scholarly journals Corrigendum to “Macrophage Migration Inhibitory Factor Promotes the Interaction between the Tumor, Macrophages, and T Cells to Regulate the Progression of Chemically Induced Colitis-Associated Colorectal Cancer”

2020 ◽  
Vol 2020 ◽  
pp. 1-2
Author(s):  
Thalia Pacheco-Fernández ◽  
Imelda Juárez-Avelar ◽  
Oscar Illescas ◽  
Luis I. Terrazas ◽  
Rogelio Hernández-Pando ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
T Cells ◽  
Migration Inhibitory Factor ◽  
Macrophage Migration Inhibitory Factor ◽  
Inhibitory Factor ◽  
Macrophage Migration ◽  
Chemically Induced

scholarly journals Macrophage Migration Inhibitory Factor Promotes the Interaction between the Tumor, Macrophages, and T Cells to Regulate the Progression of Chemically Induced Colitis-Associated Colorectal Cancer

2019 ◽  
Vol 2019 ◽  
pp. 1-16 ◽  
Author(s):  
Thalia Pacheco-Fernández ◽  
Imelda Juárez-Avelar ◽  
Oscar Illescas ◽  
Luis I. Terrazas ◽  
Rogelio Hernández-Pando ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
T Cells ◽  
Intestinal Epithelium ◽  
Migration Inhibitory Factor ◽  
Macrophage Migration Inhibitory Factor ◽  
Chemical Carcinogenesis ◽  
Inhibitory Factor ◽  
Macrophage Migration ◽  
Initial Development ◽  
The Impact

Colitis-associated colorectal cancer (CRC) development has been shown to be related to chronically enhanced inflammation. Macrophage migration inhibitory factor (MIF) is an inflammatory mediator that favors inflammatory cytokine production and has chemotactic properties for the recruitment of macrophages (Møs) and T cells. Here, we investigated the role of MIF in the inflammatory response and recruitment of immune cells in a murine model of chemical carcinogenesis to establish the impact of MIF on CRC genesis and malignancy. We used BALB/c MIF-knockout (MIF-/-) and wild-type (WT) mice to develop CRC by administering intraperitoneal (i.p.) azoxymethane and dextran sodium sulfate in drinking water. Greater tumor burdens were observed in MIF-/- mice than in WT mice. Tumors from MIF-/- mice were histologically identified to be more aggressive than tumors from WT mice. The localization of MIF suggests that it is also involved in cell differentiation. The relative gene expression of il-17, measured by real-time PCR, was higher in MIF-/- CRC mice, compared to the WT CRC and healthy MIF-/- mice. Importantly, compared to the WT intestinal epithelium, lower percentages of tumor-associated Møs were found in the MIF-/- intestinal epithelium. These results suggest that MIF plays a role in controlling the initial development of CRC by attracting Møs to the tumor, which is a condition that favors the initial antitumor responses.

scholarly journals Overexpression of Macrophage Migration Inhibitory Factor and Its Homologue D-Dopachrome Tautomerase as Negative Prognostic Factor in Neuroblastoma

2019 ◽  
Vol 9 (10) ◽  
pp. 284 ◽  
Author(s):  
Eugenio Cavalli ◽  
Emanuela Mazzon ◽  
Santa Mammana ◽  
Maria Basile ◽  
Salvo Lombardo ◽  
...  
Keyword(s):  
T Cells ◽  
Migration Inhibitory Factor ◽  
Macrophage Migration Inhibitory Factor ◽  
Cytotoxic T Cells ◽  
Hdac Inhibitors ◽  
Inhibitory Factor ◽  
Mycn Amplification ◽  
Macrophage Migration ◽  
Dopachrome Tautomerase

Neuroblastoma (NB) represents one of the most frequent pediatric solid tumors. Macrophage migration inhibitory factor (MIF) is a cytokine exerting multiple biological functions. More recently, a second member of the MIF family of cytokine has been identified, the D-dopachrome tautomerase (DDT), that exerts several overlapping functions with MIF. Growing evidence suggests a key role for MIF and DDT in the development of cancer. The aim of this study is to characterize the prognostic value of MIF and DDT in NB. We show that higher expression levels of MIF and DDT in Stage 4 NB samples are associated with a poorer prognosis, independently of the presence of MYCN amplification. Moreover, higher levels of MIF are mostly enriched by Th1 cells, while lower levels of MIF are associated with an increased proportion of B cells, Cytotoxic T cells, Dendritic cells and Natural Killer T cells. We also show that treatment with the histone deacetylase (HDAC) inhibitor, vorinostat, of the NB cell line, SH-SY5Y, determines a significant reduction in the expression of both MIF and DDT. Finally, MIF and DDT inhibition by short interfering RNA is able to revert vincristine sensitivity in vitro. Overall, our data suggest that MIF exert pro-tumorigenic properties in NB, likely by dampening antigen presentation and cytotoxic immune responses, and we propose the HDAC inhibitors as a potential therapeutic strategy for NB patients.

scholarly journals Macrophage migration inhibitory factor has a role controlling colorectal cancer (LB491)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Miriam Rodriguez‐Sosa ◽  
Thalia Pacheco‐Fernández ◽  
Imelda Juárez‐Avelar ◽  
Marco Rodríguez‐Monroy ◽  
Oscar Nieto‐Yañez ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Migration Inhibitory Factor ◽  
Macrophage Migration Inhibitory Factor ◽  
Inhibitory Factor ◽  
Macrophage Migration

scholarly journals Macrophage migration inhibitory factor promotes resistance to MEK blockade in KRAS mutant colorectal cancer cells

2018 ◽  
Vol 12 (8) ◽  
pp. 1398-1409 ◽  
Author(s):  
Seul‐Ki Cheon ◽  
Hwang‐Phill Kim ◽  
Ye‐Lim Park ◽  
Jee‐Eun Jang ◽  
Yoojoo Lim ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Migration Inhibitory Factor ◽  
Macrophage Migration Inhibitory Factor ◽  
Inhibitory Factor ◽  
Macrophage Migration ◽  
Colorectal Cancer Cells
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