scholarly journals Fruit and Vegetable Intake and the Risk of Chronic Obstructive Pulmonary Disease: A Dose-Response Meta-Analysis of Observational Studies

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Hongrui Zhai ◽  
Yu Wang ◽  
Wenjie Jiang
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Dose Response ◽  
Vegetable Intake ◽  
Meta Analysis ◽  
Fruit And Vegetable Intake ◽  
Chronic Obstructive ◽  
Response Relationship ◽  
Fruit And Vegetable ◽  
Dose Response Relationship ◽  
Obstructive Pulmonary Disease

Object. Results on the associations of fruit and vegetable intake with risk of chronic obstructive pulmonary disease (COPD) are still in conflict. Hence, we conducted a meta-analysis to quantitatively evaluate the association between fruit and vegetable intake and the risk of COPD. Methods. PubMed, Web of Science, and China National Knowledge Infrastructure (CNKI) were searched for relevant studies published up to September 2019. Combined relative risks (RRs) and 95% confidence intervals (CIs) were calculated with the random effects model (REM). Dose-response relationship was assessed by the restricted cubic spline model. Results. There are 8 studies involving 5,787 COPD cases among 244,154 participants included in this meta-analysis. For the highest versus the lowest level, the pooled RR of COPD was 0.75 (95% CI, 0.68–0.84; I2 = 46.7%) for fruits plus vegetables, 0.72 (95% CI, 0.66–0.79; I2 = 1.3%) for fruits, and 0.76 (95% CI, 0.63–0.92; I2 = 62.7%) for vegetables. In subgroup analysis of fruit plus vegetable intake and COPD risk, the inverse association exists in all three study designs. A nonlinear dose-response relationship was found for COPD risk with fruit (Pnon−linearity<0.01). Conclusions. This meta-analysis indicates that fruit and vegetable intake might be related to a lower risk of COPD.

scholarly journals Inhaled Corticosteroids and the Pneumonia Risk in Patients With Chronic Obstructive Pulmonary Disease: A Meta-analysis of Randomized Controlled Trials

2021 ◽  
Vol 12 ◽  
Author(s):  
Hong Chen ◽  
Jian Sun ◽  
Qiang Huang ◽  
Yongqi Liu ◽  
Mengxin Yuan ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Inhaled Corticosteroids ◽  
Chronic Obstructive ◽  
Controlled Trials ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Obstructive Pulmonary Disease ◽  
Randomized Controlled ◽  
Copd Patients ◽  
Baseline Characteristics

Background: Whether all types of inhaled corticosteroids (ICSs) would increase the pneumonia risk in patients with chronic obstructive pulmonary disease (COPD) remains controversial. We aimed to assess the association between ICSs treatment and pneumonia risk in COPD patients, and the impact of medication details and baseline characteristics of patients on the association.Methods: Four databases (PubMed, Embase, Cochrane Library, and Clinical Trials.gov) were searched to identify eligible randomized controlled trials (RCTs) comparing ICSs treatment with non-ICSs treatment on the pneumonia risk in COPD patients. Pooled results were calculated using Peto odds ratios (Peto ORs) with corresponding 95% confidence intervals (CIs).Results: A total of 59 RCTs enrolling 103,477 patients were analyzed. All types of ICSs significantly increased the pneumonia risk (Peto OR, 1.43; 95% CI, 1.34–1.53). Subgroup analysis showed that there was a dose-response relationship between ICSs treatment and pneumonia risk (low-dose: Peto OR, 1.33; 95% CI, 1.22–1.45; medium-dose: Peto OR, 1.50; 95% CI, 1.28–1.76; and high-dose: Peto OR, 1.64; 95% CI, 1.45–1.85). Subgroup analyses based on treatment durations and baseline characteristics (severity, age, and body mass index) of patients were consistant with the above results. Subgroup analysis based on severity of pneumonia showed that fluticasone (Peto OR, 1.75; 95% CI, 1.44–2.14) increased the risk of serious pneumonia, while budesonide and beclomethasone did not.Conclusions: ICSs treatment significantly increased the risk of pneumonia in COPD patients. There was a dose-response relationship between ICSs treatment and pneumonia risk. The pneumonia risk was related with COPD severity.

Abstract P224: Higher Fruit and Vegetable Intake Was Associated With Lower Total and Cause-Specific Mortality in a Nonlinear Dose-Response Manner

Circulation ◽  
2018 ◽  
Vol 137 (suppl_1) ◽  
Author(s):  
Dong D Wang ◽  
Shilpa N Bhupathiraju ◽  
Yanping Li ◽  
Bernard A Rosner ◽  
Qi Sun ◽  
...  
Keyword(s):  
Dose Response ◽  
Fruits And Vegetables ◽  
Vegetable Intake ◽  
Total Mortality ◽  
Fruit And Vegetable Intake ◽  
Fruit And Vegetable ◽  
Dose Response Relationship ◽  
Disease Mortality ◽  
Specific Mortality

Introduction: The strength and dose-response relationship between fruit and vegetable intake and mortality are still subjects of debate. Hypothesis: We hypothesized that higher fruit and vegetable intake was associated with lower total and cause-specific mortality in a nonlinear dose-response manner. Methods: We followed 66,719 women from the Nurses’ Health Study (1984-2012) and 42,016 men from the Health Professionals Follow-up Study (1986-2012) who were free from cardiovascular disease (CVD), cancer and diabetes at baseline. Diet was assessed using food frequency questionnaires at baseline and updated every 2 to 4 years. Results: Our study documented 28,333 deaths during follow-up. The 3rd quintile of fruit and vegetable intake was associated with the lowest hazard ratio (HR) of total mortality (HR, 0.87, 95% CI, 0.83-0.90, P nonlinear <0.001) compared to the 1st quintile. The nonlinear dose-response relationship plateaued at about 5 servings/day (svg/d), but above that level, higher intake was not associated with additional risk reduction. We found similar nonlinear associations for CVD, cancer and respiratory disease mortality. Compared to fruit and vegetable intake <1.5 svg/d, the intake level ≥5 svg/d was associated with HRs (95% CI) of 0.84 (0.75-0.93), 0.82 (0.72-0.93) and 0.55 (0.44-0.67) for cancer, CVD and respiratory disease mortality, respectively. Among individual fruits and vegetables, the associations of intakes with mortality were heterogeneous. Higher intakes of most fruit and vegetable subgroups were associated with lower total mortality, whereas higher intake of starchy vegetable such as peas and corn was not associated with total mortality. Conclusions: Higher fruit and vegetable intake was associated with lower mortality; the lowest mortality was observed among those who consumed 5 servings of fruit and vegetables per day (2 servings of fruit and 3 servings of vegetables daily). Our findings also suggest the presence of heterogeneity in the health benefits of individual fruits and vegetables.

scholarly journals Comparative validity of vitamin C and carotenoids as indicators of fruit and vegetable intake: a systematic review and meta-analysis of randomised controlled trials

2015 ◽  
Vol 114 (9) ◽  
pp. 1331-1340 ◽  
Author(s):  
Mary Pennant ◽  
Marinka Steur ◽  
Carmel Moore ◽  
Adam Butterworth ◽  
Laura Johnson
Keyword(s):  
Vitamin C ◽  
Dose Response ◽  
Vegetable Intake ◽  
Meta Analysis ◽  
Fruit And Vegetables ◽  
Fruit And Vegetable Intake ◽  
Fruit And Vegetable ◽  
Post Intervention ◽  
Blood Concentrations ◽  
Evidence Quality

AbstractCirculating vitamin C and carotenoids are used as biomarkers of fruit and vegetable intake in research, but their comparative validity has never been meta-analysed. PubMed, EMBASE, CENTRAL, CINAHL and Web of Science were systematically searched up to December 2013 for randomised trials of different amounts of fruit and vegetable provision on changes in blood concentrations of carotenoids or vitamin C. Reporting followed PRISMA guidelines. Evidence quality was assessed using the GRADE system. Random effects meta-analysis combined estimates and meta-regression tested for sub-group differences. In all, nineteen fruit and vegetable trials (n1382) measured at least one biomarker, of which nine (n667) included five common carotenoids and vitamin C. Evidence quality was low and between-trial heterogeneity (I2) ranged from 74 % for vitamin C to 94 % forα-carotene. Groups provided with more fruit and vegetables had increased blood concentrations of vitamin C,α-carotene,β-carotene,β-cryptoxanthin and lutein but not lycopene. However, no clear dose–response effect was observed. Vitamin C showed the largest between-group difference in standardised mean change from the pre-intervention to the post-intervention period (smd0·94; 95 % CI 0·66, 1·22), followed by lutein (smd0·70; 95 % CI 0·37, 1·03) andα-carotene (smd0·63; 95 % CI 0·25, 1·01), but all CI were overlapping, suggesting that none of the biomarkers responded more than the others. Therefore, until further evidence identifies a particular biomarker to be superior, group-level compliance to fruit and vegetable interventions can be indicated equally well by vitamin C or a range of carotenoids. High heterogeneity and a lack of dose–response suggest that individual-level biomarker responses to fruit and vegetables are highly variable.

Fruit and vegetable intake and risk of frailty: A systematic review and dose response meta-analysis

2021 ◽  
Vol 71 ◽  
pp. 101460
Author(s):  
Seyed Mojtaba Ghoreishy ◽  
Farzaneh Asoudeh ◽  
Ahmad Jayedi ◽  
Hamed Mohammadi
Keyword(s):  
Systematic Review ◽  
Dose Response ◽  
Vegetable Intake ◽  
Meta Analysis ◽  
Fruit And Vegetable Intake ◽  
Fruit And Vegetable
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