scholarly journals Consumption of Anthocyanin-Rich Mulberry Fruit Jelly with a High-Fat Meal Decreases Postprandial Serum Cardiometabolic Risk Factors in Dyslipidemia Subjects

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Nattira On-Nom ◽  
Uthaiwan Suttisansanee ◽  
Jutamas Tongmai ◽  
Chanakan Khemthong ◽  
Rungrat Chamchan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Risk Factors ◽  
Insulin Sensitivity ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors ◽  
Postprandial Blood Glucose ◽  
High Fat ◽  
Mulberry Fruit ◽  
Serving Size ◽  
Fat Meal

Anthocyanin content in berries has been reported to promote antioxidant properties that mitigate the occurrence of noncommunicable diseases. However, only a few studies have investigated the benefits of anthocyanin-rich food products from mulberry fruit to reduce the cardiometabolic risk factor in dyslipidemia subjects. Anthocyanin-rich mulberry fruit jelly was formulated using mulberry fruit powder (MFP), and its activities on serum cardiometabolic risk factors in dyslipidemia subjects were studied. Morus alba var. Chiang Mai was used as the ingredient for MFP jelly containing 14 g MFP (191 mg anthocyanin) per serving size (170 g). To investigate the effect of MFP jelly on reduction of cardiometabolic risk factors, sixteen dyslipidemia subjects were given one serving of MFP jelly every day for seven days. After MFP jelly intervention, fasting blood cholesterol, low-density lipoprotein (LDL), and inflammatory markers including interleukin-6 levels of the subjects were significantly lower. Postprandial blood parameters were measured at 0–240 min after consuming a high-fat meal before and after MFP jelly intervention. Postprandial blood glucose at 30 min (p<0.05) and insulin at 60 and 90 min (p<0.01) were lower in MFP than in placebo jelly. The area under the curve of insulin in MFP jelly was smaller than in placebo by 31.2%. Therefore, MFP jelly intervention increased insulin sensitivity. For antioxidant activity markers, postprandial oxygen radical absorbance capacity after MFP jelly intervention gave a smaller decrease after high-fat meal intake compared to after placebo jelly intervention. Moreover, for the oxidative stress markers, postprandial malondialdehyde level was significantly lower in MFP jelly. Seven days of intervention by one serving size of MFP jelly containing 191 mg of anthocyanins reduced cardiometabolic risk factors by lowering blood total cholesterol, LDL, and inflammation, and improving insulin sensitivity and postprandial blood antioxidant-oxidative stress activity in dyslipidemia subjects. This trial is registered with TCTR20200415003.

Changes in oxidative stress markers and cardiometabolic risk factors among Roux-en-Y gastric bypass patients after 3- and 12-months postsurgery follow-up

2019 ◽  
Vol 15 (10) ◽  
pp. 1738-1745
Author(s):  
Sônia Lopes Pinto ◽  
Leidjaira Lopes Juvanhol ◽  
Leandro Licursi de Oliveira ◽  
Rodolfo Castilho Clemente ◽  
Josefina Bressan
Keyword(s):  
Oxidative Stress ◽  
Risk Factors ◽  
Gastric Bypass ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors ◽  
Oxidative Stress Markers ◽  
Stress Markers

scholarly journals Association of Basal Metabolic Rate and Nutrients Oxidation with Cardiometabolic Risk Factors and Insulin Sensitivity in Sedentary Middle-Aged Adults

Nutrients ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 1186
Author(s):  
Francisco J. Amaro-Gahete ◽  
Lucas Jurado-Fasoli ◽  
Jonatan R. Ruiz ◽  
Manuel J. Castillo
Keyword(s):  
Risk Factors ◽  
Insulin Sensitivity ◽  
Lean Mass ◽  
Basal Metabolic Rate ◽  
Plasma Insulin ◽  
Cardiometabolic Risk ◽  
Density Lipoprotein ◽  
Cardiometabolic Risk Factors ◽  
Middle Aged ◽  
Middle Aged Adults

This cross-sectional study aimed to examine the association of basal metabolic rate (BMR) and basal fat and carbohydrate oxidation (BFox and BCHox, respectively) with cardiometabolic risk factors and insulin sensitivity in sedentary middle-aged adults. A total of 71 healthy sedentary adults (37 women) aged 40–65 years participated in the current study. Data were collected during the baseline assessments of the FIT-AGEING randomized controlled trial. BMR was measured via indirect calorimetry, and BFox and BCHox estimated by stoichiometric equations. Blood pressure, glucose, insulin, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides plasma levels were selected as cardiometabolic risk factors and assessed following standard procedures. We observed positive associations of BMR with plasma insulin and the homeostatic model assessment of insulin resistance index (HOMA; all p < 0.05) which were attenuated or disappeared after controlling by sex, age, and/or lean mass. There were positive associations between BFox and the quantitative insulin sensitivity check index (QUICKI; p < 0.015), while negative associations were noted between BFox and plasma insulin and HOMA (p < 0.015). There was a significant negative association between BCHox with QUICKI (p < 0.01), whereas significant positive relationships were obtained when BCHox was associated with plasma insulin and HOMA (p < 0.01). These associations persisted in almost all cases when controlling by sex, age and/or lean mass. No further relationships were found when BMR, BFox, and BCHox were associated with other cardiometabolic risk factors. In conclusion, our study findings support that greater BFox and lower BCHox are related to improved insulin sensitivity, whereas BMR seems to be not associated with neither cardiometabolic risk nor insulin sensitivity in sedentary middle-aged adults. Further intervention studies are necessary to well-understand the physiological mechanism implied in this relationship.

scholarly journals APO B/APO A1 RATIO AND ITS CORRELATION WITH CARDIOMETABOLIC RISK FACTORS AND OXIDATIVE STRESS IN SUBJECTS WITH METABOLIC SYNDROME

2020 ◽  
pp. 1-3
Author(s):  
Deepthy C Sahadevan* ◽  
Archna Sing ◽  
Busi Karunanand ◽  
Himani Thakkar ◽  
Ajay Kumar Gautam
Keyword(s):  
Oxidative Stress ◽  
Risk Factors ◽  
Cardiometabolic Risk ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Cardiometabolic Risk Factors ◽  
Oxidative Stress Marker ◽  
Low Density ◽  
Apo B ◽  
And Oxidative Stress

Objective: This study was designed to assess the apolipoprotein B (Apo-B), apolipoprotein A (Apo A) and Apo B/Apo A-I ratio in subjects with and withoutmetabolic syndrome andtoevaluate the correlationofApoB/ApoA-Iratiowithoxidative stressmarker andcardiovasculardisease risk. Methods:Atotal of 308 subjects including one hundred and fty- ve cases and one hundred and fty- three controls were recruited for this study. All the subjects were classied according to the NCEPATP III (National cholesterol education program – Adult treatment panel III) criteria for MetS. Anthropometric and clinical characteristics were recorded using clinical Proforma. Blood samples were collected for doing plasma glucose, Lipid prole analysis [Total Cholesterol (TC), Triglyceride (TG), high-density lipoprotein (HDL)], ApoA1, Apo B and oxidative stress marker - Malondialdehyde (MDA). Serum low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL) and Apo B/Apo A-I ratio were calculated. Comparison of data between the two groups was done by t test. Correlation coefcient of Apo B/ Apo A1 ratio with cadiometabolic risk factors were calculated. Result: We found that cardiometabolic risk factors like abdominal obesity, systolic and diastolic blood pressure, fasting plasma glucose, TG, atherogenic lipoproteins LDL, Apo B, Apo B/Apo A-I ratio and MDA were signicantly high in subjects with MetS whereas anti-atherogenic factor Apo A1 was signicantly low. We also observed that Apo B/AI ratio was positively related to cardiometabolic risk factors and with oxidative stress marker. Conclusion:Apo B/AI ratio was related to metabolic syndrome and was found to be a reliable indicator of cardiovascular risk in MetS.

scholarly journals Oxidative Stress in Healthy Subjects with Cardiometabolic Risk Factors

2015 ◽  
Vol 29 (S1) ◽  
Author(s):  
Beatriz Martinez‐Carrillo ◽  
Marisol Neri ◽  
Alejandra Benitez ◽  
Roxana Valdés‐Ramos ◽  
Jorge Escoto‐Herrera
Keyword(s):  
Oxidative Stress ◽  
Risk Factors ◽  
Healthy Subjects ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors

scholarly journals Improvements in body composition, cardiometabolic risk factors and insulin sensitivity with trenbolone in normogonadic rats

Steroids ◽  
2015 ◽  
Vol 94 ◽  
pp. 60-69 ◽  
Author(s):  
Daniel G. Donner ◽  
Belinda R. Beck ◽  
Andrew C. Bulmer ◽  
Alfred K. Lam ◽  
Eugene F. Du Toit
Keyword(s):  
Risk Factors ◽  
Body Composition ◽  
Insulin Sensitivity ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors

Perivascular Adipose Tissue Oxidative Stress On The Pathophysiology Of Cardiometabolic Diseases

2019 ◽  
Vol 15 ◽  
Author(s):  
Jamaira Aparecida Victorio ◽  
Ana Paula Davel
Keyword(s):  
Oxidative Stress ◽  
Risk Factors ◽  
Adipose Tissue ◽  
Vascular Function ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors ◽  
Pathophysiological Mechanism ◽  
Ros Production ◽  
Perivascular Adipose Tissue ◽  
New Findings

Most of the systemic blood vessels are surrounded by the perivascular adipose tissue (PVAT). Healthy PVAT is anticontractile and anti-inflammatory, but a dysfunctional PVAT has been suggested to link cardiometabolic risk factors to vascular dysfunction. Vascular oxidative stress is an important pathophysiological event in cardiometabolic complications of obesity, type 2 diabetes, and hypertension. PVAT-derived adipocytes generate reactive oxygen species (ROS) including superoxide anion and hydrogen peroxide that might signal to vascular wall. Therefore, an abnormal generation of ROS by PVAT emerges as a potential pathophysiological mechanism underlying vascular injury. This review summarizes new findings describing ROS production in PVAT of several vascular beds, major sources of ROS in this tissue including mitochondria, NADPH oxidase and eNOS uncoupled, and finally, changes in ROS production affecting vascular function in the presence of cardiometabolic risk factors and diseases.

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