scholarly journals Physicochemical Characterization of Grewia ferruginea Hochst. ex A. Rich Mucilage for Potential Use as a Pharmaceutical Excipient

2020 ◽  
Vol 2020 ◽  
pp. 1-10 ◽  
Author(s):  
Tsadkan Gebremeskel Haile ◽  
Gereziher Gebremedhin Sibhat ◽  
Fantahun Molla
Keyword(s):  
Flow Behavior ◽  
Sorption Property ◽  
Physicochemical Characterization ◽  
Moisture Sorption ◽  
Pharmaceutical Formulations ◽  
Flow Property ◽  
Microbial Load ◽  
Oral Toxicity ◽  
Pharmaceutical Excipient ◽  
Potential Use

Gum and mucilages from natural sources are in recent times increasingly investigated for pharmaceutical applications. Different studies have shown that the gum and mucilage fraction of various species of the genus Grewia were found to be effective viscosity enhancers, stabilizers, disintegrants, suspending agents, gelling agents, bioadhesives, film coating agents, and binders. However, no study has been conducted on the potential use of Grewia ferruginea mucilage (GFM) as a pharmaceutical excipient. Therefore, this study was aimed at characterizing the Grewia ferruginea bark mucilage for its potential use as a pharmaceutical excipient. The mucilage was extracted from the Grewia ferruginea inner stem bark through aqueous extraction, precipitated with 96% ethanol, dried, and powdered. The powdered mucilage was characterized for different physicochemical properties such as powder property, loss on drying, solubility and swelling index, ash value, pH, viscosity, moisture sorption property, microbial load, and acute oral toxicity. According to the results, the percentage yield of the final dried and powdered GFM was found to be 11.96% (w/w). The density and density-related properties of the mucilage showed good powder flow property. The GFM exhibited pseudoplastic flow behavior. Moisture sorption property of GFM revealed its hygroscopic nature, and its solubility and swelling property was increased with temperature. The pH of GFM was near neutral. Microbial load of the mucilage was within the pharmacopoeial limit, and the oral acute toxicity test revealed that the mucilage is safe up to 2000 mg/kg. From the investigations of this study, it can be concluded that Grewia ferruginea bark mucilage has the potential to be utilized as an excipient in pharmaceutical formulations.

scholarly journals Extraction, Characterization, and Molecular Weight Determination ofSenna tora(L.) Seed Polysaccharide

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Harshal A. Pawar ◽  
K. G. Lalitha
Keyword(s):  
Molecular Weight ◽  
Intrinsic Viscosity ◽  
Flow Behavior ◽  
Average Molecular Weight ◽  
Flow Property ◽  
Stability Study ◽  
Angle Of Repose ◽  
Molecular Weight Determination ◽  
Pharmaceutical Excipient ◽  
Accelerated Stability

The objective of the present work was extraction of polysaccharide fromSenna toraL. seed and its characterization as a pharmaceutical excipient. Polysaccharide extraction was based on mechanical separation of the endosperm of seeds ofSenna tora, water dissolution, centrifugation, and precipitation with acetone. Standard procedures were used to study the viscosity, micromeritic properties, and microbial bioburden. Accelerated stability study was carried out on isolated polysaccharide for six months at 40°C/75 RH as per ICH guidelines. The gum obtained fromS. toraseeds was an amorphous free flowing odourless powder with dull brown colour (yield = 35% w/w). The bulk density, tapped density, and angle of repose data reveal thatS. toragum possesses good flow property. The intrinsic viscosity obtained was 1.568 dL/g. The average molecular weight of purifiedS. toragum was found to be 198 kDa by intrinsic viscosity method. The results indicated that viscosity of gum solution increases with increase in temperature. FTIR study revealed the absence of degradation or decomposition of polysaccharide at accelerated stability conditions for six months. It has been concluded that extracted polysaccharide can be used as pharmaceutical excipient in terms of flow behavior, microbial properties, and stability.

scholarly journals Applicability of Cork as Novel Modifiers to Develop Electrochemical Sensor for Caffeine Determination

Materials ◽  
2020 ◽  
Vol 14 (1) ◽  
pp. 37
Author(s):  
Mayra K. S. Monteiro ◽  
Djalma R. Da Silva ◽  
Marco A. Quiroz ◽  
Vítor J. P. Vilar ◽  
Carlos A. Martínez-Huitle ◽  
...  
Keyword(s):  
Electrochemical Sensor ◽  
Linear Response ◽  
High Performance ◽  
Low Cost ◽  
Pharmaceutical Formulations ◽  
Caffeine Concentration ◽  
Real Samples ◽  
Wide Range ◽  
Potential Use

This study aims to investigate the applicability of a hybrid electrochemical sensor composed of cork and graphite (Gr) for detecting caffeine in aqueous solutions. Raw cork (RAC) and regranulated cork (RGC, obtained by thermal treatment of RAC with steam at 380 °C) were tested as modifiers. The results clearly showed that the cork-graphite sensors, GrRAC and GrRGC, exhibited a linear response over a wide range of caffeine concentration (5–1000 µM), with R2 of 0.99 and 0.98, respectively. The limits of detection (LOD), estimated at 2.9 and 6.1 µM for GrRAC and GrRGC, suggest greater sensitivity and reproducibility than the unmodified conventional graphite sensor. The low-cost cork-graphite sensors were successfully applied in the determination of caffeine in soft drinks and pharmaceutical formulations, presenting well-defined current signals when analyzing real samples. When comparing electrochemical determinations and high performance liquid chromatography measurements, no significant differences were observed (mean accuracy 3.0%), highlighting the potential use of these sensors to determine caffeine in different samples.

Differential Scanning Calorimetric Analysis for Incompatibility: Sodium Stearate/Magnesium Stearate and Acidic Compounds

2020 ◽  
Vol 859 ◽  
pp. 307-312
Author(s):  
Pornsit Chaiya ◽  
Thawatchai Phaechamud
Keyword(s):  
Sodium Stearate ◽  
Pharmaceutical Formulations ◽  
Pharmaceutical Compounds ◽  
Magnesium Stearate ◽  
Differential Scanning Calorimetric ◽  
Salt Form ◽  
Scanning Calorimetry ◽  
Calorimetric Analysis ◽  
Pharmaceutical Excipient ◽  
Acidic Compounds

Compatibility investigation was performed between stearate lubricants (sodium stearate and magnesium stearate) and acidic pharmaceutical compounds (ibuprofen, indomethacin and valproic acid) and citric acid as acidic pharmaceutical excipient using differential scanning calorimetry (DSC). Alteration in DSC thermogram was found in all mixtures. There was a presence of melting endothermic peak of stearic acid in all mixtures (except that of stearate lubricants and indomethacin) indicating breakage of salt form of stearate lubricants depended on the physicochemical properties of drug compounds and pharmaceutical excipient. Therefore, the avoidance for using stearate lubricants with acidic pharmaceutical compounds and excipient should be concerned in development of pharmaceutical formulations.

scholarly journals Surface Morphology and Physicochemical Characterization of Thermostable Moringa Gum: A Potential Pharmaceutical Excipient

ACS Omega ◽  
2020 ◽  
Vol 5 (45) ◽  
pp. 29189-29198
Author(s):  
Swati Gupta ◽  
Sumita Kachhwaha ◽  
SL Kothari ◽  
Manoj Kumar Bohra ◽  
Rohit Jain
Keyword(s):  
Surface Morphology ◽  
Physicochemical Characterization ◽  
Pharmaceutical Excipient

Tailoring Magnetic Microspheres with Controlled Porosity

2006 ◽  
Vol 969 ◽  
Author(s):  
Muhammet S Toprak ◽  
Brandon J McKenna ◽  
Herb Waite ◽  
Galen D Stucky
Keyword(s):  
Drug Delivery ◽  
Physicochemical Characterization ◽  
Single Step ◽  
Magnetic Microspheres ◽  
Toxicity Tests ◽  
Complex Coacervation ◽  
Confocal Fluorescence ◽  
Controlled Porosity ◽  
Drug Delivery Devices ◽  
Potential Use

AbstractThe synthesis of organic and inorganic nano- and microspheres has attracted much interest for a variety of applications ranging from drug delivery to chemical storage and catalysis. We recently demonstrated the assembly of magnetic nanoparticles and polycations into hybrid microspheres in a single-step synthesis via complex coacervation. These microspheres showed viability for bio-applications as indicated by toxicity tests, and are therefore potential targeted drug delivery devices, as they can be directed magnetically. This work reports the recent progress on the potential use of these assemblies in drug release by controlling their porosity. Fluorescein tagged dextran molecules with different MW have been infiltrated into these entities to determine critical pore size by confocal fluorescence microscopy. Different physicochemical characterization results are also presented.

Occurrences of kaolin in Koutaba (west Cameroon): Mineralogical and physicochemical characterization for use in ceramic products

Clay Minerals ◽  
2015 ◽  
Vol 50 (5) ◽  
pp. 593-606 ◽  
Author(s):  
A. Nkalih Mefire ◽  
A. Njoya ◽  
R. Yongue Fouateu ◽  
J.R. Mache ◽  
N.A. Tapon ◽  
...  
Keyword(s):  
Particle Size ◽  
Chemical Composition ◽  
Thermogravimetric Analysis ◽  
Raw Materials ◽  
Physicochemical Characterization ◽  
X Ray Diffraction ◽  
X Ray ◽  
Ball Clays ◽  
Potential Use ◽  
Representative Samples

AbstractThirty clay samples collected from three hills in Koutaba (west Cameroon) were characterized in order to evaluate their potential use as raw materials for ceramics. After preliminary mineralogical identification by X-ray diffraction, three representative samples from the three different hills, referred to hereafter as K1M, K2M and K3M, were selected for further investigation by X-ray fluorescence, plasticity, granularity and thermogravimetric analysis. The main clay minerals are kaolinite (32–51%) and illite (up to 12%). Additional major phases are quartz (32–52%), goethite (6–7%) and feldspars (0–4%). The chemical composition showed variable amounts of SiO2(60–72%), Al2O3(15–20%) and Fe2O3(1–9%), in accordance with the quartz abundance in all of the samples studied. The particle-size distribution showed a large proportion of silty fraction (64–88%) with moderate sandy (9–19%) and clayey fractions ( < 5% for K2M, 12% for K1M and 20% for K3M). All of the clays showed moderate plasticity-index values (8–11%). Because of these characteristics, K1M and K3M may be suitable for use in common bricks and hollow ceramic products. Sieving or the addition of ball clays is recommended to increase the plasticity of sample K2M for use in common bricks.

scholarly journals Flow behavior and physicochemical characterization of peach pulps

2012 ◽  
pp. 107-116
Author(s):  
Ernesto Muñoz Puntes ◽  
Luis A. Rubio ◽  
María S. Cabeza
Keyword(s):  
Flow Behavior ◽  
Physicochemical Characterization
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