scholarly journals Pneumatosis Intestinalis in Adult Bilateral Lung Transplant Patients: A Single Institution Experience and Literature Review

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Eric Christiansen ◽  
Nisha Singh ◽  
Amy Trahan ◽  
Sofya Tokman ◽  
David Row ◽  
...  
Keyword(s):  
Literature Review ◽  
Organ Transplantation ◽  
Lung Transplant ◽  
Intestinal Ischemia ◽  
Bowel Wall ◽  
Pneumatosis Intestinalis ◽  
Early Enteral Nutrition ◽  
Imaging Features ◽  
Radiologic Finding ◽  
Transplant Patients

Pneumatosis intestinalis (PI) is a radiologic finding which is characterized by the accumulation of gas within the bowel wall. This radiologic finding is traditionally thought of in the sense of intestinal ischemia. An uncommon cause of this finding is post organ transplantation. We did an institutional and literature review of this finding to demonstrate its distinct imaging features and benign nature. It was observed to occur in approximately 5.2% of patients post lung transplant (23/442). On imaging, it displays an expansile/bubbly appearance of gas within the bowel wall that is distinct from the traditional findings seen in intestinal ischemia. Clinical review showed that posttransplant patients with PI can be successfully managed conservatively with early enteral nutrition, oxygen, antibiotics, and limited follow-up imaging. With the increasing use of organ transplantation, PI is being diagnosed with increased frequency. It is important to let clinicians know of this entity and its potential outcomes.

Morbidity and Mortality after General Surgery in Heart and Lung Transplant Patients

2019 ◽  
Author(s):  
Alek Zywot ◽  
Amber L. Turner ◽  
Joanna Sesti ◽  
Russell C. Langan ◽  
Andrew Nguyen ◽  
...  
Keyword(s):  
General Surgery ◽  
Lung Transplant ◽  
Morbidity And Mortality ◽  
Transplant Patients

scholarly journals Large Bowel Ischemia/Infarction: How to Recognize It and Make Differential Diagnosis? A Review

Diagnostics ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 998
Author(s):  
Francesca Iacobellis ◽  
Donatella Narese ◽  
Daniela Berritto ◽  
Antonio Brillantino ◽  
Marco Di Serafino ◽  
...  
Keyword(s):  
Ischemic Colitis ◽  
Intestinal Ischemia ◽  
Bowel Wall ◽  
Clinical Laboratory ◽  
Supportive Therapy ◽  
Ischemic Necrosis ◽  
Diagnostic Investigation ◽  
Enhanced Ct ◽  
Common Etiology

Ischemic colitis represents the most frequent form of intestinal ischemia occurring when there is an acute impairment or chronic reduction in the colonic blood supply, resulting in mucosal ulceration, inflammation, hemorrhage and ischemic necrosis of variable severity. The clinical presentation is variable and nonspecific, so it is often misdiagnosed. The most common etiology is hypoperfusion, almost always associated with generalized atherosclerotic disease. The severity ranges from localized and transient ischemia to transmural necrosis of the bowel wall, becoming a surgical emergency, with significant associated morbidity and mortality. The diagnosis is based on clinical, laboratory suspicion and radiological, endoscopic and histopathological findings. Among the radiological tests, enhanced-CT is the diagnostic investigation of choice. It allows us to make the diagnosis in an appropriate clinical setting, and to define the entity of the ischemia. MR may be adopted in the follow-up in patients with iodine allergy or renal dysfunctions, or younger patients who should avoid radiological exposure. In the majority of cases, supportive therapy is the only required treatment. In this article we review the pathophysiology and the imaging findings of ischemic colitis.

scholarly journals Twelve-month effects of everolimus on renal and lung function in lung transplantation: differences in chronic lung allograft dysfunction phenotypes

2021 ◽  
Vol 12 ◽  
pp. 204062232199344
Author(s):  
Filippo Patrucco ◽  
Elias Allara ◽  
Massimo Boffini ◽  
Mauro Rinaldi ◽  
Cristina Costa ◽  
...  
Keyword(s):  
Renal Function ◽  
Lung Function ◽  
Lung Transplant ◽  
Bronchiolitis Obliterans Syndrome ◽  
Forced Expiratory Volume ◽  
Chronic Lung Allograft Dysfunction ◽  
Allograft Dysfunction ◽  
Transplant Patients ◽  
Restrictive Allograft Syndrome ◽  
Trend Data

Background: Chronic lung allograft dysfunction (CLAD), a complication affecting the survival of lung transplanted patients, includes two clinical phenotypes: bronchiolitis obliterans syndrome (BOS) and restrictive allograft syndrome (RAS). Everolimus is used in CLAD because of its antiproliferative mechanism. In lung transplant patients treated with everolimus, the clinical course of renal and lung function has not yet been assessed systematically in CLAD, BOS and RAS patients for more than 6 months. Methods: We retrospectively evaluated the 12-month follow-up of renal and lung function of lung-transplanted patients switched to everolimus and evaluated the reduction in immunosuppressant dosage (ISD) and mortality. Subgroups were based on indication for everolimus treatment: CLAD and non-CLAD patients, BOS and RAS among CLAD patients. Results: We included 26 patients, 17 with CLAD (10 BOS, seven RAS). After 1 year from the everolimus switch, we observed renal function improvement (serum creatinine −17%, estimated glomerular filtration rate +24%) and stable pulmonary function [forced expiratory volume in the first second (FEV1) −0.5%, forced vital capacity (FVC) +0.05%]. RAS patients had progressive functional loss, whereas BOS patients had FEV1 improvement and FVC stability. All-cause mortality was higher in the CLAD versus non-CLAD group (41% versus 11%), without differences between BOS and RAS patients ( p > 0.05). All patients had significant and persistent ISD reduction. Conclusion: Lung transplant patients treated with everolimus had improvements in renal function and reduced ISD. We observed sustained improvements in lung function for CLAD related to BOS subgroup results, whereas RAS confirmed the 1-year worsening functional trend. Data seem to suggest one more piece of the puzzle in CLAD phenotyping.

Comparison of Leukolysin/MT6-MMP in Bronchoalveolar Lavage Fluid from Lung Transplant Patients and Asthmatics

2006 ◽  
Vol 117 (2) ◽  
pp. S64
Author(s):  
J.P. Raasch ◽  
C.L. Liebeler ◽  
C.H. Wendt ◽  
J.B. Sweet ◽  
N.N. Jarjour ◽  
...  
Keyword(s):  
Bronchoalveolar Lavage ◽  
Lung Transplant ◽  
Bronchoalveolar Lavage Fluid ◽  
Lavage Fluid ◽  
Transplant Patients

Neuromuscular Painful Disorders: a Rare Side Effect of Voriconazole in Lung Transplant Patients Under Tacrolimus

2008 ◽  
Vol 27 (2) ◽  
pp. 229-232 ◽  
Author(s):  
V. Boussaud ◽  
N. Daudet ◽  
E.M. Billaud ◽  
A. Lillo-Le Louet ◽  
P. Chevalier ◽  
...  
Keyword(s):  
Side Effect ◽  
Lung Transplant ◽  
Transplant Patients ◽  
Rare Side Effect
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