scholarly journals Statistical Characteristics of the First Passage Time Analysis for the Gene Regulatory Circuit in Bacillus subtilis by Cell Mapping Method

Complexity ◽  
2020 ◽  
Vol 2020 ◽  
pp. 1-10 ◽  
Author(s):  
Liang Wang ◽  
Minjuan Yuan ◽  
Shichao Ma ◽  
Xiaole Yue ◽  
Ying Zhang

In this paper, we will explore the stochastic exit problem for the gene regulatory circuit in B. subtilis affected by colored noise. The stochastic exit problem studies the state transition in B. subtilis (from competent state to vegetative state in this case) through three different quantities: the probability density function of the first passage time, the mean of first passage time, and the reliability function. To satisfy the Markov nature, we convert the colored noise system into the equivalent white noise system. Then, the stochastic generalized cell mapping method can be used to explore the stochastic exit problem. The results indicate that the intensity of noise and system parameters have the effect on the transition from competent to vegetative state in B. subtilis. In addition, the effectiveness of the stochastic generalized cell mapping method is verified by Monte Carlo simulation.

2016 ◽  
Vol 2016 ◽  
pp. 1-8
Author(s):  
Djilali Ait-Aoudia

This paper investigates the two-sided first exit problem for a jump process having jumps with rational Laplace transform. The corresponding boundary value problem is solved to obtain an explicit formula for the first passage functional. Also, we derive the distribution of the first passage time to two-sided barriers and the value at the first passage time.


2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Yuzhen Wen ◽  
Chuancun Yin

We consider the two-sided first-exit problem for a jump process having jumps with rational Laplace transform. We derive the joint distribution of the first passage time to two-sided barriers and the value of process at the first passage time. As applications, we present explicit expressions of the dividend formulae for barrier strategy and threshold strategy.


1980 ◽  
Vol 45 (3) ◽  
pp. 777-782 ◽  
Author(s):  
Milan Šolc

The establishment of chemical equilibrium in a system with a reversible first order reaction is characterized in terms of the distribution of first passage times for the state of exact chemical equilibrium. The mean first passage time of this state is a linear function of the logarithm of the total number of particles in the system. The equilibrium fluctuations of composition in the system are characterized by the distribution of the recurrence times for the state of exact chemical equilibrium. The mean recurrence time is inversely proportional to the square root of the total number of particles in the system.


Author(s):  
Natalie Packham ◽  
Lutz Schloegl ◽  
Wolfgang M. Schmidt

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