk of persistence and progression of CIN.

Efficacy of corticosteroid therapy in the treatment of long- lasting olfactory disorders in COVID-19 patients

2020 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
L.A. Vaira ◽  
C. Hopkins ◽  
M. Petrocelli ◽  
J.R. Lechien ◽  
S. Cutrupi ◽  
...  
Keyword(s):  
Treatment Group ◽  
Case Control Study ◽  
Spontaneous Recovery ◽  
Olfactory Function ◽  
Control Group ◽  
Initial Control ◽  
Group A ◽  
Control Study

BACKGROUND: The growing number of COVID-19 patients with long-lasting olfactory disorders makes it necessary to identify effective treatments that enhance the spontaneous recovery of olfactory function. METHODS: Multicentre randomised case-control study that involved 18 patients with COVID-19 related anosmia or severe hyposmia for more than 30 days. Nine patients were prescribed systemic prednisone and nasal irrigation with betamethasone, ambroxol and rinazine for 15 days. The other 9, untreated, patients were used as controls. The olfactory function was evaluated with CCCRC test at 20 and 40 days from the first evaluation. RESULTS: In the control group, a median olfactory score of 20 (IQR 30) was detected at baseline. At the 20-day control there was no significant improvement in olfactory function. The improvement in olfactory performance became significant at the 40-day follow-up compared to baseline scores [60 (IQR 60) versus 20 (IQR 30)]. In the treatment group, patients had a mean olfactory score of 10 (IQR 15) at initial control. At the 20-day control, a significant im-provement in the olfactory scores, compared to the baseline, was detected [70 (IQR 40) versus 10 (IQR 15)]. Olfactory function further improved at 40 days [median score 90 (IQR 50)]. Patients in the treatment group reported significantly higher improvements of the olfactory scores than the controls at both the 20-day [40 (IQR 45) versus 10 (IQR 15)] and 40-day [60 (IQR 40) versus 30 (IQR 25)] evaluations. CONCLUSIONS: Based on the results of this study, the mix of drugs including steroids could represent a useful specific therapy to reduce the prevalence of this long-term morbidity.

scholarly journals Expressive arts therapy for hospitalized children: a pilot study measuring cortisol levels

2013 ◽  
Vol 5 (2) ◽  
pp. 7 ◽  
Author(s):  
Garret Yount ◽  
Kenneth Rachlin ◽  
Jane Siegel
Keyword(s):  
Pilot Study ◽  
Treatment Group ◽  
Expressive Arts ◽  
Control Group ◽  
Hospitalized Children ◽  
Expressive Arts Therapy ◽  
Wait List Control Group ◽  
Wait List Control ◽  
Group A ◽  
Cortisol Levels

This pilot study aimed at assessing the feasibility of capturing physiological evidence of reduced stress for hospitalized children following expressive arts therapy. Twenty-five patients were offered a novel form of expressive arts therapy, termed Healing Sock Creatures, during their stay in the hospital. Saliva samples were collected at two times in the afternoon for the purpose of measuring salivary cortisol levels. The patients were randomly assigned to two groups, a treatment group or a wait-list control group. A trend of decreased cortisol levels was apparent following therapy in the treatment group and concurrent steroid treatment, which is common in intensive care units, does not appear to interfere with the ability to measure decreased cortisol levels following therapy. Our results support the design of a formal study to assess physiological biomarkers of stress in hospital settings. To our knowledge, this is the first in-patient study assessing a biomarker of stress following expressive arts therapy for children

scholarly journals PENGARUH PEMBERIAN AIR SEDUHAN BERAS YANG DIFERMENTASI OLEH MONASCUS PURPUREUS (ANGKAK) TERHADAP PENURUNAN KADAR KOLESTEROL SERUM PADA TIKUS PUTIH

Biomedika ◽  
2014 ◽  
Vol 6 (1) ◽  
Author(s):  
Adhimass Wicaksono ◽  
Retno Sintowati ◽  
Sa’idatul Fitriyah
Keyword(s):  
Treatment Group ◽  
Serum Cholesterol ◽  
Brown Rice ◽  
Negative Control ◽  
T Test ◽  
Control Group ◽  
Control Group Design ◽  
Cholesterol Levels ◽  
White Rats ◽  
Group A

The using of plant-based medicine is a popular approach to health care. A study presented by American Hearth Association showing that brown rice can lower cholesterol level in bood serum. To know the benefi ts of Angkak’s steeping water to decrease serum cholesterol levels in mice and determine the effects of Angkak’s steeping water to decrease serum cholesterol levels in rats compared with simvastatin. This study used an experimental research design, and using pre and post test control group design, performed in the laboratory of biomedical III FK UMS on November 1, 2012 to date of January 1, 2013. The purposive sampling technique, sampel determinaton using formula Federer by the number of sample of 30 male white rats wistar strain. After the data is collected, analyzed using the Shapiro-Wilk test, ANOVA, LSD, and the unpaired t test. The result of this study demnstrate hypothesis testing using ANOVA test with signifi cant level 95% of the negative control group, the treatment group a dose of 1, 2, and 3, it was found p<0,05 were signifi cantly different meaning. In the test dose of LSD between treatment groups 2 and 3 the value of p=0,839 (p>0,05) wich means no signifi cant difference. In the unpaired T test between the treatment group a dose of 1, 2, and 3 with positive control group were signifi cant difference. The unpaired T test between the treatment group a dose of 1, 2, and 3 with white rice also found signifi cant difference. Conclusion: Angkak’s steeping water can lower serum cholesterol levels of white rat as well as the water steepimg Angkak has the same effectiveness with simvastatin to decrease serum cholesterol levels of mice.Keyword: Cholesterol, Angkak

scholarly journals Prevention Effect of TGF-β Type I Receptor Kinase Inhibitor in Esophageal Stricture Formation after Corrosive Burn

2021 ◽  
Author(s):  
Min Tae Kim ◽  
Kun Yung Kim
Keyword(s):  
Treatment Group ◽  
Esophageal Stricture ◽  
Kinase Inhibitor ◽  
Good Alternative ◽  
Esophageal Stenosis ◽  
Area Ratio ◽  
Control Group ◽  
Stricture Formation ◽  
Type I ◽  
Group A

Corrosive burns lead to progressive esophageal stricture and dysphagia. There are many trials to prevent Esophageal stricture formation after corrosive burn. This study aimed to access the effects of EW-7197 on prevention for esophageal stricture formation after corrosive esophageal burn. animal study were classified divided into three groups: a healthy group, a control group (corrosive burn without EW-7197), and a treatment group (corrosive burn with EW-7197). Corrosive esophageal burns were produced using 30% NaOH on the lower esophagus. For 3 weeks, the control group received vehicle and the treatment group received 20 mg/kg/day EW-7197. Treatment efficacy was assessed by measuring the stenosis ratio by esophagogram with contrast media on day 21. histologic staining was performed to evaluate the fibrosis area ratio, and western blotting was performed to evaluate fibrotic markers. Among 20 rats that underwent surgery, 14 survived. Three in the treatment group died because of esophageal perforation, and three in the control group died due to their debilitating status. The esophageal stenosis ratio was significantly lower in the treatment group than in the control group (12.1 &plusmn; 9.5% and 42.2 &plusmn; 8.3%, respectively; p = 0.001). The histologic fibrosis area ratio was also significantly lower in the treatment group (12.5 &plusmn; 3.0% and 21.6 &plusmn; 2.1%, respectively; p = 0.001). The treatment group showed lower expressions of profibrogenic proteins such as TGF-&beta;1, pSmad3, and &alpha;-SMA. EW-7197 may be a good alternative for the prevention esophageal stricture formation after corrosive burn.

Effects of recasts and form-focused instruction on the acquisition of novel vocabulary

2019 ◽  
Vol 10 (4) ◽  
pp. 603-624
Author(s):  
Yingli Yang ◽  
Lawrence Jun Zhang ◽  
Ling Chen
Keyword(s):  
Working Memory ◽  
Treatment Group ◽  
University Students ◽  
Vocabulary Development ◽  
Mediating Effect ◽  
Effect Sizes ◽  
Superior Performance ◽  
Control Group ◽  
Reading Span ◽  
Group A

AbstractThe present study explores the effects of recast plus form-focused instruction and form-focused instruction on vocabulary development and the mediating effect of working memory. Sixty-six university students were assigned to a recast plus form-focused instruction (FFI) group, a FFI group, and a control group. The instructor provided recasts on non-target vocabulary items in the recast plus FFI group, whereas the FFI group completed two form-focused vocabulary tasks only. Pretests, posttests, and delayed posttests were administered to examine learners’ development of target vocabulary items. A reading span test was employed to examine learners’ complex working memory capacities. Results show that the recast plus FFI group exhibited superior performance over the control group on both posttests and delayed posttests with large effect sizes. Working memory did not significantly correlate with vocabulary development in either treatment group.

scholarly journals EFFECT OF KALO JEERA SEEDS AND PAPAYA LEAF SUPPLEMENTATION ON THE PERFORMANCE OF BROILER

2016 ◽  
Vol 14 (1) ◽  
pp. 37-42 ◽  
Author(s):  
M. G. Sorwar ◽  
M. Mostofa ◽  
M. N. Hasan ◽  
M. Billah ◽  
M. T. Rahman
Keyword(s):  
Body Weight ◽  
Treatment Group ◽  
Nigella Sativa ◽  
Control Group ◽  
Growth Promoter ◽  
Final Body Weight ◽  
Live Body Weight ◽  
Significant Difference ◽  
Group A ◽  
Group B

This experiment was conducted to determine the effect of papaya leaf (Carica papaya) and kalo jeera (Nigella sativa) seeds powdered supplementation in drinking water as a growth promoter in broiler chickens. A total of 20 Cobb-500 broiler chicks (day-old) were purchased from local hatchery (Nourish Poultry and Hatchery Ltd.) and after seven days of acclimatization chicks were randomly divided into two groups, A (n=10) and B (n=10). The group A was kept as a control and not treated. The group B was supplemented with papaya leaf and kalo jeera powder with feed and water. Weekly observations were recorded for live body weight gain up to 5th weeks and hematological tests were performed at 35th day’s age of broiler to search for hematological changes between control (A) and treatment (B) groups. The initial body weight of groups A and B on 1st were 41.00±0.56 gm and 41.50±0.35 gm, respectively and after 35th day of experiment final body weight were 1470±57.35 gm and 1720±58.56 gm, respectively and economics of production were analyzed and found that net profit per broiler was Tk. 8.91 and Tk. 20.69, respectively. The treatment group B was recorded statistically significant (at 1% level) increased (17.00%) for live body weight than that of control group A. The hematological parameters total erythrocyte count (TEC), erythrocyte sedimentation rate (ESR) and hemoglobin (Hb) estimation value of treatment group shows significant difference, while hemoglobin estimation does not show significant difference from control group. The results suggest that better growth performance could be achieved in broilers supplemented with papaya leaf and kalo jeera seeds.

scholarly journals The Role of Peer- and Self-Assessment in Developing Saudi EFL Learners’ English Writing Skills

2016 ◽  
Vol 8 (3) ◽  
pp. 85
Author(s):  
Manal Obaid Alshammari
Keyword(s):  
Treatment Group ◽  
Writing Skills ◽  
Control Group ◽  
Word Choice ◽  
Self Assessment ◽  
Efl Learners ◽  
English Writing ◽  
Post Test ◽  
Group A ◽  
Group B

<p>The current study focuses on the importance of integrating peer- and self-assessment in<br />teaching English as a second/foreign language in Saudi Arabia. It pays special attention to the<br />mechanisms by which Saudi EFL learners can improve their English writing skills if they<br />engage in peer- and self-assessment regularly. To this end, the researcher administered a<br />writing composition task to measure the participants’ ability to express themselves in good<br />English, focusing on the coherence, cohesion, word choice, spelling, punctuation, and layout<br />of their essays. The researcher utilised the experimental two-groups design of a pre-test and a<br />post-test, in order to evaluate the participants’ performance prior to the application of the<br />treatment (i.e. peer- and self-assessment) and after it. For the purpose of the study, the<br />participants were divided into two groups: students in group A (i.e. the treatment group)<br />engaged in peer- and self-assessment regularly throughout the term, whilst students in group<br />B (i.e. the control group) did not. The results of group A on the pre-test and post-test were<br />compared to those of group B to determine whether the treatment had any impact on their<br />performance. The results reveal that group A outperformed their group B counterparts on the<br />post-test. The statistical analysis demonstrates that the difference between the results of the<br />two groups was statistically significant, suggesting that the treatment contributed positively to<br />the performance of the treatment group. Finally, the study concludes with recommendations<br />for further research.</p>

The Impact of an Educational Program on Improving Diabetes Knowledge and Changing Behaviors of Nurses in Long-Term Care Facilities

1995 ◽  
Vol 21 (6) ◽  
pp. 541-545 ◽  
Author(s):  
Monica Turner Parker ◽  
Nancy Leggett-Frazier ◽  
Pauline A. Vincent ◽  
Melvin S. Swanson
Keyword(s):  
Treatment Group ◽  
Diabetes Care ◽  
Educational Program ◽  
Long Term Care ◽  
Control Group ◽  
Term Care ◽  
Care Facilities ◽  
Group A ◽  
The Impact

Nursing staffs from two long-term care facilities attended a multisession educational program about the care of residents with diabetes (treatment group). A control group consisted of the nursing staffs from two other similar facilities who did not participate in the educational program. Both groups were given a knowledge pretest and posttest. A chart review also was conducted following the educational intervention to determine any changes in the diabetes care provided by the treatment group. Following the educational program, the treatment group had a significant increase in their mean score on the knowledge test compared with the control group. However, a. review of the residents' charts revealed no significant increases in specific behaviors related to diabetes care. The findings suggest that, in addition to educational programs, more focused training concerning diabetes care is needed to improve the care of residents with diabetes in long-term care facilities. Implications for diabetes educators are discussed.

scholarly journals Peculiarities of Mineral Metabolism of Holstein Heifers’ Diet Supplemented with Copper Nanopowders

2020 ◽  
pp. 492-498
Author(s):  
Irina A. Stepanova ◽  
Anna A. Nazarova ◽  
Mikhail V. Arisov
Keyword(s):  
Treatment Group ◽  
Mineral Composition ◽  
Copper Nanoparticles ◽  
Mineral Metabolism ◽  
Biologically Active ◽  
Control Group ◽  
Experimental Animals ◽  
Animal Hair ◽  
Group A ◽  
Effect Of Copper

The current study aimed to investigate the effect of copper nanopowder on physiological and mineral metabolism indicators of Holstein cattle during the growth process of the animal. There were two experimental groups (control and treatment) and each one included seven Holstein heifers. From the first month of each heifer in the experimental group, a suspension of copper nanoparticles in a dose of 0.04 mg/kg was orally administered daily to the usual diet. The biologically active additive was administered to the animal’s diet at intervals. The weight of the animals was measured monthly, a clinical blood test was performed, the mineral composition of the blood was studied, the mineral composition of animal hair was also examined. The findings indicated a positive dynamics in the increase of body weight in the treatment group, compared to the control group. As a result of clinical blood tests, it was noted that the number of erythrocytes, the level of hemoglobin, and hematocrit increased in the experimental animals due to copper nanoparticles compared to these parameters in these animals at the beginning of the tests. Mineral analysis of blood samples in the treatment group presented an increase in the levels of copper, potassium, iron, zinc, and manganese while in animals of the control groups there was an increase in sodium, calcium, and phosphorus. According to the blood serum and hair analysis, copper in the nanodispersed state indicated antagonistic effects on boron, silicon, antimony, molybdenum of the treatment group and there was a synergist in aluminum, titanium, manganese, cobalt, iron, and potassium levels compared to the beginning of the experiment. The obtained results indicated that the addition of copper nanopowder to the diet of experimental animals increased the growth, stimulated the function of hematopoiesis, and improved the characteristics of mineral metabolism of the Holstein heifers.

scholarly journals PENGARUH PEMBERIAN AIR PERASAN JERUK NIPIS (Citrus aurantifolia) TERHADAP JUMLAH PIGMEN MELANIN KULIT MENCIT (Mus musculus) YANG DIPAPARKAN SINAR MATAHARI

2015 ◽  
Vol 3 (1) ◽  
Author(s):  
Anggun R.P. Layuck ◽  
Poppy M. Lintong ◽  
Lily L. Loho
Keyword(s):  
Treatment Group ◽  
Experimental Research ◽  
Light Exposure ◽  
Skin Pigmentation ◽  
Melanin Pigment ◽  
Control Group ◽  
Group A ◽  
The Subject ◽  
Group B ◽  
Group D

Abstract: Over exposure of light can increase skin pigmentation. The aim of this study is to know the effect of lime and light exposure to the amount of melanin in mice’s skin. This is an experimental research and used mices as the subject research, which was randomly divided into 5 mice of control group and 15 mices of treatment group. Group A (K-) were given pellets for 20 days, Group B (K+) were given pellets and light exposure for 1 hour in 20 days, Group C were given pellets, smeared by lime on the back, then exposed to the light for 1 hour in 20 days, Group D were given pellets and exposed to light for 1 hour in 20 days then smeared by lime the next 10 days. The results showed that light exposure increases melanin pigment in group B compared to group A. For group C and group D, the amount of melanin pigment is less than group B. Conclusions: Lime can reduce the amount of melanin pigment in mice’s skin that had been exposed to the light.Keywords: melanin pigment, sunlight, limeAbstrak: Paparan berlebihan terhadap sinar matahari dapat meningkatkan pigmentasi kulit. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian jeruk nipis dan pemaparan sinar matahari terhadap jumlah pigmen melanin kulit mencit. Metode penelitian yang digunakan adalah metode eksperimental dengan subjek penelitian menggunakan mencit yang dibagi atas 5 ekor kontrol dan 15 ekor perlakuan. Kelompok A (K-) diberikan pelet selama 20 hari, Kelompok B (K+) diberikan pelet dan sinar matahari selama 1 jam dalam waktu 20 hari, kelompok C diberikan pelet, diolesi jeruk nipis di bagian punggung, lalu dipaparkan sinar matahari selama 1 jam dalam waktu 20 hari, kelompok D diberikan pelet, dipaparkan sinar matahari selama 1 jam dalam waktu 20 hari lalu diolesi jeruk nipis 10 hari berikutnya. Hasilnya : paparan sinar matahari menunjukkan peningkatan pigmen melanin pada kelompok B (K+) dibandingkan dengan kelompok A (K-). Sedangkan pada kelompok C dan kelompok D menunjukkan jumlah pigmen melanin yang lebih berkurang dibandingkan kelompok B. Simpulan: Pemberian jeruk nipis menurunkan jumlah pigmen melanin kulit mencit yang dipaparkan sinar matahari.Kata kunci : pigmen melanin, sinar matahari, air perasan jeruk nipis

Sign in / Sign up

Export Citation Format

Share Document