scholarly journals Tumor Volume Kinetic Analyses Might Explain Excellent Prognoses in Young Patients with Papillary Thyroid Carcinoma

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Toshihiko Kasahara ◽  
Akira Miyauchi ◽  
Yasuhiro Ito ◽  
Takumi Kudo ◽  
Hiroo Masuoka ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Tumor Growth ◽  
Cancer Cell ◽  
Tumor Volume ◽  
Advanced Disease ◽  
Young Patients ◽  
Papillary Thyroid ◽  
Volume Doubling ◽  
Single Cancer

Introduction. Young patients with papillary thyroid carcinoma (PTC) generally have excellent prognoses despite their often-advanced disease status. The reasons for this excellent prognosis are poorly understood. Objective. To investigate the natural history of PTC in young patients, we compared the observed tumor volume-doubling rate (TV-DR) with the hypothetical tumor volume-doubling rate (hTV-DR) before presentation in young PTC patients. DR is an inverse of the doubling time and indicates the number of doublings that occur in a unit of time. A negative value indicates the number of times the volume is reduced by half per unit time. Methods. We enrolled 20 patients with the following characteristics: age ≤19 years, diagnosed with PTC according to the cytology results between 2013 and 2018 and followed-up with periodical ultrasound examinations for ≥3 months before surgery for various reasons. Seventeen patients later underwent surgery confirming the diagnosis. We calculated TV-DRs using serial measurements of tumor diameters after presentation and hTV-DRs using tumor diameters and patients’ age at presentation, assuming that a single cancer cell was present at the patient’s birth and that the tumor grew at a constant rate. These values indicate the lowest growth rates necessary for a single cancer cell to achieve the full tumor size at presentation. Results. Thirteen patients had positive TV-DRs (/year) ranging from 0.09 to 1.89, indicating tumor growth, and the remaining seven patients had negative values (−0.08 to −1.21), indicating regression. The median TV-DR was 0.29. The hTV-DRs (1.48–2.66, median 1.71) were significantly larger than the TV-DRs (p<0.001), indicating much faster growth before presentation. Conclusions. These data suggest that deceleration of tumor growth had already occurred at presentation in the majority of the cases. This might explain why disease-specific survival is excellent despite frequent findings of advanced disease in young patients with PTC.

scholarly journals Spontaneous Slowing and Regressing of Tumor Growth in Childhood/Adolescent Papillary Thyroid Carcinomas Suggested by the Postoperative Thyroglobulin-Doubling Time

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Toshihiko Kasahara ◽  
Akira Miyauchi ◽  
Takumi Kudo ◽  
Eijun Nishihara ◽  
Mitsuru Ito ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Doubling Time ◽  
Tumor Volume ◽  
Young Patients ◽  
Papillary Thyroid ◽  
Thyroid Carcinomas ◽  
Volume Doubling Time ◽  
Age At Surgery ◽  
Volume Doubling ◽  
Single Cancer

Background. Children and adolescents with papillary thyroid carcinomas (PTCs) have generally excellent prognoses despite their frequent extended disease. The tumor growth of young patients’ PTCs might show spontaneous slowing postoperatively. We compared young PTC patients’ postoperative thyroglobulin-doubling time (Tg-DT) with their preoperative hypothetical tumor volume-doubling time (hTV-DT). Methods. Fourteen PTC patients aged ≤18 years who underwent total thyroidectomy at Kuma Hospital in 1998–2016 had biochemically persistent disease postoperatively. We calculated their Tg-DTs and estimated their preoperative TV-DTs with the tumor size and the patient’s age at surgery, presuming that a single cancer cell was present at the patient’s birth. Results. Twelve patients had positive Tg-DTs ranging from 2.0 to 147 years, and the remaining two had negative Tg-DTs, indicating slow growth or even regression. The hTV-DTs were 0.3–0.6 years (median 0.5 years), which were significantly shorter than the Tg-DTs (p<0.001), indicating much faster growth preoperatively. The analyses of the nine patients without radioactive iodine administration (RAI) gave similar results (p<0.01). Conclusions. Irrespective of RAI, the patients’ postoperative Tg-DTs were significantly longer than their preoperative hTV-DTs and were negative values in two patients, indicating that the growth of these young patients’ PTCs had spontaneously slowed or even regressed postoperatively.

Tumor Volume Doubling Time in Active Surveillance of Papillary Thyroid Carcinoma

Thyroid ◽  
2019 ◽  
Vol 29 (5) ◽  
pp. 642-649 ◽  
Author(s):  
Hye-Seon Oh ◽  
Hyemi Kwon ◽  
Eyun Song ◽  
Min Ji Jeon ◽  
Tae Yong Kim ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Active Surveillance ◽  
Doubling Time ◽  
Tumor Volume ◽  
Papillary Thyroid ◽  
Tumor Volume Doubling Time ◽  
Volume Doubling Time ◽  
Volume Doubling

miR-182 targets CHL1 and controls tumor growth and invasion in papillary thyroid carcinoma

2014 ◽  
Vol 450 (1) ◽  
pp. 857-862 ◽  
Author(s):  
Hongling Zhu ◽  
Jin Fang ◽  
Jichen Zhang ◽  
Zefei Zhao ◽  
Lianyong Liu ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Tumor Growth ◽  
Papillary Thyroid ◽  
Tumor Growth And Invasion

scholarly journals Management of Papillary Carcinoma of Thyroid with Pulmonary Metastases in Institute of Nuclear Medicine and Allied Sciences, Rajshahi – Two Case Reports

2018 ◽  
Vol 18 (2) ◽  
pp. 179-182
Author(s):  
Md Kabiruzzaman Shah ◽  
Nasrin Begum ◽  
Mosharof Hossain ◽  
Parvez Ahmed ◽  
Sariful Islam Chawdhuary ◽  
...  
Keyword(s):  
Nuclear Medicine ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Papillary Carcinoma ◽  
Radioactive Iodine ◽  
Pulmonary Metastases ◽  
Case Reports ◽  
Young Patients ◽  
Radioactive Iodine Therapy ◽  
Papillary Thyroid

Papillary thyroid carcinoma with pulmonary metastasis is relatively uncommon which can be treated with radioactive iodine therapy. Here, our experiences with two cases of papillary thyroid carcinoma with pulmonary metastases in young patients are discussed.Bangladesh J. Nuclear Med. 18(2): 179-182, July 2015

scholarly journals Solid papillary thyroid carcinoma with Hashimoto’s thyroiditis: description of a further case with challenging cytological features

2019 ◽  
Vol 12 (1) ◽  
pp. e226153
Author(s):  
Franco Fulciniti ◽  
Jessica Barizzi ◽  
Pierpaolo Trimboli ◽  
Luca Giovanella
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Survival Data ◽  
Hashimoto’S Thyroiditis ◽  
Young Patients ◽  
Hashimoto's Thyroiditis ◽  
Papillary Thyroid ◽  
Dismal Prognosis ◽  
History Of ◽  
Ionising Radiations

Solid papillary thyroid carcinoma (SV-PTC) is a rare variant which is mainly observed in young patients with a history of exposure to ionising radiations. Neoplasms belonging to such category generally carry RET-PTC (REarranged during Transfection- Papillary Thyroid Carcinoma) fusions and seem to have a slightly worse prognosis with respect to classical and follicular variants of papillary thyroid carcinoma (PTC), though consistent prognostic and survival data are scarce. SV-PTC should be differentiated from trabecular-insular poorly differentiated thyroid carcinomas, which occur in a different age group and carry a dismal prognosis. These latter tumours do not show the typical nuclear features of PTC and show tumour necrosis with an high mitotic activity. In this report a further case of SV-PTC is described which was associated to Hashimoto’s thyroiditis, a finding never described in the cytological literature up to now for SV-PTC; this association created further differential diagnostic problems. The neoplasm displayed RET-PTC1 fusion.

scholarly journals A High Percentage of BRAFV600E Alleles in Papillary Thyroid Carcinoma Predicts a Poorer Outcome

2012 ◽  
Vol 97 (7) ◽  
pp. 2333-2340 ◽  
Author(s):  
Anna Guerra ◽  
Laura Fugazzola ◽  
Vincenzo Marotta ◽  
Massimo Cirillo ◽  
Stefania Rossi ◽  
...  
Keyword(s):  
Lymph Node ◽  
Papillary Thyroid Carcinoma ◽  
Lymph Node Metastasis ◽  
Thyroid Carcinoma ◽  
Tumor Volume ◽  
Disease Outcome ◽  
Clinicopathological Parameters ◽  
Papillary Thyroid ◽  
Node Metastasis ◽  
Mutant Braf

Abstract Context: BRAFV600E is considered a negative prognostic marker in papillary thyroid carcinoma (PTC), but unexplained conflicting results are present in the literature. In light of the new finding that most PTC consist of a mixture of tumor cells with wild-type and mutant BRAF, we examined the associations between the percentage of BRAFV600E alleles and both the clinicopathological parameters at time of diagnosis and the disease outcome in a large series of PTCs. Study Design: Tumors from 168 patients with PTC were genotyped for BRAFV600E using BigDye Terminator sequencing and pyrosequencing, and the clinical parameters were analyzed. The associations between clinicopathological characteristics, including disease recurrence at follow-up (median 5.1 yr) and the percentage of mutant BRAF alleles were assessed. Results: The observed prevalence of BRAFV600E was higher when using pyrosequencing then when using BigDye Terminator sequencing (53.6 vs. 36.9%). In the PTC positive for BRAFV600E, the percentage of mutant alleles ranged from 5.1 to 44.7% of the total BRAF alleles, with a median of 20.6%. The presence or the percentage of BRAFV600E alleles did not correlate significantly with sex, multicentricity, lymph node metastasis, or tumor stage. The percentage of BRAFV600E alleles directly correlated with age at diagnosis and tumor volume (R2 = 0.223, P = 0.039, and R2 = 0.166, P &lt; 0.001, respectively). The percentage of BRAFV600E alleles (P = 0.014), tumor volume (P = 0.012), and lymph node metastasis (P = 0.008) predicted the disease outcome. The odds ratio of recurrence for PTC with BRAFV600E alleles of 30% or greater, compared with that for PTC with BRAFV600E alleles of less than 30%, was 5.31 (P = 0.002). Conclusions: A high percentage of BRAFV600E alleles defines a PTC molecular subtype and predicts a poorer disease outcome. The analysis of BRAF mutations by pyrosequencing is useful to refine the risk stratification of patients with PTC.

scholarly journals Unique patterns of tumor growth related with the risk of lymph node metastasis in papillary thyroid carcinoma

2010 ◽  
Vol 23 (9) ◽  
pp. 1201-1208 ◽  
Author(s):  
Chan-Kwon Jung ◽  
Yoon-Goo Kang ◽  
Ja-Seong Bae ◽  
Dong-Jun Lim ◽  
Yeong-Jin Choi ◽  
...  
Keyword(s):  
Lymph Node ◽  
Papillary Thyroid Carcinoma ◽  
Lymph Node Metastasis ◽  
Thyroid Carcinoma ◽  
Tumor Growth ◽  
Papillary Thyroid ◽  
Node Metastasis
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