scholarly journals A Case Report of an Early Response to Definitive Chemoradiation for Esophageal Carcinoma Cuniculatum

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
David E. Long ◽  
Ahmad Al-Hader ◽  
Robert Emerson ◽  
Karen Rieger ◽  
William Graham Carlos ◽  
...  
Keyword(s):  
Case Report ◽  
Esophageal Carcinoma ◽  
Aggressive Behavior ◽  
Clinical Outcomes ◽  
Verrucous Carcinoma ◽  
Locally Advanced ◽  
Early Response ◽  
Definitive Chemoradiation ◽  
Definitive Therapy ◽  
Carcinoma Cuniculatum

This case report describes a 63-year-old female with a locally advanced esophageal carcinoma cuniculatum treated with definitive chemoradiation who had a rapid and early response. This case is illustrative of an aggressive behavior with rapid response and rapid recurrence. The cases of esophageal carcinoma cuniculatum as well as the closely related clinical entity of verrucous carcinoma are reviewed suggesting good clinical outcomes after definitive therapy with chemoradiation and/or surgery.

Rare “Inverted” Verrucous Carcinoma (Carcinoma Cuniculatum) of the Sacrogluteal Region: Case Report and Literature Review

2017 ◽  
Vol 25 (5) ◽  
pp. 438-442 ◽  
Author(s):  
David John Tobias McArdle ◽  
John Patrick McArdle ◽  
Frances Lee ◽  
Emilio Dino Mignanelli
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Verrucous Carcinoma ◽  
Carcinoma Cuniculatum

scholarly journals Buschke-Löwenstein tumor in a human immunodeficiency virus-positive patient : a case report and short literature review

2021 ◽  
Vol 84 (2) ◽  
pp. 343-345
Author(s):  
V Ledouble ◽  
F Sclafani ◽  
A Hendlisz ◽  
M Gomez Galdon ◽  
G Liberale
Keyword(s):  
Human Immunodeficiency Virus ◽  
Case Report ◽  
Verrucous Carcinoma ◽  
Locally Advanced ◽  
Metastatic Potential ◽  
Management Approach ◽  
Optimal Management ◽  
Local Growth ◽  
Immunodeficiency Virus ◽  
Extensive Surgery

Giant condyloma acuminatum, also known as Buschke-Löwenstein tumor, is a rare variant of verrucous carcinoma presenting in the ano-genital region. While its metastatic potential is limited, aggressive local growth is common, with invasion and destruction of the surrounding tissues often causing important therapeutic challenges. Also, data to inform the optimal management approach are scarce and mostly limited to anectodical reports. We present the case of a human immunodeficiency virus-associated locally advanced Buschke Löwenstein tumor that was successfully treated with extensive surgery.

Treatment for locally advanced esophageal carcinoma complicated by fistulas: Case report

1996 ◽  
Vol 1 (3) ◽  
pp. 176-181 ◽  
Author(s):  
Kei Muro ◽  
Atsushi Ohtsu ◽  
Narikazu Boku ◽  
Takahiro Fujii ◽  
Yasushi Oda ◽  
...  
Keyword(s):  
Case Report ◽  
Esophageal Carcinoma ◽  
Locally Advanced

scholarly journals ADC correlation with Sirtuin1 to assess early chemoradiotherapy response of locally advanced esophageal carcinoma patients

2019 ◽  
Vol 14 (1) ◽  
Author(s):  
Ying Chen ◽  
Tieming Xie ◽  
Zhimin Ye ◽  
Fangzheng Wang ◽  
Dan Long ◽  
...  
Keyword(s):  
Esophageal Carcinoma ◽  
Locally Advanced ◽  
Rank Correlation ◽  
Correlation Coefficients ◽  
Roc Curves ◽  
Early Response ◽  
Response To Treatment ◽  
Spearman’S Rank Correlation ◽  
Adc Values ◽  
Magnetic Resonance Imaging Mri

Abstract Aims To determine the biological correlation between apparent diffusion coefficient (ADC) values and Sirtuin1 (SIRT1) levels of tumour tissues in patients with esophageal carcinoma (EC), and to ascertain the treatment biomarker of ADC in predicting the early response of patients undergoing definitive chemoradiotherapy (CRT). Methods A total of 66 patients were enrolled, and the specimens of tumour tissues were collected before treatment to perform immunohistochemical (IHC) examinations and quantify the levels of SIRT1. Then all patients were given two esophageal magnetic resonance imaging (MRI) examinations with diffused weighed imaging (DWI) including pretreatment and intra-treatment (1~2 weeks after the start of radiotherapy). The regions of interest (ROIs) were contoured according to the stipulated rules in advance using off-line software, and the values of the ADC in the ROIs were generated automatically. Then, the values of the ADC at baseline and intra-treatment were labeled as pre-ADC and intra-ADC respectively, and ΔADC, ADCratio were calculated. Pearson’s correlation coefficients were acquired to estimate the correlation between each of ADC values and SIRT1 levels. Spearman’s rank correlation coefficients were acquired to estimate the correlation between early response and the values of each ADC. Receptor operation characteristics (ROC) curves were constructed to estimate the accuracy of the ADC in predicting the early response of CRT. Results The findings of this study showed different correlations between ADC values and the levels of SIRT1 (ΔADC: r = − 0.943, P = 0.002; ADCratio: r = − 0.911, P = 0.000; intra-ADC: r = − 0.748, P = 0.002; pre-ADC: r = 0.109, P = 0.558). There was a positive correlation between ΔADC and early response to treatment (ρ = 0.615, P = 0.023), and multivariable logistic regression revealed that ΔADC was significantly associated with short-term response of CRT in esophageal carcinoma patients. Conclusions In summary, early increases in ADC may facilitate the predication of early CRT response in patients with esophageal squamous cell carcinoma (ESCC), which may be attributed to the different correlation between ADC changes and SIRT1 expression.

Treatment of locally advanced esophageal carcinoma with induction cisplatin-paclitaxel-5FU (PTF) before local therapy

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 15174-15174
Author(s):  
R. Fernandez-Rodriguez ◽  
N. Ancizar ◽  
G. Lopez de Argumedo ◽  
A. Ruiz de Lobera ◽  
G. Lopez Vivanco ◽  
...  
Keyword(s):  
Esophageal Carcinoma ◽  
Locally Advanced ◽  
Local Therapy ◽  
Stage At Diagnosis ◽  
Toxicity Profile ◽  
Survival Curves ◽  
Definitive Therapy ◽  
Related Response ◽  
Fistula Treatment ◽  
Gastrostomy Complications

15174 Background: We analyse induction therapy with PTF before local definitive therapy in terms of response, resectability, toxicity and survival. Methods: Patients (pts) with locally advanced esophageal carcinoma were included. Treatment: Paclitaxel 175 mg/m2 and CDDP 75 mg/m2 on day 1 and 5FU 800 mg/m2/day, days 1–4, every 21 days. After 2–3 cycles surgery is considered. If unresectable, Radiotherapy (64 Gy) and concomitant Carboplatin (60 mg/m2, d 1–5 during 1st and 4th week of RT) are planned. Results: From May-02 to October-06 31 pts were treated (28M, 3F) Age: 55 (32–70) PS 0–1: 6–25. Location: Upper 10, Middle 13, Distal 7, Whole 1. Pathology: Squamous 29, Adenocarcinoma 2. T3/4:14/17 N0/1:8/23 M1a: 3. Weight loss >10 kg 12 pts. 87 cycles have been delivered. Range: 2–4. Mean 2,83. Median 3. Toxicity (episodes): hematological 3/4: no episodes. Emesis 3: 2. Mucositis 3: 2. Asthenia 2/3: 8. 2 pts died in remission due to gastrostomy complications and esophago-tracheal fistula, treatment related. Response: CR 5, PR 9, SD 13, PD 4. Treatment after PTF: Surgery 10 pts (1 upper, 5 middle, 4 distal). 1 distal unresectable at surgery, 2 middle not resected because of liver cirrhosis and liver metastases at surgery. pCR: 1. pPR 6 (R0: 3, R1: 3) Chemoradiation with concomitant Carboplatin: 19, making 3 SD in PR, 2 PR in CR and 1 SD in CR. One PR and 4 SD progressed after chemoradiation. Progression: 21 (local 7, systemic 7, both 7). Died: 19 (16 of disease, 2 of complications of gastrostomy, 1 unrelated) Median PFS: 48,28 weeks (95% CI 32,80 - 63,77). Median OS: 51,14 weeks (95% CI 28,81 - 73,47). Conclusions: This schedule has a good toxicity profile. Surgical rescue is possible in almost a half of middle and distal tumours. Chemoradiation is the best approach for unresectable tumours. Considering stage at diagnosis, survival curves are promising. No significant financial relationships to disclose.

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