scholarly journals Clinical and Metabolic Effects of Alpha-Lipoic Acid Associated with Two Different Doses of Myo-Inositol in Women with Polycystic Ovary Syndrome

2020 ◽  
Vol 2020 ◽  
pp. 1-8 ◽  
Author(s):  
Franca Fruzzetti ◽  
Elena Benelli ◽  
Tiziana Fidecicchi ◽  
Massimo Tonacchera
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Lipoic Acid ◽  
Polycystic Ovary ◽  
Insulin Response ◽  
Reproductive Hormones ◽  
Metabolic Effects ◽  
Metabolic Phenotype ◽  
Ovary Syndrome ◽  
Before And After ◽  
Different Doses

The aim of this retrospective study was to evaluate the effects of a treatment with α-lipoic acid (ALA) associated with two different doses of myo-inositol (MI) on clinical and metabolic features of women with polycystic ovary syndrome (PCOS). Eighty-eight women received the treatment, and 71 among them had complete clinical charts and were considered eligible for this study. All women were treated with 800 mg of ALA per day: 43 patients received 2000 mg of MI and 28 received 1000 mg of MI per day. Menstrual cyclicity, BMI, FSH, LH, estradiol, testosterone, androstenedione, fasting insulin, HOMA-IR, and insulin response to a 2 h OGTT were evaluated before and after 6 months of treatment. The presence of diabetic relatives (DRs) was investigated. Cycle regularity was improved in 71.2% of women. The improvement of menstrual cyclicity occurred regardless of the state of IR and the presence of DRs of the patients. Women with IR mainly showed a significant improvement of metabolic parameters, while those without IR had significant changes of reproductive hormones. Patients with DRs did not show significant changes after the treatment. 85.7% of women taking 2000 mg of MI reported a higher improvement of menstrual regularity than those taking 1000 mg of MI (50%; p<0.01). In conclusion, ALA + MI positively affects the menstrual regularity of women with PCOS, regardless of their metabolic phenotype, with a more evident effect with a higher dose of MI. This effect seems to be insulin independent. The presence of IR seems to be a predictor of responsivity to the treatment in terms of an improvement of the metabolic profile.

The metabolic effects of metformin, cyproterone-acetate and their combination in women with polycystic ovary syndrome

2019 ◽  
Author(s):  
Ivana Bozic-Antic ◽  
Dusan Ilic ◽  
Tamara Bogavac ◽  
Snjezana Erceg ◽  
Mirjana Lacmanovic ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Cyproterone Acetate ◽  
Polycystic Ovary ◽  
Metabolic Effects ◽  
Ovary Syndrome

scholarly journals Ovulatory and Metabolic Effects of d-Chiro-Inositol in the Polycystic Ovary Syndrome

1999 ◽  
Vol 340 (17) ◽  
pp. 1314-1320 ◽  
Author(s):  
John E. Nestler ◽  
Daniela J. Jakubowicz ◽  
Paula Reamer ◽  
Ronald D. Gunn ◽  
Geoffrey Allan
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Metabolic Effects ◽  
Ovary Syndrome

scholarly journals Racial and ethnic differences in the polycystic ovary syndrome metabolic phenotype

2017 ◽  
Vol 216 (5) ◽  
pp. 493.e1-493.e13 ◽  
Author(s):  
Lawrence Engmann ◽  
Susan Jin ◽  
Fangbai Sun ◽  
Richard S. Legro ◽  
Alex J. Polotsky ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Ethnic Differences ◽  
Polycystic Ovary ◽  
Metabolic Phenotype ◽  
Ovary Syndrome ◽  
Racial And Ethnic Differences

Genetic polymorphisms of reproductive hormones and their receptors in assisted reproduction technology for patients with polycystic ovary syndrome

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Yulia A. Koloda ◽  
Yulia V. Denisova ◽  
Natalia M. Podzolkova
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Assisted Reproductive Technologies ◽  
Polycystic Ovary ◽  
Ovarian Response ◽  
Reproductive Technologies ◽  
Reproductive Hormones ◽  
Current Data ◽  
Nucleotide Polymorphisms ◽  
Ovary Syndrome ◽  
Art Programs

Abstract Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies in women of childbearing, which is defined by the accumulation of multiple, small fluid-filled ovarian cysts without the selection of a single dominant follicle. Most PCOS phenotypes are characterized by the absence of spontaneous ovulation, resistance toward ovulation inductors, the production of a large immature oocytes number, and the high prevalence of ovarian hyperstimulation syndrome, resulting in reduced assisted reproductive technologies (ART) programs effectiveness. The review analyses current data about the relationship between polymorphism genotypes of KISS genes, follicle stimulating hormone (FSH), luteinizing hormone (LH), anti-Müllerian hormone (AMH) and their receptors genes, gonadotropin-releasing hormone (GnRH), estrogen, and progesterone receptors genes, the PCOS risk and the features of ovarian response to stimulation during ART cycles. The use of single nucleotide polymorphisms (SNPs) as prognostic markers of ART programs outcomes would provide a personalized approach to the drugs and doses choice for ovarian stimulation and significantly increase the chance of pregnancy.

scholarly journals Effects of inositol and alpha lipoic acid combination for polycystic ovary syndrome

Medicine ◽  
2020 ◽  
Vol 99 (30) ◽  
pp. e20696
Author(s):  
Wenwen Lei ◽  
Yang Gao ◽  
Shiruo Hu ◽  
Dongying Liu ◽  
Qiu Chen
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Lipoic Acid ◽  
Polycystic Ovary ◽  
Alpha Lipoic Acid ◽  
Ovary Syndrome

scholarly journals Inositol administration reduces oxidative stress in erythrocytes of patients with polycystic ovary syndrome

2012 ◽  
Vol 166 (4) ◽  
pp. 703-710 ◽  
Author(s):  
Gabriella Donà ◽  
Chiara Sabbadin ◽  
Cristina Fiore ◽  
Marcantonio Bragadin ◽  
Francesco L Giorgino ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Serum Insulin ◽  
Band 3 ◽  
Oral Glucose ◽  
Fasting Serum ◽  
Ovary Syndrome ◽  
Inflammatory Status ◽  
Before And After

ObjectivePossibly due to a deficiency of insulin mediators, polycystic ovary syndrome (PCOS) is often associated with insulin resistance (IR) and hyperinsulinemia, likely responsible for an elevated production of reactive oxygen species. We investigated oxidative-related alterations in erythrocytes and anti-inflammatory effects of inositol in women with PCOS before and after treatment with myo-inositol (MYO).MethodsTwenty-six normal-weight PCOS patients were investigated before and after MYO administration (1200 mg/day for 12 weeks;n=18) or placebo (n=8) by evaluating serum testosterone, serum androstenedione, fasting serum insulin, fasting serum glucose, insulin area under the curve (AUC), and glucose AUC after oral glucose tolerance test and homeostasis model of assessment–IR. In erythrocytes, band 3 tyrosine phosphorylation (Tyr-P) level, glutathione (GSH) content, and glutathionylated proteins (GSSP) were also assessed.ResultsData show that PCOS patients' erythrocytes underwent oxidative stress as indicated by band 3 Tyr-P values, reduced cytosolic GSH content, and increased membrane protein glutathionylation. MYO treatment significantly improved metabolic and biochemical parameters. Significant reductions were found in IR and serum values of androstenedione and testosterone. A significant association between band 3 Tyr-P levels and insulin AUC was found at baseline but disappeared after MYO treatment, while a correlation between band 3 Tyr-P and testosterone levels was detected both before and after MYO treatment.ConclusionsPCOS patients suffer from a systemic inflammatory status that induces erythrocyte membrane alterations. Treatment with MYO is effective in reducing hormonal, metabolic, and oxidative abnormalities in PCOS patients by improving IR.

The Metabolic Effects of Resveratrol on a Rat Polycystic Ovary Syndrome Model.

2011 ◽  
Vol 85 (Suppl_1) ◽  
pp. 357-357
Author(s):  
Chi-Hong Ho ◽  
Ru-Lian Hsu ◽  
Tsung-Hsien Kuo ◽  
Po-Han Lin ◽  
Paulus S. Wang
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Metabolic Effects ◽  
Ovary Syndrome
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