scholarly journals The Association between Resting Heart Rate and Urinary Albumin/Creatinine Ratio in Middle-Aged and Elderly Chinese Population: A Cross-Sectional Study

2019 ◽  
Vol 2019 ◽  
pp. 1-7
Author(s):  
Wenfeng Mao ◽  
Xinye Jin ◽  
Haibin Wang ◽  
Yingnan Ye ◽  
Linxi Zhang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Blood Glucose ◽  
Glucose Tolerance ◽  
Normal Glucose Tolerance ◽  
Resting Heart Rate ◽  
Normal Blood Pressure ◽  
Albumin Creatinine Ratio ◽  
Normal Glucose ◽  
The Relationship

Objective. In general population, resting heart rate (RHR) is associated with cardiovascular disease. However, its relation to chronic kidney disease (CKD) is debated. We therefore investigated the relationship between RHR and urinary albumin/creatinine ratio (UACR, an indicator of early kidney injury) in general population at different levels of blood pressure and blood glucose. Methods. We screened out 32,885 subjects from the REACTION study after excluding the subjects with primary kidney disease, heart disease, tumor history, related drug application, and important data loss. The whole group was divided into four groups (Q1: RHR≤71, Q2: 72≤RHR≤78, Q3: 79≤RHR≤86, and Q4: 87≤RHR) according to the quartile of average resting heart rate. The renal function was evaluated by UACR (divided by quartiles of all data in the center to which the subject belonged). Ordinary logistic regression was carried out to explore the association between RHR and UACR at diverse blood pressure and blood glucose levels. Results. The subjects with higher RHR quartile tend to have a higher UACR, even multifactors were adjusted. After stratifying the subjects according to blood pressure and blood glucose, the positive relationship between RHR and UACR remained in the subjects with normal blood pressure and normal glucose tolerance, while in the hypertension (SBP≥140 mmHg and/or DBP≥90 mmHg) group and the diabetic mellitus (FPG≥7.0 mmol/L and/or PPG≥11.1 mmol/L) group, the relationship disappeared. In the subjects without hypertension, compared with the Q1 group, the UACR is significant higher in the Q3 group (OR: 1.11) and the Q4 group (OR: 1.22). In the subjects with normal glucose tolerance (NGT), compared with the Q1 group, the UACR is significantly higher in the Q3 group (OR: 1.13) and the Q4 group (OR: 1.19). Conclusions. The population with higher RHR tend to have a higher UACR in the normal blood pressure group and the normal glucose tolerance group.

scholarly journals Acute Effect of Black Bean (Phaseolus vulgaris L.) Hydrolyzed Protein on Glucose Levels in Adults with Prediabetes and Normal Glucose Tolerance

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 458-458
Author(s):  
Andrea Ramos-Lopez ◽  
Luis Mojica ◽  
Armando Gomez-Ojeda ◽  
Maciste Macias-Cervantes ◽  
Claudia Luevano-Contreras
Keyword(s):  
Placebo Group ◽  
Blood Glucose ◽  
Glucose Tolerance ◽  
Acute Effect ◽  
Normal Glucose Tolerance ◽  
Black Bean ◽  
Glucose Levels ◽  
Hydrolyzed Protein ◽  
Normal Glucose ◽  
Different Doses

Abstract Objectives In silico, biochemical, in vitro, and in vivo assays have shown that black bean hydrolyzed protein (HPF) could decrease glucose absorption by inhibiting digestive enzymes and blocking gastrointestinal transporters. Therefore, the objective was to evaluate the acute effect of different doses of HPF on glucose levels in adults with normal glucose tolerance (NGT) and with prediabetes. Methods A double-blind, placebo-controlled, randomized clinical trial was conducted on 31 adults with NGT and 24 adults with prediabetes. Participants were 25–50-year-old and with a body mass index (BMI) between 25–34.9 kg/m2. After consent, participants were randomized into four groups, placebo or the corresponding HPF (powder) treatment (D1:2.5 g, D2:3.7 g, D3:5 g). Subjects received the placebo, 120 mL of a commercial beverage (Be-light), or the corresponding HPF dose dissolved in 120 mL of Be-light. An oral glucose tolerance test (OGTT) (75 g glucose) was used to measure glucose tolerance before treatment (initial). A second OGTT was used to evaluate the acute effect of the HPF, and blood samples were collected at 0, 60, 120, and 150 min, and blood glucose levels were measured. Data were analyzed using a one-way ANOVA and paired Student's t-test. Results Participants with NGT: the D3 group showed a decrease in blood glucose area under the curve (AUC) when compared with the D1 group (13,639.2 ± 1585.9 vs. 16,756.6 ± 2709 mg · min/dL; P = 0.05). However, there was no difference with the placebo group (14,073.7 ± 1825.9 mg · min/dL, P = 0.9). When comparing the initial AUC vs. treatment AUC, the placebo, D2, and D3 groups decreased significantly (P = 0.01). Participants with prediabetes: the D3 group also show a significantly decreased in AUC when compared with the D2 group (19,815 ± 3153 vs. 27,545 ± 5398 mg · min/dL; P = 0.01). However, there was no difference with the placebo group (21,743.5 ± 4503 mg · min/dL, P = 0.8). Additionally, when comparing initial AUC vs. treatment AUC, only the D3 group decreased significantly (P = 0.01). Conclusions The comparison of the acute effect of three different doses of HPF showed a decrease in blood glucose (AUC) in a dose-dependent manner in participants with prediabetes. Funding Sources CONACYT Problemas Nacionales 2016-2081.

Plasma insulin and blood pressure in normotensive Japanese men with normal glucose tolerance

1995 ◽  
Vol 13 (4) ◽  
pp. 427???432 ◽  
Author(s):  
Katsuyuki Miura ◽  
Hideaki Nakagawa ◽  
Muneko Nishijo ◽  
Masaji Tabata ◽  
Yuko Morikawa ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Glucose Tolerance ◽  
Plasma Insulin ◽  
Normal Glucose Tolerance ◽  
Japanese Men ◽  
Normal Glucose

scholarly journals The Beta-Cell Function and Glucose Profile of Newly Diagnosed Acromegalic Patients with Normal Glucose Tolerance

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Quanya Sun ◽  
Xiaoqing Li ◽  
Peili Chen ◽  
Lili Chen ◽  
Xiaolong Zhao
Keyword(s):  
Blood Glucose ◽  
Glucose Tolerance ◽  
Cell Function ◽  
Normal Glucose Tolerance ◽  
Newly Diagnosed ◽  
Glucose Load ◽  
Β Cell ◽  
Glucose Profile ◽  
Normal Glucose ◽  
Β Cell Function

Objectives. Untreated acromegaly is a nature model for unveiling the diabetogenic effects of GH. CGMS can uncover more glucose profile of acromegaly. This study aimed to evaluate the insulin resistance (IR), β-cell function, and glycemic spectrum of patients with newly diagnosed acromegaly with normal glucose tolerance (NGT). Methods. This study was conducted in Huashan Hospital from January 2015 to February 2019. Eight newly diagnosed acromegalic patients without history of diabetes and eight age- and gender-matched healthy subjects were enrolled. All participants underwent oral glucose tolerance test (OGTT) and 72 h continuous glucose monitoring (CGM). Parameters on β-cell function and IR were calculated. Mean blood glucose (MBG) in 24 hours was adopted for the evaluation of the glycemic level, and standard deviation of blood glucose (SDBG) and mean amplitude of glycemic excursion (MAGE) were used for glucose fluctuation. Results. HbA1c in the acromegaly group was significantly higher than in the control. During OGTT, glucose peaked at 60 min in acromegaly and at 30 min in controls. After glucose load, the acromegaly group had significantly higher insulin levels than controls, especially in 120 min and 180 min. Both insulin sensitivity index and disposal index after glucose load of acromegaly were significantly lower than those of controls. Moreover, acromegalic subjects had significantly higher MBG than controls. Conclusions. The newly diagnosed acromegalic patients with NGT were characterized by IR and impaired β-cell function after glucose load. CGM showed that MBG of NGT acromegaly patients was higher than that of normal people.

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