scholarly journals Severe Hyponatremia-Induced Stress Cardiomyopathy: A Case Report and Review of Literature

2020 ◽  
Vol 2020 ◽  
pp. 1-3 ◽  
Author(s):  
Irushna Perera ◽  
Sanjeewa Rajapakse ◽  
Shamila T. De Silva
Keyword(s):  
Myocardial Ischemia ◽  
Plaque Rupture ◽  
Stress Cardiomyopathy ◽  
Review Of Literature ◽  
Severe Hyponatremia ◽  
Ischemic Disease ◽  
Cardiac Blood ◽  
Induced Stress ◽  
Vascular Spasm ◽  
Underlying Pathophysiology

Takotsubo or stress cardiomyopathy is a non ischemic disease affecting the myocardium, which presents with typical features of myocardial ischemia. Although the presentation with acute central chest pain and shortness of breath mimics acute myocardial ischemia, there is an absence of actual disruption of cardiac blood supply via the coronaries due to acute plaque rupture or vascular spasm. The underlying pathophysiology of this clinical entity remains largely unclear, but a definite association with physical or emotional stress has been well established, hence the term “stress cardiomyopathy.” The list of potential triggers continues to grow as the disorder is increasingly detected by clinicians and cardiologists, with better clinical insight and improved availability of cardiac investigations. We report a patient with Takotsubo cardiomyopathy associated with severe hyponatremia.

scholarly journals Copy number variants implicate cardiac function and development pathways in earthquake-induced stress cardiomyopathy

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Cameron J. Lacey ◽  
Kit Doudney ◽  
Paul G. Bridgman ◽  
Peter M. George ◽  
Roger T. Mulder ◽  
...  
Keyword(s):  
Cardiac Function ◽  
Copy Number ◽  
Copy Number Variants ◽  
Stress Cardiomyopathy ◽  
Induced Stress

Abstract 19710: Causes for Increased Cardiac Troponin I Using Gender-Specific 99th Percentiles From a High Sensitivity Assay in a US Population

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Yader Sandoval ◽  
Stephen W Smith ◽  
Karen M Schulz ◽  
MaryAnn M Murakami ◽  
Fred S Apple
Keyword(s):  
Myocardial Ischemia ◽  
Cardiac Troponin ◽  
Myocardial Injury ◽  
Troponin I ◽  
Plaque Rupture ◽  
High Sensitivity ◽  
The United States ◽  
Universal Definition ◽  
Definition Of ◽  
Gender Specific

Introduction: High-sensitivity cardiac troponin (hs-cTn) assays have not yet been FDA cleared for clinical use in the United States (US). Pending expected approval of hs-cTn assays, which will use gender-specific cutoffs (GSC), it is relevant to recognize the causes of cTn increases using hs-cTnI assays in a US population. Our purpose was to describe the frequency of distinct etiologies of hs-cTnI assay increases using GSC. Methods: Retrospective study of 310 patients with serial hs-cTnI (Abbott ARCHITECT, 99th percentiles: F:16 ng/L; M:34 ng/L) measurements. Patients with an increased hs-cTnI were adjudicated into categories according to the 3rd Universal Definition of MI. Categories included, A: primary myocardial ischemia (i.e. plaque rupture); B: injury secondary to supply/demand imbalance; C: injury not related to myocardial ischemia (i.e. cardiac contusion, ablation, shock, surgery); D: multifactorial or indeterminate myocardial injury (i.e. heart failure, critically ill, pulmonary HTN, sepsis, stroke, renal failure, pulmonary embolism); E: Unknown. Results: 127 (41%) had an increased hs-cTnI above the GSC 99th percentile, whereas 183 (59%) had a normal hs-cTnI. The most common causes of hs-cTnI increases were: a) multifactorial or indeterminate injury - 43% among all patients and 52% in males, and b) supply/demand imbalance - 39% in women (Table). Injury related to primary myocardial ischemia was present in 10% (n=13). Females had more injury related to supply/demand ischemia than males (39% vs. 18%, p=0.01), whereas males had more multifactorial or indeterminate injury (52% vs. 33%, p=0.05). Conclusions: Most increased hs-cTnI values were explained by non-plaque rupture conditions. Males tended to have hs-cTnI increases due to multifactorial/indeterminate causes, whereas in women supply/demand imbalance was the most common etiology. Investigations are needed to better understand if etiologies of myocardial injury have gender differences.

P2651Seasonal variations in the pathogenesis of acute coronary syndromes

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
O Kurihara ◽  
M Takano ◽  
E Yamamoto ◽  
T Yonetsu ◽  
T Kakuta ◽  
...  
Keyword(s):  
Plaque Rupture ◽  
Culprit Lesion ◽  
Coronary Syndrome ◽  
Plaque Erosion ◽  
Four Seasons ◽  
Incidence And Mortality ◽  
Calcified Plaque ◽  
Coronary Syndromes ◽  
Underlying Mechanisms ◽  
Underlying Pathophysiology

Abstract Background Seasonal variations in acute coronary syndrome (ACS) has been known with the winter being the peak in incidence and mortality. However, underlying pathophysiology for this variation has not been studied. Purpose We sought to compare pathobiology of the culprit lesions assessed by optical coherence tomography (OCT) among the four seasons. Methods Patients with ACS who underwent OCT were recruited from 6 countries in the Northern Hemisphere. The prevalence of 3 most common pathologies, plaque rupture, plaque erosion and calcified plaque, and other features of coronary plaques were compared among the four seasons. Results In 1113 patients with ACS, 284 (25%) patients were admitted in spring, 243 (22%) patients in summer, 290 (26%) patients in autumn and 296 (27%) patients in winter. The proportion of underlying 3 pathologies was significantly different in each season (prevalence of plaque rupture, plaque erosion, calcified plaque was 50%, 39%, and 11%, respectively in the spring; 44%, 43%, and 13% in the summer; autumn: 49%, 39%, and 12% in the autumn; 57%, 30%, and 13% in the winter; P=0.039). The proportion of plaque rupture was higher in winter but lower in summer, and that of plaque erosion was higher in summer, but lower in winter. Maximum and minimum temperatures on the day of OCT procedure were significantly lower in the plaque rupture group than in the plaque erosion group (P=0.02 and P=0.012, respectively). In the rupture group, the prevalence of hypertension was significantly higher in winter, but in the erosion group, it was not different among the four seasons. Figure 1. The proportion of culprit lesion characteristics were significantly different among the 4 season groups. (P=0.039) The proportion of plaque rupture was significantly higher in winter but lower in summer. In contrast, the proportion of plaque erosion was higher in summer, but lower in winter. Conclusions Seasonal variation of the underlying mechanisms of ACS reflects different pathobiology. The proportion of plaque rupture is highest in winter and the proportion of plaque erosion is highest in summer. A different approach may be needed for the prevention and treatment of ACS depending on the season of its occurrence.

A Broken Heart After Endoscopy: A Case Report of Endoscopy-Induced Stress Cardiomyopathy

2017 ◽  
Vol 112 ◽  
pp. S992-S994
Author(s):  
Yunseok Namn ◽  
Shawn L. Shah ◽  
Ellen J. Scherl ◽  
David Wan
Keyword(s):  
Case Report ◽  
Stress Cardiomyopathy ◽  
Induced Stress

Capture-induced stress cardiomyopathy in South American fur seal pups (Arctophoca australis gracilis)

2013 ◽  
Vol 30 (3) ◽  
pp. 1149-1157 ◽  
Author(s):  
Mauricio Seguel ◽  
Enrique Paredes ◽  
Hector Pavés ◽  
Nicole L. Gottdenker
Keyword(s):  
Stress Cardiomyopathy ◽  
South American ◽  
Induced Stress ◽  
Fur Seal

scholarly journals Mid-ventricular variant of dobutamine-induced stress cardiomyopathy

2015 ◽  
Vol 4 (2) ◽  
pp. 2
Author(s):  
Satish Chandraprakasam ◽  
Swapna Kanuri ◽  
Claire Hunter
Keyword(s):  
Stress Cardiomyopathy ◽  
Induced Stress

scholarly journals A STRESSFUL ANESTHETIC: A RARE CASE OF KETAMINE-INDUCED STRESS CARDIOMYOPATHY

2020 ◽  
Vol 75 (11) ◽  
pp. 3338
Author(s):  
Krupa K. Solanki ◽  
Rohan B. Parikh ◽  
Muhammad Umar Khalid ◽  
Gaby Aoun
Keyword(s):  
Rare Case ◽  
Stress Cardiomyopathy ◽  
Induced Stress

scholarly journals Clinical Resolution of Osmotic Demyelination Syndrome following Overcorrection of Severe Hyponatremia

2019 ◽  
Vol 2019 ◽  
pp. 1-4 ◽  
Author(s):  
Ruhin Yuridullah ◽  
Vinod Kumar ◽  
Sushant Nanavati ◽  
Monisha Singhal ◽  
Chandra Chandran
Keyword(s):  
Management Strategies ◽  
Chronic Alcoholism ◽  
Review Of Literature ◽  
Osmotic Demyelination Syndrome ◽  
Severe Hyponatremia ◽  
Term Care ◽  
Aggressive Management ◽  
Osmotic Demyelination ◽  
Chronic Hyponatremia

Osmotic Demyelination Syndrome (ODS) occurs after rapid overcorrection of severe chronic hyponatremia usually in those with a predisposition such as chronic alcoholism, malnutrition, or liver disease. Rarely, do patients make a full recovery. We report a case of ODS secondary to overcorrection of severe hyponatremia with pathognomonic clinical and radiologic signs making a complete neurological recovery. A detailed course of events, review of literature, and optimal and aggressive management strategies are discussed. There is some controversy in the literature regarding the prognosis of these patients. Our aim here is to show that, with aggressive therapy and long-term care, recovery is possible in these patients.

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