scholarly journals Relationships between Serum Uric Acid, Malondialdehyde Levels, and Carotid Intima-Media Thickness in the Patients with Metabolic Syndrome

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Shun-Sheng Wu ◽  
Chew-Teng Kor ◽  
Ting-Yu Chen ◽  
Ko-Hung Liu ◽  
Kai-Lun Shih ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Uric Acid ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Serum Markers ◽  
Oxidative Stress Biomarkers ◽  
Cross Sectional ◽  
Carotid Imt ◽  
Media Thickness

Oxidative stress is the major cause of atherosclerosis and cardiovascular diseases. This cross-sectional study is aimed at determining if parallel serum markers of oxidative stress are related to carotid intima-media thickness (IMT). We enrolled 134 participants with varied metabolic syndrome (Met-S) scores (zero, n=21; one, n=19; two, n=27; three, n=26; four, n=25; five, n=16). Biochemical profiles and potential oxidative stress biomarkers malondialdehyde (MDA) and uric acid were measured in fasting plasma. We found that carotid IMT positively correlated with both MDA and uric acid levels. Multivariate analysis revealed that both MDA (p<0.05) and uric acid (p<0.01) levels were significantly associated with carotid IMT in participants whose Met-S scores were ≥1 or ≥2. However, only uric acid (p<0.01) levels were positively associated with carotid IMT in patients with metabolic syndrome. Linear regression model analysis revealed that the prediction accuracies for carotid IMT from MDA combined with uric acid and from a combination of MDA, uric acid, and Met-S score were 0.176 and 0.237, respectively. These were better than the predication accuracies from MDA (r2=0.075) and uric acid (r2=0.148) individually. These results suggest that measuring uric acid levels along with MDA biomarkers and Met-S scores may be a promising step in the development of an effective model for monitoring the severity of carotid IMT and atherosclerosis in the patients with metabolic syndrome.

Are Uremia, Diabetes, and Atherosclerosis Linked With Impaired Antioxidant Mechanisms?

2008 ◽  
Vol 56 (2) ◽  
pp. 545-552 ◽  
Author(s):  
Belda Dursun ◽  
Evrim Dursun ◽  
Irfan Capraz ◽  
Tomris Ozben ◽  
Ali Apaydin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Intima Media Thickness ◽  
Chronic Kidney Failure ◽  
Carotid Intima Media Thickness ◽  
Diabetic Patients ◽  
Carotid Imt ◽  
Accelerated Atherosclerosis ◽  
Media Thickness ◽  
Diabetes Status ◽  
Antioxidant Mechanisms

BackgroundOxidative stress is a new risk factor for atherosclerosis. Increased oxidative stress in hemodialysis (HD) patients may arise from uremia-associated metabolic/humoral abnormalities and bioincompatibility of dialysis. Patients with diabetes mellitus (DM) may be subject to an additional risk. Respective influences of uremia, diabetes, and HD duration in accelerated atherosclerosis and oxidative stress have not been clarified yet.MethodsThe study was performed on 24 nondiabetic HD patients, 23 diabetic HD patients, 20 stages 3 to 4 chronic kidney disease patients, and 21 diabetic patients without overt nephropathy. Carotid intima-media thickness, a surrogate of atherosclerosis, was measured by high-resolution B-mode ultrasonography. Oxidant status was determined by lipid peroxidation as expressed by malondialdehyde (MDA); antioxidant status was determined by superoxide dismutase, catalase, glutathione peroxidase, reduced intracellular glutathione, and plasma thiol.ResultsIntima-media thickness (IMT) was higher in patients undergoing HD but not different between nondiabetic HD patients and diabetic HD patients. No correlation was found between the duration of HD and intima-media thickness. Antioxidants were generally lower in HD patients. Intima-media thickness was positively correlated with MDA and negatively correlated with plasma thiol. Among other risk factors, only age was correlated with intima-media thickness.ConclusionsIncreased carotid IMT in HD patients is independent of duration of HD or diabetes status. Age and MDA are the significant predictors of carotid IMT. Increased oxidative stress due to impaired antioxidant mechanisms, particularly reduced plasma thiol redox potential, may account for accelerated atherosclerosis in high-risk patients with chronic kidney failure and/or DM.

scholarly journals Relationship Between Metabolic Syndrome and Carotid Intima-Media Thickness: Cross-Sectional Comparison Between Psoriasis and Psoriatic Arthritis

2013 ◽  
Vol 66 (1) ◽  
pp. 97-103 ◽  
Author(s):  
Yih Chang Lin ◽  
Deepan Dalal ◽  
Sarah Churton ◽  
Danielle M. Brennan ◽  
Neil J. Korman ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Psoriatic Arthritis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Cross Sectional ◽  
Media Thickness

scholarly journals Carotid artery intima–media thickness, distensibility and elasticity: population epidemiology and concordance in Australian children aged 11–12 years old and their parents

BMJ Open ◽  
2019 ◽  
Vol 9 (Suppl 3) ◽  
pp. 23-33 ◽  
Author(s):  
Richard S Liu ◽  
Sophie Dunn ◽  
Anneke C Grobler ◽  
Katherine Lange ◽  
Denise Becker ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Correlation Coefficients ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Repeated Measurements ◽  
Linear Regression Models ◽  
Cross Sectional ◽  
Carotid Imt ◽  
Media Thickness ◽  
Parent Child

ObjectivesTo describe a well-established marker of cardiovascular risk, carotid intima–media thickness (IMT) and related measures (artery distensibility and elasticity) in children aged 11–12 years old and mid-life adults, and examine associations within parent–child dyads.DesignCross-sectional study (Child Health CheckPoint), nested within a prospective cohort study, the Longitudinal Study of Australian Children (LSAC).SettingAssessment centres in seven Australian major cities and eight selected regional towns, February 2015 to March 2016.ParticipantsOf all participating CheckPoint families (n=1874), 1489 children (50.0% girls) and 1476 parents (86.8% mothers) with carotid IMT data were included. Survey weights and methods were applied to account for LSAC’s complex sample design and clustering within postcodes and strata.Outcome measuresUltrasound of the right carotid artery was performed using standardised protocols. Primary outcomes were mean and maximum far-wall carotid IMT, quantified using semiautomated edge detection software. Secondary outcomes were carotid artery distensibility and elasticity. Pearson’s correlation coefficients and multivariable linear regression models were used to assess parent–child concordance. Random effects modelling on a subset of ultrasounds (with repeated measurements) was used to assess reliability of the child carotid IMT measure.ResultsThe average mean and maximum child carotid IMT were 0.50 mm (SD 0.06) and 0.58 mm (SD 0.05), respectively. In adults, average mean and maximum carotid IMT were 0.57 mm (SD 0.07) and 0.66 mm (SD 0.10), respectively. Mother–child correlations for mean and maximum carotid IMT were 0.12 (95% CI 0.05 to 0.23) and 0.10 (95% CI 0.03 to 0.21), respectively. For carotid artery distensibility and elasticity, mother–child correlations were 0.19 (95% CI 0.10 to 0.25) and 0.11 (95% CI 0.02 to 0.18), respectively. There was no strong evidence of father–child correlation in any measure.ConclusionsWe provide Australian values for carotid vascular measures and report a modest mother–child concordance. Both genetic and environmental exposures are likely to contribute to carotid IMT.

scholarly journals Association between carotid intima media thickness and metabolic syndrome

2018 ◽  
Vol 5 (6) ◽  
pp. 1503
Author(s):  
Abhishek T. G. ◽  
Arathi Darshan ◽  
Jayaprakash S. Appajigol ◽  
Naveen Angadi ◽  
Vijayalakshmi Chikkamath
Keyword(s):  
Metabolic Syndrome ◽  
Total Cholesterol ◽  
Subclinical Atherosclerosis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Cross Sectional Study ◽  
Research Centre ◽  
Cross Sectional ◽  
Media Thickness ◽  
The Mean

Background: Metabolic syndrome and its individual criteria pose a risk for atherosclerosis and cardiovascular disease (CVD). Carotid intima media thickness (CIMT) is a well-known marker of subclinical atherosclerosis. This study was aimed to assess CIMT in patients with metabolic syndrome.Methods: This one year cross-sectional study was conducted in the Department of Medicine, KLES Dr. Prabhakar Kore Hospital and Medical Research Centre, Belagavi from January 2016 to December 2016. A total of 100 patients diagnosed to have metabolic syndrome based on national cholesterol education program adult treatment panel III (NCEP ATP III) criteria were studied. All the patients were subjected to carotid B mode ultrasonography.Results: The most common age group was 51 to 60years (29%). Out of 100 individuals who were diagnosed to have metabolic syndrome, 60% had five criteria, 29% had four criteria and 3% had three criteria. Most of the of the individuals (61.00%) had normal (≤0.10cms) CIMT while high (>0.10cm) levels were noted in 39.00% of the individuals. The mean CIMT was noted as 0.13±0.16cms. The mean SBP (150.15±10.39 vs 142.98±20.09mmHg; p=0.042), DBP (94.51±6.53 vs 90.16±9.91 mmHg; p=0.017), total cholesterol levels (243.53±65.74 vs 195.95±29.8 mg/dL; p<0.001) and triglyceride levels (221.07±48.44 vs 180.85±24.74mg/dL; p <0.001) were noted in individuals with raised CIMT compared to individuals with normal CIMT. Majority of the individuals had abnormal HDL (93.00%) and 41.94% of the individuals with abnormal HDL had raised CIMT (p=0.027).Conclusions: Some individuals with metabolic syndrome are likely to have raised CIMT. The rise in CIMT among the patients with metabolic syndrome is associated with raised SBP, DBP, abnormal HDL (specifically in males), total cholesterol and triglycerides.

scholarly journals The optimal WC cut-off points for the prediction of subclinical CVD as measured by carotid intima-media thickness among African adults: a cross-sectional study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
M. C. Ringane ◽  
S. S. R. Choma
Keyword(s):  
Metabolic Syndrome ◽  
Waist Circumference ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Media Thickness ◽  
Bivariate Correlation ◽  
Subclinical Cvd

Abstract Background Increased waist circumference (WC) is one of the cardiovascular disease (CVD) risk factors used to predict cardiovascular events. Waist circumference cut-off values for predicting metabolic syndrome and other cardiovascular risks have been previously studied. Carotid intima-media thickness (CIMT) is one of the cardiovascular risk factor recently described and reported to be suitable as it is a direct measurement of vascular quality. Hence the aim of the present study was to determine the optimal WC cut-off point for the prediction of subclinical CVD. Methods The study was a cross-sectional study using quantitative methods, conducted among 1318 adults aged between 40 and 60 years old, residing in a rural Black population in Limpopo province. Carotid Intima-Media Thickness measurements were performed using a LOGIQ ultrasound system (GE Healthcare, CT, USA). Waist Circumference (WC) (cm) was measured to the nearest 0.1 cm. Bivariate correlation, logistic regression and receiver operating characteristic were analysed using the statistical package for social sciences version 26.0 software. Results Among the total population, 69% were women and 31% men with a mean age of 53 ± 7 years. Among women, WC at a cut-off value of 95 cm gave the highest sensitivity of 57%, the specificity of 55% and an area under the curve (AUC) of 0.588. In men, an optimum WC cut-off point of 82 cm yielded the highest sensitivity and specificity at 72% and 70% respectively, with an AUC of 0.767 p < 0.001. Conclusion The traditional waist circumference cut-off points (94 cm for women and 80 cm for men) that are currently used for the diagnosis of metabolic syndrome might not be suitable in the prediction of an increased CIMT.

scholarly journals Accuracy of Different Metabolic Syndrome Definitions for Detecting Increased Carotid Intima-media Thickness in Peruvian Type 2 Diabetes Mellitus Subjects without Cardiovascular Disease.

2020 ◽  
Author(s):  
Alberto Teruya-Gibu ◽  
Marlon Yovera-Aldana ◽  
Diana Urquiza-Salvador ◽  
Laurie Marcilla-Trullenque
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Type 2 Diabetes Mellitus ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Cross Sectional ◽  
Media Thickness ◽  
Bilateral Carotid

Abstract Backrgound: To estimate the accuracy of metabolic syndrome definitions for detecting Carotid Intima-Media thickness (CIMT) in Peruvian type 2 diabetes mellitus (T2DM) subjects without cardiovascular events.Methods: We performed a cross-sectional evaluation of T2DM subjects from the endocrinology service of two reference health centers without stroke or coronary disease. . Bilateral carotid intima-media thickness was measure by B mode ultrasound one only operator. We performed four definitions of Metabolic Syndrome; 1. Cholesterol Education Program Adult Treatment Panel III (ATP III), 2. Harmonized criteria; 3. Gurka's Metabolic syndrome severity score (MSSS) formula. 4. Non-glucose modified MSSS. We calculated the area under the receiver operator curve (AUROC) for detecting increased CIMT (≥ 0.86 mm) between metabolic syndrome definitions. Results: We included 184 subjects with T2DM, 29% were men with a mean age of 61.5 ± 10.5 years old. Median diabetes time was 10.8 years (IQR 4.8 to 19.4), and 26.8% achieved HbA1c goals. Non-glucose modified MSSS was the only definition significantly correlated with elevated CIMT (r = 0.19; p<0.01), and it showed the best accuracy for predicting elevated CIMT (AUC: 0.61, CI95%: 0.52-0.70). Adjusting for age, sex, and HbA1c, each point increase in the non-glucose MSSS Z score, the risk of altered CIMT increases by 59% RP 1.59 (CI 95% 1.09 - 2.35; p=0.017). Conclusions: Non-glucose modified MSSS had a weak accuracy for elevated CIMT and was the best compared to ATP III, harmonized, and original MSSS. Further research on no MS-factors is required to predict better elevated CIMT.

scholarly journals Dietary zinc intake is inversely related to subclinical atherosclerosis measured by carotid intima-media thickness

2010 ◽  
Vol 104 (8) ◽  
pp. 1202-1211 ◽  
Author(s):  
Yoon Jung Yang ◽  
Bo Youl Choi ◽  
Byung-Yeol Chun ◽  
Sun-Seog Kweon ◽  
Young-Hoon Lee ◽  
...  
Keyword(s):  
Morphological Changes ◽  
Subclinical Atherosclerosis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Epidemiological Studies ◽  
Protective Role ◽  
Cross Sectional ◽  
Carotid Imt ◽  
Media Thickness ◽  
The Relationship

The relationship between dietary Zn intake and the risk of atherosclerosis remains unclear, and no epidemiological studies have been reported on the effects of dietary Zn intake on morphological changes in the vascular wall. We examined the relationship between dietary Zn intake and common carotid intima-media thickness (IMT) as a marker of subclinical atherosclerosis among the middle-aged and elderly populations. A cross-sectional analysis of a prospective cohort baseline study was performed with 4564 adults aged 40–89 years and free of clinical CVD. Dietary data were collected by trained interviewers using an FFQ. Common carotid IMT was measured using a B-mode ultrasound imaging technique. Subclinical atherosclerosis was determined using carotid IMT, and defined as >80th percentile of carotid IMT or ≥ 1 mm of carotid IMT. After adjustment for potential confounders, the mean carotid IMT in the low Zn intake group was higher than that in the high Zn intake group. When subclinical atherosclerosis was defined as >80th percentile value of IMT or ≥ 1 mm of carotid IMT, after adjustment for potential confounders, Zn intake was inversely related to subclinical atherosclerosis (5thv.1st quintile, OR 0·64, 95 % CI 0·45, 0·90,Pfor trend = 0·069; 5thv.1st quintile, OR 0·34, 95 % CI 0·16, 0·70,Pfor trend = 0·005, respectively). In persons free of clinical CVD, dietary Zn intake was inversely correlated with subclinical atherosclerosis. The present findings suggest a putative protective role of dietary Zn intake against the development of atherosclerosis.

RELATONSHIP BETWEEN SERUM LIPOPROTEIN-ASSOCIATED PHOSPHOLIPSAE A2 AND CAROTD INTMAMEDIA THICKNESS WITH CEREBRAL INFARCTON

2016 ◽  
pp. 20-24
Author(s):  
Van Tam Le ◽  
Phuong Thao Tien Nguyen ◽  
Dinh Toan Nguyen ◽  
Thi Yen Le ◽  
Thi Phuong Anh Le
Keyword(s):  
Cerebral Infarction ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Serum Lipoprotein ◽  
University Hospital ◽  
External Carotid ◽  
Cross Sectional ◽  
Carotid Imt ◽  
Media Thickness ◽  
Carotid Intimamedia Thickness

Background and Purpose: Cerebral atherosclerosis is the leading cause of mechanical obstruction of blood flow that final event is cerebral infarction. Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an inflammatory biomarkers specific for blood vessels, is an important factor predicted extent of atherosclerosis. The study aimed to assess the association between serum Lp-PLA2 concentration with carotid intimamedia thickness (IMT). Materials andMethod: The cross – sectional study, in 37 patients who presented to Department of Cardiology - Hue University Hospital and Hue Central Hospital. Vulnerability asessment of the external carotid artery into the skull through ultrasound by measuring carotid intima-media thickness. Testing serum Lp-PLA2 concentration, lipid profile, blood glucose. Results: Group of patients with thickness of carotid IMT levels of serum Lp-PLA2 was 27.73 IU/ml higher than the group with thickness normal carotid IMT was 14.35 IU/ml; p < 0.05. Total cholesterol, LDL cholestrol, triglycerid and Lp-PLA2 are the factors capable of predict the changes in size IMT; (p <0.05). There is moderate correlation between Lp-PLA2 levels and carotid intima-media thickness (r = 0.47; p < 0.05). Conclusion: Higher Lp-PLA2 levels is significantly associated with carotid intimamedia thickness in patients who have cerebral infarction. Key words: Stroke, atherosclerosis, inflammation, biomarker.

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