scholarly journals Multifocal Metastatic Breast Carcinoma to the Thyroid Gland Histologically Mimicking C Cell Lesions

2019 ◽  
Vol 2019 ◽  
pp. 1-5 ◽  
Author(s):  
Adeeba F. Ghias ◽  
Gregory Epps ◽  
Elizabeth Cottrill ◽  
Stacey K. Mardekian
Keyword(s):  
Breast Carcinoma ◽  
Thyroid Gland ◽  
Thyroid Nodule ◽  
Metastatic Breast ◽  
Primary Source ◽  
Cell Hyperplasia ◽  
Metastatic Breast Carcinoma ◽  
C Cell Hyperplasia ◽  
C Cell ◽  
History Of

The thyroid gland is an uncommon site of metastatic disease. Renal cell carcinoma is the most common primary source, while metastasis from breast carcinoma is very rare. However, given that thyroid nodules are more common in women, and women with a history of breast cancer are at higher risk of developing thyroid cancer, the possibility of metastatic breast carcinoma must be considered when evaluating a thyroid nodule. We present the case of a 67-year-old woman who presented with dysphonia and dysphagia secondary to multinodular goiter and was found to have multifocal metastatic breast carcinoma in her surgical resection specimen. The histologic appearance focally mimicked C cell hyperplasia and medullary thyroid carcinoma, so immunohistochemistry was critical for establishing the diagnosis. Metastasis to the thyroid should always be included in the differential diagnosis for a thyroid nodule in a patient with a history of previous malignancy.

scholarly journals Excision of metastatic breast cancer from sternum and reconstruction in two patients with solitary metastatic spread

2020 ◽  
Vol 2020 (8) ◽  
Author(s):  
Saifullah Mohamed ◽  
Khurum Mazhar ◽  
Ahmed Osman ◽  
Akshay Patel ◽  
Lakshmi Srinivasan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Carcinoma ◽  
Previous History ◽  
Metastatic Breast ◽  
Extent Of Resection ◽  
Left Breast ◽  
Term Survival ◽  
Metastatic Breast Carcinoma ◽  
History Of ◽  
Treated Breast

Abstract Metastatic breast carcinoma is a relatively common clinical entity. However, the prognosis of oligometastatic and polygometastatic disease differs considerably pertaining to five-year survival. Metastatic breast carcinoma to the sternum has been described as early as 1988. We describe two cases in our institution who presented with solitary sternal metastases with a previous history of treated breast cancer. In both cases, there had been a history of previous left breast cancer treated aggressively with surgical resection and adjuvant oncological therapy and maintenance hormonal therapy. Partial sternectomy or total sternectomy for solitary metastatic sternal deposits is well established with relatively low morbidity and mortality and improvement in quality of life and possible improvement in long-term survival. Furthermore, reconstructive options are inherently dependent on extent of resection performed. These techniques can incorporate the use of sternal plates in order to approximate defects and reinforce the sternum in the setting of partial sternectomy.

scholarly journals Thyroid gland metastasis from breast cancer: A rare case report and literature overview

2018 ◽  
Vol 146 (7-8) ◽  
pp. 466-469 ◽  
Author(s):  
Zorka Inic ◽  
Aleksandar Martinovic ◽  
Momcilo Inic ◽  
Dijana Pilcevic ◽  
Gordana Pupic
Keyword(s):  
Breast Cancer ◽  
Thyroid Gland ◽  
Rare Case ◽  
Metastatic Breast ◽  
Breast Cancer Case ◽  
Left Breast ◽  
Cancer Case ◽  
Thyroid Lesion ◽  
Metastatic Breast Carcinoma ◽  
History Of

Introduction. The thyroid gland is a rare site for metastatic lesions from non-thyroid cancers. Due to the fact that achieving a diagnosis of thyroid gland metastasis from breast cancer prior to operation is challenging, the diagnosis thereof is mainly based on a pathological biopsy and immunohistochemical staining. The aim of this study was to present a rare case of thyroid gland metastasis from lobular breast cancer. Case outline. The patient was a 33-year-old female who had already had a five-year history of lobular cancer of the right breast and was thereafter found to have two suspicious tumors in the left breast, as well as a thyroid mass diagnosed as metastatic breast carcinoma. Conclusion. Patients who have a thyroid lesion and a history of malignancy are at a higher risk for metastasis and require additional caution during diagnosis and treatment.

A Case of Metastatic Breast Carcinoma of the Thyroid Gland

2009 ◽  
Vol 102 (6) ◽  
pp. 473-476
Author(s):  
Yuzuru Sainoo ◽  
Yasuo Osato ◽  
Haruo Takahashi
Keyword(s):  
Breast Carcinoma ◽  
Thyroid Gland ◽  
Metastatic Breast ◽  
Metastatic Breast Carcinoma

Megakaryocytes Mimicking Metastatic Breast Carcinoma

2002 ◽  
Vol 126 (5) ◽  
pp. 618-620
Author(s):  
Syed A. Hoda ◽  
Erika Resetkova ◽  
Yasmin Yusuf ◽  
Anthony Cahan ◽  
Paul P. Rosen
Keyword(s):  
Lymph Node ◽  
Breast Carcinoma ◽  
Lymph Nodes ◽  
Metastatic Breast ◽  
Metastatic Carcinoma ◽  
Metastatic Breast Carcinoma ◽  
False Positive Diagnosis ◽  
History Of ◽  
Von Willebrand ◽  
Willebrand Factor

Abstract False-positive diagnosis of lymph nodes occurs when a benign element in a lymph node, or in its capsule, is interpreted as metastatic carcinoma. This report describes a patient with breast carcinoma who had megakaryocytes in axillary sentinel lymph nodes mimicking metastatic carcinoma. The patient had no history of a hematologic disease, and we found no evidence of a concurrent hematopoietic disorder. The megakaryocytes were reactive for CD31, CD61, and von Willebrand factor, but not for cytokeratin (AE1/AE3). Megakaryocytes should be added to the list of benign histologic abnormalities that may simulate metastatic carcinoma in a sentinel lymph node.

scholarly journals Metastatic Breast Carcinoma to The Uterine Cervix - An Unusual Presentation

2021 ◽  
Vol 8 (2) ◽  
pp. C32-34
Author(s):  
Maymol P Varghese ◽  
Sreeja Raju ◽  
Savithri MC ◽  
Joy Augustine ◽  
Mathew Varghese
Keyword(s):  
Breast Carcinoma ◽  
Uterine Cervix ◽  
Lobular Carcinoma ◽  
Metastatic Breast ◽  
Vaginal Wall ◽  
Anterior Vaginal Wall ◽  
Present Case Report ◽  
Metastatic Breast Carcinoma ◽  
History Of ◽  
A Site

Uterine cervix involvement as a site of metastasis from a distant primary tumor is rare. Metastasis from breast carcinoma in a patient undergoing treatment is even rarer.  The present case report is of a 47-year-old lady with history of carcinoma breast on treatment and who was referred to our hospital with complaints of lower limb oedema, low backache and postmenopausal whitish discharge per vaginum. Per vaginal examination revealed a lesion arising in the cervix extending up to the anterior vaginal wall suggestive of a clinical diagnosis of carcinoma cervix. Subsequent biopsy from the lesion showed malignant cells arranged in Indian file pattern and focal alveolar pattern, hinting at a diagnosis of Invasive lobular carcinoma metastasis.  The neoplasm was positive for ER, PR and GATA-3 and negative for Her2/neu and E-cadherin confirming our diagnosis. Although rare, the poor outcome in such patients makes it even more important for its identification and the need for them to undergo careful routine gynecologic examination.

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