scholarly journals Concentrated Growth Factor: A Novel Platelet Concentrate for Revascularization of Immature Permanent Teeth—A Report of Two Cases

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
M. S. Nivedhitha ◽  
Benoy Jacob ◽  
Aishwarya Ranganath
Keyword(s):  
Growth Factor ◽  
Mineral Trioxide Aggregate ◽  
Stage Iv ◽  
Platelet Concentrate ◽  
Permanent Teeth ◽  
Old Patients ◽  
Regenerative Endodontics ◽  
Patient Consent ◽  
Root Dentin ◽  
Dentin Thickness

This article elucidates the utilization of a novel platelet concentrate-concentrated growth factor (CGF) for rapid and successful healing outcome in regenerative endodontics. This case report focusses on two cases: 23-year-old and 21-year-old patients with incomplete root formation and periapical lesion. Case 1 and case 2 are classified as stage IV and stage II, respectively, in accordance with Cvek’s classification of open apex and had varied outcomes. The extent of open apex, root dentin thickness, and lesion were assessed using periapical radiograph and CBCT. Revascularization procedure was carried out after obtaining patient consent. Following bleeding induction, CGF was prepared, placed, and condensed using pluggers in the root canal space, followed by the placement of mineral trioxide aggregate (MTA) up to the level of CEJ. At 1-year follow-up, apical closure with increased root dentin thickness and reduced periapical radiolucency was evident.

scholarly journals A Prospective Study of Long-Term Regenerative Endodontics Outcomes of Necrotic Immature Permanent Teeth: An 8-Year Follow-Up

Healthcare ◽  
2021 ◽  
Vol 9 (12) ◽  
pp. 1670
Author(s):  
Sawsan T. Abu Zeid ◽  
Ruaa A. Alamoudi ◽  
Osama S. Alothmani ◽  
Abeer A. Mokeem Saleh ◽  
Amna Y. Siddiqui
Keyword(s):  
Prospective Study ◽  
Mineral Trioxide Aggregate ◽  
Qualitative Evaluation ◽  
Permanent Teeth ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Regenerative Endodontics ◽  
Canal Diameter

For the management of necrotic immature teeth, regenerative endodontics offers the advantage of further root lengthening, thickening of dentin wall, and apical closure. This prospective study aimed to evaluate the long-term outcome of regenerative endodontics in immature necrotic permanent teeth. A total of 23 immature roots were medicated by triple antibiotic paste. After 21 days, bleeding was induced by over-instrumentation, and then mineral trioxide aggregate and coronal restoration were applied. Patients were scheduled for clinical and radiographic follow-up for 8 years. The radiographic changes of root dimensions were assessed using the ImageJ Plugin and statistically analyzed by Kruskal–Wallis test at a 95% confidence level. For qualitative evaluation, images were overlapped and analyzed using Photoshop software. All teeth were asymptomatic one month after the treatment. All teeth (n = 18) with preoperative periapical radiolucency showed complete resolution within 6–9 months. Recall rate at two, three, and eight years was 69.6%, 56.5%, and 34.8%, respectively. Continuous root development with a significant increase in root length and thickening of dentin wall accompanied by a significant decrease in apical canal diameter was seen at the end of the observation period (p < 0.001). In conclusion, the long-term outcome of regenerative endodontics revealed successful clinical and radiographic results with appropriate case selection.

APEXIFICATION REVISITED

2021 ◽  
pp. 68-71
Author(s):  
Jaziya Z ◽  
Suchithra M S ◽  
Rita Zarina A ◽  
Fathima. S
Keyword(s):  
Calcium Hydroxide ◽  
Mineral Trioxide Aggregate ◽  
Permanent Teeth ◽  
Survival Prognosis ◽  
Crown Root ◽  
The Past ◽  
Regenerative Endodontics ◽  
Open Apices ◽  
Thin Walled

Pulpal necrosis in permanent teeth with immature roots leads to development of roots which are very short, thin walled and an inadequate crown-root ratio, which overshadows their survival prognosis. Traditionally, the apexication procedure has consisted of multiple and long-term applications of calcium hydroxide to create an apical barrier to aid the obturation. Recently, articial apical barriers such as those made with mineral trioxide aggregate (MTA) have been used in teeth with necrotic pulps and open apices. More recently, procedures referred to as regenerative endodontics have received much attention as an option for these teeth. This paper reviews the past, present and recent concepts used for apexication.

Remaining root dentin thickness in mesiobuccal canals of maxillary first molars after attempted removal of broken instrument fragments

2015 ◽  
Vol 41 (3) ◽  
pp. 122-127 ◽  
Author(s):  
Yuan Gao ◽  
Ya Shen ◽  
Xuedong Zhou ◽  
Markus Haapasalo
Keyword(s):  
Root Dentin ◽  
Dentin Thickness

scholarly journals Prospective cohort study of regenerative potential of non vital immature permanent maxillary central incisors using platelet rich fibrin scaffold

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Selvakumar Kritika ◽  
V. Sujatha ◽  
N. Srinivasan ◽  
Senthil Kumar Renganathan ◽  
Sekar Mahalaxmi
Keyword(s):  
Gradual Increase ◽  
Mineral Trioxide Aggregate ◽  
Permanent Teeth ◽  
Bonferroni Correction ◽  
Platelet Rich Fibrin ◽  
Triple Antibiotic Paste ◽  
Fibrin Scaffold ◽  
The Mean ◽  
Post Hoc

AbstractRegenerative endodontic procedures have gained momentum as a treatment modality of young immature permanent teeth. Literature reports reveal that platelet-rich fibrin (PRF) stimulates growth factors and induces regeneration. This study was undertaken to assess the regenerative potential of non-vital immature permanent maxillary central incisors using PRF with a follow-up for 2 yrs. 19 patients in the age group of 9–25 yrs with immature, non-vital permanent maxillary central incisors (n = 23) with/without signs and/or symptoms of periapical pathosis and open apex were included in this study. In the first appointment, access opening, canal disinfection and triple antibiotic paste placement were done. In the subsequent visit, PRF was prepared and placed inside the canal. Access was sealed with Mineral trioxide aggregate plug and composite. The patient was reviewed up to 24 mths. The mean difference was statistically analyzed using Friedman test followed by Dunn post hoc test and adjusted by Bonferroni correction (p < 0.05). As per AAE guidelines, the primary and secondary goals were achieved. A significant (p < 0.001) gradual increase in the root length, thickness of dentinal walls and decrease in apical diameter were observed. Within the limitations of this study, PRF placement was clinically and radiographically effective in inducing regeneration of non-vital immature permanent teeth.

Localized synthesis of the Vg1 protein during early Xenopus development

Development ◽  
1989 ◽  
Vol 106 (4) ◽  
pp. 775-785 ◽  
Author(s):  
D. Tannahill ◽  
D.A. Melton
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Small Proportion ◽  
Stage Iv ◽  
Early Embryo ◽  
Mesoderm Induction ◽  
Gastrula Stage ◽  
Small Peptide ◽  
Amphibian Embryo ◽  
Maternal Mrna

The Xenopus Vg1 gene encodes a maternal mRNA that is localized to the vegetal hemisphere of both oocytes and embryos and encodes a protein related to the TGF-beta family of small secreted growth factors. We have raised antibodies to recombinant Vg1 protein and used them to show that Vg1 protein is first detected in stage IV oocytes and reaches maximal levels in stage VI oocytes and eggs. During embryogenesis, Vg1 protein is synthesized until the gastrula stage. The embryonically synthesized Vg1 protein is present only in vegetal cells of an early blastula. We find that Vg1 protein is glycosylated and associated with membranes in the early embryo. Our results also suggest that a small proportion of the full-length Vg1 protein is cleaved to give a small peptide of M(r) = approximately 17 × 10(3). These results support the proposal that the Vg1 protein is an endogenous growth-factor-like molecule involved in mesoderm induction within the amphibian embryo.

Higher serum levels of fibroblast growth factor 21 in old patients with cachexia

Nutrition ◽  
2019 ◽  
Vol 63-64 ◽  
pp. 81-86 ◽  
Author(s):  
Kristina Franz ◽  
Mario Ost ◽  
Lindsey Otten ◽  
Catrin Herpich ◽  
Verena Coleman ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Serum Levels ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth ◽  
Old Patients

scholarly journals Revascularization versus apical barrier technique with mineral trioxide aggregate plug: A systematic review

2018 ◽  
Vol 32 (1) ◽  
pp. 9-16 ◽  
Author(s):  
Luiz Alexandre Chisini ◽  
Guillermo Grazioli ◽  
Alejandro Francia ◽  
Alissa Schmidt San Martin ◽  
Flavio Fernando Demarco ◽  
...  
Keyword(s):  
Clinical Success ◽  
Mineral Trioxide Aggregate ◽  
Clinical Success Rate ◽  
Permanent Teeth ◽  
Radiographic Outcomes ◽  
Bias Risk ◽  
Radiographic Measurements ◽  
High Bias ◽  
The Mean

Aim: To compare the clinical and radiographic outcomes observed in Necrotic Immature Permanent Teeth (NIPT) after revascularization or apexification with MTA-apical plug. Methodology: PubMed/MEDLINE, Web of science and Scopus were the databases used, up to July 30th, 2017, for article research. Independent reviewers read the titles and abstracts of all reports that met inclusion/exclusion criteria: prospective or retrospective clinical studies comparing the revascularization of root canal and apexification. Clinical success of therapies, deposition and thickening of lateral dentinal walls (root width) and the continuation of root development (root length) were investigated. Bias risk of included studies was assessed using the Cochrane risk of bias. Results: From 1642 records, five papers fulfilled all inclusion criteria. Overall, 91 teeth were submitted to revascularization and 64 teeth to apexification with MTA. The mean follow-up was 23.2 months in revascularization and 21.8 in apexification. Clinical success rate was of 87.9% in the revascularization group and 90.6% in the apexification group. An increase on lateral dentinal walls thickening was observed in most revascularization cases (13%) while MTA as apical plug suggest a mild resorption of the root (1.3%). High bias risk was observed on included studies. Conclusions: Apexification with MTA-apical plug provides similar clinical success to revascularization. However, radiographic measurements showed an improvement in thickening of lateral dentinal walls in most of the revascularization cases in addition to a higher dental development. However, these results should be interpreted with caution.

scholarly journals The hypothalamo-hypophyseal system in patients with multinodular colloid euthyroid goiter

1994 ◽  
Vol 40 (3) ◽  
pp. 22-25
Author(s):  
A. D. Makarov ◽  
Yu. M. Keda ◽  
I. V. Kryukova ◽  
N. P. Goncharov ◽  
S. S. Pankova ◽  
...  
Keyword(s):  
Growth Factor ◽  
Clinical Diagnosis ◽  
Stage Iv ◽  
Thyrotropin Releasing Hormone ◽  
Test Results ◽  
Trh Test ◽  
Releasing Hormone ◽  
Clear Cut ◽  
Healthy Women

Eighty patients with multinodular colloidal euthyroid goiter were examined. Thyrotropin-releasing hormone (TRH) test was carried out in 22 patients and 7 healthy women. The results of the test indicate a clear-cut tendency to reduction of hypophyseal TTH reserve in patients with multinodular euthyroid goiter with enlarged thyroid. In other words, clinical diagnosis of an euthyroid condition in the examinees appears to be groundless, particularly in patients with stage IV multinodular euthyroid goiter who may be referred to latent hyperthyrosis group on the basis of TRH test results. Three types of STH reaction were revealed by TRH test in these patients. The authors put forward a hypothesis on STH contribution as a growth factor to the pathogenesis of multinodular colloid euthyroid goiter.

scholarly journals Comparison of Medicaments Used in Regenerative Endodontics in Terms of Dentin Microhardness and Adhesion of Mineral in Terms of Dentin Microhardness and Adhesion of Mineral Trioxide Aggregate Trioxide Aggregat

2020 ◽  
Vol 27 (3) ◽  
Author(s):  
Esma Saricam ◽  
◽  
Neslihan Bulak ◽  
Esra Özyurt ◽  
Suat Özcan ◽  
...  
Keyword(s):  
Bond Strength ◽  
Clavulanic Acid ◽  
Root Canal ◽  
Mineral Trioxide Aggregate ◽  
Significance Level ◽  
Regenerative Endodontics ◽  
Significant Difference ◽  
Amoxicillin Clavulanic Acid ◽  
Root Canal Dentin ◽  
Push Out

Eliminating microorganisms in the root canal system is important for the success of regenerative endodontics. Objective: This study evaluated the effects of different antibiotic pastes used for regenerative endodontic procedures on dentin microhardness and the push-out bond strength of mineral trioxide aggregate (MTA) to root canal dentin. Methods: Sixty-four maxillary central incisors were instrumented and randomly divided into the following four groups (n = 16) for medicament treatment: triple antibiotic paste, amoxicillin+clavulanic acid, cefaclor, and control (no dressing). After 21 days, two root segments were obtained by sectioning the roots horizontally for push-out and microhardness evaluations. MTA was placed into the root canal of the sectioned segment for the push-out test. In the microhardness evaluation, three indentations were made at 500 and 1,000 μm from the canal lumen. The arithmetic mean was then calculated for each distance. ANOVA with post hoc Scheffe test and t test were used for the statistical analyses. The significance level was set at p < 0.05. Results: No significant difference was found between the groups in terms of push-out bond strength (p > 0.05). Cefaclor and amoxicillin+clavulanic acid reduced the microhardness values of the dentin at 500 μm (p < 0.05) while cefaclor had the lowest value at 1,000 μm (p < 0.05). Conclusion: Cefaclor reduced the microhardness value more than the other medicaments did at a depth of 1,000 μm. The pastes provided similar adhesion of MTA.

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