scholarly journals Efficacy of Diltiazem for the Control of Blood Pressure in Puerperal Patients with Severe Preeclampsia: A Randomized, Single-Blind, Controlled Trial

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Gilberto Arias-Hernández ◽  
Cruz Vargas-De-León ◽  
Claudia C Calzada-Mendoza ◽  
María Esther Ocharan-Hernández
Keyword(s):  
Blood Pressure ◽  
Intensive Care Unit ◽  
Heart Rate ◽  
Intensive Care ◽  
Outcome Measures ◽  
Repeated Measures ◽  
Severe Preeclampsia ◽  
Secondary Outcome ◽  
Control Group ◽  
Single Blind

Background. Postpartum preeclampsia is a serious disease related to high blood pressure that occurs commonly within the first six days after delivery. Objective. To evaluate if diltiazem improves blood pressure parameters in early puerperium patients with severe preeclampsia. Methodology. A randomized, single-blind longitudinal clinical trial of 42 puerperal patients with severe preeclampsia was carried out. Patients were randomized into two groups: the experimental group (n = 21) received diltiazem (60 mg) and the control group (n = 21) received nifedipine (10 mg). Both drugs were orally administered every 8 hours. Systolic, diastolic, and mean blood pressures as well as the heart rate were recorded and analyzed (two-way repeated measures ANOVA) at baseline and after 6, 12, 18, 24, 30, 36, 42, and 48 hours. Primary outcome measures were all the aforementioned blood pressure parameters. Secondary outcome measures included the number of hypertension and hypotension episodes along with the length of stay in the intensive care unit. Results. No statistical differences were found between groups (diltiazem vs. nifedipine) regarding basal blood pressure parameters. Interarm differences in blood pressure (systolic, diastolic, and mean) and heart rate were statistically significant between treatment groups from 6 to 48 hours. Patients in the diltiazem group had lower blood pressure levels than patients in the nifedipine group. Significantly, patients who received diltiazem had fewer hypertension and hypotension episodes and stayed fewer days in the intensive care unit than those treated with nifedipine. Conclusions. Diltiazem controlled arterial hypertension in a more effective and uniform manner in patients under study than nifedipine. Patients treated with diltiazem had fewer collateral effects and spent less time in the hospital. This trial is registered with NCT04222855.

scholarly journals Effects of Three Months of Detraining on the Health Profile of Older Women after a Multicomponent Exercise Program

2019 ◽  
Vol 16 (20) ◽  
pp. 3881 ◽  
Author(s):  
Luis Leitão ◽  
Ana Pereira ◽  
Mauro Mazini ◽  
Gabriela Venturini ◽  
Yuri Campos ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Older Women ◽  
Repeated Measures ◽  
Pulmonary Ventilation ◽  
Exercise Program ◽  
Control Group ◽  
Health Profile ◽  
Older Individuals ◽  
Negative Effects

Physical exercise results in very important benefits including preventing disease and promoting the quality of life of older individuals. Common interruptions and training cessation are associated with the loss of total health profile, and specifically cardiorespiratory fitness. Would detraining (DT) promote different effects in the cardiorespiratory and health profiles of trained and sedentary older women? Forty-seven older women were divided into an experimental group (EG) and a control group (CG) (EG: n = 28, 70.3 ± 2.3 years; CG: n = 19, 70.1 ± 5.6 years). Oxygen uptake (VO2) and health profile assessments were conducted after the exercise program and after three months of detraining. The EG followed a nine-month multicomponent exercise program before a three-month detraining period. The CG maintained their normal activities. Repeated measures ANOVA showed significant increases in total heath and VO2 (p < 0.01) profile over a nine-month exercise period in the EG and no significant increases in the CG. DT led to greater negative effects on total cholesterol (4.35%, p < 0.01), triglycerides (3.89%, p < 0.01), glucose (4.96%, p < 0.01), resting heart rate (5.15%, p < 0.01), systolic blood pressure (4.13%, p < 0.01), diastolic blood pressure (3.38%, p < 0.01), the six-minute walk test (7.57%, p < 0.01), Pulmonary Ventilation (VE) (10.16%, p < 0.01), the Respiratory Exchange Ratio (RER) (9.78, p < 0.05), and VO2/heart rate (HR) (16.08%, p < 0.01) in the EG. DT may induce greater declines in total health profile and in VO2, mediated, in part, by the effectiveness of multicomponent training particularly developed for older women.

scholarly journals Characterization of Dexmedetomidine Dosing and Safety in Neonates and Infants

2015 ◽  
Vol 20 (2) ◽  
pp. 112-118 ◽  
Author(s):  
Lauren M. Estkowski ◽  
Jennifer L. Morris ◽  
Elizabeth A. Sinclair
Keyword(s):  
Blood Pressure ◽  
Intensive Care Unit ◽  
Heart Rate ◽  
Intensive Care ◽  
Systolic Blood Pressure ◽  
Vital Signs ◽  
Pediatric Intensive Care ◽  
Neonates And Infants ◽  
To Receive

OBJECTIVES: To describe and compare off-label use and cardiovascular (CV) adverse effects of dexmedetomidine in neonates and infants in the pediatric intensive care unit (PICU). METHODS: Patients younger than 12 months with corrected gestational ages of at least 37 weeks who were receiving continuous infusion of dexmedetomidine at a tertiary pediatric referral center between October 2007 and August 2012 were assessed retrospectively. Patients were excluded if dexmedetomidine was used for procedural sedation, postoperative CV surgery, or if postanesthesia infusion weaning orders existed at the time of PICU admission. RESULTS: The median minimum dexmedetomidine dose was similar between infants and neonates at 0.2 mcg/kg/hr (IQR, 0.17–0.3) versus 0.29 mcg/kg/hr (IQR, 0.2–0.31), p = 0.35. The median maximum dose was higher for infants than neonates (0.6 mcg/kg/hr [IQR, 0.4–0.8] vs. 0.4 mcg/kg/hr [IQR, 0.26–0.6], p &lt; 0.01). Additional sedative use was more common in infants than neonates (75/99 [76%] vs. 15/28 [54%], p = 0.02). At least 1 episode of hypotension was noted in 34/127 (27%) patients and was similar between groups. An episode of bradycardia was identified more frequently in infants than neonates (55/99 [56%] vs. 2/28 [7%], p &lt; 0.01). Significant reduction in heart rate and systolic blood pressure was noted when comparing baseline vital signs to lowest heart rate and systolic blood pressure during infusion (p &lt; 0.01). CONCLUSIONS: Dexmedetomidine dose ranges were similar to US Food and Drug Administration–labeled dosages for intensive care unit sedation in adults. More infants than neonates experienced a bradycardia episode, but infants were also more likely to receive higher dosages of dexmedetomidine and additional sedatives.

scholarly journals The Effect of Live Spontaneous Harp Music on Patients in the Intensive Care Unit

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Ann Marie Chiasson ◽  
Ann Linda Baldwin ◽  
Carrol Mclaughlin ◽  
Paula Cook ◽  
Gulshan Sethi
Keyword(s):  
Blood Pressure ◽  
Intensive Care Unit ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Intensive Care ◽  
Oxygen Saturation ◽  
Respiratory Rate ◽  
Rest Period ◽  
Underlying Mechanism ◽  
To Receive

This study was performed to investigate the effect of live, spontaneous harp music on individual patients in an intensive care unit (ICU), either pre- or postoperatively. The purpose was to determine whether this intervention would serve as a relaxation or healing modality, as evidenced by the effect on patient’s pain, heart rate, respiratory rate, blood pressure, oxygen saturation, and heart rate variability. Each consenting patient was randomly assigned to receive either a live 10-minute concert of spontaneous music played by an expert harpist or a 10-minute rest period. Spontaneous harp music significantly decreased patient perception of pain by 27% but did not significantly affect heart rate, respiratory rate, oxygen saturation, blood pressure, or heart rate variability. Trends emerged, although being not statistically significant, that systolic blood pressure increased while heart rate variability decreased. These findings may invoke patient engagement, as opposed to relaxation, as the underlying mechanism of the decrease in the patients’ pain and of the healing benefit that arises from the relationship between healer, healing modality, and patient.

scholarly journals Effects of Pre-cooling and Per-cooling on Neural, Physiological, and Functional Responses in Active Young Girls

2020 ◽  
Vol 18 (3) ◽  
Author(s):  
Seyedeh Somayeh Razavi ◽  
Amirabbas Monazzami ◽  
Zahra Nikosefat
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Body Temperature ◽  
Repeated Measures ◽  
Blood Pressure Monitoring ◽  
Core Body Temperature ◽  
Control Group ◽  
Functional Responses ◽  
Young Girls ◽  
Core Body

Background: Stressful environments, especially air temperature, have significant effects on human physiological responses to physical activity. Objectives: The current study aimed to determine the effects of pre-cooling and per-cooling on neural, physiological, and functional responses in active young girls. Methods: Twelve active girls (age 24.6 ± 1.4, weight 55.46 ± 8.18, height 165.1 ± 5.91) were tested in three separate sessions with intervals of three days between each session. All subjects performed the Balke test in three groups either without an ice vest (control and pre-cooling) or with an ice vest (per-cooling) in each session, randomly. Pre-cooling was applied with an ice vest for 30 min just before the test, while per-cooling was used with an ice vest from the beginning of the test to exhaustion. A Buerer FT-70 digital thermometer, polar-FT60 heart rate monitoring, Microlife blood pressure monitoring, and ELISA technique were used to measure core body temperature, heart rate, blood pressure, dopamine, cortisol, and lactate dehydrogenase, respectively. Two-way repeated-measures ANOVA was applied to analyze the data with a confidence interval of 95%. Results: The heart rate and core body temperature significantly decreased at the end of the test in the pre-cooling and per-cooling groups (P < 0.05). There was an improved performance with an increase in Tmax in the per-cooling group compared to the control group (P < 0.05) although this difference was not significant in the pre-cooling group compared to the control group (P > 0.05). Dopamine, cortisol, and lactate dehydrogenize increased in the groups in comparison with the pretest (P < 0.05) even though these differences were not significant in the comparison between the groups (P > 0.05). Conclusion: The findings suggest that pre-cooling and per-cooling could be used as a beneficial method to improve performance due to not only a decrease in core body temperature and heart rate but also an increase in the level of dopamine and cortisol. Moreover, per-cooling was more effective than pre-cooling to increase performance.

Circadian heart rate and blood pressure variability in intensive care unit patients

2013 ◽  
Vol 45 (2) ◽  
pp. 285-292 ◽  
Author(s):  
Taheni Ben Lazreg ◽  
Ilhem Ben Charfeddine ◽  
Ons Mammai ◽  
Abdelbacet Amara ◽  
Oualid Naiija ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Intensive Care Unit ◽  
Heart Rate ◽  
Intensive Care ◽  
Blood Pressure Variability

scholarly journals The Effects of Aromatherapy on Intensive Care Unit Patients’ Stress and Sleep Quality: A Nonrandomised Controlled Trial

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Eun Hee Cho ◽  
Mi-Young Lee ◽  
Myung-Haeng Hur
Keyword(s):  
Blood Pressure ◽  
Intensive Care Unit ◽  
Intensive Care ◽  
Sleep Quality ◽  
Controlled Trial ◽  
Experimental Treatment ◽  
Stress Index ◽  
Control Group ◽  
Nursing Interventions ◽  
Significant Difference

Background. Stress has both physiological and psychological effects and can negatively impact patients’ treatment and recovery. We examined whether the aromatherapy alleviated patients’ stress and improved their sleep quality and provided data that can be utilized in clinical settings. Methods. This was a nonrandomised controlled experimental study. Participants included lucid adult patients who were admitted to the intensive care unit and had spent more than two nights there. The experimental treatment required participants to engage in deep breathing with essential oils as part of the aromatherapy. The control group was instructed to go to sleep without receiving the lavender aroma oil. Results. The experimental group and control group showed a significant difference in perceived stress (F=60.11, p<.001), objective stress index (F=25.65, p<.001), systolic blood pressure (F=9.09, p<.001), diastolic blood pressure (F=2.47, p=.046), heart rate (F=5.71, p<.001), and sleep quality (F=109.46, p<.001). Conclusions. The results revealed that aromatherapy alleviated stress and improved sleep quality in intensive care unit patients after 2 days of the experimental treatment. These results demonstrate that aromatherapy affects stress and sleep quality, thus indicating its value in nursing interventions. This trial is registered with KCT0002344.

scholarly journals Sodium Valproate versus Continuous Infusion of Haloperidol in Management of Agitated Critically Ill Patients

2019 ◽  
Vol 7 (15) ◽  
pp. 2440-2443
Author(s):  
Ramadan Khalil ◽  
Mohamed Soliman ◽  
Mohamed Omer ◽  
Kamel Abdel Aziz ◽  
Khaled Hussein
Keyword(s):  
Blood Pressure ◽  
Intensive Care Unit ◽  
Heart Rate ◽  
Intensive Care ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Sedation Score ◽  
Efficacy And Safety ◽  
Qtc Prolongation ◽  
Sedative Drugs

AIM: Describe the efficacy and safety of valproate and haloperidol infusion in controlling agitation in the intensive care unit (ICU). MATERIAL AND METHODS: Prospective study on 100 critically ill patients with agitation in Kasralainy Hospital over the period from May 2016 to June 2017.patients were divided into two groups, each group included 50 patients, 1st group patients received Depakene orally, and 2nd group patients received haloperidol by i.v infusion for 72 h. Richmond agitation sedation score and doses of additional sedative drugs were noted and calculated daily in the first three days. RESULTS: Our study showed that valproate was equal in efficacy in controlling agitation; decreasing the RAAS significantly after 48 h from initiation (2.52 ± 0.61 vs 0.28 ± 0.54 with p < 0.001) for Depakene and (2.6 ± 0.67 vs 0.34 ± 0.48 with p < 0.001) for haloperidol. There was also a decrease in the doses of additional sedative drugs used to control agitation (midazolam & propofol) after 48 h from drug initiation. Both drugs therapy was associated with decrease in heart rate (89 ± 20 vs 86.6 ± 13.6 with p = 0.002 for valproate and 99.8 ± 23.3 vs 91 ± 16.7 with p < 0.001 for haloperidol). They did not affect blood pressure. Haloperidol therapy was associated with significant QTc prolongation. CONCLUSION: Valproate was equal in efficacy as haloperidol infusion in controlling agitation in ICU and decreasing the doses of additional sedative drugs used after 48 h from initiation.

scholarly journals Effects of different doses of dexmedetomidine on heart rate and blood pressure in intensive care unit patients

2015 ◽  
Vol 11 (1) ◽  
pp. 360-366 ◽  
Author(s):  
XIAOYAN ZHANG ◽  
RUILAN WANG ◽  
JIAN LU ◽  
WEI JIN ◽  
YONGBIN QIAN ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Intensive Care Unit ◽  
Heart Rate ◽  
Intensive Care ◽  
Different Doses
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