scholarly journals A Clinical TB Detection Method Based on Molecular Typing Technique with Quality Control

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Tienan Feng ◽  
Yan Cheng ◽  
Suwen Yu ◽  
Feng Jiang ◽  
Min Su ◽  
...  
Keyword(s):  
Quality Control ◽  
Molecular Typing ◽  
Waiting Times ◽  
High Sensitivity ◽  
Variable Number ◽  
Tubercle Bacillus ◽  
Control Scheme ◽  
Quality Control Scheme ◽  
Positive Results ◽  
Typing Technique

The gold standard for diagnosing pulmonary Mycobacterium tuberculosis (TB) is the detection of tubercle bacillus in patient sputum samples. However, current methods either require long waiting times to culture the bacteria or have a risk of getting false-positive results due to cross-contamination. In this study, a method to detect tubercle bacillus based on the molecular typing technique is presented. This method can detect genetic units, variable number of tandem repeat (VNTR), which are the characteristic of tuberculosis (TB), and performs quality control using a mathematical model, ensuring the reliability of the results. Compared to other methods, the proposed method was able to process and diagnose a large volume of samples in a run time of six hours, with high sensitivity and specificity. Our method is also in the pipeline for implementation in clinical testing. Reliable and confirmed results are stored into a database, and these data are used to further refine the model. As the volume of data processed from reliable samples increases, the diagnostic power of the model improves. In addition to improving the quality control scheme, the collected data can be also used to support other TB research, such as that regarding the evolution of the tubercle bacillus.

scholarly journals Paracetamol: A Report of a Regional Quality Control Scheme

1979 ◽  
Vol 16 (1-6) ◽  
pp. 265-270 ◽  
Author(s):  
J. Epton
Keyword(s):  
Quality Control ◽  
Group Performance ◽  
Clinical Importance ◽  
External Quality Control ◽  
External Quality ◽  
Limits Of Detection ◽  
Trouble Shooting ◽  
Control Scheme ◽  
Considerable Impact ◽  
Quality Control Scheme

The results from an external quality control scheme for the assay of paracetamol in serum are reported. A preferential method of assay has not become evident, but, as a result of the scheme, some laboratories have changed or modified their techniques or have re-established the limits of detection. The majority of laboratories were able to estimate paracetamol satisfactorily at those levels which are of clinical importance. The overall group performance has shown little change. The programme has had considerable impact in so far as it has led to a mutually useful interchange of information and trouble shooting.

Data warehouse quality control scheme for electricity market analysis

2015 ◽  
pp. 393-398
Author(s):  
YanMin Guo ◽  
SuYan Long ◽  
GaoQin Wang ◽  
ZhongYuan Chen ◽  
HaiChao Wang ◽  
...  
Keyword(s):  
Quality Control ◽  
Data Warehouse ◽  
Electricity Market ◽  
Market Analysis ◽  
Control Scheme ◽  
Data Warehouse Quality ◽  
Quality Control Scheme

The Italian Quality Control Scheme for Crossmatching Procedures and HLA Sera Screening: The 2002 Pilot Study

2005 ◽  
Vol 129 (11) ◽  
pp. 1470-1475
Author(s):  
Raffaele Conca ◽  
Loredana Praticò-Barbato ◽  
Anna Maria Dall'Omo ◽  
Antonio Amoroso
Keyword(s):  
Quality Control ◽  
Serum Antibody ◽  
Hla Typing ◽  
European Federation ◽  
Antibody Specificity ◽  
Control Scheme ◽  
National Quality ◽  
Transplant Immunology ◽  
Quality Control Scheme

Abstract Context.—The first national quality control (QC) program of histocompatibility serum testing was performed in Italy in 2002. Objective.—To monitor the performance of HLA typing laboratories while meeting the accreditation requirements of the European Federation for Immunogenetics (EFI), which require HLA typing laboratories to participate in external QC of their crossmatch and antibody analyses. Design.—The Turin Transplant Immunology Service was asked to organize a QC survey of 17 HLA typing laboratories in Italy. Each laboratory received 12 serum specimens and 6 blood samples and was required to perform 36 crossmatches and 12 serum antibody specificity determinations. Settings.—Data of participating centers were compared to establish whether EFI requirements were satisfied. Results.—In crossmatch analysis, the results of 32 of 36 crossmatches reached the 75% consensus target, with all the participating laboratories meeting the standards of the EFI. In antibody analysis, only 7 of 17 laboratories met the EFI standards. Conclusion.—The first Italian QC program shows that the participating laboratories obtained consistent results in crossmatching, whereas the results were less satisfactory in the determination of serum antibody specificity, where consensus was reached only with monospecific sera and antibody-negative samples.

scholarly journals An Adaptive Indoor Air Quality Control Scheme for Minimizing Volatile Organic Compounds Density

IEEE Access ◽  
2020 ◽  
Vol 8 ◽  
pp. 22357-22365 ◽  
Author(s):  
Faan Hei Hung ◽  
Kim-Fung Tsang ◽  
Chung Kit Wu ◽  
Yucheng Liu ◽  
Hao Wang ◽  
...  
Keyword(s):  
Quality Control ◽  
Air Quality ◽  
Volatile Organic Compounds ◽  
Indoor Air Quality ◽  
Organic Compounds ◽  
Indoor Air ◽  
Control Scheme ◽  
Volatile Organic ◽  
Air Quality Control ◽  
Quality Control Scheme

Analytical Bias in a Quality Control Scheme

1969 ◽  
Vol 15 (11) ◽  
pp. 1039-1044 ◽  
Author(s):  
John R Allen ◽  
Rachel Earp ◽  
E Christis Farrell ◽  
H D Grümer
Keyword(s):  
Quality Control ◽  
Clinical Chemistry ◽  
Control Program ◽  
Chemistry Laboratory ◽  
Quality Control Program ◽  
Control Scheme ◽  
Clinical Chemistry Laboratory ◽  
Random Times ◽  
Quality Control Scheme ◽  
Control Samples

Abstract A quality control program utilizing both "known" and "blind" control specimens was analyzed in the routine clinical chemistry laboratory. The results obtained with the control samples of 18 automated and nonautomated procedures demonstrated the presence of analytical bias. Only through the evaluation of blind control samples tested at random times can a reliable measure of the proficiency of the laboratory be achieved.

scholarly journals Quality control of the isolation rate of pathogens in medical microbiology laboratories

1976 ◽  
Vol 77 (3) ◽  
pp. 359-367 ◽  
Author(s):  
Hilary E. Tillett ◽  
P. B. Crone
Keyword(s):  
Quality Control ◽  
Statistical Analyses ◽  
Success Rates ◽  
Isolation Rate ◽  
Medical Microbiology ◽  
Control Scheme ◽  
Pathogenic Organisms ◽  
Quality Control Scheme

SUMMARYTwo statistical analyses are suggested to compare the success rates in isolating and identifying pathogenic organisms from specimens achieved by different laboratories participating in a quality control scheme. An example is given in which the analyses are applied to 25 laboratories that received 30 simulated specimens.

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