scholarly journals Comparison of Serum Inhibin B and Follicle-Stimulating Hormone (FSH) Level between Normal and Infertile Men in Yaoundé

2020 ◽  
Vol 2020 ◽  
pp. 1-9 ◽  
Author(s):  
Tchoula Mamiafo Corinne ◽  
Pieme Constant Anatole ◽  
Ngogang Yonkeu Jeanne
Keyword(s):  
Semen Quality ◽  
Follicle Stimulating Hormone ◽  
Sperm Concentration ◽  
Reproductive Hormones ◽  
Inhibin B ◽  
World Health ◽  
Infertile Couple ◽  
Male Reproductive Function ◽  
Significant Difference ◽  
Stimulating Hormone

Objective. Hormones play a vital role in initiating and maintaining male reproductive function. The present study explores the influence and predictive ability of two reproductive hormones on semen quality among men who were partners in an infertile couple. Design. During our cross sectional study, men were recruited from private and public hospital and laboratories for clinical evaluation of fertility status. Methods. Fresh semen samples were assessed for quality (concentration, motility and morphology) according to the 2010 World Health Organization manual and the serum levels of hormones, including follicle-stimulating hormone (FSH), Inhibin B was measured (ELISA). Results. We found a significant difference in the two groups regarding sperm concentration (p<0.0001), total sperm count (p<0.0001), progressive motility (p<0.0001), vitality (p<0.0001) and the percentage of normal forms (p=0.043). We found a strong and negative correlation between FSH and Inhibin B in the overall population, the normozoospermic reference group and the case group. Our study confirmed that Inhibin B was significantly and positively correlated with sperm concentration and leucocytes, and that FSH was negatively correlated to sperm concentration and vitality. Conclusion. Consistent with other studies, our results show strong association between semen quality and FSH and Inhibin B.

scholarly journals Inhibin B as a Serum Marker of Spermatogenesis: Correlation to Differences in Sperm Concentration and Follicle-Stimulating Hormone Levels. A Study of 349 Danish Men1

1997 ◽  
Vol 82 (12) ◽  
pp. 4059-4063 ◽  
Author(s):  
Tina Kold Jensen ◽  
Anna-Maria Andersson ◽  
Niels Henrik I. Hjollund ◽  
Thomas Scheike ◽  
Henrik Kolstad ◽  
...  
Keyword(s):  
Follicle Stimulating Hormone ◽  
Sperm Concentration ◽  
Serum Marker ◽  
Inhibin B ◽  
Hormone Levels ◽  
Stimulating Hormone

scholarly journals Comparison of time frame critical for feed supplement on reproductive hormones of Azawak cattle in semi–arid zone of Niger Republic.

2020 ◽  
Vol 45 (3) ◽  
Author(s):  
N.A. Alassan ◽  
I.R. Muhammad ◽  
S.A. Maigandi ◽  
M.I. Ghude
Keyword(s):  
Arid Zone ◽  
Follicle Stimulating Hormone ◽  
Cattle Breed ◽  
Time Frame ◽  
Reproductive Hormones ◽  
P Value ◽  
Feed Supplement ◽  
Feed Supplementation ◽  
Significant Difference ◽  
Stimulating Hormone

This experiment was conducted to evaluate the effects of feed supplementation on laying reproductive hormones level. In total, 36 Azawak cattle breed (18 bulls and 18 heifers) with an average initial body weight (BW) of 184±40 kg aged 3 to 4 years owned by CERRA, Maradi ranch were used for this experiment. A time frame critical for utilization of supplement (NS: No supplementation, SMD: Supplementation early at 8:00 am in the morning daily before moving out for grazing, SED: Supplementation in evening at 5:00 pm daily after the afternoon grazing, SMED: Supplementation in the morning at 8:00 am and in the evening at 5:00 pm daily, S2DM: Supplementation once every two days in the morning at 8:00 am before morning out for grazing and S2DE: Supplementation once every two days in the evening at 5:00 pm). The feeding trial lasted for 90 days. The data of chemical composition of feed supplement were analyzed by the following statistical procedures: one way ANOVA. The data from reproductive hormone levels after feeding supplementation were analyzed by using 2 x 6 factorial laid in Completely Randomized Design (CRD). The factors evaluated were two sexes (bull and heifer) by the six time and frame (treatments) of supplementation. Differences between sex and treatment were determined by the T-test mean±SD separation and Least Significant Difference (LSD). For all analyses, a P value 0.05 was considered not significant. The results showed that effects of inorganic minerals on reproductive hormones per treatment were obtained. The higher (2.78±5.68 ng/mL) and lower (0.34±0.37 ng/mL) values of testosterone content was obtained from SMD and NS followed by (1.79±0.60 ng/mL) and (1.17±0.25 ng/mL) from progesterone in NS and S2DE while values of estradiol E were (281.67±70.48 pg/mL) and (217.17±52.06 pg/mL) in NS and SMD respectively. However, a higher (5.20±0.67 mlU/mL) and lower (4.25±0.88 mlU/mL) values of follicle–stimulating hormone was obtained from S2DM and SMD. Accordingly, result obtained of heifer indicated higher (0.47±0.49 ng/ml) and lower (0.18±0.02 ng/ml) values of testosterone content was obtained from SMD and NS followed by (1.60±0.65 ng/mL) and (1.02±0.21 ng/mL) from progesterone in NS and SMD while values of estradiol E were(237.33±44.28 pg/mL) and (198.33±32.08 pg/mL) in NS and SMD, respectively. However, a higher (5.23±0.84 mlU/mL) and lower (4.10±0.98 mlU/mL) values of follicle–stimulating hormone was obtained from S2DMand SMED, respectively. According to result obtained of bull, the higher (5.09±8.02 ng/mL) and lower (0.49±0.52 ng/mL) values of testosterone content was obtained from SMD and NS followed by (1.97±0.60 ng/mL) and (1.16±0.07 ng/mL) from progesterone in NS and S2DE while values of estradiol E were (326.00±67.55pg/mL) and (234.00±32.14 pg/mL) in NS and SMED respectively. However, a higher (5.17±0.64 mlU/mL) and lower (4.13±0.50 mlU/mL) values of follicle-stimulating hormone was obtained from S2DM and SED. Conclusively, inorganic minerals in feed supplementation have beneficial effect on reproductive hormones ofAzawak cattle breed.

scholarly journals Association between GH receptor polymorphism (exon 3 deletion), serum IGF1, semen quality, and reproductive hormone levels in 838 healthy young men

2014 ◽  
Vol 170 (4) ◽  
pp. 555-563 ◽  
Author(s):  
M Andreassen ◽  
R B Jensen ◽  
N Jørgensen ◽  
A Juul
Keyword(s):  
Semen Quality ◽  
Final Height ◽  
Reproductive Function ◽  
Postnatal Growth ◽  
Reproductive Hormones ◽  
Inhibin B ◽  
Sex Hormone Binding Globulin ◽  
Gh Receptor ◽  
Male Reproductive Function ◽  
Semen Volume

IntroductionGH activity may be involved in male reproductive function. A common genetic polymorphism in the gene encoding the GH receptor (GHR) results in deletion of the entire exon 3 sequence (GHRd3 isoform). The short GHRd3/d3 isoform seems more sensitive compared with full-length receptors (GHRfl/fl).AimTo investigate the associations between GH activity, evaluated by exon 3 GHR polymorphism, and serum IGF1 vs reproductive hormones, semen quality, and pre- and postnatal growth in healthy young males (n=838, mean age: 19.4 years).ResultsCompared with GHRfl/fl homozygous individuals (n=467) GHRd3/d3 homozygous individuals (n=69) tended to have larger semen volume (3.2 (2.4–4.3) vs 3.6 (2.6–4.7) ml, P=0.053) and higher serum inhibin-B levels (208 pg/ml (158–257) vs 227 pg/ml (185–264), P=0.050). Semen quality, levels of gonadotropins, testosterone, estradiol, sex hormone-binding globulin, and IGF1 were not associated with GHRd3 genotype.A twofold increase in serum IGF1 was associated with a 13% (4–23) increase in calculated free testosterone (P=0.004). By contrast IGF1 was inversely associated with serum inhibin-B (P=0.027), but showed no associations to semen quality. GHR genotype and serum IGF1 were not associated with size at birth or final height.ConclusionsGHRd3 polymorphism seemed only to have a weak influence on male reproductive function of borderline significance. The sensitive GHRd3/d3 genotype may slightly increase testicular function, as evaluated by semen volume and levels of inhibin-B, but does not seem to influence Leydig cell steroidogenesis. GHR genotype did not influence pre- and postnatal growth.

ORIGINAL ARTICLES Toxoplasmosis Seropositivity and Male Sex Hormones

2018 ◽  
Vol 1 (3) ◽  
pp. 12-25
Author(s):  
Mustafa Riadh Hussien
Keyword(s):  
Follicle Stimulating Hormone ◽  
Protozoan Parasite ◽  
Free Testosterone ◽  
Reproductive Hormones ◽  
High Rate ◽  
Total Testosterone ◽  
Chronic Infections ◽  
Significant Difference ◽  
Almost All ◽  
Stimulating Hormone

Background: Toxoplasmosis is a cosmopolitan disease with acute and chronic infections, caused by the obligate intracellular protozoan parasite Toxoplasma gondii that can infect a variety of cells in almost all warm blooded animals including humans. Aim: The study aimed to determine the seroprevalence of T. gondii infection among males in Duhok city. Materials and methods: Using ELISA (IgG and IgM), the relationship between toxoplasmosis and reproductive hormones including testosterone, free testosterone, and follicle stimulating hormone (FSH) levels and its association with male sterility were also investigated. Results: 22.98% of male samples appeared to be affected by T. gondii infection. The mean concentrations of the male reproductive hormones were 6.15±1.03 ng/ml (total testosterone), 14.81±4.71pg/ml (Free Testosterone), 4.84±2.20 IU/ml (Follicle-stimulating hormone), 0.54±0.22 (IgM), and 0.62±0.75 (IgG). A significant difference was found in the samples in terms of infertility (p<0.0001), while p-values for testosterone (P>0.05), free testosterone (P>0.05) and follicle-stimulating hormone (P>0.05), were non-significant. Conclusion: The present study showed a high rate of T. gondii among males in Duhok city with significant difference (P<0.05) in infertility between T. gondii seropositive and seronegative samples.

scholarly journals Semen Analysis and Insight into Male Infertility

2021 ◽  
Vol 9 (A) ◽  
pp. 252-256
Author(s):  
Batool Mutar Mahdi
Keyword(s):  
Retrospective Study ◽  
Male Infertility ◽  
Semen Analysis ◽  
Male Partner ◽  
Sperm Concentration ◽  
World Health ◽  
Semen Parameters ◽  
Infertile Couple ◽  
Male Reproductive Function ◽  
The World

Objectives: Semen analysis is the cornerstone for the valuation of the male partner in the infertile couples. This test has been standardized throughout the world through the World Health Organization (WHO) since the1970s by producing, editing, updating, and disseminating a semen analysis manual and guidelines. A retrospective study to give an insight about  male infertility. Methods: This retrospective study assessed the semen findings of 1000 men evaluated at the  Department of Urology, Al-Kindy Teaching Hospital in Baghdad-Iraq  between January 2016 and May 2019. Semen analysis were done for them. Results: According to WHO standard for semen normality, 1000 samples that were analyzed, normospermia was shown in 835 (83.5%)males (95% CI=0.811-0.857) and 12% had oligospermia and the rest 4.5% was azospermia. The normospermic samples had significantly higher levels regarding the following parameters: count per ml (51.30±1.24) (P= 0.001), volume(3.34±2.31)(P=0.0001), pus cell (8.04±1.02)(P=0.0001), motility (22.81±5.8)(P=0.0001), abnormal motility (22.81±5.8)(P=0.0001) and  normal (V)(P=0.0001)or abnormal morphology (25.86 ±12.4)(P=0.0002) when compared with oligospermia. Conclusions: Semen analysis is the keystone of infertile couple. Semen parameters like sperm concentration, motility and morphology, are indicators for male reproductive function. Sperm concentration is declining and there is a significant association between sperm concentration and sperm parameters.

scholarly journals Lack of Specificity of Plasma Concentrations of Inhibin B and Follicle-Stimulating Hormone for Identification of Azoospermic Survivors of Childhood Cancer: A Report From the St Jude Lifetime Cohort Study

2013 ◽  
Vol 31 (10) ◽  
pp. 1324-1328 ◽  
Author(s):  
Daniel M. Green ◽  
Liang Zhu ◽  
Nan Zhang ◽  
Charles A. Sklar ◽  
Raymond W. Ke ◽  
...  
Keyword(s):  
Positive Predictive Value ◽  
Childhood Cancer ◽  
Predictive Value ◽  
Roc Analysis ◽  
Follicle Stimulating Hormone ◽  
Sperm Concentration ◽  
Inhibin B ◽  
Male Survivors ◽  
Survivors Of Childhood Cancer ◽  
Stimulating Hormone

Purpose Many male survivors of childhood cancer are at risk for azoospermia. Although both the levels of follicle-stimulating hormone (FSH) and inhibin B are correlated with sperm concentration, their ability to predict azoospermia in survivors of childhood cancer remains uncertain. Patients and Methods Semen analysis was performed and serum levels of FSH and inhibin B were measured in 275 adult male survivors of childhood cancer who had received gonadotoxic therapy. Receiver operating characteristic (ROC) analysis was performed to determine the optimal inhibin B and FSH values for identifying patients with azoospermia. The patient sample was divided into a learning set and a validation set. Sensitivity, specificity, and positive and negative predictive value were calculated. Results Inhibin B was dichotomized as ≤ 31 ng/L or more than 31 ng/L and FSH was dichotomized as ≤ 11.5 mIU/mL or more than 11.5 mIU/mL based on results of the ROC analysis. Using these values, the specificity of the serum level of inhibin B for identifying azoospermic survivors was 45.0%, and the positive predictive value was 52.1%. The specificity for FSH was 74.1%, and the positive predictive value was 65.1%. Conclusion Neither serum inhibin B nor FSH is a suitable surrogate for determination of sperm concentration in a semen sample. Young men and their physicians should be aware of the limitations of these measures for assessment of fertility potential.

The Prevalence of Bacteriospermia in Infertile Men and Association with Semen Quality in Southwestern Iran

2020 ◽  
Vol 20 (2) ◽  
pp. 198-202 ◽  
Author(s):  
Mohammad Motamedifar ◽  
Yalda Malekzadegan ◽  
Parisa Namdari ◽  
Behzad Dehghani ◽  
Bahia Namavar Jahromi ◽  
...  
Keyword(s):  
Semen Quality ◽  
Sperm Quality ◽  
Reproductive Function ◽  
World Health ◽  
Public Health Issue ◽  
Control Group ◽  
Microbiological Analysis ◽  
Male Reproductive Function ◽  
Infertile Men ◽  
Southwestern Iran

Introduction: Infertility considered as a social and public health issue and estimated that most of these infertile couples are residents of developing countries. Infectious diseases including the history of Sexually Transmitted Infections (STIs) may impact on male reproductive function. Therefore, the present study aimed to investigate the prevalence of bacterial contaminants of semen and probable association with sperm quality of infertile men in Iranian population. Methods: The study population consisted of 200 infertile men and 150 fertile men attending an infertility Center in southwestern Iran during the study period in 2015. The assessment of sperm parameters was according to the World Health Organization (WHO) guidelines. The presumptive pathogens were identified using standard microbiology tests and confirmed by specific PCR primers. Results: The prevalence of bacteriospermia in the semen of the infertile group was significantly higher than that in the fertile group (48% vs. 26.7%, P <0.001). The microbiological analysis of samples showed that the most abundant species of bacteria in semen of infertile men were Chlamydia trachomatis (12.5%) followed by Neisseria gonorrhoeae (11%). On the other hand, in the control group, Lactobacillus spp. (17.3%) was the most isolated pathogen. Results showed that the presence of N. gonorrhoeae, C. trachomatis, Mycoplasma genitalium, Haemophilus, and Klebsiella was significantly associated with sperm abnormality. Conclusion: Based on our findings, it seems that bacteriospermia is associated with alterations in the properties of semen which may lead to a decrease in the fertilization potential of sperm. Therefore, immediate and appropriate treatment is necessary before investigating every other possible cause of infertility.

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