scholarly journals A Successful Pregnancy with Amyotrophic Lateral Sclerosis

2020 ◽  
Vol 2020 ◽  
pp. 1-3
Author(s):  
P. D. M. Pathiraja ◽  
S. K. Ranaraja
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Sensory System ◽  
Caesarian Section ◽  
Motor Neurone ◽  
Successful Pregnancy ◽  
History Of ◽  
Background History ◽  
Restricted Mobility ◽  
Obstetric Population ◽  
Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a degenerative motor neurone disease that is rarely seen in the obstetric population. We present a 32-year-old patient who presented in her fourth pregnancy with a background history of ALS. There was complete involvement of the upper and lower motor neurone system and bulbar system without involvement of the sensory system. At 34 weeks of gestation, she had a full course of steroids and an elective caesarian section under general anaesthesia due to extreme restricted mobility and difficulty of breathing. A multidisciplinary team managed the pregnancy, and both maternal and fetal outcomes were good.

scholarly journals Impact of traumatic brain injury on amyotrophic lateral sclerosis: from bedside to bench

2019 ◽  
Vol 122 (3) ◽  
pp. 1174-1185 ◽  
Author(s):  
Colin K. Franz ◽  
Divya Joshi ◽  
Elizabeth L. Daley ◽  
Rogan A. Grant ◽  
Kyriakos Dalamagkas ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Amyotrophic Lateral Sclerosis ◽  
Brain Injury ◽  
Motor Neurons ◽  
Induced Pluripotent Stem Cell ◽  
Epidemiological Studies ◽  
History Of ◽  
Induced Pluripotent ◽  
Progressive Weakness ◽  
Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the loss of upper and lower motor neurons, which manifests clinically as progressive weakness. Although several epidemiological studies have found an association between traumatic brain injury (TBI) and ALS, there is not a consensus on whether TBI is an ALS risk factor. It may be that it can cause ALS in a subset of susceptible patients, based on a history of repetitive mild TBI and genetic predisposition. This cannot be determined based on clinical observational studies alone. Better preclinical models are necessary to evaluate the effects of TBI on ALS onset and progression. To date, only a small number of preclinical studies have been performed, mainly in the superoxide dismutase 1 transgenic rodents, which, taken together, have mixed results and notable methodological limitations. The more recent incorporation of additional animal models such as Drosophila flies, as well as patient-induced pluripotent stem cell-derived neurons, should facilitate a better understanding of a potential functional interaction between TBI and ALS.

The motor neurone disorders

2011 ◽  
Author(s):  
Pamela Shaw
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Muscular Atrophy ◽  
Motor Neurone ◽  
System Control ◽  
Loss Of Function ◽  
The United Kingdom ◽  
System Degeneration ◽  
Motor Neurones ◽  
Related Group ◽  
Lateral Sclerosis

The motor neurone diseases are a group of disorders in which there is selective loss of function of upper and/or lower motor neurones in the motor cortex, brainstem, and spinal cord resulting in impairment in the nervous system control of voluntary movement. The term ‘motor neurone disease’, often abbreviated to ‘MND’, is used differently in different countries. In the United Kingdom it is used as an umbrella term to cover the related group of neurodegenerative disorders including amyotrophic lateral sclerosis, the commonest variant, as well as progressive muscular atrophy, primary lateral sclerosis, and progressive bulbar palsy. However, in many other countries amyotrophic lateral sclerosis, referred to as ALS, has been adopted as the umbrella term for this group of clinical variants of motor system degeneration. There is a tendency now internationally to use the ALS/MND abbreviation to cover this group of conditions. Careful diagnosis within the motor neurone diseases is essential for advising about prognosis, potential genetic implications, and for identifying those with acquired lower motor neurone syndromes who may benefit for the administration of immunomodulatory therapy.

Su2028 – Natural History of Percutaneous Enteral Gastrostomy Tube in Patients with Amyotrophic Lateral Sclerosis

2019 ◽  
Vol 156 (6) ◽  
pp. S-695
Author(s):  
Mohanad T. Al-Qaisi ◽  
Richard Gerkin ◽  
Logan Cobb ◽  
Mary Chew ◽  
Katherine Petersen ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Natural History ◽  
Gastrostomy Tube ◽  
History Of ◽  
Lateral Sclerosis
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