scholarly journals Oxidized Low-Density Lipoprotein (Ox-LDL) and Triggering Receptor-Expressed Myeloid Cell (TREM-1) Levels Are Associated with Cardiometabolic Risk in Nonobese, Clinically Healthy, and Young Adults

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Cecilia Maria Passos Vázquez ◽  
Jamille Oliveira Costa ◽  
Lays Gisele Santos Bomfim ◽  
Liliane Viana Pires ◽  
Danielle Góes da Silva ◽  
...  
Keyword(s):  
Cardiometabolic Risk ◽  
Lipid Fraction ◽  
Low Density Lipoprotein ◽  
Plasma Concentrations ◽  
Density Lipoprotein ◽  
Atherogenic Index ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein ◽  
Fat Percentage ◽  
Anthropometric Parameters

Oxidative and inflammatory substances play an important role in the genesis of processes related to cardiometabolic risk. High levels of oxidized low-density lipoprotein (Ox-LDL) and of triggering receptor-expressed myeloid cells (TREM-1) are associated with cardiovascular and inflammatory diseases. In this study, we evaluate the association of the plasma concentrations of Ox-LDL and serum levels of circulating TREM-1 (sTREM-1) with the components of cardiometabolic risk (CMR) and other associated risk parameters. Although the individuals in this study were young, nonobese, and did not have signs, symptoms, and diagnosis of diseases, they already presented components of CMR. Ox-LDL lipid fraction correlated positively with CMR-related markers: body mass index (BMI), waist circumference (WC), body fat percentage, total cholesterol, LDL-c, VLDL-c, triglycerides, atherogenic cholesterol, and atherogenic index. Among these parameters, atherogenic cholesterol had a greater predictive effect for Ox-LDL alterations. Individuals with higher serum concentrations of sTREM-1 presented higher values for BMI, WC, triglycerides, VLDL-c, and atherogenic cholesterol. WC showed an effect on the association between the sTREM-1’s inflammatory response and the components of CMR. The association of oxidative and inflammatory markers with anthropometric parameters and atherogenic cholesterol in nonobese, clinically healthy, and young individuals suggests the importance of early evaluation of these markers in order to prevent future cardiac events.

scholarly journals Association of a polymorphism in the 3' untranslated region of the <i>OLR1</i> gene with milk fat and protein in dairy cows

2013 ◽  
Vol 56 (1) ◽  
pp. 328-334
Author(s):  
M. Soltani-Ghombavani ◽  
S. Ansari-Mahyari ◽  
M. A. Edriss
Keyword(s):  
Milk Fat ◽  
Untranslated Region ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Cell Surface Receptor ◽  
Low Density ◽  
Production Traits ◽  
Oxidized Low Density Lipoprotein ◽  
Fat Percentage ◽  
Surface Receptor

Abstract. Oxidized low density lipoprotein receptor 1 (OLR1) is the major cell surface receptor for oxidized low density lipoprotein (Ox-LDL). The role of OLR1 in lipid metabolism and the existence of milk-related QTL in the vicinity of the OLR1 gene have prompted the investigation of OLR1 as a candidate gene influencing milk production traits. The present study explored the association of a single nucleotide polymorphism (SNP) in the 3' untranslated region of the OLR1 gene (OLR1g.8232 C>A) with milk-related traits in 408 Iranian Holstein cows. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was performed for genotyping the animals. Animals with genotype CC had the highest and animals with genotype AA had the lowest fat percentage while genotype AC was intermediate (P<0.05). Cows carrying genotype CC showed more milk fat yield compared to the genotypes AC (P<0.1) and AA (P<0.01). Cows of genotypes CC and AC had a higher milk protein percentage than those of genotype AA (P<0.01). Regarding the association revealed, the SNP has the potential to be considered as a marker in marker-assisted selection.

scholarly journals Oxidized Low-Density Lipoprotein Predicts the Development of Renal Dysfunction in Atrial Fibrillation

2016 ◽  
Vol 7 (1) ◽  
pp. 31-41 ◽  
Author(s):  
Marija Polovina ◽  
Ivana Petrović ◽  
Voin Brković ◽  
Milika Ašanin ◽  
Jelena Marinković ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Sinus Rhythm ◽  
Low Density Lipoprotein ◽  
Plasma Concentrations ◽  
Density Lipoprotein ◽  
Control Group ◽  
Study Cohort ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein

Background/Aim: To investigate the role of oxidative stress (OS) in the development of chronic kidney disease (CKD) in atrial fibrillation (AF). Methods: We compared OS burden, determined at study inclusion as plasma concentrations of oxidized low-density lipoprotein (oxLDL), between stable AF patients (n = 256, mean age: 62.8 ± 9.3 years; 60.9% males) with preserved renal function, defined as an estimated glomerular filtration rate (eGFR) ≥60 ml/min/1.73 m2, and a matched control group in sinus rhythm (n = 138, mean age: 61.5 ± 11.2 years; 60.9% males). During the prospective follow-up of AF patients, we investigated the association and prognostic validity of oxLDL for CKD development, diagnosed as a sustained decline in eGFR to <60 ml/min/1.73 m2. Results: AF patients had a higher mean oxLDL (76.2 ± 21.7 U/l) compared to sinus rhythm controls (61.6 ± 13.1 U/l; p < 0.001). AF presence independently predicted increased oxLDL levels in the study cohort [β = 14.7; 95% confidence interval (CI), 10.7-18.7; p < 0.001]. Over a median 4-year follow-up, 19.9% of AF patients developed CKD. Adjusting for all clinical covariates, oxLDL (per tertile) was associated with a hazard ratio of 2.17 for CKD occurrence (95% CI, 1.40-3.35; p < 0.001). AF patients in the upper oxLDL tertile (≥88.7 U/l) had a 3.70-fold (95% CI, 1.55-8.81) higher risk for CKD compared to the lower oxLDL tertile (<67.0 U/l) patients (p < 0.001). oxLDL improved discriminative validity (c-statistic increment: 0.041, 95% CI, 0.007-0.075, p = 0.017), and increased the net reclassification and integrated discrimination for CKD risk by 12.4 and 6.0%, respectively (both p < 0.001). Conclusions: oxLDL is increased in AF patients compared to sinus rhythm controls. oxLDL has an independent association and an incremental predictive value that might complement clinical CKD risk assessment in AF patients following further research.

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