scholarly journals Pachychoroid Pigment Epitheliopathy and Choroidal Thickness Changes in Coeliac Disease

2019 ◽  
Vol 2019 ◽  
pp. 1-6 ◽  
Author(s):  
Selim Bolukbasi ◽  
Burak Erden ◽  
Akin Cakir ◽  
Alper Halil Bayat ◽  
Mustafa Nuri Elcioglu ◽  
...  
Keyword(s):  
Coeliac Disease ◽  
Choroidal Thickness ◽  
Healthy Controls ◽  
Prospective Comparative Study ◽  
The Mean ◽  
Thickness Measurements ◽  
Choroidal Vessels ◽  
Pachychoroid Pigment Epitheliopathy ◽  
Fellow Eyes ◽  
Sd Oct

Purpose. To evaluate choroidal thickness in patients with coeliac disease (CD) using spectral domain optical coherence tomography (SD-OCT) and to compare the results to normal eyes. Methods. Seventy patients with CD and 70 healthy controls were included in this prospective, comparative study. All participants underwent a complete ophthalmologic evaluation and SD-OCT. Subfoveal, nasal (nasal distance to fovea 500 μm, 1000 μm, and 1500 μm), and temporal (temporal distance to fovea 500 μm, 1000 μm, and 1500 μm) choroidal thickness measurements were performed using SD-OCT. Results. There were no significant differences in sex, ages, and axial lengths between the groups (p=1.0, p=0.601, p=0.314, respectively). The mean choroidal thickness measurements at all predefined measurement point areas were higher in the coeliac group than in the healthy controls (p<0.001). Of all patients with coeliac disease (70 eyes of 70 patients), 64 eyes (84.2%) had uncomplicated pachychoroid (UCP), one eye had pachychoroid pigment epitheliopathy (PPE), and five eyes in the UCP group had PPE in fellow eyes. Conclusion. It is probable that systemic inflammation in coeliac patients causes the enlargement of choroidal vessels and increasing choroidal thickness. PPE, which is believed to be the precursor of central serous chorioretinopathy, can be observed in coeliac patients.

scholarly journals Evaluation of Retinal and Choroidal Thickness in Fuchs’ Uveitis Syndrome

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Ozlem Balci ◽  
Mustafa Ozsutcu
Keyword(s):  
Choroidal Thickness ◽  
Macular Thickness ◽  
Fiber Layer ◽  
Control Subjects ◽  
Healthy Control ◽  
Fuchs Uveitis Syndrome ◽  
The Mean ◽  
Foveal Center ◽  
Thickness Measurements ◽  
Fellow Eyes

Purpose.We aimed to investigate retinal and choroidal thickness in the eyes of patients with Fuchs’ uveitis syndrome (FUS).Methods.Fifteen patients with unilateral FUS and 20 healthy control subjects were enrolled. Spectral domain optical coherence tomography (Spectralis HRA+OCT, 870 nm; Heidelberg Engineering, Heidelberg, Germany) was used to obtain retinal and choroidal thickness measurements. The retinal nerve fiber layer (RNFL) thickness, macular thickness, and choroidal thickness of the eyes with FUS were compared with the unaffected eye and the eyes of healthy control subjects.Results.The mean choroidal thickness at fovea and at each point within the horizontal nasal and temporal quadrants at 500 μm intervals to a distance of 1500 µm from the foveal center was significantly thinner in the affected eye of FUS patients compared with the unaffected eye of FUS patients or the eyes of healthy control subjects. However, there were no significant differences in RNFL or macular thickness between groups.Conclusions.Affected eyes in patients with FUS tend to have thinner choroids as compared to eyes of unaffected fellow eyes and healthy individuals, which might be a result of the chronic inflammation associated with the disease.

scholarly journals Comparison of choroidal thickness between amblyopic and non-amblyopic eyes

2018 ◽  
Vol 14 (3) ◽  
pp. 364-367
Author(s):  
Elly Liyana Zainodin ◽  
Chen Ai-Hong
Keyword(s):  
Choroidal Thickness ◽  
Enhanced Depth Imaging ◽  
Temporal Region ◽  
Depth Imaging ◽  
Corrected Visual Acuity ◽  
The Mean ◽  
Nasal Region ◽  
Thickness Measurements ◽  
Horizontal And Vertical Distribution ◽  
Fellow Eyes

Our study examined the choroidal thickness profile of children with myopic anisometropic amblyopia and compared the thickness with the fellow eyes. The choroidal thickness was measured with the enhanced depth imaging with spectral-domain optical coherence tomography. Manual segmentations of the choroid were performed on a 25-raster horizontal scan. The choroidal thickness measurements of the 9 subfields defined by the Early Treatment Diabetic Retinopathy Study (ETDRS) were evaluated. The mean spherical equivalent of the amblyopic eyes was -10.80 ± 0.41 D and the fellow eyes was -4.40 ± 2.05 D. The mean best corrected visual acuity of the amblyopic eyes and the fellow eyes were 0.94 ± 0.27 and 0.14 ± 0.05 logMAR respectively. The amblyopic eyes have longer axial length (26.46 ± 0.44 mm) compared to the fellow eyes (23.59 ± 1.18 mm). The average subfoveal choroidal thickness was 124.30 ± 40.71 µm in the amblyopic eyes and 246.80 ± 58.63 µm in the fellow eyes. The horizontal and vertical distribution pattern of choroidal thickness in amblyopic eyes was different from the fellow eyes. In amblyopic eye the choroidal thickness reduced from the temporal region to the nasal region. The fellow eyes had thickest choroid at the subfoveal area, followed by the temporal region and nasal region. In conclusion, the choroid was thinner in the amblyopic eyes than that of the fellow eyes at all regions.

scholarly journals Choroidal Thickening in Patients with Coronavirus Disease – 2019

2021 ◽  
Author(s):  
Mojtaba Abrishami ◽  
Zahra Emamverdian ◽  
Ramin Daneshvar ◽  
Neda Saeedian ◽  
Fariba Tohidinezhad ◽  
...  
Keyword(s):  
Choroidal Thickness ◽  
Outcome Measure ◽  
Normal Population ◽  
Retinal Pigment ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
The Mean ◽  
Choroidal Vessels ◽  
Sd Oct

Abstract Objective: To evaluate choroidal thickness in the macular region of patients with coronavirus disease 2019 (COVID-19).Methods: Patients recovered from COVID-19 were included in this cross-sectional study. Macular imaging with an SD-OCT device was performed at least 2 weeks after recovery from systemic COVID-19 and choroidal thickness was measured as the main outcome measure.Results: Thirty-four subjects were included in this study. One patient was monocular and high-quality SD-OCT images were available for the remaining 67 eyes. Dilated choroidal vessels were observed in 55 eyes (82%) and retinal pigment epitheliopathy was noticeable in 4 eyes (6%); these findings resemble those of the pachychoroid spectrum. The mean subfoveal choroidal thickness (SFCT) in our patients was 380.3±12.40 µm, which was significantly thicker than the previously reported SFCT in the normal population (310.7 ± 57.5 µm) (p<0.001).Conclusion: Patients with COVID-19 demonstrate remarkable changes in the choroid of the macular region.

scholarly journals Choroidal Thickness in Eyes with Unilateral Ocular Ischemic Syndrome

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Dong Yoon Kim ◽  
Soo Geun Joe ◽  
Joo Yong Lee ◽  
June-Gone Kim ◽  
Sung Jae Yang
Keyword(s):  
Carotid Artery ◽  
Retrospective Review ◽  
Carotid Artery Stenosis ◽  
Choroidal Thickness ◽  
Choroidal Circulation ◽  
Ocular Ischemic Syndrome ◽  
The Mean ◽  
Ischemic Syndrome ◽  
Choroidal Volume ◽  
Fellow Eyes

Aim. To analyze the subfoveal choroid thickness and choroidal volume in unilateral ocular ischemic syndrome (OIS).Methods. A retrospective review was conducted for all patients with unilateral OIS from October 2010 through June 2014. The subfoveal choroidal thickness (SFChT) and choroidal volume of both eyes were compared.Results. 19 unilateral OIS patients were included in this study. The mean SFChT of OIS eyes was significantly lower than that of fellow eyes (OIS eyes: 208.89 ± 82.62 μm and fellow eyes: 265.31 ± 82.77 μm,P<0.001). The choroidal volume of OIS eyes was significantly smaller than that of fellow eyes (OIS eyes: 0.16 ± 0.05 mm3and fellow eyes: 0.21 ± 0.05 mm3,P<0.001).Conclusion. The choroidal thickness and volume of OIS eyes were smaller than those of unaffected fellow eyes. Decreased choroidal circulation caused by carotid artery stenosis might affect the discordance of choroidal thickness and choroidal volume.

scholarly journals Comparison of Choroidal Thickness Measurements between Spectral-domain Optical Coherence Tomography and Swept-source Optical Coherence Tomography in Children

2021 ◽  
Author(s):  
Chun On Lee ◽  
Xiujuan Zhang ◽  
Shumin Tang ◽  
Li Jia Chen ◽  
Carol Cheung ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Correlation Coefficient ◽  
Choroidal Thickness ◽  
Relative Difference ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Normal Children ◽  
Swept Source ◽  
Thickness Measurements ◽  
Sd Oct

Abstract PURPOSE: Choroidal thickness is associated with many ocular conditions, interchangeability among different generations of optical coherence tomography is therefore important for both research purpose and clinical application. Hence, we compared choroidal thickness measurements between spectral-domain optical coherence tomography (SD-OCT) and swept-source optical coherence tomography (SS-OCT) in healthy pediatric eyes.METHODS: Children from the population–based Hong Kong Children Eye Study were recruited. Choroidal thickness was measured by both devices. Intra-class correlation coefficient (ICC) was used to compare the measurements.RESULTS: A total of 114 children with mean age of 7.38±0.82 years were included. The central foveal choroidal thickness (CFCT) measured by SD-OCT and SS-OCT was 273.24±54.29μm and 251.84±47.12μm respectively. Inter-device correlation coefficient was 0.840 (95%CI: 0.616-0.918). However, choroidal thickness obtained by SD-OCT was significantly thicker than that measured by SS-OCT with a mean difference of 21.40±33.13μm (P<0.001). Bland-Altman limit of agreement on the relative difference scale for SD-OCT/SS-OCT was 86.33μm. Validated conversion equation for translating SD-OCT CFCT measurement into SS-OCT was SS-OCT = 35.261 + 0.810 x SD-OCT. CONCLUSIONS: ICC shows an acceptable agreement between SD-OCT and SS-OCT, however, there was a significant inter-device difference of choroidal thickness measurements in normal children eyes. Therefore, the measurements are not interchangeable.

scholarly journals Validation of Macular Choroidal Thickness Measurements from Automated SD-OCT Image Segmentation

2016 ◽  
Vol 93 (11) ◽  
pp. 1387-1398 ◽  
Author(s):  
Michael D. Twa ◽  
Krystal L. Schulle ◽  
Stephanie J. Chiu ◽  
Sina Farsiu ◽  
David A. Berntsen
Keyword(s):  
Image Segmentation ◽  
Choroidal Thickness ◽  
Thickness Measurements ◽  
Oct Image ◽  
Sd Oct

scholarly journals The Impact of Migraine on Posterior Ocular Structures

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Süleyman Demircan ◽  
Mustafa Ataş ◽  
Sevgi Arık Yüksel ◽  
Melek D. Ulusoy ◽  
İsa Yuvacı ◽  
...  
Keyword(s):  
Choroidal Thickness ◽  
Healthy Controls ◽  
Ischemic Insult ◽  
Fiber Layer ◽  
Horizontal Section ◽  
Rnfl Thickness ◽  
Migraine Group ◽  
The Mean ◽  
The Impact ◽  
The Relationship

Purpose. To investigate the thickness of the retinal nerve fiber layer (RNFL) and choroid in patients who have migraines in comparison to healthy controls.Methods. This study included 76 eyes and patients in the migraine group, 36 with aura (MWA group) and 40 without (MWoA group), and 38 eyes as control subjects. The RNFL and macular thicknesses were analysed with standard OCT protocol while choroidal thickness was analysed with EDI protocol in all subjects. Choroidal thickness was measured at the fovea, 1500 µm nasal and 1500 µm temporal to the fovea in a horizontal section.Results. The mean RNFL thickness for nasal and nasal inferior sectors was significantly thinner (P≤0.018) in the migraineurs’ eyes than in those of the controls, as was the mean choroid thickness at the fovea and measured points (P<0.0001). However, the mean macular thickness was not significantly different between the groups.Conclusions. This study suggests that migraine leads to a reduction in the peripapillary RNFL thickness and to thinning in choroidal structures. These findings can be explained by a chronic ischemic insult related to migraine pathogenic mechanisms and these findings are considered supportive of the relationship between glaucoma and migraine.

scholarly journals Involvement of Inner Choroidal Layer in Choroidal Thinning during Regression of Multiple Evanescent White Dot Syndrome

2019 ◽  
Vol 2019 ◽  
pp. 1-6 ◽  
Author(s):  
Yuki Hashimoto ◽  
Wataru Saito ◽  
Yuka Hasegawa ◽  
Kousuke Noda ◽  
Susumu Ishida
Keyword(s):  
Regression Analysis ◽  
Linear Regression ◽  
Choroidal Thickness ◽  
Linear Regression Analysis ◽  
Case Series ◽  
Enhanced Depth Imaging ◽  
Initial Visit ◽  
White Dot Syndrome ◽  
The Mean ◽  
Fellow Eyes

Purpose. To investigate relationships between total thickness and the thickness of inner and outer layers in the choroid during regression in patients with multiple evanescent white dot syndrome (MEWDS). Methods. This retrospective observational case series included 15 unilaterally affected eyes and 13 unaffected fellow eyes from 15 MEWDS patients (4 men and 11 women; mean age, 37.6 ± 17.6 years). Using enhanced depth imaging optical coherence tomography, whole, inner, and outer choroidal layer thicknesses at the fovea and perifovea were manually measured at the initial visit and at 1 and 3 months after the initial visit. The mean thickness values of the layers were compared at each stage. Results. With regression of MEWDS, the mean subfoveal whole and inner choroidal layer thicknesses significantly decreased at 1 and 3 months compared to baseline values in MEWDS eyes (P=0.01 and P<0.0001, respectively), but not in fellow eyes. The outer layer in MEWDS eyes tended to thin. Changes in the inner and outer layers at the perifovea in MEWDS eyes also showed the same trends. Simple linear regression analysis revealed significant positive correlations in choroidal thickness changes between the whole and inner layers (R = 0.53, P=0.04) and between the whole and outer layers (R = 0.91, P<0.0001) from baseline to 3 months. Multiple linear regression analysis revealed that choroidal thickness changes in the whole layer were significantly correlated with those in the inner (β = 0.51, P<0.0001) and outer (β = 0.73, P<0.0001) layers. Conclusion. The inner choroidal layer significantly thinned with regression of MEWDS, correlating with the thinning of total choroidal thickness. These results suggest that MEWDS lesions in the choroid are likely to lie mainly in the inner layer.

Choroidal thickness and vessel pattern in myopic eyes with dome-shaped macula

2021 ◽  
pp. bjophthalmol-2021-319066
Author(s):  
Pierre Negrier ◽  
Aude Couturier ◽  
David Gaucher ◽  
Sara Touhami ◽  
Guillaume Le Guern ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Retrospective Study ◽  
Retinal Detachment ◽  
Choroidal Thickness ◽  
Serous Retinal Detachment ◽  
Wide Field ◽  
Macular Area ◽  
The Mean ◽  
Choroidal Vessels ◽  
Bulge Height

AimTo analyse the choroidal thickness (CT) and vessel pattern of myopic patients with dome-shaped macula (DSM) and their association with the DSM axis and serous retinal detachment (SRD).MethodsRetrospective study. The CT and vessel pattern were assessed on optical coherence tomography (OCT), OCT-angiography and ultra-wide-field photography.Results27 eyes of 18 subjects (mean age: 65 years) were included. Compared with the 11 eyes (41%) with horizontal DSM, the 16 eyes (59%) with vertical DSM had a shorter axial length (25.8±2 mm vs 28.3±2.5 mm; p=0.01), a higher mean macular bulge height (624.4±207 µm vs 255.4±160.3 µm; p=0.0001) and a thicker CT (183.1±91.1 µm vs 72±38.3 µm; p<0.001). Large choroidal vessels crossed the macular area in 75% of eyes with vertical DSM vs 27% of eyes with horizontal DSM (p=0.02), whereas a watershed zone framing the macula was more often seen in horizontal DSM (72% vs 25%, p=0.02). Thirteen eyes (48%) had an SRD that was not associated with the DSM axis, the mean bulge height, the CT or the vessel pattern.ConclusionThe presence of an SRD did not correlate with the DSM axis, the CT or the vessel pattern. However, the rate of large choroidal vessels crossing the macula was higher in vertical DSM than in horizontal DSM.

scholarly journals Pachychoroid as a biomarker using optical coherence tomography – swept-source in central serous choroidopathy

2019 ◽  
Vol 2 ◽  
pp. 3
Author(s):  
René Alfredo Cano-Hidalgo ◽  
Tatiana Urrea-Victoria
Keyword(s):  
Optical Coherence Tomography ◽  
Choroidal Thickness ◽  
Invasive Technique ◽  
Optical Coherence ◽  
Horizontal Section ◽  
Swept Source ◽  
Non Invasive ◽  
The Mean ◽  
Foveal Center ◽  
Fellow Eyes

Objective The objective of the study was to describe and evaluate the subfoveal choroidal thickness (SFCT) in the fellow eyes of patients with central serous chorioretinopathy (CSC) using swept source optical coherence tomography (SS-OCT). Methods This was a transversal, retrospective, and observational study. The SFCT was measured in patients with unilateral CSC using SS-OCT. The choroidal thickness in symptomatic and fellow eyes was measured using the attached measuring software in SS-OCT. The SFCT dimension was obtained from the horizontal section under the foveal center from the OCT data and these data were analyzed. Results The mean age of subjects undergoing imaging SS-OCT was 44.23 years old (standard deviation, 11.57). 30 out of 60 patients (63.3%) were men, and 20 (33.3%) patients had acute clinical disease. The median choroidal thicknesses of the affected eyes were greater than those of the unaffected fellow eyes (P = 0.06). The choroidal thickness measured in 120 eyes of (60 patients) was 421 µm (interquartile range 352–490), which was greater than the choroidal thickness reported in normal eyes. Conclusions The measuring of the choroidal thickness using SS-OCT is useful as a non-invasive technique to evaluate the subclinical choroidal abnormalities in CSC.

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